Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P60524

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
2	MEP peptidase (nematode)	1-146	N		MS	Williamson et al., 2004
4	necepsin-1	1-146	N		NT	Williamson et al., 2003
5	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
8	necepsin-1	1-146	N		NT	Williamson et al., 2003
9	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
10	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
11	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
12	cathepsin B-like peptidase, nematode	1-146	N		MS	Williamson et al., 2004
13	MEP peptidase (nematode)	1-146	N		MS	Williamson et al., 2004
14	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
15	cathepsin B-like peptidase, nematode	1-146	N		MS	Williamson et al., 2004
16	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
20	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
22	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
25	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
27	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
28	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
29	cathepsin B-like peptidase, nematode	1-146	N		MS	Williamson et al., 2004
30	cathepsin B-like peptidase, nematode	1-146	N		MS	Williamson et al., 2004
31	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
32	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
34	cathepsin B-like peptidase, nematode	1-146	N		MS	Williamson et al., 2004
35	cathepsin B-like peptidase, nematode	1-146	N		MS	Williamson et al., 2004
36	cathepsin B-like peptidase, nematode	1-146	N		MS	Williamson et al., 2004
38	cathepsin B-like peptidase, nematode	1-146	N		MS	Williamson et al., 2004
39	cathepsin B-like peptidase, nematode	1-146	N		MS	Williamson et al., 2004
41	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
42	necepsin-1	1-146	N		NT	Williamson et al., 2003
45	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
47	MEP peptidase (nematode)	1-146	N		MS	Williamson et al., 2004
50	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
52	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
53	necepsin-1	1-146	N		NT	Williamson et al., 2003
56	cathepsin B-like peptidase, nematode	1-146	N		MS	Williamson et al., 2004
57	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
58	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
64	necepsin-1	1-146	N		NT	Williamson et al., 2003
65	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
68	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
69	cathepsin B-like peptidase, nematode	1-146	N		MS	Williamson et al., 2004
72	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
73	cathepsin B-like peptidase, nematode	1-146	N		MS	Williamson et al., 2004
76	MEP peptidase (nematode)	1-146	N		MS	Williamson et al., 2004
77	MEP peptidase (nematode)	1-146	N		MS	Williamson et al., 2004
78	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
79	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
80	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
81	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
83	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
85	necepsin-1	1-146	N	normal turnover		Williamson et al., 2004
86	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
88	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
92	necepsin-1	1-146	N		NT	Williamson et al., 2003
94	necepsin-1	1-146	N		NT	Williamson et al., 2003
96	cathepsin B-like peptidase, nematode	1-146	N		MS	Williamson et al., 2004
99	cathepsin B-like peptidase, nematode	1-146	N		MS	Williamson et al., 2004
102	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
103	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
105	MEP peptidase (nematode)	1-146	N		MS	Williamson et al., 2004
106	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
108	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
110	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
111	necepsin-1	1-146	N	normal turnover		Williamson et al., 2004
111	cathepsin B-like peptidase, nematode	1-146	N		MS	Williamson et al., 2004
112	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
117	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
121	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
125	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
127	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
128	MEP peptidase (nematode)	1-146	N		MS	Williamson et al., 2004
129	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
134	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
135	MEP peptidase (nematode)	1-146	N		MS	Williamson et al., 2004
136	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2003
139	necepsin-1	1-146	N		NT	Williamson et al., 2003
139	cathepsin B-like peptidase, nematode	1-146	N		MS	Williamson et al., 2004
140	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004
142	necepsin-1	1-146	N	normal turnover	MS	Williamson et al., 2004