$VAR1 = undef;

Summary for peptidase A01.022: plasmepsin-1

Names
MEROPS Name	plasmepsin-1
Other names	aspartic hemoglobinase I (Plasmodium falciparum), PFAPG, plasmepsin I, plasmepsin Pf-I

Domain architecture

MEROPS Classification
Classification	Clan AA >> Subclan (none) >> Family A1 >> Subfamily A >> A01.022
Holotype	plasmepsin-1 (Plasmodium falciparum), Uniprot accession P39898 (peptidase unit: 126-449), MERNUM MER0001799
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Aspartic
Peplist	Included in the Peplist with identifier PL00018
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.23 (Aspartic endopeptidases) >> Peptidase 3.4.23.38
Enzymology	BRENDA database
Proteolytic events	CutDB database (1 cleavage)
Physiology	Digestion of haemoglobin in the nutrition of the malaria organism Plasmodium falciparum (Francis et al., 1997).
Pharmaceutical relevance	Potential drug target for malaria (Francis et al., 1997).
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/Plasmepsin
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	e/-/-/F-/-/lf/- (based on 13 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	1	1	0	0	0	0	1
Pro	1	1	0	0	0	0	0	3
Ala	0	0	2	1	0	3	0	0
Val	1	1	1	0	0	1	1	1
Leu	1	2	0	2	3	2	4	0
Ile	0	0	1	0	0	0	0	0
Met	0	0	2	0	0	0	0	0
Phe	1	2	0	10	2	0	3	1
Tyr	0	0	0	0	1	0	0	1
Trp	0	0	0	0	0	0	0	0
Ser	1	0	0	0	0	3	2	1
Thr	1	1	0	0	1	0	1	0
Cys	0	0	0	0	0	0	0	0
Asn	0	0	2	0	0	0	0	0
Gln	0	2	0	0	0	2	0	0
Asp	0	0	0	0	1	0	0	0
Glu	6	0	0	0	0	1	0	0
Lys	1	0	1	0	1	1	2	3
Arg	0	3	2	0	0	0	0	0
His	0	0	1	0	0	0	0	1