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Literature for peptidase A01.022: plasmepsin-1

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, K Knockout, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2020
  1. Nasamu,A.S., Polino,A.J., Istvan,E.S. and Goldberg,D.E.
    Malaria parasite plasmepsins: more than just plain old degradative pepsins
    J Biol Chem (2020) PubMed  Europe PubMed DOI
    2. 2019
  2. Bobrovs,R., Jaudzems,K. and Jirgensons,A.
    Exploiting structural dynamics to design open-flap inhibitors of malarial aspartic proteases
    J Med Chem (2019) 62, 8931-8950. PubMed  Europe PubMed DOI  I
  3. Thillainayagam,M., Malathi,K., Anbarasu,A., Singh,H., Bahadur,R. and Ramaiah,S.
    Insights on inhibition of Plasmodium falciparum plasmepsin I by novel epoxyazadiradione derivatives - molecular docking and comparative molecular field analysis
    J Biomol Struct Dyn (2019) 37, 3168-3182. PubMed  Europe PubMed DOI  I
    4. 2016
  4. Chaudhary,K.K., Raj,U., Varadwaj,P.K. and Mishra,N.
    Novel potent plasmepsin-I (PMI) inhibitors: an in-silico approach
    Curr Proteomics (2016) 13, 196-205. DOI  I
  5. Ponsuwanna,P., Kochakarn,T., Bunditvorapoom,D., Kumpornsin,K., Otto,T.D., Ridenour,C., Chotivanich,K., Wilairat,P., White,N.J., Miotto,O. and Chookajorn,T.
    Comparative genome-wide analysis and evolutionary history of haemoglobin-processing and haem detoxification enzymes in malarial parasites
    Malar J (2016) 15, 51-51. PubMed  Europe PubMed DOI  PMC  EPMC
  6. Rasina,D., Otikovs,M., Leitans,J., Recacha,R., Borysov,O.V., Kanepe-Lapsa,I., Domraceva,I., Pantelejevs,T., Tars,K., Blackman,M.J., Jaudzems,K. and Jirgensons,A.
    Fragment-based discovery of 2-aminoquinazolin-4(3h)-ones as novel class nonpeptidomimetic inhibitors of the plasmepsins I, II, and IV
    J Med Chem (2016) 59, 374-387. PubMed  Europe PubMed DOI  I
    7. 2015
  7. McGillewie,L. and Soliman,M.E.
    Flap flexibility amongst plasmepsins I, II, III, IV, and V: sequence, structural, and molecular dynamics analyses
    Proteins (2015) 83, 1693-1705. PubMed  Europe PubMed DOI
    8. 2014
  8. Levita,J., Chao,K.H. and Mutakin
    Interactions of ganoderiol-F with aspartic proteases of HIV and plasmepsin for anti-HIV and anti-malaria discovery
    Int J Pharmcy Pharm Sci (2014) 6, 561-566.  I
  9. Lolupiman,S., Siripurkpong,P. and Yuvaniyama,J.
    Disulfide linkages in Plasmodium falciparum plasmepsin-I are essential elements for its processing activity and multi-milligram recombinant production yield
    PLoS ONE (2014) 9, e89424-e89424. PubMed  Europe PubMed DOI  PMC  EPMC  E
    10. 2013
  10. Aureggi,V., Ehmke,V., Wieland,J., Schweizer,W.B., Bernet,B., Bur,D., Meyer,S., Rottmann,M., Freymond,C., Brun,R., Breit,B. and Diederich,F.
    Potent inhibitors of malarial aspartic proteases, the plasmepsins, by hydroformylation of substituted 7-azanorbornenes
    Chemistry (2013) 19, 155-164. PubMed  Europe PubMed DOI  I
    11. 2012
  11. Berry,C. and Goldberg,D.E.
    Food vacuole plasmepsins
    [ISSN:978-0-12-407744-7] (2012) 3, 98-103. DOI
  12. Bhaumik,P., Gustchina,A. and Wlodawer,A.
    Structural studies of vacuolar plasmepsins
    Biochim Biophys Acta (2012) 1824, 207-223. PubMed  Europe PubMed DOI  S
  13. Meyers,M.J. and Goldberg,D.E.
    Recent advances in plasmepsin medicinal chemistry and implications for future antimalarial drug discovery efforts
    Curr Top Med Chem (2012) 12, 445-455. PubMed  Europe PubMed DOI  I
    14. 2011
  14. Bhaumik,P., Horimoto,Y., Xiao,H., Miura,T., Hidaka,K., Kiso,Y., Wlodawer,A., Yada,R.Y. and Gustchina,A.
    Crystal structures of the free and inhibited forms of plasmepsin I (PMI) from Plasmodium falciparum
    J Struct Biol (2011) 175, 73-84. PubMed  Europe PubMed DOI  S  I
  15. Gil,L., Valiente,P.A., Pascutti,P.G. and Pons,T.
    Computational perspectives into plasmepsins structure-function relationship: implications to inhibitors design
    J Trop Med (2011) 2011, 657483-657483. PubMed  Europe PubMed DOI  PMC  EPMC  V
    16. 2009
  16. Liu,P., Marzahn,M.R., Robbins,A.H., Gutierrez-de-Teran,H., Rodriguez,D., McClung,S.H., Stevens,S.M., Jr., Yowell,C.A., Dame,J.B., McKenna,R. and Dunn,B.M.
    Recombinant plasmepsin 1 from the human malaria parasite Plasmodium falciparum: enzymatic characterization, active site inhibitor design, and structural analysis
    Biochemistry (2009) 48, 4086-4099. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
  17. Moura,P.A., Dame,J.B. and Fidock,D.A.
    Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors
    Antimicrobial Agents Chemother (2009) 53, 4968-4978. PubMed  Europe PubMed DOI  I
    18. 2008
  18. Drew,M.E., Banerjee,R., Uffman,E.W., Gilbertson,S., Rosenthal,P.J. and Goldberg,D.E.
    Plasmodium food vacuole plasmepsins are activated by falcipains
    J Biol Chem (2008) 283, 12870-12876. PubMed  Europe PubMed DOI  PMC  EPMC
    19. 2007
  19. Bonilla,J.A., Moura,P.A., Bonilla,T.D., Yowell,C.A., Fidock,D.A. and Dame,J.B.
    Effects on growth, hemoglobin metabolism and paralogous gene expression resulting from disruption of genes encoding the digestive vacuole plasmepsins of Plasmodium falciparum
    Int J Parasitol (2007) 37, 317-327. PubMed  Europe PubMed DOI  K
  20. Bonilla,J.A., Bonilla,T.D., Yowell,C.A., Fujioka,H. and Dame,J.B.
    Critical roles for the digestive vacuole plasmepsins of Plasmodium falciparum in vacuolar function
    Mol Microbiol (2007) 65, 64-75. PubMed  Europe PubMed DOI  K
  21. Xiao,H., Tanaka,T., Ogawa,M. and Yada,R.Y.
    Expression and enzymatic characterization of the soluble recombinant plasmepsin I from Plasmodium falciparum
    Protein Eng Des Sel (2007) 20, 625-633. PubMed  Europe PubMed DOI  E
    22. 2006
  22. Boss,C., Corminboeuf,O., Grisostomi,C., Meyer,S., Jones,A.F., Prade,L., Binkert,C., Fischli,W., Weller,T. and Bur,D.
    Achiral, cheap, and potent inhibitors of plasmepsins I, II, and IV
    ChemMedChem (2006) 1, 1341-1345. PubMed  Europe PubMed DOI  S  I
  23. [YEAR:14-12-2006]Dell'Agli,M., Parapini,S., Galli,G., Vaiana,N., Taramelli,D., Sparatore,A., Liu,P., Dunn,B.M., Bosisio,E. and Romeo,S.
    High antiplasmodial activity of novel plasmepsins I and II inhibitors
    J Med Chem (14-12-2006) 49, 7440-7449. PubMed  Europe PubMed DOI  I
  24. [YEAR:21-11-2006]Ersmark,K., Nervall,M., Gutierrez-de-Teran,H., Hamelink,E., Janka,L.K., Clemente,J.C., Dunn,B.M., Gogoll,A., Samuelsson,B., Qvist,J. and Hallberg,A.
    Macrocyclic inhibitors of the malarial aspartic proteases plasmepsin I, II, and IV
    Bioorg Med Chem (21-11-2006) 14, 2197-2208. PubMed  Europe PubMed DOI  I
  25. Hof,F., Schutz,A., Fah,C., Meyer,S., Bur,D., Liu,J., Goldberg,D.E. and Diederich,F.
    Starving the malaria parasite: inhibitors active against the aspartic proteases plasmepsins I, II, and IV
    Angew Chem Int Ed Engl (2006) 45, 2138-2141. PubMed  Europe PubMed DOI  I
  26. [YEAR:6-6-2006]Liu,J., Istvan,E.S., Gluzman,I.Y., Gross,J. and Goldberg,D.E.
    Plasmodium falciparum ensures its amino acid supply with multiple acquisition pathways and redundant proteolytic enzyme systems
    Proc Natl Acad Sci U S A (6-6-2006) 103, 8840-8845. PubMed  Europe PubMed DOI  PMC  EPMC
    27. 2005
  27. [YEAR:22-9-2005]Ersmark,K., Nervall,M., Hamelink,E., Janka,L.K., Clemente,J.C., Dunn,B.M., Blackman,M.J., Samuelsson,B., Aqvist,J. and Hallberg,A.
    Synthesis of malarial plasmepsin inhibitors and prediction of binding modes by molecular dynamics simulations
    J Med Chem (22-9-2005) 48, 6090-6106. PubMed  Europe PubMed DOI  I
  28. [YEAR:30-6-2005]Johansson,P.O., Lindberg,J., Blackman,M.J., Kvarnstrom,I., Vrang,L., Hamelink,E., Hallberg,A., Rosenquist,A. and Samuelsson,B.
    Design and synthesis of potent inhibitors of plasmepsin I and II: X-ray crystal structure of inhibitor in complex with plasmepsin II
    J Med Chem (30-6-2005) 48, 4400-4409. PubMed  Europe PubMed DOI  S  I
  29. [YEAR:28-10-2005]Liu,J., Gluzman,I.Y., Drew,M.E. and Goldberg,D.E.
    The role of Plasmodium falciparum food vacuole plasmepsins
    J Biol Chem (28-10-2005) 280, 1432-1437. PubMed  Europe PubMed DOI
    30. 2004
  30. Berry,C. and Goldberg,D.E.
    Plasmepsins
    [ISSN:0-12-079610-4] (2004) 2, 70-73.  V
  31. [YEAR:1-1-2004]Ersmark,K., Feierberg,I., Bjelic,S., Hamelink,E., Hackett,F., Blackman,M.J., Hulten,J., Samuelsson,B., Aqvist,J. and Hallberg,A.
    Potent inhibitors of the Plasmodium falciparum enzymes plasmepsin I and II devoid of cathepsin D inhibitory activity
    J Med Chem (1-1-2004) 47, 110-122. PubMed  Europe PubMed DOI  I
  32. [YEAR:17-6-2004]Johansson,P.O., Chen,Y., Belfrage,A.K., Blackman,M.J., Kvarnstrom,I., Jansson,K., Vrang,L., Hamelink,E., Hallberg,A., Rosenquist,A. and Samuelsson,B.
    Design and synthesis of potent inhibitors of the malaria aspartyl proteases plasmepsin I and II. Use of solid-phase synthesis to explore novel statine motifs
    J Med Chem (17-6-2004) 47, 3353-3366. PubMed  Europe PubMed DOI  I
  33. [YEAR:24-12-2004]Omara-Opyene,A.L., Moura,P.A., Sulsona,C.R., Bonilla,J.A., Yowell,C.A., Fujioka,H., Fidock,D.A. and Dame,J.B.
    Genetic disruption of the Plasmodium falciparum digestive vacuole plasmepsins demonstrates their functional redundancy
    J Biol Chem (24-12-2004) 279, 54088-54096. PubMed  Europe PubMed DOI
    34. 2003
  34. Banerjee,R., Francis,S.E. and Goldberg,D.E.
    Food vacuole plasmepsins are processed at a conserved site by an acidic convertase activity in Plasmodium falciparum
    Mol Biochem Parasitol (2003) 129, 157-165. PubMed  Europe PubMed DOI
  35. [YEAR:5-8-2003]Dahlgren,A., Kvarnstrom,I., Vrang,L., Hamelink,E., Hallberg,A., Rosenquist,A. and Samuelsson,B.
    New inhibitors of the malaria aspartyl proteases plasmepsin I and II
    Bioorg Med Chem (5-8-2003) 11, 3423-3437. PubMed  Europe PubMed DOI
  36. Dahlgren,A., Kvarnstrom,I., Vrang,L., Hamelink,E., Hallberg,A., Rosenquist,A. and Samuelsson,B.
    Solid-phase library synthesis of reversed-statine type inhibitors of the malarial aspartyl proteases plasmepsin I and II
    Bioorg Med Chem (2003) 11, 827-841. PubMed  Europe PubMed DOI  I
  37. [YEAR:22-7-2003]Nezami,A., Kimura,T., Hidaka,K., Kiso,A., Liu,J., Kiso,Y., Goldberg,D.E. and Freire,E.
    High-affinity inhibition of a family of Plasmodium falciparum proteases by a designed adaptive inhibitor
    Biochemistry (22-7-2003) 42, 8459-8464. PubMed  Europe PubMed DOI  I
  38. [YEAR:27-2-2003]Noteberg,D., Hamelink,E., Hulten,J., Wahlgren,M., Vrang,L., Samuelsson,B. and Hallberg,A.
    Design and synthesis of plasmepsin I and plasmepsin II inhibitors with activity in Plasmodium falciparum-infected cultured human erythrocytes
    J Med Chem (27-2-2003) 46, 734-746. PubMed  Europe PubMed DOI
  39. Noteberg,D., Schaal,W., Hamelink,E., Vrang,L. and Larhed,M.
    High-speed optimization of inhibitors of the malarial proteases plasmepsin I and II
    J Comb Chem (2003) 5, 456-464. PubMed  Europe PubMed DOI  I
  40. [YEAR:3-4-2003]Oscarsson,K., Oscarson,S., Vrang,L., Hamelink,E., Hallberg,A. and Samuelsson,B.
    New potent C2-symmetric malaria plasmepsin I and II inhibitors
    Bioorg Med Chem (3-4-2003) 11, 1235-1246. PubMed  Europe PubMed DOI
    41. 2002
  41. [YEAR:22-1-2002]Banerjee,R., Liu,J., Beatty,W., Pelosof,L., Klemba,M. and Goldberg,D.E.
    Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine
    Proc Natl Acad Sci U S A (22-1-2002) 99, 990-995. PubMed  Europe PubMed DOI  PMC  EPMC
  42. Nezami,A. and Freire,E.
    The integration of genomic and structural information in the development of high affinity plasmepsin inhibitors
    Int J Parasitol (2002) 32, 1669-1676. PubMed  Europe PubMed DOI  I
  43. [YEAR:25-10-2002]Siripurkpong,P., Yuvaniyama,J., Wilairat,P. and Goldberg,D.E.
    Active site contribution to specificity of the aspartic proteases plasmepsins I and II
    J Biol Chem (25-10-2002) 277, 41009-41013. PubMed  Europe PubMed DOI
    44. 2001
  44. [YEAR:19-10-2001]Brinkworth,R.I., Prociv,P., Loukas,A. and Brindley,P.J.
    Hemoglobin-degrading, aspartic proteases of blood-feeding parasites: substrate specificity revealed by homology models
    J Biol Chem (19-10-2001) 276, 38844-38851. PubMed  Europe PubMed DOI  I
  45. Coombs,G.H., Goldberg,D.E., Klemba,M., Berry,C., Kay,J. and Mottram,J.C.
    Aspartic proteases of Plasmodium falciparum and other parasitic protozoa as drug targets
    Trends Parasitol (2001) 17, 532-537. PubMed  Europe PubMed DOI
    46. 1999
  46. [YEAR:10-12-1999]Humphreys,M.J., Moon,R.P., Klinder,A., Fowler,S.D., Rupp,K., Bur,D., Ridley,R.G. and Berry,C.
    The aspartic proteinase from the rodent parasite Plasmodium berghei as a potential model for plasmepsins from the human malaria parasite, Plasmodium falciparum
    FEBS Lett (10-12-1999) 463, 43-48. PubMed  Europe PubMed DOI
  47. [YEAR:9-7-1999]Tyas,L., Gluzman,I., Moon,R.P., Rupp,K., Westling,J., Ridley,R.G., Kay,J., Goldberg,D.E. and Berry,C.
    Naturally-occurring and recombinant forms of the aspartic proteinases plasmepsins I and II from the human malaria parasite Plasmodium falciparum
    FEBS Lett (9-7-1999) 454, 210-214. PubMed  Europe PubMed DOI
    48. 1998
  48. Tyas,L., Moon,R.P., Loetscher,H., Dunn,B.M., Kay,J., Ridley,R.G. and Berry,C.
    Plasmepsins I and II from the malarial parasite Plasmodium falciparum
    Adv Exp Med Biol (1998) 436, 407-411. PubMed  Europe PubMed
    49. 1997
  49. Francis,S.E., Sullivan,D.J., Jr. and Goldberg,D.E.
    Hemoglobin metabolism in the malaria parasite Plasmodium falciparum
    Annu Rev Microbiol (1997) 51, 97-123. PubMed  Europe PubMed DOI
  50. Francis,S.E., Banerjee,R. and Goldberg,D.E.
    Biosynthesis and maturation of the malaria aspartic hemoglobinases plasmepsins I and II
    J Biol Chem (1997) 272, 14961-14968. PubMed  Europe PubMed DOI
  51. Moon,R.P., Tyas,L., Certa,U., Rupp,K., Bur,D., Jacquet,C., Matile,H., Loetscher,H., Grueninger-Leitch,F., Kay,J., Dunn,B.M., Berry,C. and Ridley,R.G.
    Expression and characterisation of plasmepsin I from Plasmodium falciparum
    Eur J Biochem (1997) 244, 552-560. PubMed  Europe PubMed
    52. 1996
  52. Luker,K.E., Francis,S.E., Gluzman,I.Y. and Goldberg,D.E.
    Kinetic analysis of plasmepsins I and II, aspartic proteases of the Plasmodium falciparum digestive vacuole
    Mol Biochem Parasitol (1996) 79, 71-78. PubMed  Europe PubMed DOI
    53. 1994
  53. [YEAR:15-1-1994]Francis,S.E., Gluzman,I.Y., Oksman,A., Knickerbocker,A., Mueller,R., Bryant,M.L., Sherman,D.R., Russell,D.G. and Goldberg,D.E.
    Molecular characterization and inhibition of a Plasmodium falciparum aspartic hemoglobinase
    EMBO J (15-1-1994) 13, 306-317. PubMed  Europe PubMed  PMC  EPMC
  54. Gluzman,I.Y., Francis,S.E., Oksman,A., Smith,C.E., Duffin,K.L. and Goldberg,D.E.
    Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway
    J Clin Invest (1994) 93, 1602-1608. PubMed  Europe PubMed DOI  PMC  EPMC

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