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Literature for peptidase A01.022: plasmepsin-1

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, K Knockout, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2020
  1. Nasamu,A.S., Polino,A.J., Istvan,E.S. and Goldberg,D.E.<br>Malaria parasite plasmepsins: more than just plain old degradative pepsins<br>J Biol Chem (2020) PubMed  Europe PubMed DOI
    2. 2019
  2. Bobrovs,R., Jaudzems,K. and Jirgensons,A.<br>Exploiting structural dynamics to design open-flap inhibitors of malarial aspartic proteases<br>J Med Chem (2019) 62, 8931-8950. PubMed  Europe PubMed DOI  I
  3. Thillainayagam,M., Malathi,K., Anbarasu,A., Singh,H., Bahadur,R. and Ramaiah,S.<br>Insights on inhibition of Plasmodium falciparum plasmepsin I by novel epoxyazadiradione derivatives - molecular docking and comparative molecular field analysis<br>J Biomol Struct Dyn (2019) 37, 3168-3182. PubMed  Europe PubMed DOI  I
    4. 2016
  4. Chaudhary,K.K., Raj,U., Varadwaj,P.K. and Mishra,N.<br>Novel potent plasmepsin-I (PMI) inhibitors: an in-silico approach<br>Curr Proteomics (2016) 13, 196-205. DOI  I
  5. Ponsuwanna,P., Kochakarn,T., Bunditvorapoom,D., Kumpornsin,K., Otto,T.D., Ridenour,C., Chotivanich,K., Wilairat,P., White,N.J., Miotto,O. and Chookajorn,T.<br>Comparative genome-wide analysis and evolutionary history of haemoglobin-processing and haem detoxification enzymes in malarial parasites<br>Malar J (2016) 15, 51-51. PubMed  Europe PubMed DOI  PMC  EPMC
  6. Rasina,D., Otikovs,M., Leitans,J., Recacha,R., Borysov,O.V., Kanepe-Lapsa,I., Domraceva,I., Pantelejevs,T., Tars,K., Blackman,M.J., Jaudzems,K. and Jirgensons,A.<br>Fragment-based discovery of 2-aminoquinazolin-4(3h)-ones as novel class nonpeptidomimetic inhibitors of the plasmepsins I, II, and IV<br>J Med Chem (2016) 59, 374-387. PubMed  Europe PubMed DOI  I
    7. 2015
  7. McGillewie,L. and Soliman,M.E.<br>Flap flexibility amongst plasmepsins I, II, III, IV, and V: sequence, structural, and molecular dynamics analyses<br>Proteins (2015) 83, 1693-1705. PubMed  Europe PubMed DOI
    8. 2014
  8. Levita,J., Chao,K.H. and Mutakin<br>Interactions of ganoderiol-F with aspartic proteases of HIV and plasmepsin for anti-HIV and anti-malaria discovery<br>Int J Pharmcy Pharm Sci (2014) 6, 561-566.  I
  9. Lolupiman,S., Siripurkpong,P. and Yuvaniyama,J.<br>Disulfide linkages in Plasmodium falciparum plasmepsin-I are essential elements for its processing activity and multi-milligram recombinant production yield<br>PLoS ONE (2014) 9, e89424-e89424. PubMed  Europe PubMed DOI  PMC  EPMC  E
    10. 2013
  10. Aureggi,V., Ehmke,V., Wieland,J., Schweizer,W.B., Bernet,B., Bur,D., Meyer,S., Rottmann,M., Freymond,C., Brun,R., Breit,B. and Diederich,F.<br>Potent inhibitors of malarial aspartic proteases, the plasmepsins, by hydroformylation of substituted 7-azanorbornenes<br>Chemistry (2013) 19, 155-164. PubMed  Europe PubMed DOI  I
    11. 2012
  11. Berry,C. and Goldberg,D.E.<br>Food vacuole plasmepsins<br>[ISSN:978-0-12-407744-7] (2012) 3, 98-103. DOI
  12. Bhaumik,P., Gustchina,A. and Wlodawer,A.<br>Structural studies of vacuolar plasmepsins<br>Biochim Biophys Acta (2012) 1824, 207-223. PubMed  Europe PubMed DOI  S
  13. Meyers,M.J. and Goldberg,D.E.<br>Recent advances in plasmepsin medicinal chemistry and implications for future antimalarial drug discovery efforts<br>Curr Top Med Chem (2012) 12, 445-455. PubMed  Europe PubMed DOI  I
    14. 2011
  14. Bhaumik,P., Horimoto,Y., Xiao,H., Miura,T., Hidaka,K., Kiso,Y., Wlodawer,A., Yada,R.Y. and Gustchina,A.<br>Crystal structures of the free and inhibited forms of plasmepsin I (PMI) from Plasmodium falciparum<br>J Struct Biol (2011) 175, 73-84. PubMed  Europe PubMed DOI  S  I
  15. Gil,L., Valiente,P.A., Pascutti,P.G. and Pons,T.<br>Computational perspectives into plasmepsins structure-function relationship: implications to inhibitors design<br>J Trop Med (2011) 2011, 657483-657483. PubMed  Europe PubMed DOI  PMC  EPMC  V
    16. 2009
  16. Liu,P., Marzahn,M.R., Robbins,A.H., Gutierrez-de-Teran,H., Rodriguez,D., McClung,S.H., Stevens,S.M., Jr., Yowell,C.A., Dame,J.B., McKenna,R. and Dunn,B.M.<br>Recombinant plasmepsin 1 from the human malaria parasite Plasmodium falciparum: enzymatic characterization, active site inhibitor design, and structural analysis<br>Biochemistry (2009) 48, 4086-4099. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
  17. Moura,P.A., Dame,J.B. and Fidock,D.A.<br>Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors<br>Antimicrobial Agents Chemother (2009) 53, 4968-4978. PubMed  Europe PubMed DOI  I
    18. 2008
  18. Drew,M.E., Banerjee,R., Uffman,E.W., Gilbertson,S., Rosenthal,P.J. and Goldberg,D.E.<br>Plasmodium food vacuole plasmepsins are activated by falcipains<br>J Biol Chem (2008) 283, 12870-12876. PubMed  Europe PubMed DOI  PMC  EPMC
    19. 2007
  19. Bonilla,J.A., Moura,P.A., Bonilla,T.D., Yowell,C.A., Fidock,D.A. and Dame,J.B.<br>Effects on growth, hemoglobin metabolism and paralogous gene expression resulting from disruption of genes encoding the digestive vacuole plasmepsins of Plasmodium falciparum<br>Int J Parasitol (2007) 37, 317-327. PubMed  Europe PubMed DOI  K
  20. Bonilla,J.A., Bonilla,T.D., Yowell,C.A., Fujioka,H. and Dame,J.B.<br>Critical roles for the digestive vacuole plasmepsins of Plasmodium falciparum in vacuolar function<br>Mol Microbiol (2007) 65, 64-75. PubMed  Europe PubMed DOI  K
  21. Xiao,H., Tanaka,T., Ogawa,M. and Yada,R.Y.<br>Expression and enzymatic characterization of the soluble recombinant plasmepsin I from Plasmodium falciparum<br>Protein Eng Des Sel (2007) 20, 625-633. PubMed  Europe PubMed DOI  E
    22. 2006
  22. Boss,C., Corminboeuf,O., Grisostomi,C., Meyer,S., Jones,A.F., Prade,L., Binkert,C., Fischli,W., Weller,T. and Bur,D.<br>Achiral, cheap, and potent inhibitors of plasmepsins I, II, and IV<br>ChemMedChem (2006) 1, 1341-1345. PubMed  Europe PubMed DOI  S  I
  23. [YEAR:14-12-2006]Dell'Agli,M., Parapini,S., Galli,G., Vaiana,N., Taramelli,D., Sparatore,A., Liu,P., Dunn,B.M., Bosisio,E. and Romeo,S.<br>High antiplasmodial activity of novel plasmepsins I and II inhibitors<br>J Med Chem (14-12-2006) 49, 7440-7449. PubMed  Europe PubMed DOI  I
  24. [YEAR:21-11-2006]Ersmark,K., Nervall,M., Gutierrez-de-Teran,H., Hamelink,E., Janka,L.K., Clemente,J.C., Dunn,B.M., Gogoll,A., Samuelsson,B., Qvist,J. and Hallberg,A.<br>Macrocyclic inhibitors of the malarial aspartic proteases plasmepsin I, II, and IV<br>Bioorg Med Chem (21-11-2006) 14, 2197-2208. PubMed  Europe PubMed DOI  I
  25. Hof,F., Schutz,A., Fah,C., Meyer,S., Bur,D., Liu,J., Goldberg,D.E. and Diederich,F.<br>Starving the malaria parasite: inhibitors active against the aspartic proteases plasmepsins I, II, and IV<br>Angew Chem Int Ed Engl (2006) 45, 2138-2141. PubMed  Europe PubMed DOI  I
  26. [YEAR:6-6-2006]Liu,J., Istvan,E.S., Gluzman,I.Y., Gross,J. and Goldberg,D.E.<br>Plasmodium falciparum ensures its amino acid supply with multiple acquisition pathways and redundant proteolytic enzyme systems<br>Proc Natl Acad Sci U S A (6-6-2006) 103, 8840-8845. PubMed  Europe PubMed DOI  PMC  EPMC
    27. 2005
  27. [YEAR:22-9-2005]Ersmark,K., Nervall,M., Hamelink,E., Janka,L.K., Clemente,J.C., Dunn,B.M., Blackman,M.J., Samuelsson,B., Aqvist,J. and Hallberg,A.<br>Synthesis of malarial plasmepsin inhibitors and prediction of binding modes by molecular dynamics simulations<br>J Med Chem (22-9-2005) 48, 6090-6106. PubMed  Europe PubMed DOI  I
  28. [YEAR:30-6-2005]Johansson,P.O., Lindberg,J., Blackman,M.J., Kvarnstrom,I., Vrang,L., Hamelink,E., Hallberg,A., Rosenquist,A. and Samuelsson,B.<br>Design and synthesis of potent inhibitors of plasmepsin I and II: X-ray crystal structure of inhibitor in complex with plasmepsin II<br>J Med Chem (30-6-2005) 48, 4400-4409. PubMed  Europe PubMed DOI  S  I
  29. [YEAR:28-10-2005]Liu,J., Gluzman,I.Y., Drew,M.E. and Goldberg,D.E.<br>The role of Plasmodium falciparum food vacuole plasmepsins<br>J Biol Chem (28-10-2005) 280, 1432-1437. PubMed  Europe PubMed DOI
    30. 2004
  30. Berry,C. and Goldberg,D.E.<br>Plasmepsins<br>[ISSN:0-12-079610-4] (2004) 2, 70-73.  V
  31. [YEAR:1-1-2004]Ersmark,K., Feierberg,I., Bjelic,S., Hamelink,E., Hackett,F., Blackman,M.J., Hulten,J., Samuelsson,B., Aqvist,J. and Hallberg,A.<br>Potent inhibitors of the Plasmodium falciparum enzymes plasmepsin I and II devoid of cathepsin D inhibitory activity<br>J Med Chem (1-1-2004) 47, 110-122. PubMed  Europe PubMed DOI  I
  32. [YEAR:17-6-2004]Johansson,P.O., Chen,Y., Belfrage,A.K., Blackman,M.J., Kvarnstrom,I., Jansson,K., Vrang,L., Hamelink,E., Hallberg,A., Rosenquist,A. and Samuelsson,B.<br>Design and synthesis of potent inhibitors of the malaria aspartyl proteases plasmepsin I and II. Use of solid-phase synthesis to explore novel statine motifs<br>J Med Chem (17-6-2004) 47, 3353-3366. PubMed  Europe PubMed DOI  I
  33. [YEAR:24-12-2004]Omara-Opyene,A.L., Moura,P.A., Sulsona,C.R., Bonilla,J.A., Yowell,C.A., Fujioka,H., Fidock,D.A. and Dame,J.B.<br>Genetic disruption of the Plasmodium falciparum digestive vacuole plasmepsins demonstrates their functional redundancy<br>J Biol Chem (24-12-2004) 279, 54088-54096. PubMed  Europe PubMed DOI
    34. 2003
  34. Banerjee,R., Francis,S.E. and Goldberg,D.E.<br>Food vacuole plasmepsins are processed at a conserved site by an acidic convertase activity in Plasmodium falciparum<br>Mol Biochem Parasitol (2003) 129, 157-165. PubMed  Europe PubMed DOI
  35. [YEAR:5-8-2003]Dahlgren,A., Kvarnstrom,I., Vrang,L., Hamelink,E., Hallberg,A., Rosenquist,A. and Samuelsson,B.<br>New inhibitors of the malaria aspartyl proteases plasmepsin I and II<br>Bioorg Med Chem (5-8-2003) 11, 3423-3437. PubMed  Europe PubMed DOI
  36. Dahlgren,A., Kvarnstrom,I., Vrang,L., Hamelink,E., Hallberg,A., Rosenquist,A. and Samuelsson,B.<br>Solid-phase library synthesis of reversed-statine type inhibitors of the malarial aspartyl proteases plasmepsin I and II<br>Bioorg Med Chem (2003) 11, 827-841. PubMed  Europe PubMed DOI  I
  37. [YEAR:22-7-2003]Nezami,A., Kimura,T., Hidaka,K., Kiso,A., Liu,J., Kiso,Y., Goldberg,D.E. and Freire,E.<br>High-affinity inhibition of a family of Plasmodium falciparum proteases by a designed adaptive inhibitor<br>Biochemistry (22-7-2003) 42, 8459-8464. PubMed  Europe PubMed DOI  I
  38. [YEAR:27-2-2003]Noteberg,D., Hamelink,E., Hulten,J., Wahlgren,M., Vrang,L., Samuelsson,B. and Hallberg,A.<br>Design and synthesis of plasmepsin I and plasmepsin II inhibitors with activity in Plasmodium falciparum-infected cultured human erythrocytes<br>J Med Chem (27-2-2003) 46, 734-746. PubMed  Europe PubMed DOI
  39. Noteberg,D., Schaal,W., Hamelink,E., Vrang,L. and Larhed,M.<br>High-speed optimization of inhibitors of the malarial proteases plasmepsin I and II<br>J Comb Chem (2003) 5, 456-464. PubMed  Europe PubMed DOI  I
  40. [YEAR:3-4-2003]Oscarsson,K., Oscarson,S., Vrang,L., Hamelink,E., Hallberg,A. and Samuelsson,B.<br>New potent C2-symmetric malaria plasmepsin I and II inhibitors<br>Bioorg Med Chem (3-4-2003) 11, 1235-1246. PubMed  Europe PubMed DOI
    41. 2002
  41. [YEAR:22-1-2002]Banerjee,R., Liu,J., Beatty,W., Pelosof,L., Klemba,M. and Goldberg,D.E.<br>Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine<br>Proc Natl Acad Sci U S A (22-1-2002) 99, 990-995. PubMed  Europe PubMed DOI  PMC  EPMC
  42. Nezami,A. and Freire,E.<br>The integration of genomic and structural information in the development of high affinity plasmepsin inhibitors<br>Int J Parasitol (2002) 32, 1669-1676. PubMed  Europe PubMed DOI  I
  43. [YEAR:25-10-2002]Siripurkpong,P., Yuvaniyama,J., Wilairat,P. and Goldberg,D.E.<br>Active site contribution to specificity of the aspartic proteases plasmepsins I and II<br>J Biol Chem (25-10-2002) 277, 41009-41013. PubMed  Europe PubMed DOI
    44. 2001
  44. [YEAR:19-10-2001]Brinkworth,R.I., Prociv,P., Loukas,A. and Brindley,P.J.<br>Hemoglobin-degrading, aspartic proteases of blood-feeding parasites: substrate specificity revealed by homology models<br>J Biol Chem (19-10-2001) 276, 38844-38851. PubMed  Europe PubMed DOI  I
  45. Coombs,G.H., Goldberg,D.E., Klemba,M., Berry,C., Kay,J. and Mottram,J.C.<br>Aspartic proteases of Plasmodium falciparum and other parasitic protozoa as drug targets<br>Trends Parasitol (2001) 17, 532-537. PubMed  Europe PubMed DOI
    46. 1999
  46. [YEAR:10-12-1999]Humphreys,M.J., Moon,R.P., Klinder,A., Fowler,S.D., Rupp,K., Bur,D., Ridley,R.G. and Berry,C.<br>The aspartic proteinase from the rodent parasite Plasmodium berghei as a potential model for plasmepsins from the human malaria parasite, Plasmodium falciparum<br>FEBS Lett (10-12-1999) 463, 43-48. PubMed  Europe PubMed DOI
  47. [YEAR:9-7-1999]Tyas,L., Gluzman,I., Moon,R.P., Rupp,K., Westling,J., Ridley,R.G., Kay,J., Goldberg,D.E. and Berry,C.<br>Naturally-occurring and recombinant forms of the aspartic proteinases plasmepsins I and II from the human malaria parasite Plasmodium falciparum<br>FEBS Lett (9-7-1999) 454, 210-214. PubMed  Europe PubMed DOI
    48. 1998
  48. Tyas,L., Moon,R.P., Loetscher,H., Dunn,B.M., Kay,J., Ridley,R.G. and Berry,C.<br>Plasmepsins I and II from the malarial parasite Plasmodium falciparum<br>Adv Exp Med Biol (1998) 436, 407-411. PubMed  Europe PubMed
    49. 1997
  49. Francis,S.E., Sullivan,D.J., Jr. and Goldberg,D.E.<br>Hemoglobin metabolism in the malaria parasite Plasmodium falciparum<br>Annu Rev Microbiol (1997) 51, 97-123. PubMed  Europe PubMed DOI
  50. Francis,S.E., Banerjee,R. and Goldberg,D.E.<br>Biosynthesis and maturation of the malaria aspartic hemoglobinases plasmepsins I and II<br>J Biol Chem (1997) 272, 14961-14968. PubMed  Europe PubMed DOI
  51. Moon,R.P., Tyas,L., Certa,U., Rupp,K., Bur,D., Jacquet,C., Matile,H., Loetscher,H., Grueninger-Leitch,F., Kay,J., Dunn,B.M., Berry,C. and Ridley,R.G.<br>Expression and characterisation of plasmepsin I from Plasmodium falciparum<br>Eur J Biochem (1997) 244, 552-560. PubMed  Europe PubMed
    52. 1996
  52. Luker,K.E., Francis,S.E., Gluzman,I.Y. and Goldberg,D.E.<br>Kinetic analysis of plasmepsins I and II, aspartic proteases of the Plasmodium falciparum digestive vacuole<br>Mol Biochem Parasitol (1996) 79, 71-78. PubMed  Europe PubMed DOI
    53. 1994
  53. [YEAR:15-1-1994]Francis,S.E., Gluzman,I.Y., Oksman,A., Knickerbocker,A., Mueller,R., Bryant,M.L., Sherman,D.R., Russell,D.G. and Goldberg,D.E.<br>Molecular characterization and inhibition of a Plasmodium falciparum aspartic hemoglobinase<br>EMBO J (15-1-1994) 13, 306-317. PubMed  Europe PubMed  PMC  EPMC
  54. Gluzman,I.Y., Francis,S.E., Oksman,A., Smith,C.E., Duffin,K.L. and Goldberg,D.E.<br>Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway<br>J Clin Invest (1994) 93, 1602-1608. PubMed  Europe PubMed DOI  PMC  EPMC

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