Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P02668

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
21	unknown peptidase	1-190	P	release of a signal peptide	NT
41	lactocepin-3	22-190	P		NT	Reid et al., 1999
44	lactocepin I	22-190	P		NT	Reid et al., 1994
44	lactocepin-3	22-190	P		NT	Reid et al., 1994
45	trypsin 1	22-190	P	release of an amino acid	NT	Clare & Swaisgood, 2000
50	Nysius proteinase	22-190	N			Every et al., 2005
53	lactocepin I	22-190	P		NT	Reid et al., 1994
53	lactocepin-3	22-190	P		NT	Reid et al., 1994
55	trypsin 1	22-190	P	release of a bioactive peptide	NT	Clare & Swaisgood, 2000
62	lactocepin I	22-190	P		NT	Reid et al., 1994
62	lactocepin-3	22-190	P		NT	Reid et al., 1999
65	lactocepin-3	22-190	P		NT	Reid et al., 1999
86	lactocepin-3	22-190	P		NT	Reid et al., 1994
92	lactocepin I	22-190	P		NT	Reid et al., 1994
92	lactocepin-3	22-190	P		NT	Reid et al., 1994
93	Nysius proteinase	22-190	N			Every et al., 2005
100	lactocepin I	22-190	P		NT	Reid et al., 1994
100	lactocepin-3	22-190	P		NT	Reid et al., 1994
106	lactocepin-3	22-190	P		NT	Reid et al., 1999
116	lactocepin I	22-190	P		NT	Reid et al., 1994
116	lactocepin-3	22-190	P		NT	Reid et al., 1994
121	lactocepin I	22-190	P		NT	Reid et al., 1994
123	lactocepin I	22-190	P		NT	Reid et al., 1994
125	endothiapepsin	22-190	N			Cooper, 2004
126	pepsin A	22-190	P	release of a bioactive peptide		Drohse & Foltmann, 1989
126	gastricsin	22-190	P	release of a bioactive peptide		Drohse & Foltmann, 1989
126	chymosin	22-190	P	release of a bioactive peptide		Foltmann & Szecsi, 2004
126	mucorpepsin	22-190	N			Beppu & Nishiyama, 2004
126	polyporopepsin	22-190	N			Kobayashi, 2004
126	phytepsin	22-190	N			Pires, 1998
126	unknown peptidase	22-190	N			<%Rawlings, 1998[]%>
127	lactocepin I	22-190	P		NT	Reid et al., 1994
127	lactocepin-3	22-190	P		NT	Reid et al., 1994
132	trypsin 1	22-190	P	normal turnover	NT	Clare & Swaisgood, 2000
137	trypsin 1	22-190	P	release of an amino acid	NT	Clare & Swaisgood, 2000
152	lactocepin-3	22-190	P		NT	Reid et al., 1999
163	lactocepin-3	22-190	P		NT	Reid et al., 1999
172	lactocepin-3	22-190	P		NT	Reid et al., 1994
181	lactocepin-3	22-190	P		NT	Reid et al., 1994
186	lactocepin-3	22-190	P		NT	Reid et al., 1999
188	lactocepin-3	22-190	P		NT	Reid et al., 1999