Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Count of substrate cleavages for peptidases

Aspartic, Cysteine, Glutamic, Metallo, Serine, Threonine, Unknown, Compound Peptidase,

ASPARTIC PEPTIDASE
MEROPS IDPeptidaseTotal substratesPhysiological substratesNon-physiological substrates
A01.001 pepsin A970 21 949
A01.002 pepsin B25 1 24
A01.003 gastricsin50 6 44
A01.004 BACE1 g.p. (Homo sapiens)25 16 9
A01.006 chymosin20 11 9
A01.007 renin10 1 9
A01.008 renin-23 1 2
A01.009 cathepsin D924 686 238
A01.010 cathepsin E1596 1256 340
A01.011 penicillopepsin17 0 17
A01.012 rhizopuspepsin249 0 249
A01.013 mucorpepsin9 1 8
A01.014 candidapepsin SAP126 1 25
A01.015 barrierpepsin1 1 0
A01.016 aspergillopepsin I157 1 156
A01.017 endothiapepsin11 0 11
A01.018 saccharopepsin14 3 11
A01.019 polyporopepsin11 0 11
A01.020 phytepsin62 7 55
A01.021 plasmepsin (Plasmodium sp.)5 0 5
A01.022 plasmepsin-113 7 6
A01.023 plasmepsin-215 4 11
A01.026 peptidase F0 0 0
A01.027 trichodermapepsin1 0 1
A01.028 embryonic pepsin (Gallus gallus)0 0 0
A01.030 yapsin-146 5 41
A01.031 yapsin-216 0 16
A01.035 yapsin-39 4 5
A01.036 axp peptidase (Yarrowia lipolytica)3 1 2
A01.037 canditropsin9 2 7
A01.038 candiparapsin5 0 5
A01.040 nepenthesin733 0 733
A01.041 BACE2 g.p. (Homo sapiens)33 5 28
A01.042 syncephapepsin18 0 18
A01.043 histoaspartic peptidase (Plasmodium falciparum)4 0 4
A01.044 podosporapepsin0 0 0
A01.045 nothepsin1 0 1
A01.046 napsin A7 3 4
A01.050 CND41 peptidase0 0 0
A01.051 pepsin F3 2 1
A01.052 Mername-AA045 peptidase0 0 0
A01.053 necepsin-1133 0 133
A01.054 tick heme-binding aspartic proteinase (Rhipicephalus microplus)2 0 2
A01.055 Mername-AA047 peptidase1 0 1
A01.056 Yps1 protein (Schizosaccharomyces pombe)3 0 3
A01.057 Mername-AA034 peptidase0 0 0
A01.058 eimepsin0 0 0
A01.059 plasmepsin-48 2 6
A01.060 candidapepsin SAP222 1 21
A01.061 candidapepsin SAP321 1 20
A01.062 candidapepsin SAP40 0 0
A01.063 candidapepsin SAP50 0 0
A01.064 candidapepsin SAP622 0 22
A01.065 candidapepsin SAP70 0 0
A01.066 candidapepsin SAP80 0 0
A01.067 candidapepsin SAP917 14 3
A01.068 necepsin-245 0 45
A01.069 CDR1 peptidase (Arabidopsis-type)2 0 2
A01.070 pepsin A44 4 0
A01.071 pepsin A5 (Homo sapiens)10 3 7
A01.073 nucellin1 1 0
A01.074 PCS1 peptidase0 0 0
A01.075 plasmepsin-5 (Plasmodium sp.)7 1 6
A01.076 Sapp2p peptidase (Candida parapsilosis)7 1 6
A01.077 CtsD peptidase (Aspergillus-type)0 0 0
A01.078 CnAP1 peptidase0 0 0
A01.079 PepAa peptidase0 0 0
A01.080 PepAb peptidase0 0 0
A01.081 PepAc peptidase0 0 0
A01.082 SA76 peptidase (Trichoderma sp.)0 0 0
A01.083 hCG1733572 (Homo sapiens)-type putative peptidase0 0 0
A01.084 yolk cathepsin (Boophilus sp.)17 0 17
A01.085 candidapepsin SAP1016 14 2
A01.086 S5 peptidase (Oryza sativa)0 0 0
A01.087 toxomepsin 10 0 0
A01.088 pepsin (fish)2 0 2
A01.089 pregnancy-associated glycoprotein 21 0 1
A01.092 CAD2 peptidase (Musca domestica)0 0 0
A01.093 CAD3 peptidase (Musca domestica)2 1 1
A01.094 pregnancy-associated glycoprotein 121 0 1
A01.095 shewasin A (Shewanella amazonensis)5 0 5
A01.096 chlapsin1 0 1
A01.097 GPI-anchored aspartic peptidase (Saccharomyces-type)1 0 1
A01.098 ASP5 g.p. (Toxoplasma gondii)1 0 1
A01.099 rhodotorulapepsin0 0 0
A01.A01 CG31926 g.p. (Drosophila melanogaster)0 0 0
A01.A02 At1g62290 (Arabidopsis thaliana)0 0 0
A01.A03 At4g04460 (Arabidopsis thaliana)0 0 0
A01.A04 CG17283-RA g.p. (Drosophila melanogaster)0 0 0
A01.A05 At1g01300 (Arabidopsis thaliana)-type peptidase0 0 0
A01.A06 At1g25510 (Arabidopsis thaliana)-type peptidase0 0 0
A01.A07 At1g79720 (Arabidopsis thaliana)-type peptidase0 0 0
A01.A08 At2g42980 (Arabidopsis thaliana)0 0 0
A01.A09 ASPG1 peptidase0 0 0
A01.A10 At3g20015 (Arabidopsis thaliana)-type peptidase0 0 0
A01.A11 At3g25700 (Arabidopsis thaliana)-type peptidase0 0 0
A01.A12 At3g59080 (Arabidopsis thaliana)0 0 0
A01.A13 At3g61820 (Arabidopsis thaliana)0 0 0
A01.A14 At5g10760 (Arabidopsis thaliana)0 0 0
A01.A15 At5g10770 (Arabidopsis thaliana)0 0 0
A01.A16 At1g31450 (Arabidopsis thaliana)0 0 0
A01.A17 At1g64830 (Arabidopsis thaliana)0 0 0
A01.A18 At2g28010 (Arabidopsis thaliana)0 0 0
A01.A19 At2g28030 (Arabidopsis thaliana)0 0 0
A01.A20 At2g28040 (Arabidopsis thaliana)0 0 0
A01.A21 At2g28220 (Arabidopsis thaliana)0 0 0
A01.A22 At2g35615 (Arabidopsis thaliana)0 0 0
A01.A23 At3g02740 (Arabidopsis thaliana)-type peptidase0 0 0
A01.A24 At1g44130 (Arabidopsis thaliana)-type peptidase0 0 0
A01.A25 At1g49050 (Arabidopsis thaliana)-type peptidase0 0 0
A01.A26 At1g77480 (Arabidopsis thaliana)0 0 0
A01.A27 At4g33490 (Arabidopsis thaliana)-type peptidase0 0 0
A01.A28 At1g66180 (Arabidopsis thaliana)0 0 0
A01.A29 At2g39710 (Arabidopsis thaliana)-type peptidase0 0 0
A01.A30 At3g12700 (Arabidopsis thaliana)-type peptidase0 0 0
A01.A31 At5g37540 (Arabidopsis thaliana)0 0 0
A01.A32 At1g69100 (Arabidopsis thaliana)0 0 0
A01.A33 At4g22050 (Arabidopsis thaliana)0 0 0
A01.A34 At1g05840 (Arabidopsis thaliana)-type peptidase0 0 0
A01.A35 At1g08210 (Arabidopsis thaliana)0 0 0
A01.A36 At1g09750 (Arabidopsis thaliana)-type peptidase0 0 0
A01.A37 A39 g.p. (Arabidopsis thaliana)0 0 0
A01.A38 At2g17760 (Arabidopsis thaliana)-type peptidase0 0 0
A01.A39 At2g23945 (Arabidopsis thaliana)-type peptidase0 0 0
A01.A40 At2g36670 (Arabidopsis thaliana)-type peptidase0 0 0
A01.A41 At3g42550 (Arabidopsis thaliana)0 0 0
A01.A42 At3g50050 (Arabidopsis thaliana)0 0 0
A01.A43 At3g51330 (Arabidopsis thaliana)0 0 0
A01.A44 At3g51340 (Arabidopsis thaliana)0 0 0
A01.A45 At3g51350 (Arabidopsis thaliana)0 0 0
A01.A46 At3g51360 (Arabidopsis thaliana)0 0 0
A01.A47 At3g52500 (Arabidopsis thaliana)-type peptidase0 0 0
A01.A48 At3g54400 (Arabidopsis thaliana)-type peptidase0 0 0
A01.A49 At4g12920 (Arabidopsis thaliana)0 0 0
A01.A50 At4g16560 (Arabidopsis thaliana)-type peptidase0 0 0
A01.A51 At4g30030 (Arabidopsis thaliana)0 0 0
A01.A52 At4g30040 (Arabidopsis thaliana)0 0 0
A01.A53 At4g35880 (Arabidopsis thaliana)-type peptidase0 0 0
A01.A54 At5g07030 (Arabidopsis thaliana)-type peptidase0 0 0
A01.A55 At5g10080 (Arabidopsis thaliana)-type peptidase0 0 0
A01.A56 At5g22850 (Arabidopsis thaliana)-type peptidase0 0 0
A01.A57 At5g24820-type peptidase0 0 0
A01.A58 A36 g.p. (Arabidopsis thaliana)0 0 0
A01.A59 At5g43100 (Arabidopsis thaliana)-type peptidase0 0 0
A01.A60 At5g45120 (Arabidopsis thaliana)-type peptidase0 0 0
A01.A62 yapsin-6 (Saccharomyces cerevisiae)0 0 0
A01.A63 CG13374 g.p. (Drosophila melanogaster)0 0 0
A01.A64 CG10104 g.p.(Drosophila melanogaster)0 0 0
A01.A65 CG5863 g.p. (Drosophila melanogaster)0 0 0
A01.A66 CG5860 g.p. (Drosophila melanogaster)0 0 0
A01.A67 CG31928 g.p. (Drosophila melanogaster)0 0 0
A01.A68 CG10872 g.p. (Drosophila melanogaster)0 0 0
A01.A69 asp-3 g.p. (Caenorhabditis elegans)0 0 0
A01.A70 K10C2.3 protein (Caenorhabditis elegans)0 0 0
A01.A71 asp-6 g.p. (Caenorhabditis elegans)0 0 0
A01.A72 F59D6.3 protein (Caenorhabditis elegans)0 0 0
A01.A73 Y39B6B.h protein (Caenorhabditis elegans)0 0 0
A01.A74 F21F8.4 protein (Caenorhabditis elegans)0 0 0
A01.A75 C11D2.2 g.p. (Caenorhabditis elegans)0 0 0
A01.A76 C15C8.3 g.p. (Caenorhabditis elegans)0 0 0
A01.A77 F59D6.2 g.p. (Caenorhabditis elegans)0 0 0
A01.A78 CG17134 g.p. (Drosophila melanogaster)0 0 0
A01.A79 CG6508 g.p. (Drosophila melanogaster)0 0 0
A01.A81 CG10872 g.p. (Drosophila melanogaster)0 0 0
A01.A82 Ceasp1 protein (Caenorhabditis elegans)0 0 0
A01.A83 F28A12.4 g.p. (Caenorhabditis elegans)0 0 0
A01.A84 asp-2 g.p. (Caenorhabditis elegans)0 0 0
A01.A85 Y39B6A.23 g.p. (Caenorhabditis elegans)0 0 0
A01.A86 Y39B6A.24 g.p. (Caenorhabditis elegans)0 0 0
A01.A87 ZK384.3 g.p. domain 1 (Caenorhabditis elegans)0 0 0
A01.A88 DDB_0205773 (Dictyostelium discoideum)0 0 0
A01.A89 DDB_G0279411 (Dictyostelium discoideum)0 0 0
A01.A90 DDB_G0277581 (Dictyostelium discoideum)0 0 0
A01.A91 Sxa1 peptidase (Schizosaccharomyces pombe)0 0 0
A01.A92 DDB_G0270722 g.p. (Dictyostelium discoideum)0 0 0
A01.A93 plasmepsin-100 0 0
A01.A94 SCRG_02223 g.p. (Saccharomyces cerevisiae)0 0 0
A01.A95 plasmepsin-90 0 0
A01.A96 hCG39993 g.p. (Homo sapiens)0 0 0
A02.001 HIV-1 retropepsin1046 15 1031
A02.002 HIV-2 retropepsin30 10 20
A02.003 simian immunodeficiency virus retropepsin0 0 0
A02.004 equine infectious anaemia virus retropepsin13 0 13
A02.005 bovine immunodeficiency virus retropepsin11 11 0
A02.006 Visna lentivirus-type retropepsin0 0 0
A02.007 feline immunodeficiency virus retropepsin28 11 17
A02.008 murine leukemia virus-type retropepsin20 6 14
A02.009 Mason-Pfizer leukemia virus retropepsin18 4 14
A02.010 mouse mammary tumor virus retropepsin13 3 10
A02.011 human endogenous retrovirus K retropepsin100 1 99
A02.012 retropepsin (human T-cell leukemia virus)15 9 6
A02.013 bovine leukemia virus retropepsin20 6 14
A02.015 Rous sarcoma virus retropepsin18 2 16
A02.016 intracisternal A-particle retropepsin7 4 3
A02.018 simian T-cell lymphotropic virus retropepsin0 0 0
A02.019 multiple-sclerosis-associated retrovirus retropepsin0 0 0
A02.020 porcine endogenous retrovirus peptidase6 2 4
A02.021 Gypsy transposon peptidase0 0 0
A02.022 Ty3 transposon peptidase5 5 0
A02.024 rabbit endogenous retrovirus endopeptidase1 1 0
A02.051 retrotransposon peptidase (Schizosaccharomyces pombe)0 0 0
A02.052 retrotransposon 17.6 peptidase0 0 0
A02.053 S71-related human endogenous retropepsin0 0 0
A02.054 Osvaldo retrotransposon peptidase0 0 0
A02.055 RTVL-H-type putative peptidase0 0 0
A02.056 human endogenous retrovirus retropepsin homologue 10 0 0
A02.057 human endogenous retrovirus retropepsin homologue 20 0 0
A02.060 type D-like endogenous retrovirus peptidase (Mus musculus)0 0 0
A02.061 Ulysses retrotransposon retropepsin6 0 6
A02.062 TED retrotransposon peptidase (Trichoplusia ni)0 0 0
A02.063 walleye dermal sarcoma virus retropepsin25 13 12
A03.001 cauliflower mosaic virus-type peptidase1 1 0
A03.002 bacilliform virus peptidase6 6 0
A03.003 banana streak virus peptidase0 0 0
A03.004 Commelina yellow mottle virus peptidase0 0 0
A03.005 cassava vein mosaic virus-type peptidase0 0 0
A03.006 retrotransposon peptidase (Nicotiana-type)0 0 0
A05.001 thermopsin18 1 17
A08.001 signal peptidase II5 1 4
A09.001 spumapepsin11 10 1
A11.001 Copia transposon peptidase9 2 7
A11.002 Tnt1 retrotransposon (plant) peptidase0 0 0
A11.003 Ty1 transposon peptidase3 3 0
A11.004 Evelknievel retrotransposon peptidase0 0 0
A11.005 Melmoth transposon peptidase0 0 0
A11.051 SIRE-1 peptidase0 0 0
A22.001 presenilin 119 16 3
A22.002 presenilin 20 0 0
A22.003 impas 1 peptidase6 3 3
A22.004 signal peptide peptidase-like protein 2B5 4 1
A22.005 impas 2 peptidase0 0 0
A22.006 signal peptide peptidase-like protein 2C0 0 0
A22.007 signal peptide peptidase-like protein 2A5 0 5
A22.008 yeast presenilin fold 10 0 0
A22.009 SEL-12 peptidase (Caenorhabditis-type)0 0 0
A22.010 hop-1 peptidase0 0 0
A22.012 SPE-4 peptidase0 0 0
A22.013 mSPP peptidase (Plasmodium-type)0 0 0
A22.014 Psn peptidase (Drosophila-type)0 0 0
A22.015 intramembrane aspartyl peptidase (Methanoculleus marisnigri JR1)8 0 8
A22.A01 AtPS1 protein (Arabidopsis thaliana)0 0 0
A22.A02 AtPS2 protein (Arabidopsis thaliana)0 0 0
A22.A03 At1g01650 (Arabidopsis thaliana)0 0 0
A22.A04 At1g05820 (Arabidopsis thaliana)0 0 0
A22.A05 At1g63690 (Arabidopsis thaliana)0 0 0
A22.A06 At2g43105 (Arabidopsis thaliana)-type peptidase0 0 0
A22.A07 imp-3 g.p. (Caenorhabditis elegans)0 0 0
A22.A08 imp-1 g.p. (Caenorhabditis elegans)0 0 0
A22.A09 psenA (Dictyostelium discoideum)0 0 0
A22.A10 psenB (Dictyostelium discoideum)0 0 0
A22.A11 SPAC25B8.17 (Schizosaccharomyces pombe)0 0 0
A22.A12 DDB_G0292836 (Dictyostelium discoideum)0 0 0
A22.A13 DDB_G0287521 (Dictyostelium discoideum)0 0 0
A22.A14 At4g33410 g.p. (Arabidopsis thaliana)0 0 0
A22.A15 At2g03120 g.p. (Arabidopsis thaliana)0 0 0
A24.001 type 4 prepilin peptidase 116 7 9
A24.003 type 4 prepilin peptidase 20 0 0
A24.016 FlaK peptidase6 1 5
A24.017 PibD peptidase18 3 15
A24.018 EppA peptidase2 2 0
A24.019 ComC peptidase0 0 0
A24.A01 PppA protein (Escherichia coli)0 0 0
A24.A10 gspO g.p. (Escherichia coli)0 0 0
A25.001 gpr peptidase32 0 32
A26.001 omptin54 16 38
A26.002 OmpP peptidase11 1 10
A26.003 plasminogen activator Pla16 2 14
A26.004 protein E (Salmonella sp.)2 1 1
A26.005 IcsP peptidase (Shigella flexneri)1 1 0
A28.001 DNA-damage inducible protein 10 0 0
A28.002 nuclear receptor-interacting protein 30 0 0
A28.003 DNA-damage inducible protein 20 0 0
A28.004 skin SASPase15 0 15
A28.A01 gene name 1700011N24Rik (Mus musculus)0 0 0
A28.A02 C01G5.6 (Caenorhabditis elegans)0 0 0
A28.A03 At3g13235 (Arabidopsis thaliana)0 0 0
A28.A04 DDB_G0288187 (Dictyostelium discoideum)0 0 0
A28.A05 CG4420 g.p. (Drosophila melanogaster)0 0 0
A28.A06 putative v-snare binding protein (Schizosaccharomyces pombe)0 0 0
A28.A07 PF14_0090 (Plasmodium falciparum)0 0 0
A28.A08 DDB_G0279931 (Dictyostelium discoideum)0 0 0
A28.A09 K02A2.6 (Caenorhabditis elegans)0 0 0
A28.A10 nuclear receptor interacting protein 20 0 0
A31.001 HybD peptidase4 3 1
A31.002 HyaD peptidase0 0 0
A31.003 HycI peptidase1 1 0
A31.004 hoxW peptidase0 0 0
A31.005 hupW peptidase1 1 0
A31.006 FrxA peptidase1 1 0
A31.007 TK2004 peptidase0 0 0
A31.008 TK2066 peptidase0 0 0
A32.001 PerP peptidase (Caulobacter sp.)0 0 0
A32.002 RC1339 g.p. (Rickettsia conorii)800 0 800
A36.001 sporulation factor SpoIIGA4 1 3
A37.001 sso1175 g.p. (Sulfolobus solfataricus)6 0 6
A39.001 TseI g.p. (Aeromonas dhakensis)4 0 4
A9G.001 aspartic peptidase, plasma0 0 0
A9G.010 pycnoporopepsin8 0 8
A9G.017 acid peptidase (Cladosporium)8 0 8
A9G.018 acid peptidase (Paecilomyces)0 0 0
A9G.019 acrocylindropepsin6 0 6
A9G.020 yapsin A9 0 9

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