Structure for peptidase C03.008: foot-and-mouth disease virus picornain 3C

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

 

PDB Organism Resolution Comment
2J92_A foot-and-mouth disease virus 2.20 Å type A10(61); crystal packing mutant (Lys51Gln)
Catalytic residues are shown in ball-and-stick representation: His1699 in purple, Asp1734 in pink and Cys1813 in yellow.
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TERTIARY STRUCTURE DATA
Comment Resolution PDB PDBe SCOP CATH PDBSum Proteopedia Reference
foot-and-mouth disease virus
mature  peptidase 1.90 Å 1QMY 1QMY 1QMY 1QMY 1QMY 1QMY Guarne et al., 2000
mature  peptidase 3.00 Å 1QOL 1QOL 1QOL 1QOL 1QOL 1QOL Guarne et al., 1998
mature  peptidase 1.90 Å 1QQP 1QQP 1QQP 1QQP 1QQP 1QQP Fry et al., 1999
type A10(61); crystal packing mutant (Lys51Gln) 2.20 Å 2J92 2J92 2J92 2J92 2J92 2J92 Sweeney et al., 2007
mature  peptidase 0.00 Å 2JQF 2JQF 2JQF 2JQF 2JQF 2JQF Cencic et al., 2007
mature  peptidase 0.00 Å 2JQG 2JQG 2JQG 2JQG 2JQG 2JQG Cencic et al., 2007
complex with a decameric peptide corresponding to the vp1-2a cleavage junction 2.50 Å 2WV4 2WV4 2WV4 2WV4 2WV4 2WV4
complex with a decameric peptide corresponding to the vp1-2a cleavage junction with a gln to glu substitution at p1 2.70 Å 2WV5 2WV5 2WV5 2WV5 2WV5 2WV5
mature  peptidase 1.60 Å 4QBB 4QBB 4QBB 4QBB 4QBB 4QBB Steinberger et al., 2014
crystal structure of the 3c protease from south african territories type 2 foot-and-mouth disease virus 3.20 Å 5HM2 5HM2 5HM2 5HM2 5HM2 5HM2
fmdv leader protease bound to substrate isg15 1.50 Å 6FFA 6FFA 6FFA 6FFA 6FFA 6FFA