Substrates for peptidase C03.008: foot-and-mouth disease virus picornain 3C

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Dabcyl-Ala-Pro-Ala-Lys-Gln-Leu-Leu-Asp(EDANS)-Phe-Asp-Leu-Leu-Lys Dabcyl-Ala-Pro-Ala-Lys-Gln+Leu-Leu-Asp(EDANS)-Phe-Asp-Leu-Leu-Lys S Pro Ala Lys Gln Leu Leu Asp Phe Jaulent et al., 2007
genome polyprotein P49303 1-2336 peptide-Glu504+Gly-peptide P NT Pro Ser Lys Glu Gly Ile Val Pro Kristensen et al., 2018
genome polyprotein P49303 1-2336 peptide-Gln725+Thr-peptide P NT Pro Arg Ser Gln Thr Thr Ser Thr Kristensen et al., 2018
genome polyprotein P49303 1-2336 peptide-Gln936+Leu-peptide P NT Pro Ala Lys Gln Leu Leu Asn Phe Kristensen et al., 2018
histone H3.1 P68432 2-136 peptide-Leu21+Ala-peptide P Arg Lys Gln Leu Ala Thr Lys Ala Falk et al., 1990