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Literature for peptidase C03.008: foot-and-mouth disease virus picornain 3C

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Sahoo,S., Lee,H.K. and Shin,D.<br>Elucidating the structural dynamics induced by active site mutations in 3C protease of foot-and-mouth disease virus<br>PLoS ONE (2025) 20, e0321079-e0321079. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2024
  2. Wu,J., Sun,C., Guan,J., Abdullah,S.W., Wang,X., Ren,M., Qiao,L., Sun,S. and Guo,H.<br>Nuclear ribonucleoprotein RALY downregulates foot-and-mouth disease virus replication but antagonized by viral 3C protease<br>Microbiol Spectr (2024) 12, e0365823-e0365823. PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2023
  3. Wu,X., Chen,L., Sui,C., Hu,Y., Jiang,D., Yang,F., Miller,L.C., Li,J., Cong,X., Hrabchenko,N., Lee,C., Du,Y. and Qi,J.<br>3C(pro) of FMDV inhibits type II interferon-stimulated JAK-STAT signaling pathway by blocking STAT1 nuclear translocation<br>Virol Sin (2023) 38, 387-397. PubMed  Europe PubMed DOI  PMC  EPMC
    4. 2022
  4. Kristensen,T., Normann,P. and Belsham,G.J.<br>The N-terminal region (VP4) of the foot-and-mouth disease capsid precursor (P1-2A) is not required during its synthesis to allow subsequent processing by the 3C protease<br>Virology (2022) 570, 29-34. PubMed  Europe PubMed DOI
  5. Wu,X., Hu,Y., Sui,C., Pan,L., Yoo,D., Miller,L.C., Lee,C., Cong,X., Li,J., Du,Y. and Qi,J.<br>Multiple-Site SUMOylation of FMDV 3C Protease and Its Negative Role in Viral Replication<br>J Virol (2022) 96, e0061222-e0061222. PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2020
  6. Abdullah,S.W., Han,S., Wu,J., Zhang,Y., Bai,M., Jin,Y., Zhi,X., Guan,J., Sun,S. and Guo,H.<br>The DDX23 Negatively Regulates Translation and Replication of Foot-and-Mouth Disease Virus and Is Degraded by 3C Proteinase<br>Viruses (2020) 12 PubMed  Europe PubMed DOI  K
    7. 2019
  7. Kristensen,T. and Belsham,G.J.<br>Identification of a short, highly conserved, motif required for picornavirus capsid precursor processing at distal sites<br>PLoS Pathog (2019) 15, e1007509-e1007509. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Martel,E., Forzono,E., Kurker,R., Clark,B.A., Neilan,J.G. and Puckette,M.<br>Effect of foot-and-mouth disease virus 3C protease B2 beta-strand proline mutagenesis on expression and processing of the P1 polypeptide using a plasmid expression vector<br>J Gen Virol (2019) 100, 446-456. PubMed  Europe PubMed DOI
    9. 2018
  9. Kristensen,T., Newman,J., Guan,S.H., Tuthill,T.J. and Belsham,G.J.<br>Cleavages at the three junctions within the foot-and-mouth disease virus capsid precursor (P1-2A) by the 3C protease are mutually independent<br>Virology (2018) 522, 260-270. PubMed  Europe PubMed DOI
    10. 2017
  10. Kristensen,T., Normann,P., Gullberg,M., Fahnoe,U., Polacek,C., Rasmussen,T.B. and Belsham,G.J.<br>Determinants of the VP1/2A junction cleavage by the 3C protease in foot-and-mouth disease virus-infected cells<br>J Gen Virol (2017) 98, 385-395. PubMed  Europe PubMed DOI
  11. Puckette,M., Clark,B.A., Smith,J.D., Turecek,T., Martel,E., Gabbert,L., Pisano,M., Hurtle,W., Pacheco,J.M., Barrera,J., Neilan,J.G. and Rasmussen,M.<br>Foot-and-mouth disease virus 3C protease mutant L127P: Implications for FMD vaccine development<br>J Virol (2017) 91, e00924-17-e00924-17. PubMed  Europe PubMed DOI  E
    12. 2016
  12. Yang,J., Leen,E.N., Maree,F.F. and Curry,S.<br>Crystal structure of the 3C protease from Southern African Territories type 2 foot-and-mouth disease virus<br>PeerJ (2016) 4, e1964-e1964. PubMed  Europe PubMed DOI  PMC  EPMC  S
    13. 2015
  13. Nsamba,P., de Beer,T.A., Chitray,M., Scott,K., Vosloo,W. and Maree,F.F.<br>Determination of common genetic variants within the non-structural proteins of foot-and-mouth disease viruses isolated in sub-Saharan Africa<br>Vet Microbiol (2015) 177, 106-122. PubMed  Europe PubMed DOI  M
    14. 2014
  14. Du,Y., Bi,J., Liu,J., Liu,X., Wu,X., Jiang,P., Yoo,D., Zhang,Y., Wu,J., Wan,R., Zhao,X., Guo,L., Sun,W., Cong,X., Chen,L. and Wang,J.<br>3Cpro of foot-and-mouth disease virus antagonizes the interferon signaling pathway by blocking STAT1/STAT2 nuclear translocation<br>J Virol (2014) 88, 4908-4920. PubMed  Europe PubMed DOI
  15. Gullberg,M., Polacek,C. and Belsham,G.J.<br>Sequence adaptations affecting cleavage of the VP1/2A junction by the 3C protease in foot-and-mouth disease virus-infected cells<br>J Gen Virol (2014) 95, 2402-2410. PubMed  Europe PubMed DOI
  16. Roque Rosell,N.R., Mokhlesi,L., Milton,N.E., Sweeney,T.R., Zunszain,P.A., Curry,S. and Leatherbarrow,R.J.<br>Design and synthesis of irreversible inhibitors of foot-and-mouth disease virus 3C protease<br>Bioorg Med Chem Lett (2014) 24, 490-494. PubMed  Europe PubMed DOI  I
  17. van der Linden,L., Ulferts,R., Nabuurs,S.B., Kusov,Y., Liu,H., George,S., Lacroix,C., Goris,N., Lefebvre,D., Lanke,K.H., De Clercq,K., Hilgenfeld,R., Neyts,J. and van Kuppeveld,F.J.<br>Application of a cell-based protease assay for testing inhibitors of picornavirus 3C proteases<br>Antiviral Res (2014) 103, 17-24. PubMed  Europe PubMed DOI  I
    18. 2013
  18. Porta,C., Xu,X., Loureiro,S., Paramasivam,S., Ren,J., Al-Khalil,T., Burman,A., Jackson,T., Belsham,G.J., Curry,S., Lomonossoff,G.P., Parida,S., Paton,D., Li,Y., Wilsden,G., Ferris,N., Owens,R., Kotecha,A., Fry,E., Stuart,D.I., Charleston,B. and Jones,I.M.<br>Efficient production of foot-and-mouth disease virus empty capsids in insect cells following down regulation of 3C protease activity<br>J Virol Methods (2013) 187, 406-412. PubMed  Europe PubMed DOI
  19. Zhou,J.H., You,Y.N., Chen,H.T., Zhang,J., Ma,L.N., Ding,Y.Z., Pejsak,Z. and Liu,Y.S.<br>The effects of the synonymous codon usage and tRNA abundance on protein folding of the 3C protease of foot-and-mouth disease virus<br>Infect Genet Evol (2013) 16, 270-274. PubMed  Europe PubMed DOI
  20. Zhou,Z., Mogensen,M.M., Powell,P.P., Curry,S. and Wileman,T.<br>Foot-and-mouth disease virus 3C protease induces fragmentation of the Golgi compartment and blocks intra-Golgi transport<br>J Virol (2013) 87, 11721-11729. PubMed  Europe PubMed DOI
    21. 2012
  21. Lawrence,P., Schafer,E.A. and Rieder,E.<br>The nuclear protein Sam68 is cleaved by the FMDV 3C protease redistributing Sam68 to the cytoplasm during FMDV infection of host cells<br>Virology (2012) 425, 40-52. PubMed  Europe PubMed DOI
  22. Schrauf,S., Kurz,M., Taucher,C., Mandl,C.W. and Skern,T.<br>Generation and genetic stability of tick-borne encephalitis virus mutants dependent on processing by the foot-and-mouth disease virus 3C protease<br>J Gen Virol (2012) 93, 504-515. PubMed  Europe PubMed DOI
  23. Skern,T.<br>Picornain 3C<br>[ISSN:978-0-12-407743-0] (2012) 3, 2396-2402. DOI
  24. Wang,D., Fang,L., Li,K., Zhong,H., Fan,J., Ouyang,C., Zhang,H., Duan,E., Luo,R., Zhang,Z., Liu,X., Chen,H. and Xiao,S.<br>Foot-and-mouth disease virus 3C protease cleaves NEMO to impair innate immune signaling<br>J Virol (2012) 86, 9311-9322. PubMed  Europe PubMed DOI
    25. 2010
  25. Zunszain,P.A., Knox,S.R., Sweeney,T.R., Yang,J., Roque-Rosell,N., Belsham,G.J., Leatherbarrow,R.J. and Curry,S.<br>Insights into cleavage specificity from the crystal structure of foot-and-mouth disease virus 3C protease complexed with a peptide substrate<br>J Mol Biol (2010) 395, 375-389. PubMed  Europe PubMed DOI  P  S
    26. 2008
  26. Armer,H., Moffat,K., Wileman,T., Belsham,G.J., Jackson,T., Duprex,W.P., Ryan,M. and Monaghan,P.<br>Foot-and-mouth disease virus, but not bovine enterovirus, targets the host cell cytoskeleton via the nonstructural protein 3Cpro<br>J Virol (2008) 82, 10556-10566. PubMed  Europe PubMed DOI  PMC  EPMC
  27. Busch,G.K., Tate,E.W., Gaffney,P.R., Rosivatz,E., Woscholski,R. and Leatherbarrow,R.J.<br>Specific N-terminal protein labelling: use of FMDV 3Cpro protease and native chemical ligation<br>Chem Commun (Camb) (2008) 2008, 3369-3371. PubMed  Europe PubMed DOI
    28. 2007
  28. Curry,S., Roque-Rosell,N., Sweeney,T.R., Zunszain,P.A. and Leatherbarrow,R.J.<br>Structural analysis of foot-and-mouth disease virus 3C protease: a viable target for antiviral drugs?<br>Biochem Soc Trans (2007) 35, 594-598. PubMed  Europe PubMed DOI  V  T
  29. [YEAR:14-8-2007]Curry,S., Roque-Rosell,N., Zunszain,P.A. and Leatherbarrow,R.J.<br>Foot-and-mouth disease virus 3C protease: recent structural and functional insights into an antiviral target<br>Int J Biochem Cell Biol (14-8-2007) 39, 1-6. PubMed  Europe PubMed DOI  T
  30. Jaulent,A.M., Fahy,A.S., Knox,S.R., Birtley,J.R., Roque-Rosell,N., Curry,S. and Leatherbarrow,R.J.<br>A continuous assay for foot-and-mouth disease virus 3C protease activity<br>Anal Biochem (2007) 368, 130-137. PubMed  Europe PubMed DOI  A  I
  31. Sweeney,T.R., Roque-Rosell,N., Birtley,J.R., Leatherbarrow,R.J. and Curry,S.<br>Structural and mutagenic analysis of foot-and-mouth disease virus 3C protease reveals the role of the beta-ribbon in proteolysis<br>J Virol (2007) 81, 115-124. PubMed  Europe PubMed DOI  PMC  EPMC  S
    32. 2005
  32. [YEAR:1-5-2005]Birtley,J.R. and Curry,S.<br>Crystallization of foot-and-mouth disease virus 3C protease: surface mutagenesis and a novel crystal-optimization strategy<br>Acta Crystallogr D Biol Crystallogr (1-5-2005) 61, 646-650. PubMed  Europe PubMed DOI
  33. [YEAR:14-1-2005]Birtley,J.R., Knox,S.R., Jaulent,A.M., Brick,P., Leatherbarrow,R.J. and Curry,S.<br>Crystal structure of foot-and-mouth disease virus 3C protease. New insights into catalytic mechanism and cleavage specificity<br>J Biol Chem (14-1-2005) 280, 11520-11527. PubMed  Europe PubMed DOI  S
  34. [YEAR:7-3-2005]Dus Santos,M.J., Carrillo,C., Ardila,F., Rios,R.D., Franzone,P., Piccone,M.E., Wigdorovitz,A. and Borca,M.V.<br>Development of transgenic alfalfa plants containing the foot and mouth disease virus structural polyprotein gene P1 and its utilization as an experimental immunogen<br>Vaccine (7-3-2005) 23, 1838-1843. PubMed  Europe PubMed DOI
    35. 2004
  35. Skern,T.<br>Picornain 3C<br>[ISSN:0-12-079610-4] (2004) 2, 1353-1357.  V
  36. Strong,R. and Belsham,G.J.<br>Sequential modification of translation initiation factor eIF4GI by two different foot-and-mouth disease virus proteases within infected baby hamster kidney cells: identification of the 3Cpro cleavage site<br>J Gen Virol (2004) 85, 2953-2962. PubMed  Europe PubMed DOI
    37. 2002
  37. Hinton,T.M., Ross-Smith,N., Warner,S., Belsham,G.J. and Crabb,B.S.<br>Conservation of L and 3C proteinase activities across distantly related aphthoviruses<br>J Gen Virol (2002) 83, 3111-3121. PubMed  Europe PubMed
  38. [YEAR:1-5-2002]van Rensburg,H., Haydon,D., Joubert,F., Bastos,A., Heath,L. and Nel,L.<br>Genetic heterogeneity in the foot-and-mouth disease virus Leader and 3C proteinases<br>Gene (1-5-2002) 289, 19-29. PubMed  Europe PubMed DOI
    39. 2001
  39. [YEAR:19-10-2001]Li,W., Ross-Smith,N., Proud,C.G. and Belsham,G.J.<br>Cleavage of translation initiation factor 4AI (eIF4AI) but not eIF4AII by foot-and-mouth disease virus 3C protease: identification of the eIF4AI cleavage site<br>FEBS Lett (19-10-2001) 507, 1-5. PubMed  Europe PubMed DOI
    40. 2000
  40. Belsham,G.J., McInerney,G.M. and Ross-Smith,N.<br>Foot-and-mouth disease virus 3C protease induces cleavage of translation initiation factors eIF4A and eIF4G within infected cells<br>J Virol (2000) 74, 272-280. PubMed  Europe PubMed  PMC  EPMC
    41. 1997
  41. Ryan,M.D. and Flint,M.<br>Virus-encoded proteinases of the picornavirus super-group<br>J Gen Virol (1997) 78, 699-723. PubMed  Europe PubMed
    42. 1995
  42. Grubman,M.J., Zellner,M., Bablanian,G., Mason,P.W. and Piccone,M.E.<br>Identification of the active-site residues of the 3C proteinase of foot-and-mouth disease virus<br>Virology (1995) 213, 581-589. PubMed  Europe PubMed DOI
    43. 1993
  43. Bablanian,G.M. and Grubman,M.J.<br>Characterization of the foot-and-mouth disease virus 3C protease expressed in Escherichia coli<br>Virology (1993) 197, 320-327. PubMed  Europe PubMed DOI  E
    44. 1990
  44. Falk,M.M., Grigera,P.R., Bergmann,I.E., Zibert,A., Multhaup,G. and Beck,E.<br>Foot-and-mouth disease virus protease 3C induces specific proteolytic cleavage of host cell histone H3<br>J Virol (1990) 64, 748-756. PubMed  Europe PubMed  PMC  EPMC
    45. 1989
  45. Ryan,M.D., Belsham,G.J. and King,A.M.<br>Specificity of enzyme-substrate interactions in foot-and-mouth disease virus polyprotein processing<br>Virology (1989) 173, 35-45. PubMed  Europe PubMed

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