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Literature for peptidase C03.008: foot-and-mouth disease virus picornain 3C

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Sahoo,S., Lee,H.K. and Shin,D.
    Elucidating the structural dynamics induced by active site mutations in 3C protease of foot-and-mouth disease virus
    PLoS ONE (2025) 20, e0321079-e0321079. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2024
  2. Wu,J., Sun,C., Guan,J., Abdullah,S.W., Wang,X., Ren,M., Qiao,L., Sun,S. and Guo,H.
    Nuclear ribonucleoprotein RALY downregulates foot-and-mouth disease virus replication but antagonized by viral 3C protease
    Microbiol Spectr (2024) 12, e0365823-e0365823. PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2023
  3. Wu,X., Chen,L., Sui,C., Hu,Y., Jiang,D., Yang,F., Miller,L.C., Li,J., Cong,X., Hrabchenko,N., Lee,C., Du,Y. and Qi,J.
    3C(pro) of FMDV inhibits type II interferon-stimulated JAK-STAT signaling pathway by blocking STAT1 nuclear translocation
    Virol Sin (2023) 38, 387-397. PubMed  Europe PubMed DOI  PMC  EPMC
    4. 2022
  4. Kristensen,T., Normann,P. and Belsham,G.J.
    The N-terminal region (VP4) of the foot-and-mouth disease capsid precursor (P1-2A) is not required during its synthesis to allow subsequent processing by the 3C protease
    Virology (2022) 570, 29-34. PubMed  Europe PubMed DOI
  5. Wu,X., Hu,Y., Sui,C., Pan,L., Yoo,D., Miller,L.C., Lee,C., Cong,X., Li,J., Du,Y. and Qi,J.
    Multiple-Site SUMOylation of FMDV 3C Protease and Its Negative Role in Viral Replication
    J Virol (2022) 96, e0061222-e0061222. PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2020
  6. Abdullah,S.W., Han,S., Wu,J., Zhang,Y., Bai,M., Jin,Y., Zhi,X., Guan,J., Sun,S. and Guo,H.
    The DDX23 Negatively Regulates Translation and Replication of Foot-and-Mouth Disease Virus and Is Degraded by 3C Proteinase
    Viruses (2020) 12 PubMed  Europe PubMed DOI  K
    7. 2019
  7. Kristensen,T. and Belsham,G.J.
    Identification of a short, highly conserved, motif required for picornavirus capsid precursor processing at distal sites
    PLoS Pathog (2019) 15, e1007509-e1007509. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Martel,E., Forzono,E., Kurker,R., Clark,B.A., Neilan,J.G. and Puckette,M.
    Effect of foot-and-mouth disease virus 3C protease B2 beta-strand proline mutagenesis on expression and processing of the P1 polypeptide using a plasmid expression vector
    J Gen Virol (2019) 100, 446-456. PubMed  Europe PubMed DOI
    9. 2018
  9. Kristensen,T., Newman,J., Guan,S.H., Tuthill,T.J. and Belsham,G.J.
    Cleavages at the three junctions within the foot-and-mouth disease virus capsid precursor (P1-2A) by the 3C protease are mutually independent
    Virology (2018) 522, 260-270. PubMed  Europe PubMed DOI
    10. 2017
  10. Kristensen,T., Normann,P., Gullberg,M., Fahnoe,U., Polacek,C., Rasmussen,T.B. and Belsham,G.J.
    Determinants of the VP1/2A junction cleavage by the 3C protease in foot-and-mouth disease virus-infected cells
    J Gen Virol (2017) 98, 385-395. PubMed  Europe PubMed DOI
  11. Puckette,M., Clark,B.A., Smith,J.D., Turecek,T., Martel,E., Gabbert,L., Pisano,M., Hurtle,W., Pacheco,J.M., Barrera,J., Neilan,J.G. and Rasmussen,M.
    Foot-and-mouth disease virus 3C protease mutant L127P: Implications for FMD vaccine development
    J Virol (2017) 91, e00924-17-e00924-17. PubMed  Europe PubMed DOI  E
    12. 2016
  12. Yang,J., Leen,E.N., Maree,F.F. and Curry,S.
    Crystal structure of the 3C protease from Southern African Territories type 2 foot-and-mouth disease virus
    PeerJ (2016) 4, e1964-e1964. PubMed  Europe PubMed DOI  PMC  EPMC  S
    13. 2015
  13. Nsamba,P., de Beer,T.A., Chitray,M., Scott,K., Vosloo,W. and Maree,F.F.
    Determination of common genetic variants within the non-structural proteins of foot-and-mouth disease viruses isolated in sub-Saharan Africa
    Vet Microbiol (2015) 177, 106-122. PubMed  Europe PubMed DOI  M
    14. 2014
  14. Du,Y., Bi,J., Liu,J., Liu,X., Wu,X., Jiang,P., Yoo,D., Zhang,Y., Wu,J., Wan,R., Zhao,X., Guo,L., Sun,W., Cong,X., Chen,L. and Wang,J.
    3Cpro of foot-and-mouth disease virus antagonizes the interferon signaling pathway by blocking STAT1/STAT2 nuclear translocation
    J Virol (2014) 88, 4908-4920. PubMed  Europe PubMed DOI
  15. Gullberg,M., Polacek,C. and Belsham,G.J.
    Sequence adaptations affecting cleavage of the VP1/2A junction by the 3C protease in foot-and-mouth disease virus-infected cells
    J Gen Virol (2014) 95, 2402-2410. PubMed  Europe PubMed DOI
  16. Roque Rosell,N.R., Mokhlesi,L., Milton,N.E., Sweeney,T.R., Zunszain,P.A., Curry,S. and Leatherbarrow,R.J.
    Design and synthesis of irreversible inhibitors of foot-and-mouth disease virus 3C protease
    Bioorg Med Chem Lett (2014) 24, 490-494. PubMed  Europe PubMed DOI  I
  17. van der Linden,L., Ulferts,R., Nabuurs,S.B., Kusov,Y., Liu,H., George,S., Lacroix,C., Goris,N., Lefebvre,D., Lanke,K.H., De Clercq,K., Hilgenfeld,R., Neyts,J. and van Kuppeveld,F.J.
    Application of a cell-based protease assay for testing inhibitors of picornavirus 3C proteases
    Antiviral Res (2014) 103, 17-24. PubMed  Europe PubMed DOI  I
    18. 2013
  18. Porta,C., Xu,X., Loureiro,S., Paramasivam,S., Ren,J., Al-Khalil,T., Burman,A., Jackson,T., Belsham,G.J., Curry,S., Lomonossoff,G.P., Parida,S., Paton,D., Li,Y., Wilsden,G., Ferris,N., Owens,R., Kotecha,A., Fry,E., Stuart,D.I., Charleston,B. and Jones,I.M.
    Efficient production of foot-and-mouth disease virus empty capsids in insect cells following down regulation of 3C protease activity
    J Virol Methods (2013) 187, 406-412. PubMed  Europe PubMed DOI
  19. Zhou,J.H., You,Y.N., Chen,H.T., Zhang,J., Ma,L.N., Ding,Y.Z., Pejsak,Z. and Liu,Y.S.
    The effects of the synonymous codon usage and tRNA abundance on protein folding of the 3C protease of foot-and-mouth disease virus
    Infect Genet Evol (2013) 16, 270-274. PubMed  Europe PubMed DOI
  20. Zhou,Z., Mogensen,M.M., Powell,P.P., Curry,S. and Wileman,T.
    Foot-and-mouth disease virus 3C protease induces fragmentation of the Golgi compartment and blocks intra-Golgi transport
    J Virol (2013) 87, 11721-11729. PubMed  Europe PubMed DOI
    21. 2012
  21. Lawrence,P., Schafer,E.A. and Rieder,E.
    The nuclear protein Sam68 is cleaved by the FMDV 3C protease redistributing Sam68 to the cytoplasm during FMDV infection of host cells
    Virology (2012) 425, 40-52. PubMed  Europe PubMed DOI
  22. Schrauf,S., Kurz,M., Taucher,C., Mandl,C.W. and Skern,T.
    Generation and genetic stability of tick-borne encephalitis virus mutants dependent on processing by the foot-and-mouth disease virus 3C protease
    J Gen Virol (2012) 93, 504-515. PubMed  Europe PubMed DOI
  23. Skern,T.
    Picornain 3C
    [ISSN:978-0-12-407743-0] (2012) 3, 2396-2402. DOI
  24. Wang,D., Fang,L., Li,K., Zhong,H., Fan,J., Ouyang,C., Zhang,H., Duan,E., Luo,R., Zhang,Z., Liu,X., Chen,H. and Xiao,S.
    Foot-and-mouth disease virus 3C protease cleaves NEMO to impair innate immune signaling
    J Virol (2012) 86, 9311-9322. PubMed  Europe PubMed DOI
    25. 2010
  25. Zunszain,P.A., Knox,S.R., Sweeney,T.R., Yang,J., Roque-Rosell,N., Belsham,G.J., Leatherbarrow,R.J. and Curry,S.
    Insights into cleavage specificity from the crystal structure of foot-and-mouth disease virus 3C protease complexed with a peptide substrate
    J Mol Biol (2010) 395, 375-389. PubMed  Europe PubMed DOI  P  S
    26. 2008
  26. Armer,H., Moffat,K., Wileman,T., Belsham,G.J., Jackson,T., Duprex,W.P., Ryan,M. and Monaghan,P.
    Foot-and-mouth disease virus, but not bovine enterovirus, targets the host cell cytoskeleton via the nonstructural protein 3Cpro
    J Virol (2008) 82, 10556-10566. PubMed  Europe PubMed DOI  PMC  EPMC
  27. Busch,G.K., Tate,E.W., Gaffney,P.R., Rosivatz,E., Woscholski,R. and Leatherbarrow,R.J.
    Specific N-terminal protein labelling: use of FMDV 3Cpro protease and native chemical ligation
    Chem Commun (Camb) (2008) 2008, 3369-3371. PubMed  Europe PubMed DOI
    28. 2007
  28. Curry,S., Roque-Rosell,N., Sweeney,T.R., Zunszain,P.A. and Leatherbarrow,R.J.
    Structural analysis of foot-and-mouth disease virus 3C protease: a viable target for antiviral drugs?
    Biochem Soc Trans (2007) 35, 594-598. PubMed  Europe PubMed DOI  V  T
  29. [YEAR:14-8-2007]Curry,S., Roque-Rosell,N., Zunszain,P.A. and Leatherbarrow,R.J.
    Foot-and-mouth disease virus 3C protease: recent structural and functional insights into an antiviral target
    Int J Biochem Cell Biol (14-8-2007) 39, 1-6. PubMed  Europe PubMed DOI  T
  30. Jaulent,A.M., Fahy,A.S., Knox,S.R., Birtley,J.R., Roque-Rosell,N., Curry,S. and Leatherbarrow,R.J.
    A continuous assay for foot-and-mouth disease virus 3C protease activity
    Anal Biochem (2007) 368, 130-137. PubMed  Europe PubMed DOI  A  I
  31. Sweeney,T.R., Roque-Rosell,N., Birtley,J.R., Leatherbarrow,R.J. and Curry,S.
    Structural and mutagenic analysis of foot-and-mouth disease virus 3C protease reveals the role of the beta-ribbon in proteolysis
    J Virol (2007) 81, 115-124. PubMed  Europe PubMed DOI  PMC  EPMC  S
    32. 2005
  32. [YEAR:1-5-2005]Birtley,J.R. and Curry,S.
    Crystallization of foot-and-mouth disease virus 3C protease: surface mutagenesis and a novel crystal-optimization strategy
    Acta Crystallogr D Biol Crystallogr (1-5-2005) 61, 646-650. PubMed  Europe PubMed DOI
  33. [YEAR:14-1-2005]Birtley,J.R., Knox,S.R., Jaulent,A.M., Brick,P., Leatherbarrow,R.J. and Curry,S.
    Crystal structure of foot-and-mouth disease virus 3C protease. New insights into catalytic mechanism and cleavage specificity
    J Biol Chem (14-1-2005) 280, 11520-11527. PubMed  Europe PubMed DOI  S
  34. [YEAR:7-3-2005]Dus Santos,M.J., Carrillo,C., Ardila,F., Rios,R.D., Franzone,P., Piccone,M.E., Wigdorovitz,A. and Borca,M.V.
    Development of transgenic alfalfa plants containing the foot and mouth disease virus structural polyprotein gene P1 and its utilization as an experimental immunogen
    Vaccine (7-3-2005) 23, 1838-1843. PubMed  Europe PubMed DOI
    35. 2004
  35. Skern,T.
    Picornain 3C
    [ISSN:0-12-079610-4] (2004) 2, 1353-1357.  V
  36. Strong,R. and Belsham,G.J.
    Sequential modification of translation initiation factor eIF4GI by two different foot-and-mouth disease virus proteases within infected baby hamster kidney cells: identification of the 3Cpro cleavage site
    J Gen Virol (2004) 85, 2953-2962. PubMed  Europe PubMed DOI
    37. 2002
  37. Hinton,T.M., Ross-Smith,N., Warner,S., Belsham,G.J. and Crabb,B.S.
    Conservation of L and 3C proteinase activities across distantly related aphthoviruses
    J Gen Virol (2002) 83, 3111-3121. PubMed  Europe PubMed
  38. [YEAR:1-5-2002]van Rensburg,H., Haydon,D., Joubert,F., Bastos,A., Heath,L. and Nel,L.
    Genetic heterogeneity in the foot-and-mouth disease virus Leader and 3C proteinases
    Gene (1-5-2002) 289, 19-29. PubMed  Europe PubMed DOI
    39. 2001
  39. [YEAR:19-10-2001]Li,W., Ross-Smith,N., Proud,C.G. and Belsham,G.J.
    Cleavage of translation initiation factor 4AI (eIF4AI) but not eIF4AII by foot-and-mouth disease virus 3C protease: identification of the eIF4AI cleavage site
    FEBS Lett (19-10-2001) 507, 1-5. PubMed  Europe PubMed DOI
    40. 2000
  40. Belsham,G.J., McInerney,G.M. and Ross-Smith,N.
    Foot-and-mouth disease virus 3C protease induces cleavage of translation initiation factors eIF4A and eIF4G within infected cells
    J Virol (2000) 74, 272-280. PubMed  Europe PubMed  PMC  EPMC
    41. 1997
  41. Ryan,M.D. and Flint,M.
    Virus-encoded proteinases of the picornavirus super-group
    J Gen Virol (1997) 78, 699-723. PubMed  Europe PubMed
    42. 1995
  42. Grubman,M.J., Zellner,M., Bablanian,G., Mason,P.W. and Piccone,M.E.
    Identification of the active-site residues of the 3C proteinase of foot-and-mouth disease virus
    Virology (1995) 213, 581-589. PubMed  Europe PubMed DOI
    43. 1993
  43. Bablanian,G.M. and Grubman,M.J.
    Characterization of the foot-and-mouth disease virus 3C protease expressed in Escherichia coli
    Virology (1993) 197, 320-327. PubMed  Europe PubMed DOI  E
    44. 1990
  44. Falk,M.M., Grigera,P.R., Bergmann,I.E., Zibert,A., Multhaup,G. and Beck,E.
    Foot-and-mouth disease virus protease 3C induces specific proteolytic cleavage of host cell histone H3
    J Virol (1990) 64, 748-756. PubMed  Europe PubMed  PMC  EPMC
    45. 1989
  45. Ryan,M.D., Belsham,G.J. and King,A.M.
    Specificity of enzyme-substrate interactions in foot-and-mouth disease virus polyprotein processing
    Virology (1989) 173, 35-45. PubMed  Europe PubMed

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