Searches of the MEROPS database
Display Known Cleavages for a Protein
Please enter a UniProt accession (eg P05067):
Sequence Q04637
,
Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.
Peptide and protein substrates that are thought to be physiologically relevant are indicated by P.
Peptide and protein substrates that are not physiologically relevant are indicated by N.
How cleavage sites have been identified are indicated by the following evidence codes:
NT = N-terminal sequencing,
MS = mass spectroscopy,
MU = mutation,
CS = consensus sequence,
LC = liquid chromatography.
To see all annotated cleavages for a peptidase, click on the peptidase name.
| Cleavage Site |
Peptidase |
Residue range |
Cleavage type |
Description |
Evidence |
Reference |
|---|
| 88 |
unknown peptidase |
88-1599 |
P |
release of an initiating methionine |
MS |
Van Damme P et al., 2005 |
| 94 |
HtrA2 peptidase |
1-1599 |
P |
|
|
Vande Walle et al., 2007 |
| 183 |
meprin alpha subunit |
1-1599 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 183 |
meprin beta subunit |
1-1599 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 532 |
caspase-3 |
1-1599 |
P |
normal turnover |
|
Bushell et al., 2000 |
| 656 |
trypsin 1 |
1-1599 |
N |
|
MS |
Schilling & Overall, 2008 |
| 665 |
granzyme B (Homo sapiens-type) |
1-1599 |
N |
|
MS |
Van Damme et al., 2010 |
| 674 |
foot-and-mouth disease virus L-peptidase |
1-1599 |
N |
|
|
Kuehnel et al., 2004 |
| 675 |
trypsin 1 |
1-1599 |
N |
|
MS |
Schilling & Overall, 2008 |
| 681 |
enterovirus picornain 2A |
1-1599 |
N |
|
|
Goldstaub et al., 2000 |
| 681 |
rhinovirus picornain 2A |
1-1599 |
N |
|
|
Gradi et al., 2004 |
| 718 |
HIV-1 retropepsin |
1-1599 |
N |
pathological turnover |
|
Ventoso et al., 2001 |
| 719 |
murine leukemia virus-type retropepsin |
1-1599 |
N |
|
|
Alvarez et al., 2003 |
| 721 |
HIV-1 retropepsin |
1-1599 |
N |
pathological turnover |
|
Ventoso et al., 2001 |
| 721 |
murine leukemia virus-type retropepsin |
1-1599 |
N |
|
|
Alvarez et al., 2003 |
| 770 |
trypsin 1 |
1-1599 |
N |
|
MS |
Schilling & Overall, 2008 |
| 781 |
trypsin 1 |
1-1599 |
N |
|
MS |
Schilling & Overall, 2008 |
| 795 |
trypsin 1 |
1-1599 |
N |
|
MS |
Schilling & Overall, 2008 |
| 804 |
trypsin 1 |
1-1599 |
N |
|
MS |
Schilling & Overall, 2008 |
| 900 |
trypsin 1 |
1-1599 |
N |
|
MS |
Schilling & Overall, 2008 |
| 907 |
trypsin 1 |
1-1599 |
N |
|
MS |
Schilling & Overall, 2008 |
| 909 |
trypsin 1 |
1-1599 |
N |
|
MS |
Schilling & Overall, 2008 |
| 922 |
trypsin 1 |
1-1599 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1032 |
trypsin 1 |
1-1599 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1042 |
trypsin 1 |
1-1599 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1099 |
cathepsin B |
1096-1114 |
N |
|
MS |
Biniossek et al., 2011 |
| 1110 |
meprin beta subunit |
1107-1122 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 1126 |
HIV-1 retropepsin |
1-1599 |
N |
pathological turnover |
|
Ventoso et al., 2001 |
| 1176 |
caspase-3 |
1-1599 |
P |
normal turnover |
|
Bushell et al., 2000 |
| 1206 |
granzyme A |
1-1599 |
N |
|
|
Van Damme et al., 2010 |
| 1223 |
trypsin 1 |
1-1599 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1234 |
trypsin 1 |
1-1599 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1404 |
trypsin 1 |
1-1599 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1421 |
trypsin 1 |
1-1599 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1436 |
trypsin 1 |
1-1599 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1445 |
trypsin 1 |
1-1599 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1459 |
trypsin 1 |
1-1599 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1480 |
trypsin 1 |
1-1599 |
N |
|
MS |
Schilling & Overall, 2008 |
| 1564 |
cathepsin L |
1557-1575 |
N |
|
MS |
Biniossek et al., 2011 |
