Substrates for peptidase A02.008: murine leukemia virus-type retropepsin
Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.
| Substrate | Uniprot | Residue range | Cleavage Site | Cleavage type | Evidence | P4 | P3 | P2 | P1 | P1' | P2' | P3' | P4' | Reference | CutDB | MERNUM |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| eukaryotic translation initiation factor 4 gamma 1 | Q04637 | 1-1599 | peptide-Thr718+Val-peptide | N | Ile | Ile | Ala | Thr | Val | Leu | Met | Thr | Alvarez et al., 2003 | 26052 | ||
| eukaryotic translation initiation factor 4 gamma 1 | Q04637 | 1-1599 | peptide-Leu720+Met-peptide | N | Ala | Thr | Val | Leu | Met | Thr | Glu | Asp | Alvarez et al., 2003 | 26053 | ||
| gag polyprotein | P03333 | 2-235 | peptide-Tyr131+Pro-peptide | P | NT | Ser | Ser | Leu | Tyr | Pro | Ala | Leu | Thr | |||
| gag polyprotein | P03333 | 2-235 | peptide-Phe215+Pro-peptide | P | NT | Ser | Gln | Ala | Phe | Pro | Leu | Arg | Thr | |||
| pol polyprotein | P03355 | 1-1738 | peptide-Leu658+Thr-peptide | P | Leu | Gln | Val | Leu | Thr | Leu | Asn | Ile | Fodor & Vogt, 2002 | 15986 | ||
| pol polyprotein | P03355 | 1-1738 | peptide-Ile1330+Glu-peptide | P | Thr | Leu | Leu | Ile | Glu | Asn | Ser | Ser | Fodor & Vogt, 2002 | 15985 | ||
| pol polyprotein (feline leukemia virus) | O89811 | 1-1786 | peptide-Leu701+Thr-peptide | P | Leu | Gln | Val | Leu | Thr | Leu | Gln | Leu | Fodor & Vogt, 2002 | 15983 | ||
| pol polyprotein (feline leukemia virus) | Q85521 | 1-1784 | peptide-Thr1370+Glu-peptide | P | Ile | Leu | Pro | Thr | Glu | Leu | Ile | Glu | Fodor & Vogt, 2002 | |||
| Val-Ser-Ala-Asn-Tyr-Pro-Ile-Val-Gln | peptide-Tyr5+Pro-peptide | N | AA | Ser | Ala | Asn | Tyr | Pro | Ile | Val | Gln | Eizert et al., 2008 | ||||
| Val-Ser-Gln-Asn-Leu-Pro-Ile-Val-Gln | peptide-Leu5+Pro-peptide | N | AA | Ser | Gln | Asn | Leu | Pro | Ile | Val | Gln | Eizert et al., 2008 | ||||
| Val-Ser-Gln-Asn-Met-Pro-Ile-Val-Gln | peptide-Met5+Pro-peptide | N | AA | Ser | Gln | Asn | Met | Pro | Ile | Val | Gln | Eizert et al., 2008 | ||||
| Val-Ser-Gln-Asn-Phe-Pro-Ile-Val-Gln | peptide-Phe5+Pro-peptide | N | AA | Ser | Gln | Asn | Phe | Pro | Ile | Val | Gln | Eizert et al., 2008 | ||||
| Val-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln | Val-Ser-Gln-Asn-Tyr+Pro-Ile-Val-Gln | N | Ser | Gln | Asn | Tyr | Pro | Ile | Val | Gln | Menendez-Arias et al., 2004 | |||||
| Val-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln | peptide-Tyr5+Pro-peptide | N | AA | Ser | Gln | Asn | Tyr | Pro | Ile | Val | Gln | Eizert et al., 2008 | ||||
| Val-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln | peptide-Tyr5+Pro-peptide | N | AA | Ser | Gln | Asn | Tyr | Pro | Ile | Val | Gln | Eizert et al., 2008 | ||||
| Val-Ser-Gly-Asn-Tyr-Pro-Ile-Val-Gln | peptide-Tyr5+Pro-peptide | N | AA | Ser | Gly | Asn | Tyr | Pro | Ile | Val | Gln | Eizert et al., 2008 | ||||
| Val-Ser-Leu-Asn-Tyr-Pro-Ile-Val-Gln | peptide-Tyr5+Pro-peptide | N | AA | Ser | Leu | Asn | Tyr | Pro | Ile | Val | Gln | Eizert et al., 2008 | ||||
| Val-Ser-Lys-Asn-Tyr-Pro-Ile-Val-Gln | peptide-Tyr5+Pro-peptide | N | AA | Ser | Lys | Asn | Tyr | Pro | Ile | Val | Gln | Eizert et al., 2008 | ||||
| Val-Ser-Phe-Asn-Tyr-Pro-Ile-Val-Gln | peptide-Tyr5+Pro-peptide | N | AA | Ser | Phe | Asn | Tyr | Pro | Ile | Val | Gln | Eizert et al., 2008 | ||||
| Val-Ser-Val-Asn-Tyr-Pro-Ile-Val-Gln | peptide-Tyr5+Pro-peptide | N | AA | Ser | Val | Asn | Tyr | Pro | Ile | Val | Gln | Eizert et al., 2008 |
