Substrates for peptidase A02.008: murine leukemia virus-type retropepsin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
eukaryotic translation initiation factor 4 gamma 1 Q04637 1-1599 peptide-Thr718+Val-peptide N Ile Ile Ala Thr Val Leu Met Thr Alvarez et al., 2003 26052
eukaryotic translation initiation factor 4 gamma 1 Q04637 1-1599 peptide-Leu720+Met-peptide N Ala Thr Val Leu Met Thr Glu Asp Alvarez et al., 2003 26053
gag polyprotein P03333 2-235 peptide-Tyr131+Pro-peptide P NT Ser Ser Leu Tyr Pro Ala Leu Thr
gag polyprotein P03333 2-235 peptide-Phe215+Pro-peptide P NT Ser Gln Ala Phe Pro Leu Arg Thr
pol polyprotein P03355 1-1738 peptide-Leu658+Thr-peptide P Leu Gln Val Leu Thr Leu Asn Ile Fodor & Vogt, 2002 15986
pol polyprotein P03355 1-1738 peptide-Ile1330+Glu-peptide P Thr Leu Leu Ile Glu Asn Ser Ser Fodor & Vogt, 2002 15985
pol polyprotein (feline leukemia virus) O89811 1-1786 peptide-Leu701+Thr-peptide P Leu Gln Val Leu Thr Leu Gln Leu Fodor & Vogt, 2002 15983
pol polyprotein (feline leukemia virus) Q85521 1-1784 peptide-Thr1370+Glu-peptide P Ile Leu Pro Thr Glu Leu Ile Glu Fodor & Vogt, 2002
Val-Ser-Ala-Asn-Tyr-Pro-Ile-Val-Gln peptide-Tyr5+Pro-peptide N AA Ser Ala Asn Tyr Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Gln-Asn-Leu-Pro-Ile-Val-Gln peptide-Leu5+Pro-peptide N AA Ser Gln Asn Leu Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Gln-Asn-Met-Pro-Ile-Val-Gln peptide-Met5+Pro-peptide N AA Ser Gln Asn Met Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Gln-Asn-Phe-Pro-Ile-Val-Gln peptide-Phe5+Pro-peptide N AA Ser Gln Asn Phe Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln Val-Ser-Gln-Asn-Tyr+Pro-Ile-Val-Gln N Ser Gln Asn Tyr Pro Ile Val Gln Menendez-Arias et al., 2004
Val-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln peptide-Tyr5+Pro-peptide N AA Ser Gln Asn Tyr Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln peptide-Tyr5+Pro-peptide N AA Ser Gln Asn Tyr Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Gly-Asn-Tyr-Pro-Ile-Val-Gln peptide-Tyr5+Pro-peptide N AA Ser Gly Asn Tyr Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Leu-Asn-Tyr-Pro-Ile-Val-Gln peptide-Tyr5+Pro-peptide N AA Ser Leu Asn Tyr Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Lys-Asn-Tyr-Pro-Ile-Val-Gln peptide-Tyr5+Pro-peptide N AA Ser Lys Asn Tyr Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Phe-Asn-Tyr-Pro-Ile-Val-Gln peptide-Tyr5+Pro-peptide N AA Ser Phe Asn Tyr Pro Ile Val Gln Eizert et al., 2008
Val-Ser-Val-Asn-Tyr-Pro-Ile-Val-Gln peptide-Tyr5+Pro-peptide N AA Ser Val Asn Tyr Pro Ile Val Gln Eizert et al., 2008