Substrates for peptidase C28.001: foot-and-mouth disease virus L-peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
eukaryotic translation initiation factor 4 gamma 1	Q04637	1-1599	peptide-Gly674+Arg-peptide	N		Ala	Asn	Leu	Gly	Arg	Thr	Thr	Leu	Kuehnel et al., 2004	20475
eukaryotic translation initiation factor 4 gamma 3	O43432	1-1585	peptide-Val699+Gly-peptide	N		Leu	Leu	Asn	Val	Gly	Ser	Arg	Arg	Gradi et al., 2004
eukaryotic translation initiation factor 4 gamma 3	O43432	1-1585	peptide-Gly700+Ser-peptide	N		Leu	Asn	Val	Gly	Ser	Arg	Arg	Ser	Kuehnel et al., 2004	20478
initiation factor eIF-4G	Q6NZJ6	1-1600	peptide-Gly678+Arg-peptide	P		Ala	Asn	Leu	Gly	Arg	Pro	Ala	Leu	Grubman, 2004	16299
initiation factor eIF-4G	Q6NZJ6	1-1600	peptide-Lys517+Argpeptide	P		Ser	Val	Pro	Lys	Arg	Arg	Arg	Lys	Grubman, 2004	16298
ubiquitin-like protein ISG15	P05161	2-157	peptide-Arg155+Gly-Gly	P	MS	Leu	Arg	Leu	Arg	Gly	Gly	'-'	'-'	Swatek et al., 2018
VP4 protein (foot-and-mouth disease virus)			peptide-Lys+Gly-peptide	N		Arg	Lys	Leu	Lys	Gly	Ala	Gly	Asn	Grubman, 2004