Substrates for peptidase C03.020: enterovirus picornain 2A

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
dystrophin	P11531	1-3678	peptide-Thr2427+Gly-peptide	N		Leu	Ser	Thr	Thr	Gly	Ala	Ser	Ala	Badorff, 2004
dystrophin {Homo sapiens}	P11532	1-3685	peptide-Ile2434+Gly-peptide	N		Leu	Thr	Thr	Ile	Gly	Ala	Ser	Pro	Skern, 2004
eukaryotic translation initiation factor 4 gamma 1	Q04637	1-1599	peptide-Arg486+Gly-peptide	N		Leu	Ser	Thr	Arg	Gly	Pro	Pro	Arg	Goldstaub et al., 2000	16162
eukaryotic translation initiation factor 4 gamma 3	O43432	1-1585	peptide-Arg691+Gly-peptide	N		Pro	Gly	Gly	Arg	Gly	Val	Pro	Leu	Badorff, 2004
eukaryotic translation initiation factor 4 gamma 3	O43432	1-1585	peptide-Val699+Gly-peptide	N		Leu	Leu	Asn	Val	Gly	Ser	Arg	Arg	Skern, 2004
Gly-Leu-Gly-Gln-Met-OCH3			Gly-Leu-Gly-Gln-Met+OCH3	N		Leu	Gly	Gln	Met	OMe	-	-	-	Skern, 2004
karatin, type II cytoskeletal 8	P05787	2-483	peptide-Ser14+Gly-peptide	N		Val	Ser	Thr	Ser	Gly	Pro	Arg	Ala	Badorff, 2004	16170
polyadenylate-binding protein 1	P11940	1-636	peptide-Met490+Gly-peptide	N		Thr	Gln	Thr	Met	Gly	Pro	Arg	Pro	Joachims et al., 1999	16163
polyprotein	P03300	2-2209	peptide-Tyr879+Gly-peptide	P		Leu	Thr	Thr	Tyr	Gly	Phe	Gly	His		16164
polyprotein	Q66282	2-2185	peptide-Thr851+Gly-peptide	P		Met	Thr	Asn	Thr	Gly	Ala	Phe	Gly	Badorff, 2004
polyprotein	P08292	2-2183	peptide-Thr849+Gly-peptide	P		Leu	Ile	Thr	Thr	Gly	Pro	Tyr	Gly	Skern, 2004
TATA-box-binding protein	P20226	1-339	Peptide-Tyr34+Gly-Peptide	P	MU	Met	Met	Pro	Tyr	Gly	Thr	Gly	Leu	Yalamanchili et al., 1997