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Substrates for peptidase M13.091: PHEX peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Abz-Arg-Arg-Asp-Asp-Ser-Ser-Glu-Gln-EDDnp Abz-Arg-Arg-Asp+Asp-Ser-Ser-Glu-Gln-EDDnp S Abz Arg Arg Asp Asp Ser Ser Glu Campos et al., 2003
Abz-Arg-Arg-His-Thr-Arg-Ser-Ala-Glu-Asp-Asp-Ser-Glu-Arg-Gln-EDDnp Abz-Arg-Arg-His-Thr-Arg-Ser-Ala-Glu-Asp+Asp-Ser-Glu-Arg-Gln-EDDnp S Ser Ala Glu Asp Asp Ser Glu Gln Campos et al., 2003
Abz-Arg-Arg-His-Thr-Gln-Ser-Ala-Glu-Asp-Asp-Ser-Glu-Arg-Gln-EDDnp Abz-Arg-Arg-His-Thr-Gln-Ser-Ala-Glu-Asp+Asp-Ser-Glu-Arg-Gln-EDDnp S Ser Ala Glu Asp Asp Ser Glu Gln Campos et al., 2003
Abz-Asp-His-Leu-Ser_Asp-Thr-Ser-Thr-Gln-EDDnp Abz-Asp-His-Leu-Ser+Asp-Thr-Ser-Thr-Gln-EDDnp S Asp His Leu Ser Asp Thr Ser Thr Campos et al., 2003
Abz-Gly-Phe-Ser-Asp-Tyr-Lys(Dnp)-OH Abz-Gly-Phe-Ser+Asp-Tyr-Lys(Dnp)-OH S Abz Gly Phe Ser Asp Tyr Lyd OH Campos et al., 2003
Abz-Gly-Ser-Ser-Asp-Ala-Ala-Glu-Gln-EDDnp Abz-Gly-Ser-Ser+Asp-Ala-Ala-Glu-Gln-EDDnp S Abz Gly Ser Ser Asp Ala Ala Glu Campos et al., 2003
Abz-Ile-Pro-Ser-Asp-Phe-Glu-Gly-Gln-EDDnp Abz-Ile-Pro-Ser+Asp-Phe-Glu-Gly-Gln-EDDnp S Abz Ile Pro Ser Asp Phe Glu Gln Campos et al., 2003
Abz-Leu-Glu-Leu-Asp-Ser-Arg-Gln-EDDnp Abz-Leu-Glu-Leu+Asp-Ser-Arg-Gln-EDDnp S Abz Leu Glu Leu Asp Ser Arg Gln Campos et al., 2003
Abz-Leu-Met-Met-Asp-Phe-Arg-Gly-Gln-EDDnp Abz-Leu-Met-Met+Asp-Phe-Arg-Gly-Gln-EDDnp S Abz Leu Met Met Asp Phe Arg Gly Campos et al., 2003
matrix extracellular phosphoglycoprotein Q9NQ76 507-525 Arg-Asp-Asp-Ser-Ser+Glu-Ser-Ser-Asp-Ser-Gly-Ser-Ser-Ser-Glu-Ser-Asp-Gly-Asp P MS Asp Asp Ser Ser Glu Ser Ser Asp Addison et al., 2008
matrix extracellular phosphoglycoprotein Q8K4L6 424-441 Arg-Asp-Ser-Ser+Glu-Ser-Ser-Ser-Ser-Gly-Ser-Ser-Ser-Glu-Ser-His-Gly-Asp P MS Arg Asp Ser Ser Glu Ser Ser Ser Addison et al., 2008
matrix extracellular phosphoglycoprotein Q8K4L6 424-441 Arg-Asp-Ser-Ser-Glu-Ser-Ser-Ser-Ser-Gly-Ser-Ser-Ser+Glu-Ser-His-Gly-Asp P MS Gly Ser Ser Ser Glu Ser His Gly Addison et al., 2008
Osteopontin P10451 115-132 DDSHQ(pS)+DESHH(pS)DE(pS)DEL S MS Ser His Gln Ser Asp Glu Ser His Addison et al., 2009
Osteopontin P10451 115-132 DDSHQ(pS)DESHH(pS)+DE(pS)DEL S MS Ser His His Ser Asp Glu Ser Asp Addison et al., 2009
osteopontin P10451-5 17-300 peptide-Pro37+Asp-peptide P MS Asn Lys Tyr Pro Asp Ala Val Ala Barros et al., 2013
Osteopontin isoform 2 P10451-5 17-300 peptide-His68+Asp-peptide P MS Asn Glu Ser His Asp His Met Asp Barros et al., 2013
Osteopontin isoform 2 P10451-5 17-300 peptide-Met74+Asp-peptide P MS Met Asp Asp Met Asp Asp Glu Asp Barros et al., 2013
Osteopontin isoform 2 P10451-5 17-300 peptide-Glu77+Asp-peptide P MS Met Asp Asp Glu Asp Asp Asp Asp Barros et al., 2013
Osteopontin isoform 2 P10451-5 17-300 peptide-Asp80+Asp-peptide P MS Glu Asp Asp Asp Asp His Val Asp Barros et al., 2013
Osteopontin isoform 2 P10451-5 17-300 peptide-Val83+Asp-peptide P MS Asp Asp His Val Asp Ser Gln Asp Barros et al., 2013
Osteopontin isoform 2 P10451-5 17-300 peptide-Ile89+Asp-peptide P MS Gln Asp Ser Ile Asp Ser Asn Asp Barros et al., 2013
Osteopontin isoform 2 P10451-5 17-300 peptide-Ser94+Asp-peptide P MS Ser Asn Asp Ser Asp Asp Val Asp Barros et al., 2013
Osteopontin isoform 2 P10451-5 17-300 peptide-Val97+Asp-peptide P MS Ser Asp Asp Val Asp Asp Thr Asp Barros et al., 2013
Osteopontin isoform 2 P10451-5 17-300 peptide-Ser106+Asp-peptide P MS Ser His Gln Ser Asp Glu Ser His Barros et al., 2013
Osteopontin isoform 2 P10451-5 17-300 peptide-Asp107+Glu-peptide P MS His Gln Ser Asp Glu Ser His His Barros et al., 2013
Osteopontin isoform 2 P10451-5 17-300 peptide-Ser112+Asp-peptide P MS Ser His His Ser Asp Glu Ser Asp Barros et al., 2013
Osteopontin isoform 2 P10451-5 17-300 peptide-Asp113+Glu-peptide P MS His His Ser Asp Glu Ser Asp Glu Barros et al., 2013
Osteopontin isoform 2 P10451-5 17-300 peptide-Asp116+Glu-peptide P MS Asp Glu Ser Asp Glu Leu Val Thr Barros et al., 2013
Osteopontin isoform 2 P10451-5 17-300 peptide-Thr120+Asp-peptide P MS Glu Leu Val Thr Asp Phe Pro Thr Barros et al., 2013
Osteopontin isoform 2 P10451-5 17-300 peptide-Thr124+Asp-peptide P MS Asp Phe Pro Thr Asp Leu Pro Ala Barros et al., 2013
Osteopontin isoform 2 P10451-5 17-300 peptide-Val139+Asp-peptide P MS Val Pro Thr Val Asp Thr Tyr Asp Barros et al., 2013
Osteopontin isoform 2 P10451-5 17-300 peptide-Tyr142+Asp-peptide P MS Val Asp Thr Tyr Asp Gly Arg Gly Barros et al., 2013
Osteopontin isoform 2 P10451-5 17-300 peptide-Gly146+Asp-peptide P MS Asp Gly Arg Gly Asp Ser Val Val Barros et al., 2013
Osteopontin isoform 2 P10451-5 17-300 peptide-Pro163+Asp-peptide P MS Phe Arg Arg Pro Asp Ile Gln Tyr Barros et al., 2013
Osteopontin isoform 2 P10451-5 17-300 peptide-Thr171+Asp-peptide P MS Pro Asp Ala Thr Asp Glu Asp Ile Barros et al., 2013
Osteopontin isoform 2 P10451-5 17-300 peptide-Ser181+Glu-peptide P MS His Met Glu Ser Glu Glu Leu Asn Barros et al., 2013
Osteopontin isoform 2 P10451-5 17-300 peptide-Glu182+Glu-peptide P MS Met Glu Ser Glu Glu Leu Asn Gly Barros et al., 2013
Osteopontin isoform 2 P10451-5 17-300 peptide-Gln195+Asp-peptide P MS Pro Val Ala Gln Asp Leu Asn Ala Barros et al., 2013
Osteopontin isoform 2 P10451-5 17-300 peptide-Ser201+Asp-peptide P MS Asn Ala Pro Ser Asp Trp Asp Ser Barros et al., 2013
Osteopontin isoform 2 P10451-5 17-300 peptide-Trp203+Asp-peptide P MS Pro Ser Asp Trp Asp Ser Arg Gly Barros et al., 2013
Osteopontin isoform 2 P10451-5 17-300 peptide-Tyr211+Glu-peptide P MS Lys Asp Ser Tyr Glu Thr Ser Gln Barros et al., 2013
Osteopontin isoform 2 P10451-5 17-300 peptide-Asp217+Asp-peptide P MS Ser Gln Leu Asp Asp Gln Ser Ala Barros et al., 2013
Osteopontin isoform 2 P10451-5 17-300 peptide-Asp238+Glu-peptide P MS Lys Ala Asn Asp Glu Ser Asn Glu Barros et al., 2013
Osteopontin isoform 2 P10451-5 17-300 peptide-Ser244+Asp-peptide P MS Asn Glu His Ser Asp Val Ile Asp Barros et al., 2013
Osteopontin isoform 2 P10451-5 17-300 peptide-Gln250+Glu-peptide P MS Ile Asp Ser Gln Glu Leu Ser Lys Barros et al., 2013
Osteopontin isoform 2 P10451-5 17-300 peptide-Arg257+Glu-peptide P MS Lys Val Ser Arg Glu Phe His Ser Barros et al., 2013
Osteopontin isoform 2 P10451-5 17-300 peptide-His262+Glu-peptide P MS Phe His Ser His Glu Phe His Ser Barros et al., 2013
Osteopontin isoform 2 P10451-5 17-300 peptide-Glu268+Asp-peptide P MS His Ser His Glu Asp Met Leu Val Barros et al., 2013
Osteopontin isoform 2 P10451-5 17-300 peptide-Lys278+Glu-peptide P MS Pro Lys Ser Lys Glu Glu Asp Lys Barros et al., 2013
Osteopontin isoform 2 P10451-5 17-300 peptide-Glu280+Asp-peptide P MS Ser Lys Glu Glu Asp Lys His Leu Barros et al., 2013
Osteopontin isoform 2 P10451-5 17-300 peptide-Ser297+Glu-Val-Asn P MS Ser Ala Ser Ser Glu Val Asn '-' Barros et al., 2013
Osteostatin P12272 143-175 Peptide-Leu148+Asp-Peptide P MS Ser Ala Trp Leu Asp Ser Gly Val Boileau et al., 2001
Osteostatin P12272 143-175 Peptide-Ser163+Asp-Peptide P MS Asp His Leu Ser Asp Thr Ser Thr Boileau et al., 2001
Osteostatin P12272 143-175 Peptide-Leu172+Asp-Ser-Arg P MS Ser Leu Glu Leu Asp Ser Arg - Boileau et al., 2001 26984

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