Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P09651

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-372	P		NT	<%Agarwal et al., 2012[]%>
3	granzyme A	1-372	N			Van Damme et al., 2010
5	astacin	2-15	N		MS	Becker-Pauly et al., 2011
7	cathepsin L	16-31	N		MS	Biniossek et al., 2011
19	cathepsin S	16-31	N		MS	Biniossek et al., 2011
20	matrix metallopeptidase-2	15-31	N		MS	Schilling & Overall, 2008
31	trypsin 1	2-320	N		MS	Schilling & Overall, 2008
35	glutamyl endopeptidase I	31-52	N		MS	Schilling & Overall, 2008
52	trypsin 1	2-320	N		MS	Schilling & Overall, 2008
66	meprin beta subunit	63-78	N		MS	Becker-Pauly et al., 2011
109	elastase-2	107-122	N		MS	Schilling & Overall, 2008
122	trypsin 1	2-320	N		MS	Schilling & Overall, 2008
125	meprin beta subunit	2-372	N		MS	Becker-Pauly et al., 2011
129	peptidyl-Lys metallopeptidase	1-320	N		MS
143	peptidyl-Lys metallopeptidase	1-320	N		MS
149	cathepsin B	147-161	N		MS	Biniossek et al., 2011
150	HIV-1 retropepsin	146-161	N		MS	Schilling & Overall, 2008
150	cathepsin L	147-161	N		MS	Biniossek et al., 2011
151	elastase-2	146-161	N		MS	Schilling & Overall, 2008
153	LAST_MAM peptidase (Limulus-type)	150-166	N		MS	Becker-Pauly et al., 2011
156	meprin beta subunit	153-166	N		MS	Becker-Pauly et al., 2011
161	trypsin 1	2-320	N		MS	Schilling & Overall, 2008
196	granzyme B (Homo sapiens-type)	2-372	N		MS	Van Damme et al., 2010
287	caspase-3	2-372	P			Thiede et al., 2001
307	cathepsin S	266-318	N		MS	Biniossek et al., 2011
313	meprin beta subunit	310-329	N		MS	Becker-Pauly et al., 2011
314	caspase-3	2-372	P	normal turnover		Thiede et al., 2001
318	unknown peptidase	2-372	P			Van Damme et al., 2009
336	trypsin 1	2-372	N			Van Damme et al., 2009
341	LAST_MAM peptidase (Limulus-type)	338-352	N		MS	Becker-Pauly et al., 2011
352	granzyme A	1-372	N			Van Damme et al., 2010