Substrates for peptidase S09.007: fibroblast activation protein alpha subunit

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Ala-Pro-aminotrifluoromethylcoumarin Ala-Pro+aminotrifluoromethylcoumarin S - - Ala Pro FMC - - - Park & Rettig, 2004
Alpha-2-antiplasmin P08697 40-491 Peptide-Pro39+Asn-Peptide P MS - - - Pro Asn Gln Glu Gln Lee et al., 2006
Alpha-2-antiplasmin P08697 40-491 Peptide-Pro30+Leu-Peptide P MS Ala Met Glu Pro Leu Gly Arg Gln Lee et al., 2006
Alpha-2-antiplasmin precursor P08697 12-491 peptide-Pro39+Asn-peptide P - Thr Ser Gly Pro Asn Gln Glu Gln Edosada et al., 2006
Alpha-2-antiplasmin precursor P08697 1-491 Peptide-Pro39+Asn-Peptide P MS Thr Ser Gly Pro Asn Gln Glu Gln Lee et al., 2006
Gly-Pro-aminotrifluoromethylcoumarin Gly-Pro+aminotrifluoromethylcoumarin S - - Gly Pro FMC - - - Rettig, 1998
major prion protein (Gly>Pro,Trp>Phe mutant) P04925 23-230 peptide-Gly62+Gly-peptide N NT Pro His Gly Pro Gly Phe Gly Gln
major prion protein (Gly>Pro,Trp>Phe mutant) P04925 23-230 peptide-Gly70+Ser-peptide N NT Pro His Gly Pro Ser Phe Gly Gln
major prion protein (Gly>Pro,Trp>Phe mutant) P04925 23-230 peptide-Gly78+Ser-peptide N NT Pro His Gly Pro Ser Phe Gly Gln
major prion protein (Gly>Pro,Trp>Phe mutant) P04925 23-230 peptide-Gly86+Gly-peptide N NT Pro His Gly Pro Gly Phe Gly Gln