Peptide and protein substrates that are thought to be physiologically relevant are indicated by P.
Peptide and protein substrates that are not physiologically relevant are indicated by N.
How cleavage sites have been identified are indicated by the following evidence codes:
NT = N-terminal sequencing,
MS = mass spectroscopy,
MU = mutation,
CS = consensus sequence,
LC = liquid chromatography.
To see all annotated cleavages for a peptidase, click on the peptidase name.
| Cleavage Site |
Peptidase |
Residue range |
Cleavage type |
Description |
Evidence |
Reference |
|---|
| 22 |
unknown peptidase |
1-1463 |
P |
|
NT |
<%Agarwal et al., 2012[]%> |
| 88 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 99 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 161 |
unknown peptidase |
1-1463 |
P |
|
NT |
<%Agarwal et al., 2012[]%> |
| 173 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 194 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 244 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 254 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 264 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 268 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 269 |
MCP-01 peptidase |
1-1463 |
N |
|
|
Zhao et al., 2008 |
| 278 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 369 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 383 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 522 |
cathepsin L2 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 544 |
cathepsin L2 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 549 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 559 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 590 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 590 |
cathepsin L2 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 611 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 611 |
cathepsin L2 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 655 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 662 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 666 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 673 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 683 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 692 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 727 |
cathepsin L2 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 746 |
cathepsin L2 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 764 |
brachyurin-C |
162-1215 |
N |
|
NT |
Tsu et al., 1994 |
| 882 |
cathepsin L2 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 894 |
cathepsin L2 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 902 |
cathepsin L2 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 911 |
cathepsin L2 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 941 |
hypodermin C |
162-1215 |
N |
|
NT |
Lecroisey et al., 1985 |
| 950 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 952 |
matrix metallopeptidase-1 |
162-1215 |
P |
normal turnover |
|
Aimes & Quigley, 1995 |
| 952 |
matrix metallopeptidase-2 |
162-1215 |
P |
normal turnover |
|
Aimes & Quigley, 1995 |
| 953 |
hypodermin C |
162-1215 |
P |
|
|
Lecroisey & Keil, 1985 |
| 956 |
brachyurin-C |
162-1215 |
N |
|
NT |
Tsu et al., 1994 |
| 957 |
brachyurin-C |
162-1215 |
N |
|
NT |
Tsu et al., 1994 |
| 959 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 959 |
hypodermin C |
162-1215 |
N |
|
NT |
Lecroisey et al., 1985 |
| 965 |
brachyurin-C |
162-1215 |
N |
|
NT |
Tsu et al., 1994 |
| 966 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 967 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 967 |
cathepsin L2 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 986 |
cathepsin L2 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 1078 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 1088 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 1103 |
cathepsin L2 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 1119 |
cathepsin L2 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 1156 |
cathepsin L2 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 1160 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 1161 |
cathepsin L2 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 1169 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 1195 |
chymotrypsin A (cattle-type) |
23-1464 |
N |
|
|
Sassi et al., 2000 |
| 1197 |
cathepsin D |
162-1215 |
P |
normal turnover |
|
Scott & Pearson, 1981 |
| 1215 |
unknown peptidase |
1-1463 |
P |
|
NT |
<%Agarwal et al., 2012[]%> |
| 1219 |
cathepsin L2 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 1223 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 1229 |
cathepsin L2 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 1234 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 1245 |
cathepsin L2 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 1262 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 1280 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 1304 |
cathepsin L2 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 1324 |
cathepsin L2 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 1335 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 1347 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 1360 |
cathepsin L2 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 1373 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 1376 |
cathepsin L2 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 1377 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 1379 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 1387 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 1389 |
cathepsin L2 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 1403 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 1408 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 1410 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
| 1417 |
cathepsin L3 (Fasciola sp.) |
1-1463 |
N |
|
MS |
Robinson et al., 2011 |
