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Substrates for peptidase C01.142: cathepsin L2 (Fasciola sp.)

Summary Alignment Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Abz-GFSPFRSSRQ-EDDnp Abz-Gly-Phe-Ser-Pro-Phe-Arg+Ser-SerArg-Gln-Glu-Asp-Aspnp S Ser Pro Phe Arg Ser Ser Arg Gln Cordova et al., 2001
Abz-MISLMKRPQ-EDDnp Abz-Met-Ile-Ser-Leu-Met+Lys-Arg-Pro-Gln-Glu-Asp-Aspnp S Ile Ser Leu Met Lys Arg Pro Gln Cordova et al., 2001
Cap-Leu-CyB-NHMec Cap-Leu-CyB+NHMec S - Cap Leu CyB AMC - - - Cordova et al., 2001
Cap-Leu-Phe-NHMec Cap-Leu-Phe+NHMec S - Cap Leu Phe AMC - - - Cordova et al., 2001
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Pro522+Gly-Peptide N MS Lys Gly Ser Pro Gly Glu Ala Gly Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Gly544+Ser-Peptide N MS Gly Ser Pro Gly Ser Pro Gly Pro Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Glu590+Pro-Peptide N MS Ala Ala Gly Glu Pro Gly Lys Ala Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Lys611+Asp-Peptide N MS Pro Ala Gly Lys Asp Gly Glu Ala Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Gly727+Met-Peptide N MS Gly Leu Gln Gly Met Pro Gly Glu Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Asp746+Ala-Peptide N MS Asp Arg Gly Asp Ala Gly Pro Lys Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Val882+Gly-Peptide N MS Ala Gly Arg Val Gly Pro Pro Gly Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Pro894+Gly-Peptide N MS Ala Gly Pro Pro Gly Pro Pro Gly Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Lys902+Glu-Peptide N MS Pro Ala Gly Lys Glu Gly Ser Lys Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Glu911+Thr-Peptide N MS Pro Arg Gly Glu Thr Gly Pro Ala Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Gly967+Glu-Peptide N MS Gly Gln Arg Gly Glu Arg Gly Phe Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Pro986+Ser-Peptide N MS Lys Gln Gly Pro Ser Gly Ala Ser Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Asp1103+Arg-Peptide N MS Glu Gln Gly Asp Arg Gly Ile Lys Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Pro1119+Gly-Peptide N MS Gln Gly Pro Pro Gly Pro Pro Gly Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Gly1156+Leu-Peptide N MS Gly Leu Asn Gly Leu Pro Gly Pro Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Ile1161+Gly-Peptide N MS Pro Gly Pro Ile Gly Pro Pro Gly Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Asp1219+Ala-Peptide N MS Arg Ala Asp Asp Ala Asn Val Val Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Glu1229+Val-Peptide N MS Arg Asp Leu Glu Val Asp Thr Thr Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Arg1245+Ser-Peptide N MS Glu Asn Ile Arg Ser Pro Glu Gly Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Pro1304+Ser-Peptide N MS Pro Thr Gln Pro Ser Val Ala Gln Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Trp1324+Tyr-Peptide N MS Arg His Val Trp Tyr Gly Glu Ser Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Glu1360+Ala-Peptide N MS Met Ser Thr Glu Ala Ser Gln Asn Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Met1376+Asp-Peptide N MS Val Ala Tyr Met Asp Gln Gln Thr Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Leu1389+Gln-Peptide N MS Ala Leu Leu Leu Gln Gly Ser Asn Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Pro172+Gly-Peptide N MS Pro Gly Leu Pro Gly Phe Lys Gly Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Gly176+Ile-Peptide N MS Gly Phe Lys Gly Ile Arg Gly His Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Gly311+Leu-Peptide N MS Gly Ala Ala Gly Leu Pro Gly Val Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Pro330+Val-Peptide N MS Ile Pro Gly Pro Val Gly Ala Ala Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Gly356+Asn-Peptide N MS Gly Glu Ser Gly Asn Lys Gly Glu Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Gln366+Pro-Peptide N MS Ala Val Gly Gln Pro Gly Pro Pro Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Pro868+Gly-Peptide N MS Leu Gly Ala Pro Gly Phe Leu Gly Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Phe870+Leu-Peptide N MS Ala Pro Gly Phe Leu Gly Leu Pro Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Ala886+Gly-Peptide N MS Pro Gly Val Ala Gly Ser Val Gly Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Ser888+Val-Peptide N MS Val Ala Gly Ser Val Gly Glu Pro Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Gly1010+Asp-Peptide N MS Gly Glu Pro Gly Asp Lys Gly Pro Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Gln1027+Gly-Peptide N MS Asn Gly Leu Gln Gly Leu Pro Gly Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-His1223+Val-Peptide N MS Ala Lys Lys His Val Trp Val Gly Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Gly1233+Thr-Peptide N MS Ile Asn Gly Gly Thr Gln Phe Glu Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Gln1235+Phe-Peptide N MS Gly Gly Thr Gln Phe Glu Tyr Asn Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Ile1266+Thr-Peptide N MS Ser Gln Asn Ile Thr Tyr His Cys Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Tyr1268+His-Peptide N MS Asn Ile Thr Tyr His Cys Lys Asn Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Asn1283+Leu-Peptide N MS Glu Thr Gly Asn Leu Lys Lys Ala Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Leu1290+Gln-Peptide N MS Ala Val Ile Leu Gln Gly Ser Asn Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Ile1326+Ile-Peptide N MS Gln Lys Thr Ile Ile Glu Tyr Lys Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Asn1332+Lys-Peptide N MS Tyr Lys Thr Asn Lys Pro Ser Arg Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Lys1333+Pro-Peptide N MS Lys Thr Asn Lys Pro Ser Arg Leu Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Leu1340+Asp-Peptide N MS Leu Pro Ile Leu Asp Ile Ala Pro Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Leu1345+Asp-Peptide N MS Ile Ala Pro Leu Asp Ile Gly Gly Robinson et al., 2011
Collagen alpha-2(I) chain precursor precursor P02465 1-1364 Peptide-Ile1342+Ala-Peptide N MS Ile Leu Asp Ile Ala Pro Leu Asp Robinson et al., 2011
Tos-Gly-Pro-Arg-NHMec Tos-Gly-Pro-Arg+NHMec S Tos Gly Pro Arg AMC - - - Smooker et al., 2000

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