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Substrates for peptidase C01.129: cathepsin L3 (Fasciola sp.)

Summary Alignment Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Thr88+Asp-Peptide N MS Lys Val Pro Thr Asp Glu Cys Cys Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Gln99+Glu-Peptide N MS Pro Glu Gly Gln Glu Ser Pro Thr Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Gly173+Ile-Peptide N MS Lys Ser Thr Gly Ile Ser Val Pro Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Ala194+Pro-Peptide N MS Pro Pro Gly Ala Pro Gly Pro Gln Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Gly244+Pro-Peptide N MS Gly Glu Arg Gly Pro Pro Gly Pro Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Leu254+Pro-Peptide N MS Ala Arg Gly Leu Pro Gly Thr Ala Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Lys264+Gly-Peptide N MS Pro Gly Met Lys Gly His Arg Gly Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Gly268+Phe-Peptide N MS Gly His Arg Gly Phe Ser Gly Leu Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Asp278+Ala-Peptide N MS Ala Lys Gly Asp Ala Gly Pro Ala Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Arg369+Gly-Peptide N MS Gln Gly Val Arg Gly Glu Pro Gly Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Pro383+Ala-Peptide N MS Ala Ala Gly Pro Ala Gly Asn Pro Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Asp549+Gly-Peptide N MS Pro Gly Pro Asp Gly Lys Thr Gly Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Gly559+Gln-Peptide N MS Gly Pro Ala Gly Gln Asp Gly Arg Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Glu590+Pro-Peptide N MS Ala Ala Gly Glu Pro Gly Lys Ala Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Lys611+Asp-Peptide N MS Pro Ala Gly Lys Asp Gly Glu Ala Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Gly655+Lys-Peptide N MS Gly Glu Ala Gly Lys Pro Gly Glu Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Val662+Pro-Peptide N MS Glu Gln Gly Val Pro Gly Asp Leu Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Leu666+Gly-Peptide N MS Pro Gly Asp Leu Gly Ala Pro Gly Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Gly673+Ala-Peptide N MS Gly Pro Ser Gly Ala Arg Gly Glu Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Glu683+Arg-Peptide N MS Phe Pro Gly Glu Arg Gly Val Gln Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Pro692+Ala-Peptide N MS Pro Pro Gly Pro Ala Gly Pro Arg Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Pro950+Gln-Peptide N MS Thr Pro Gly Pro Gln Gly Ile Ala Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Val959+Val-Peptide N MS Gln Arg Gly Val Val Gly Leu Pro Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Arg966+Gly-Peptide N MS Pro Gly Gln Arg Gly Glu Arg Gly Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Gly967+Glu-Peptide N MS Gly Gln Arg Gly Glu Arg Gly Phe Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Gly1078+Pro-Peptide N MS Gly Pro Ile Gly Pro Val Gly Ala Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Pro1088+Gln-Peptide N MS Pro Ala Gly Pro Gln Gly Pro Arg Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Pro1160+Ile-Peptide N MS Leu Pro Gly Pro Ile Gly Pro Pro Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Arg1169+Thr-Peptide N MS Pro Arg Gly Arg Thr Gly Asp Ala Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Val1223+Arg-Peptide N MS Ala Asn Val Val Arg Asp Arg Asp Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Leu1234+Lys-Peptide N MS Asp Thr Thr Leu Lys Ser Leu Ser Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Lys1262+Met-Peptide N MS Arg Asp Leu Lys Met Cys His Ser Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Gly1280+Cys-Peptide N MS Pro Asn Gln Gly Cys Asn Leu Asp Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Phe1335+Glu-Peptide N MS Gly Phe Gln Phe Glu Tyr Gly Gly Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Val1347+Ala-Peptide N MS Pro Ala Asp Val Ala Ile Gln Leu Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Val1373+Ala-Peptide N MS Lys Asn Ser Val Ala Tyr Met Asp Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Asp1377+Gln-Peptide N MS Ala Tyr Met Asp Gln Gln Thr Gly Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Gln1379+Thr-Peptide N MS Met Asp Gln Gln Thr Gly Asn Leu Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Leu1387+Leu-Peptide N MS Lys Lys Ala Leu Leu Leu Gln Gly Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Ser1403+Arg-Peptide N MS Glu Gly Asn Ser Arg Phe Thr Tyr Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Ser1408+Val-Peptide N MS Phe Thr Tyr Ser Val Thr Tyr Asp Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-Thr1410+Tyr-Peptide N MS Tyr Ser Val Thr Tyr Asp Gly Cys Robinson et al., 2011
Collagen alpha-1(I) chain precursor P02453 1-1463 Peptide-His1417+Thr-Peptide N MS Cys Thr Ser His Thr Gly Ala Trp Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Pro136+Gly-Peptide N MS Pro Gly Pro Pro Gly Lys Ala Gly Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-His144+Pro-Peptide N MS Glu Asp Gly His Pro Gly Lys Pro Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Gly173+Phe-Peptide N MS Gly Leu Pro Gly Phe Lys Gly Ile Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Asn181+Gly-Peptide N MS Arg Gly His Asn Gly Leu Asp Gly Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Ser453+Pro-Peptide N MS Phe Pro Gly Ser Pro Gly Asn Ile Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Lys462+Glu-Peptide N MS Pro Ala Gly Lys Glu Gly Pro Val Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Asp472+Gly-Peptide N MS Pro Gly Ile Asp Gly Arg Pro Gly Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Ala481+Gly-Peptide N MS Ile Gly Pro Ala Gly Ala Arg Gly Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Phe552+Gln-Peptide N MS Pro Pro Gly Phe Gln Gly Leu Pro Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Ala562+Gly-Peptide N MS Ala Gly Thr Ala Gly Glu Ala Gly Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Glu843+Lys-Peptide N MS Phe Val Gly Glu Lys Gly Pro Ser Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Thr858+Pro-Peptide N MS Pro Pro Gly Thr Pro Gly Pro Gln Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Leu895+Gly-Peptide N MS Pro Gly Pro Leu Gly Ile Ala Gly Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Pro906+Pro-Peptide N MS Ala Arg Gly Pro Pro Gly Asn Val Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Pro961+Gly-Peptide N MS Ala Gly Ala Pro Gly Pro Gln Gly Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Gly971+Lys-Peptide N MS Gly Pro Val Gly Lys His Gly Asn Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Gly1043+Ala-Peptide N MS Gly Ala Pro Gly Ala Val Gly Pro Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Ala1054+Gly-Peptide N MS Arg Gly Pro Ala Gly Pro Ser Gly Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Asp1208+Ile-Peptide N MS Gln Pro Glu Asp Ile Pro Val Lys Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Lys1221+Lys-Peptide N MS Ser Lys Ala Lys Lys His Val Trp Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Val1224+Trp-Peptide N MS Lys Lys His Val Trp Val Gly Glu Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Phe1236+Glu-Peptide N MS Gly Thr Gln Phe Glu Tyr Asn Val Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Ile1274+Ala-Peptide N MS Lys Asn Ser Ile Ala Tyr Met Asp Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Asp1278+Glu-Peptide N MS Ala Tyr Met Asp Glu Glu Thr Gly Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Glu1280+Thr-Peptide N MS Met Asp Glu Glu Thr Gly Asn Leu Robinson et al., 2011
Collagen alpha-2(I) chain precursor P02465 1-1364 Peptide-Val1288+Ile-Peptide N MS Lys Lys Ala Val Ile Leu Gln Gly Robinson et al., 2011
Tos-Gly-Pro-Arg-NHMec Tos-Gly-Pro-Arg+NHMec S Tos Gly Pro Arg AMC - - - Corvo et al., 2009
Z-Phe-Arg-NHMec Z-Phe-Arg+NHMec S - Z Phe Arg AMC - - - Corvo et al., 2009
Z-Val-Leu-Lys-NHMec Z-Val-Leu-Lys+NHMec S Z Val Leu Lys AMC - - - Corvo et al., 2009

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