Substrates for peptidase S01.121: hypodermin C

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
collagen alpha-1(I) chain P02453 162-1215 peptide-Ile953+Ala-peptide P Pro Gln Gly Ile Ala Gly Gln Arg Lecroisey & Keil, 1985
Collagen alpha-1(I) chain P02453 162-1215 Peptide-Pro941+Ala-Peptide N NT Ala Asp Gly Pro Ala Gly Ala Pro Lecroisey et al., 1985
Collagen alpha-1(I) chain P02453 162-1215 Peptide-Val959+Val-Peptide N NT Gln Arg Gly Val Val Gly Leu Pro Lecroisey et al., 1985
Collagen alpha-2(I) chain P02465 80-1100 Peptide-Thr852+Ala-Peptide N NT Glu Pro Gly Thr Ala Gly Pro Pro Lecroisey et al., 1985
Collagen alpha-2(I) chain P02465 80-1100 Peptide-Ser888+Val-Peptide N NT Val Ala Gly Ser Val Gly Glu Pro Lecroisey et al., 1985
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu+Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Val Glu Ala Leu Tyr Leu Val Cya Lecroisey & Keil, 1985
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg+Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Cya Gly Glu Arg Gly Phe Phe Tyr Lecroisey & Keil, 1985
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys+Ala N Tyr Thr Pro Lys Ala - - - Lecroisey & Keil, 1985