Substrates for peptidase M12.158: russellysin

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
Abz-Gly-Phe-Arg-Leu-Leu-2,4-dinitroanilinoethylamide			Abz-Gly-Phe-Arg+Leu-Leu-2,4-dinitroanilinoethylamide	S		Abz	Gly	Phe	Arg	Leu	Leu	NAE	-	Takeya et al., 1993
coagulation factor IX	P00740	29-461	peptide-Arg18+Tyr-peptide	N		Arg	Pro	Lys	Arg	Tyr	Asn	Ser	Gly	Kawabata & Iwanaga, 2004	16858
Coagulation factor IX	P00740	222-230	Peptide-Arg226+Val-Peptide	S	MS	Asp	Phe	Thr	Arg	Val	Val	Gly	Gly	Siigur et al., 2001
coagulation factor X	P00742	32-488	peptide-Arg51+Ile-peptide	N		Asn	Leu	Thr	Arg	Ile	Val	Gly	Gly	Kawabata & Iwanaga, 2004	16859
coagulation factor X heavy chain	P00742	183-488	peptide-Arg234+Ile-peptide	N	NT	Asn	Leu	Thr	Arg	Ile	Val	Gly	Gly	Siigur et al., 2005
Factor X heavy chain	P00742	230-238	Peptide-Arg234+Ile-Peptide	S	MS	Asn	Leu	Thr	Arg	Ile	Val	Gly	Gly	Siigur et al., 2001
protein C precursor	P04070	33-461	peptide-Arg10+Ala-peptide	N		Ile	Arg	Lys	Arg	Ala	Asn	Ser	Phe	Kawabata & Iwanaga, 2004	16860