Substrates for peptidase M12.151: ecarin

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
thrombin precursor P00735 44-625 peptide-Arg323+Ile-peptide P Ile Glu Gly Arg Ile Val Glu Gly Kawabata & Iwanaga, 2004 16826
thrombin precursor P00734 44-622 peptide-Gly158+Ser-peptide N Arg Ser Glu Gly Ser Ser Val Asn Kawabata & Iwanaga, 2004 16828
thrombin precursor P00734 44-622 peptide-Arg320+Ile-peptide N Ile Asp Gly Arg Ile Val Glu Gly Kawabata & Iwanaga, 2004 16827
Tos-Gly-Pro-Arg-NHPhNO2 [Chromozym-TRY] Tos-Gly-Pro-Arg+NHPhNO2 S Tos Gly Pro Arg NAN - - - Paine & Laing, 2004