$VAR1 = undef;

Summary for peptidase M13.002: endothelin-converting enzyme 1

Names
MEROPS Name	endothelin-converting enzyme 1
Other names	ECE-1

Domain architecture

MEROPS Classification
Classification	Clan MA >> Subclan MA(E) >> Family M13 >> Subfamily (none) >> M13.002
Holotype	endothelin-converting enzyme 1 (Bos taurus), Uniprot accession P42891 (peptidase unit: 78-754), MERNUM MER0001056
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Metallo
Peplist	Included in the Peplist with identifier PL00202
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.71
Enzymology	BRENDA database
Proteolytic events	CutDB database (21 cleavages)
Physiology	Ectoenzyme activating endothelin precursor.
Knockout	Null mutation of the gene in mouse resulted in embryos that exhibited craniofacial and cardiac abnormalities closely similar to those in mice deficient in endothelin-1 or endothelin A receptor (Yanagisawa et al., 1998), and mutations are associated with Hirschsprung disease in humans (Hofstra et al., 1999).
Pharmaceutical relevance	Drug target in hypertension.
Other databases	TREEFAM	http://www.treefam.org/family/TF315192
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/-flv/-/-/- (based on 34 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	4	2	0	2	0	1	1	1
Pro	2	2	0	4	1	1	2	4
Ala	0	1	2	2	2	1	2	2
Val	1	2	4	1	5	4	2	3
Leu	1	3	3	4	6	3	5	4
Ile	0	4	3	1	4	3	0	0
Met	0	0	0	0	0	2	0	1
Phe	1	5	1	3	9	2	2	2
Tyr	2	0	2	3	4	1	1	1
Trp	0	0	0	3	0	1	1	0
Ser	1	3	5	1	1	1	1	3
Thr	1	0	0	1	0	0	3	0
Cys	2	2	0	0	2	1	1	0
Asn	0	0	0	0	0	3	1	2
Gln	1	2	3	1	0	0	0	0
Asp	4	2	1	1	0	0	1	3
Glu	2	1	2	2	0	2	3	0
Lys	2	0	3	1	0	2	0	2
Arg	2	2	2	2	0	3	1	0
His	4	2	2	2	0	3	3	0