Literature for peptidase M13.002: endothelin-converting enzyme 1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

(Topics flags: A Assay, S Structure, K Knockout, P Specificity, E Expression, V Review, M Mutation, I Inhibitor, R Splicing, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

  1. Miners,J.S. & Love,S.
    Endothelin-converting enzymes degrade alpha-synuclein and are reduced in dementia with Lewy bodies.
    J Neurochem (2017) 141, 275-286. PubMed  Europe PubMed DOI
  2. 2016
  3. Smith,A.I., Rajapakse,N.W., Kleifeld,O., Lomonte,B., Sikanyika,N.L., Spicer,A.J., Hodgson,W.C., Conroy,P.J., Small,D.H., Kaye,D.M., Parkington,H.C., Whisstock,J.C. & Kuruppu,S.
    N-terminal domain of Bothrops asper myotoxin II enhances the activity of endothelin converting enzyme-1 and neprilysin.
    Sci Rep (2016) 6, 22413. PubMed  Europe PubMed DOI  PMC  EPMC
  4. 2014
  5. Miners,J.S., Palmer,J.C., Tayler,H., Palmer,L.E., Ashby,E., Kehoe,P.G. & Love,S.
    Abeta degradation or cerebral perfusion? Divergent effects of multifunctional enzymes.
    Front Aging Neurosci (2014) 6, 238. PubMed  Europe PubMed DOI  PMC  EPMC
  6. 2013
  7. Cattaruzza,F., Poole,D.P. & Bunnett,N.W.
    Arresting inflammation: contributions of plasma membrane and endosomal signalling to neuropeptide-driven inflammatory disease.
    Biochem Soc Trans (2013) 41, 137-143. PubMed  Europe PubMed DOI
  8. Martinez-Miguel,P., Medrano-Andres,D., Lopes-Martin,V., Arribas-Gomez,I., Rodriguez-Puyol,M., Rodriguez-Puyol,D. & Lopez-Ongil,S.
    Regulation of endothelin-converting enzyme-1 (ECE-1) by the calcimimetic R-568.
    Pharmacol Res (2013) 76, 106-118. PubMed  Europe PubMed DOI  I
  9. Tanneeru,K., Sahu,I. & Guruprasad,L.
    Ligand-based drug design for human endothelin converting enzyme-1 inhibitors.
    Med Chem Res (2013) 22, 4401-4409. DOI  I
  10. 2012
  11. Kuruppu,S. & Smith,A.I.
    Endothelin converting enzyme-1 phosphorylation and trafficking.
    FEBS Lett (2012) 586, 2212-2217. PubMed  Europe PubMed DOI
  12. Kuruppu,S., Tochon-Danguy,N. & Smith,A.I.
    Protein kinase C recognition sites in the cytoplasmic domain of endothelin converting enzyme-1c.
    Biochem Biophys Res Commun (2012) 427, 606-610. PubMed  Europe PubMed DOI
  13. Nakayama,K., Emoto,N., Suzuki,Y., Vignon-Zellweger,N., Yagi,K. & Ken-Ichi,H.
    Physiological relevance of hydrolysis of atrial natriuretic peptide by endothelin-converting enzyme-1.
    Kobe J Med Sci (2012) 58, E12-E18. PubMed  Europe PubMed
  14. Ul-Haq,Z., Iqbal,S. & Moin,S.T.
    Dynamic changes in the secondary structure of ECE-1 and XCE account for their different substrate specificities.
    BMC Bioinformatics (2012) 13, 285. PubMed  Europe PubMed DOI  P
  15. Whyteside,A.R. & Turner,A.J.
    Endothelin-converting enzyme 1 (ECE-1).
    In Handbook of Proteolytic Enzymes, 3 edn (Rawlings,N.D. & Salvesen,G.S. eds), p.624-631, Elsevier, Amsterdam (2012) DOI
  16. 2011
  17. Hong,Y., MacNab,S., Lambert,L.A., Turner,A.J., Whitehouse,A. & Usmani,B.A.
    Herpesvirus saimiri-based endothelin-converting enzyme-1 shRNA expression decreases prostate cancer cell invasion and migration.
    Int J Cancer (2011) 129, 586-598. PubMed  Europe PubMed DOI  K
  18. 2010
  19. Jullien,N., Makritis,A., Georgiadis,D., Beau,F., Yiotakis,A. & Dive,V.
    Phosphinic tripeptides as dual angiotensin-converting enzyme C-domain and endothelin-converting enzyme-1 inhibitors.
    J Med Chem (2010) 53, 208-220. PubMed  Europe PubMed DOI  I
  20. Kuruppu,S., Tochon-Danguy,N. & Smith,A.I.
    Role of protein kinase C in endothelin converting enzyme-1 trafficking and shedding from endothelial cells.
    Biochem Biophys Res Commun (2010) 398, 173-177. PubMed  Europe PubMed DOI
  21. Whyteside,A.R., Hinsley,E.E., Lambert,L.A., McDermott,P.J. & Turner,A.J.
    ECE-1 influences prostate cancer cell invasion via ET-1-mediated FAK phosphorylation and ET-1-independent mechanisms.
    Can J Physiol Pharmacol (2010) 88, 850-854. PubMed  Europe PubMed DOI
  22. 2009
  23. Cottrell,G.S., Padilla,B.E., Amadesi,S., Poole,D.P., Murphy,J.E., Hardt,M., Roosterman,D., Steinhoff,M. & Bunnett,N.W.
    Endosomal endothelin-converting enzyme-1: a regulator of beta-arrestin-dependent ERK signaling.
    J Biol Chem (2009) 284, 22411-22425. PubMed  Europe PubMed DOI  PMC  EPMC
  24. Dive,V., Chang,C.F., Yiotakis,A. & Sturrock,E.D.
    Inhibition of zinc metallopeptidases in cardiovascular disease - from unity to trinity, or duality?.
    Curr Pharm Des (2009) 15, 3606-3621. PubMed  Europe PubMed DOI  V  I
  25. Jin,Z., Luxiang,C., Huadong,Z., Zhiqiang,X., Lihua,H. & Huiyun,L.
    C-338A polymorphism of the endothelin-converting enzyme-1 gene and the susceptibility to carotid atherosclerosis.
    Microvasc Res (2009) 78, 128-131. PubMed  Europe PubMed DOI  M
  26. Schulz,H., Dale,G.E., Karimi-Nejad,Y. & Oefner,C.
    Structure of human endothelin-converting enzyme I complexed with phosphoramidon.
    J Mol Biol (2009) 385, 178-187. PubMed  Europe PubMed DOI  S  I
  27. 2008
  28. Carty,N.C., Nash,K., Lee,D., Mercer,M., Gottschall,P.E., Meyers,C., Muzyczka,N., Gordon,M.N. & Morgan,D.
    Adeno-associated viral (AAV) serotype 5 vector mediated gene delivery of endothelin-converting enzyme reduces Abeta deposits in APP + PS1 transgenic mice.
    Mol Ther (2008) 16, 1580-1586. PubMed  Europe PubMed DOI  PMC  EPMC
  29. Cerdeira,A.S., Bras-Silva,C. & Leite-Moreira,A.F.
    Endothelin-converting enzyme inhibitors: their application in cardiovascular diseases.
    Rev Port Cardiol (2008) 27, 385-408. PubMed  Europe PubMed  I
  30. Lambert,L.A., Whyteside,A.R., Turner,A.J. & Usmani,B.A.
    Isoforms of endothelin-converting enzyme-1 (ECE-1) have opposing effects on prostate cancer cell invasion.
    Br J Cancer (2008) 99, 1114-1120. PubMed  Europe PubMed DOI  PMC  EPMC
  31. Rayhman,O., Klipper,E., Muller,L., Davidson,B., Reich,R. & Meidan,R.
    Small interfering RNA molecules targeting endothelin-converting enzyme-1 inhibit endothelin-1 synthesis and the invasive phenotype of ovarian carcinoma cells.
    Cancer Res (2008) 68, 9265-9273. PubMed  Europe PubMed DOI
  32. Roosterman,D., Kempkes,C., Cottrell,G.S., Padilla,B.E., Bunnett,N.W., Turck,C.W. & Steinhoff,M.
    Endothelin-converting enzyme-1 degrades internalized somatostatin-14.
    Endocrinology (2008) 149, 2200-2207. PubMed  Europe PubMed DOI  PMC  EPMC
  33. 2007
  34. Banno,M., Hanada,H., Kamide,K., Kokubo,Y., Kada,A., Yang,J., Tanaka,C., Takiuchi,S., Horio,T., Matayoshi,T., Yasuda,H., Nagura,J., Tomoike,H., Kawano,Y. & Miyata,T.
    Association of genetic polymorphisms of endothelin-converting enzyme-1 gene with hypertension in a Japanese population and rare missense mutation in preproendothelin-1 in Japanese hypertensives.
    Hypertens Res (2007) 30, 513-520. PubMed  Europe PubMed DOI  M
  35. Kuruppu,S., Reeve,S. & Ian Smith,A.
    Characterisation of endothelin converting enzyme-1 shedding from endothelial cells.
    FEBS Lett (2007) 581, 4501-4506. PubMed  Europe PubMed DOI
  36. Padilla,B.E., Cottrell,G.S., Roosterman,D., Pikios,S., Muller,L., Steinhoff,M. & Bunnett,N.W.
    Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins.
    J Cell Biol (2007) 179, 981-997. PubMed  Europe PubMed DOI  PMC  EPMC
  37. Roosterman,D., Cottrell,G.S., Padilla,B.E., Muller,L., Eckman,C.B., Bunnett,N.W. & Steinhoff,M.
    Endothelin-converting enzyme 1 degrades neuropeptides in endosomes to control receptor recycling.
    Proc Natl Acad Sci U S A (2007) 104, 11838-11843. PubMed  Europe PubMed DOI  PMC  EPMC
  38. 2006
  39. Choi,D.S., Wang,D., Yu,G.Q., Zhu,G., Kharazia,V.N., Paredes,J.P., Chang,W.S., Deitchman,J.K., Mucke,L. & Messing,R.O.
    PKCepsilon increases endothelin converting enzyme activity and reduces amyloid plaque pathology in transgenic mice.
    Proc Natl Acad Sci U S A (2006) 103, 8215-8220. PubMed  Europe PubMed DOI  PMC  EPMC  U
  40. Dawson,L.A., Maitland,N.J., Berry,P., Turner,A.J. & Usmani,B.A.
    Expression and localization of endothelin-converting enzyme-1 in human prostate cancer.
    Exp Biol Med (Maywood) (2006) 231, 1106-1110. PubMed  Europe PubMed  R
  41. Eckman,E.A., Adams,S.K., Troendle,F.J., Stodola,B.A., Kahn,M.A., Fauq,A.H., Xiao,H.D., Bernstein,K.E. & Eckman,C.B.
    Regulation of steady-state beta-amyloid levels in the brain by neprilysin and endothelin-converting enzyme but not angiotensin-converting enzyme.
    J Biol Chem (2006) 281, 30471-30478. PubMed  Europe PubMed DOI  K
  42. Fisk,L., Nalivaeva,N.N. & Turner,A.J.
    Regulation of endothelin-converting enzyme-1 expression in human neuroblastoma cells.
    Exp Biol Med (Maywood) (2006) 231, 1048-1053. PubMed  Europe PubMed
  43. Gokhale,N.H. & Cowan,J.A.
    Metallopeptide-promoted inactivation of angiotensin-converting enzyme and endothelin-converting enzyme 1: Toward dual-action therapeutics.
    J Biol Inorg Chem (2006) 11, 937-947. PubMed  Europe PubMed DOI  I
  44. Hunter,A.R. & Turner,A.J.
    Expression and localization of endothelin-converting enzyme-1 isoforms in human endothelial cells.
    Exp Biol Med (Maywood) (2006) 231, 718-722. PubMed  Europe PubMed
  45. Jackson,C.D., Barnes,K., Homer-Vanniasinkam,S. & Turner,A.J.
    Expression and localization of human endothelin-converting enzyme-1 isoforms in symptomatic atherosclerotic disease and saphenous vein.
    Exp Biol Med (Maywood) (2006) 231, 794-801. PubMed  Europe PubMed
  46. Jafri,F. & Ergul,A.
    Phosphorylation of endothelin converting enzyme-1 isoforms: relevance to subcellular localization.
    Exp Biol Med (Maywood) (2006) 231, 713-717. PubMed  Europe PubMed
  47. Klipper,E., Levy,N., Gilboa,T., Muller,L. & Meidan,R.
    Identification of a novel alternatively spliced variant endothelin converting enzyme-1 lacking a transmembrane domain.
    Exp Biol Med (Maywood) (2006) 231, 723-728. PubMed  Europe PubMed
  48. Navarrete,C. & Suguihara,C.
    Endothelin-converting enzyme inhibitors.
    Curr Enzyme Inhib (2006) 2, 373-378. DOI  I
  49. Smith,A.I., Lew,R.A., Thomas,W.G. & Tochon-Danguy,N.
    Protein kinase C regulates the cell surface activity of endothelin-converting enzyme-1.
    Int J Pept Res Ther (2006) 12, 291-295. PubMed  Europe PubMed DOI  PMC  EPMC
  50. 2005
  51. Battistini,B., Daull,P. & Jeng,A.Y.
    CGS 35601, a triple inhibitor of angiotensin converting enzyme, neutral endopeptidase and endothelin converting enzyme.
    Cardiovasc Drug Rev (2005) 23, 317-330. PubMed  Europe PubMed  I
  52. Berger,Y., Dehmlow,H., Blum-Kaelin,D., Kitas,E.A., Loffler,B.M., Aebi,J.D. & Juillerat-Jeanneret,L.
    Endothelin-converting enzyme-1 inhibition and growth of human glioblastoma cells.
    J Med Chem (2005) 48, 483-498. PubMed  Europe PubMed DOI
  53. Meidan,R., Klipper,E., Gilboa,T., Muller,L. & Levy,N.
    Endothelin-converting enzyme-1, abundance of isoforms a-d and identification of a novel alternatively spliced variant lacking a transmembrane domain.
    J Biol Chem (2005) 280, 40867-40874. PubMed  Europe PubMed DOI  R
  54. 2004
  55. Ahn,K. & Johnson,G.D.
    Endothelin-converting enzyme 1.
    In Handbook of Proteolytic Enzymes, 2 edn (Barrett,A.J., Rawlings,N.D. & Woessner,J.F. eds), p.429-434, Elsevier, London (2004)  V
  56. Chang,C.Z., Yen,C.P., Winadi,D., Wu,S.C., Howng,S.L., Lin,T.K., Jeng,A.Y., Kassell,N.F. & Kwan,A.L.
    Neuroprotective effect of CGS 26303, an endothelin-converting enzyme inhibitor, on transient middle cerebral artery occlusion in rats.
    J Cardiovasc Pharmacol (2004) 44, S487-S489. PubMed  Europe PubMed DOI  I
  57. Funalot,B., Ouimet,T., Claperon,A., Fallet,C., Delacourte,A., Epelbaum,J., Subkowski,T., Leonard,N., Codron,V., David,J.P., Amouyel,P., Schwartz,J.C. & Helbecque,N.
    Endothelin-converting enzyme-1 is expressed in human cerebral cortex and protects against Alzheimer's disease.
    Mol Psychiatry (2004) 9, 1122-1128. PubMed  Europe PubMed DOI
  58. Inguimbert,N., Poras,H., Dhotel,H., Beslot,F., Scalbert,E., Bennejean,C., Renard,P., Fournie-Zaluski,M.C. & Roques,B.P.
    In vivo properties of thiol inhibitors of the three vasopeptidases NEP, ACE and ECE are improved by introduction of a 7-azatryptophan in P2' position.
    J Pept Res (2004) 63, 99-107. PubMed  Europe PubMed DOI  I
  59. Macours,N., Poels,J., Hens,K., Francis,C. & Huybrechts,R.
    Structure, evolutionary conservation, and functions of angiotensin- and endothelin-converting enzymes.
    Int Rev Cytol (2004) 239, 47-97. PubMed  Europe PubMed DOI  V
  60. Trapani,A.J., Beil,M.E., Bruseo,C.W., Savage,P., Firooznia,F. & Jeng,A.Y.
    CGS 35601 and its orally active prodrug CGS 37808 as triple inhibitors of endothelin-converting enzyme-1, neutral endopeptidase 24.11, and angiotensin-converting enzyme.
    J Cardiovasc Pharmacol (2004) 44 Suppl 1, S211-S215. PubMed  Europe PubMed DOI  I
  61. 2003
  62. Funke-Kaiser,H., Lemmer,J., Langsdorff,C.V., Thomas,A., Kovacevic,S.D., Strasdat,M., Behrouzi,T., Zollmann,F.S., Paul,M. & Orzechowski,H.D.
    Endothelin-converting enzyme-1 (ECE-1) is a downstream target of the homeobox transcription factor Nkx2-5.
    FASEB J (2003) 17, 1487-1489. PubMed  Europe PubMed DOI
  63. Funke-Kaiser,H., Thomas,A., Bremer,J., Kovacevic,S.D., Scheuch,K., Bolbrinker,J., Theis,S., Lemmer,J., Zimmermann,A., Zollmann,F.S., Herrmann,S.M., Paul,M. & Orzechowski,H.D.
    Regulation of the major isoform of human endothelin-converting enzyme-1 by a strong housekeeping promoter modulated by polymorphic microsatellites.
    J Hypertens (2003) 21, 2111-2124. PubMed  Europe PubMed DOI
  64. Gentile,M.T. & Lembo,G.
    Polymorphisms in human endothelin-converting enzyme (ECE-1) promoter can modulate ECE-1 gene expression.
    J Hypertens (2003) 21, 2013-2014. PubMed  Europe PubMed DOI  M
  65. Isaka,D., Emoto,N., Raharjo,S.B., Yokoyama,M. & Matsuo,M.
    The effects of phosphoramidon on the expression of human endothelin-converting enzyme-1 (ECE-1) isoforms.
    J Cardiovasc Pharmacol (2003) 42, 136-141. PubMed  Europe PubMed DOI  I
  66. Jeng,A.Y.
    Utility of endothelin-converting enzyme inhibitors for the treatment of cardiovascular diseases.
    Curr Opin Investig Drugs (2003) 4, 1076-1081. PubMed  Europe PubMed  I
  67. Muller,L., Barret,A., Etienne,E., Meidan,R., Valdenaire,O., Corvol,P. & Tougard,C.
    Heterodimerization of endothelin-converting enzyme-1 isoforms regulates the subcellular distribution of this metalloprotease.
    J Biol Chem (2003) 278, 545-555. PubMed  Europe PubMed DOI
  68. 2002
  69. Firooznia,F., Gude,C., Chan,K., Tan,J., Fink,C.A., Savage,P., Beil,M.E., Bruseo,C.W., Trapani,A.J. & Jeng,A.Y.
    Synthesis and biological activity of potent heterocyclic thiol-based inhibitors of endothelin-converting enzyme-1.
    Bioorg Med Chem Lett (2002) 12, 3059-3062. PubMed  Europe PubMed DOI  I
  70. Jeng,A.Y., Mulder,P., Kwan,A.L. & Battistini,B.
    Nonpeptidic endothelin-converting enzyme inhibitors and their potential therapeutic applications.
    Can J Physiol Pharmacol (2002) 80, 440-449. PubMed  Europe PubMed DOI  I
  71. Johnson,G.D., Swenson,H.R., Ramage,R. & Ahn,K.
    Mapping the active site of endothelin-converting enzyme-1 through subsite specificity and mutagenesis studies: A comparison with neprilysin.
    Arch Biochem Biophys (2002) 398, 240-248. PubMed  Europe PubMed DOI
  72. Kulathila,R., Clark,K., Savage,P., Bowen,B.R., Emoto,N., Yanagisawa,M. & Jeng,A.Y.
    Expression, purification and characterization of the monomeric and dimeric forms of soluble bovine endothelin converting enzyme-1a.
    Clin Sci (Lond) (2002) 103 Suppl 48, 94S-97S. PubMed  Europe PubMed DOI
  73. Yamazaki,K., Hasegawa,H., Umekawa,K., Ueki,Y., Ohashi,N. & Kanaoka,M.
    Design, synthesis and biological activity of novel non-peptidyl endothelin converting enzyme inhibitors, 1-phenyl-tetrazole-formazan analogues.
    Bioorg Med Chem Lett (2002) 12, 1275-1278. PubMed  Europe PubMed DOI  I
  74. 2001
  75. Barker,S., Khan,N.Q., Wood,E.G. & Corder,R.
    Effect of an antisense oligodeoxynucleotide to endothelin-converting enzyme-1c (ECE-1c) on ECE-1c mRNA, ECE-1 protein and endothelin-1 synthesis in bovine pulmonary artery smooth muscle cells.
    Mol Pharmacol (2001) 59, 163-169. PubMed  Europe PubMed
  76. Bur,D., Dale,G.E. & Oefner,C.
    A three-dimensional model of endothelin-converting enzyme (ECE) based on the X-ray structure of neutral endopeptidase 24.11 (NEP).
    Protein Eng (2001) 14, 337-341. PubMed  Europe PubMed  S  I
  77. Eckman,E.A., Reed,D.K. & Eckman,C.B.
    Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme.
    J Biol Chem (2001) 276, 24540-24548. PubMed  Europe PubMed DOI  I
  78. Luciani,N., de Rocquigny,H., Turcaud,S., Romieu,A. & Roques,B.P.
    Highly sensitive and selective fluorescence assays for rapid screening of endothelin-converting enzyme inhibitors.
    Biochem J (2001) 356, 813-819. PubMed  Europe PubMed DOI  PMC  EPMC  A
  79. MacLeod,K.J., Fuller,R.S., Scholten,J.D. & Ahn,K.
    Conserved cysteine and tryptophan residues of the endothelin-converting enzyme-1 CXAW motif are critical for protein maturation and enzyme activity.
    J Biol Chem (2001) 276, 30608-30614. PubMed  Europe PubMed DOI
  80. Uhlmann,D., Witzigmann,H., Senninger,N., Hauss,J. & Spiegel,H.U.
    Protective role of an endothelin-converting enzyme inhibitor (FR901533) in hepatic ischemia/reperfusion injury.
    Microvasc Res (2001) 62, 43-54. PubMed  Europe PubMed DOI  I
  81. Uhlmann,D., Witzigmann,H., Senninger,N., Hauss,J. & Spiegel,H.
    Improvement of postischemic hepatic microhemodynamics by an endothelin converting enzyme inhibitor (FR 901533).
    Transplant Proc (2001) 33, 2549-2550. PubMed  Europe PubMed DOI  I
  82. Zhang,J., Leontovich,A. & Sarras,M.P., Jr.
    Molecular and functional evidence for early divergence of an endothelin-like system during metazoan evolution: analysis of the Cnidarian, hydra.
    Development (2001) 128, 1607-1615. PubMed  Europe PubMed
  83. 2000
  84. Brooks,S.C., Fernandez,L. & Ergul,A.
    Secretion of endothelin converting enzyme-1a: The hydrophobic signal anchor domain alone is not sufficient to promote membrane localization.
    Mol Cell Biochem (2000) 208, 45-51. PubMed  Europe PubMed
  85. Davenport,A.P. & Kuc,R.E.
    Cellular expression of isoforms of endothelin-converting enzyme-1 (ECE-1c, ECE-1b and ECE-1a) and endothelin-converting enzyme-2.
    J Cardiovasc Pharmacol (2000) 36, S12-S14. PubMed  Europe PubMed
  86. De Lombaert,S., Blanchard,L., Stamford,L.B., Tan,J., Wallace,E.M., Satoh,Y., Fitt,J., Hoyer,D., Simonsbergen,D., Moliterni,J., Marcopoulos,N., Savage,P., Chou,M., Trapani,A.J. & Jeng,A.Y.
    Potent and selective non-peptidic inhibitors of endothelin-converting enzyme-1 with sustained duration of action.
    J Med Chem (2000) 43, 488-504. PubMed  Europe PubMed DOI  I
  87. Fahnoe,D.C., Johnson,G.D., Herman,S.B. & Ahn,K.
    Disulfide bonds in big ET-1 are essential for the specific cleavage at the Trp(21)-Val(22) bond by soluble endothelin converting enzyme-1 from baculovirus/insect cells.
    Arch Biochem Biophys (2000) 373, 385-393. PubMed  Europe PubMed DOI  A  E
  88. Jeng,A.Y., De Lombaert,S., Beil,M.E., Bruseo,C.W., Savage,P., Chou,M. & Trapani,A.J.
    Design and synthesis of a potent and selective endothelin-converting enzyme inhibitor, CGS 35066.
    J Cardiovasc Pharmacol (2000) 36, S36-S39. PubMed  Europe PubMed  I
  89. Johnson,G.D. & Ahn,K.
    Development of an internally quenched fluorescent substrate selective for endothelin-converting enzyme-1.
    Anal Biochem (2000) 286, 112-118. PubMed  Europe PubMed DOI  A
  90. Letourneau,M., Roby,P., Tremblay,F., Carette,J. & Fournier,A.
    New short peptide substrates of endothelin-converting enzyme and characterization of the enzyme.
    J Cardiovasc Pharmacol (2000) 36, S28-S29. PubMed  Europe PubMed
  91. Loffler,B.M.
    Endothelin-converting enzyme inhibitors: current status and perspectives.
    J Cardiovasc Pharmacol (2000) 35, S79-S82. PubMed  Europe PubMed DOI  I
  92. Lopez-Ongil,S., Senchak,V., Saura,M., Zaragoza,C., Ames,M., Ballermann,B., Rodriguez-Puyol,M., Rodriguez-Puyol,D. & Lowenstein,C.J.
    Superoxide regulation of endothelin-converting enzyme.
    J Biol Chem (2000) 275, 26423-26427. PubMed  Europe PubMed DOI
  93. Martin,P., Tzanidis,A., Stein-Oakley,A. & Krum,H.
    Effect of a highly selective endothelin-converting enzyme inhibitor on cardiac remodeling in rats after myocardial infarction.
    J Cardiovasc Pharmacol (2000) 36, S367-S370. PubMed  Europe PubMed  I
  94. Matsumura,Y., Kuro,T., Kobayashi,Y., Umekawa,K., Ohashi,N. & Takaoka,M.
    Protective effect of SM-19712, a novel and potent endothelin converting enzyme inhibitor, on ischemic acute renal failure in rats.
    Jpn J Pharmacol (2000) 84, 16-24. PubMed  Europe PubMed DOI  I
  95. Muller,L., Valdenaire,O., Barret,A., Korth,P., Pinet,F., Corvol,P. & Tougard,C.
    Expression of the endothelin-converting enzyme-1 isoforms in endothelial cells.
    J Cardiovasc Pharmacol (2000) 36, S15-S18. PubMed  Europe PubMed
  96. Umekawa,K., Hasegawa,H., Tsutsumi,Y., Sato,K., Matsumura,Y. & Ohashi,N.
    Pharmacological characterization of a novel sulfonylureid-pyrazole derivative, SM-19712, a potent nonpeptidic inhibitor of endothelin converting enzyme.
    Jpn J Pharmacol (2000) 84, 7-15. PubMed  Europe PubMed DOI  I
  97. Yanagisawa,H., Hammer,R.E., Richardson,J.A., Emoto,N., Williams,S.C., Takeda,S., Clouthier,D.E. & Yanagisawa,M.
    Disruption of ECE-1 and ECE-2 reveals a role for endothelin-converting enzyme-2 in murine cardiac development.
    J Clin Invest (2000) 105, 1373-1382. PubMed  Europe PubMed DOI  PMC  EPMC  K
  98. 1999
  99. Barnes,K. & Turner,A.J.
    Endothelin converting enzyme is located on alpha-actin filaments in smooth muscle cells.
    Cardiovasc Res (1999) 42, 814-822. PubMed  Europe PubMed DOI
  100. Cailler,F., Zappulla,J.P., Boileau,G. & Crine,P.
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