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Literature for peptidase M13.002: endothelin-converting enzyme 1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, R Splicing, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Ulku,I., Ansari,F.E., Hancock,M.A., Zhou,H., Cagnone,G., Joyal,J.S., Fisher,T.A.J., Kennedy,T.E., Liebsch,F. and Multhaup,G.
    Characterization of endothelin-converting enzyme 1 as a key enzyme in the multienzyme Abeta degradation pathway
    Proc Natl Acad Sci U S A (2025) 122, e2507450122-e2507450122. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Zhang,S., Yan,Z., Nurmamat,A., Zhuang,R., Zhou,Y., Xiu,M., Pang,Y., Li,D., Zhao,L., Liu,X. and Han,Y.
    Exploring the evolutionary conservation and functional implications of Endothelin Converting Enzyme 1 (ECE1) in lamprey (Lethenteron reissneri)
    Fish Physiol Biochem (2025) 51, 174-174. PubMed  Europe PubMed DOI
    3. 2024
  3. Adu-Gyamfi,M., Goettsch,C., Kamhieh-Milz,J., Chen,L., Pfefferkorn,A.M., Hofmann,A., Brunssen,C., Muller,G., Walther,T., Ashraf,M.I., Morawietz,H., Witowski,J. and Catar,R.
    The Role of NOX2-Derived Reactive Oxygen Species in the Induction of Endothelin-Converting Enzyme-1 by Angiotensin II
    Antioxidants (Basel) (2024) 13 PubMed  Europe PubMed DOI  PMC  EPMC
  4. Almarza,C., Villalobos-Nova,K., Toro,M.A., Gonzalez,M., Niechi,I., Brown-Brown,D.A., Lopez-Munoz,R.A., Silva-Pavez,E., Gaete-Ramirez,B., Varas-Godoy,M., Burzio,V.A., Jara,L., Aguayo,F. and Tapia,J.C.
    Cisplatin-resistance and aggressiveness are enhanced by a highly stable endothelin-converting enzyme-1c in lung cancer cells
    Biol Res (2024) 57, 74-74. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Chen,L., Lu,Y., Zhao,M., Xu,J., Wang,Y., Xu,Q., Cao,Y. and Liu,H.
    A non-canonical role of endothelin converting enzyme 1 (ECE1) in promoting lung cancer development via directly targeting protein kinase B (AKT)
    J Gene Med (2024) 26, e3612-e3612. PubMed  Europe PubMed DOI  K
  6. Zukowska,J., Moss,S.J., Subramanian,V. and Acharya,K.R.
    Molecular basis of selective amyloid-beta degrading enzymes in Alzheimer's disease
    FEBS J (2024) 291, 2999-3029. PubMed  Europe PubMed DOI  V
    7. 2023
  7. Zhu,Y., Saint-Pol,J., Nguyen,V., Rubinstein,E., Boucheix,C. and Greco,C.
    The Tetraspanin Tspan8 Associates with Endothelin Converting Enzyme ECE1 and Regulates Its Activity
    Cancers (Basel) (2023) 15 PubMed  Europe PubMed DOI  PMC  EPMC
    8. 2020
  8. Arfian,N., Suzuki,Y., Hartopo,A.B., Anggorowati,N., Nugrahaningsih,D.A.A. and Emoto,N.
    Endothelin converting enzyme-1 (ECE-1) deletion in association with Endothelin-1 downregulation ameliorates kidney fibrosis in mice
    Life Sci (2020) 258, 118223-118223. PubMed  Europe PubMed DOI  K
  9. Perez-Moreno,P., Indo,S., Niechi,I., Huerta,H., Cabello,P., Jara,L., Aguayo,F., Varas-Godoy,M., Burzio,V.A. and Tapia,J.C.
    Endothelin-converting enzyme-1c promotes stem cell traits and aggressiveness in colorectal cancer cells
    Mol Oncol (2020) 14, 347-362. PubMed  Europe PubMed DOI
  10. Perez-Moreno,P., Quezada-Meza,C., Chavez-Almarza,C., Niechi,I., Silva-Pavez,E., Trigo-Hidalgo,C., Aguayo,F., Jara,L., Caceres-Verschae,A., Varas-Godoy,M., Diaz,V.M., Garcia de Herreros,A., Burzio,V.A. and Tapia,J.C.
    Phosphorylation of Endothelin-Converting Enzyme-1c at Serines 18 and 20 by CK2 Promotes Aggressiveness Traits in Colorectal Cancer Cells
    Front Oncol (2020) 10, 1004-1004. PubMed  Europe PubMed DOI  PMC  EPMC
    11. 2019
  11. Tapia,J.C. and Niechi,I.
    Endothelin-converting enzyme-1 in cancer aggressiveness
    Cancer Lett (2019) 452, 152-157. PubMed  Europe PubMed DOI
    12. 2017
  12. Miners,J.S. and Love,S.
    Endothelin-converting enzymes degrade alpha-synuclein and are reduced in dementia with Lewy bodies
    J Neurochem (2017) 141, 275-286. PubMed  Europe PubMed DOI
    13. 2016
  13. Smith,A.I., Rajapakse,N.W., Kleifeld,O., Lomonte,B., Sikanyika,N.L., Spicer,A.J., Hodgson,W.C., Conroy,P.J., Small,D.H., Kaye,D.M., Parkington,H.C., Whisstock,J.C. and Kuruppu,S.
    N-terminal domain of Bothrops asper myotoxin II enhances the activity of endothelin converting enzyme-1 and neprilysin
    Sci Rep (2016) 6, 22413-22413. PubMed  Europe PubMed DOI  PMC  EPMC
    14. 2014
  14. Miners,J.S., Palmer,J.C., Tayler,H., Palmer,L.E., Ashby,E., Kehoe,P.G. and Love,S.
    Abeta degradation or cerebral perfusion? Divergent effects of multifunctional enzymes
    Front Aging Neurosci (2014) 6, 238-238. PubMed  Europe PubMed DOI  PMC  EPMC
    15. 2013
  15. Cattaruzza,F., Poole,D.P. and Bunnett,N.W.
    Arresting inflammation: contributions of plasma membrane and endosomal signalling to neuropeptide-driven inflammatory disease
    Biochem Soc Trans (2013) 41, 137-143. PubMed  Europe PubMed DOI
  16. Martinez-Miguel,P., Medrano-Andres,D., Lopes-Martin,V., Arribas-Gomez,I., Rodriguez-Puyol,M., Rodriguez-Puyol,D. and Lopez-Ongil,S.
    Regulation of endothelin-converting enzyme-1 (ECE-1) by the calcimimetic R-568
    Pharmacol Res (2013) 76, 106-118. PubMed  Europe PubMed DOI  I
  17. Tanneeru,K., Sahu,I. and Guruprasad,L.
    Ligand-based drug design for human endothelin converting enzyme-1 inhibitors
    Med Chem Res (2013) 22, 4401-4409. DOI  I
    18. 2012
  18. Kuruppu,S. and Smith,A.I.
    Endothelin converting enzyme-1 phosphorylation and trafficking
    FEBS Lett (2012) 586, 2212-2217. PubMed  Europe PubMed DOI
  19. Kuruppu,S., Tochon-Danguy,N. and Smith,A.I.
    Protein kinase C recognition sites in the cytoplasmic domain of endothelin converting enzyme-1c
    Biochem Biophys Res Commun (2012) 427, 606-610. PubMed  Europe PubMed DOI
  20. Nakayama,K., Emoto,N., Suzuki,Y., Vignon-Zellweger,N., Yagi,K. and Ken-Ichi,H.
    Physiological relevance of hydrolysis of atrial natriuretic peptide by endothelin-converting enzyme-1
    Kobe J Med Sci (2012) 58, E12-E18. PubMed  Europe PubMed
  21. Ul-Haq,Z., Iqbal,S. and Moin,S.T.
    Dynamic changes in the secondary structure of ECE-1 and XCE account for their different substrate specificities
    BMC Bioinformatics (2012) 13, 285-285. PubMed  Europe PubMed DOI  P
  22. Whyteside,A.R. and Turner,A.J.
    Endothelin-converting enzyme 1 (ECE-1)
    [ISSN:978-0-12-407744-7] (2012) 3, 624-631. DOI
    23. 2011
  23. Hong,Y., MacNab,S., Lambert,L.A., Turner,A.J., Whitehouse,A. and Usmani,B.A.
    Herpesvirus saimiri-based endothelin-converting enzyme-1 shRNA expression decreases prostate cancer cell invasion and migration
    Int J Cancer (2011) 129, 586-598. PubMed  Europe PubMed DOI  K
    24. 2010
  24. Jullien,N., Makritis,A., Georgiadis,D., Beau,F., Yiotakis,A. and Dive,V.
    Phosphinic tripeptides as dual angiotensin-converting enzyme C-domain and endothelin-converting enzyme-1 inhibitors
    J Med Chem (2010) 53, 208-220. PubMed  Europe PubMed DOI  I
  25. Kuruppu,S., Tochon-Danguy,N. and Smith,A.I.
    Role of protein kinase C in endothelin converting enzyme-1 trafficking and shedding from endothelial cells
    Biochem Biophys Res Commun (2010) 398, 173-177. PubMed  Europe PubMed DOI
  26. Whyteside,A.R., Hinsley,E.E., Lambert,L.A., McDermott,P.J. and Turner,A.J.
    ECE-1 influences prostate cancer cell invasion via ET-1-mediated FAK phosphorylation and ET-1-independent mechanisms
    Can J Physiol Pharmacol (2010) 88, 850-854. PubMed  Europe PubMed DOI
    27. 2009
  27. Cottrell,G.S., Padilla,B.E., Amadesi,S., Poole,D.P., Murphy,J.E., Hardt,M., Roosterman,D., Steinhoff,M. and Bunnett,N.W.
    Endosomal endothelin-converting enzyme-1: a regulator of beta-arrestin-dependent ERK signaling
    J Biol Chem (2009) 284, 22411-22425. PubMed  Europe PubMed DOI  PMC  EPMC
  28. Dive,V., Chang,C.F., Yiotakis,A. and Sturrock,E.D.
    Inhibition of zinc metallopeptidases in cardiovascular disease - from unity to trinity, or duality?
    Curr Pharm Des (2009) 15, 3606-3621. PubMed  Europe PubMed DOI  V  I
  29. Jin,Z., Luxiang,C., Huadong,Z., Zhiqiang,X., Lihua,H. and Huiyun,L.
    C-338A polymorphism of the endothelin-converting enzyme-1 gene and the susceptibility to carotid atherosclerosis
    Microvasc Res (2009) 78, 128-131. PubMed  Europe PubMed DOI  M
  30. Schulz,H., Dale,G.E., Karimi-Nejad,Y. and Oefner,C.
    Structure of human endothelin-converting enzyme I complexed with phosphoramidon
    J Mol Biol (2009) 385, 178-187. PubMed  Europe PubMed DOI  S  I
    31. 2008
  31. Carty,N.C., Nash,K., Lee,D., Mercer,M., Gottschall,P.E., Meyers,C., Muzyczka,N., Gordon,M.N. and Morgan,D.
    Adeno-associated viral (AAV) serotype 5 vector mediated gene delivery of endothelin-converting enzyme reduces Abeta deposits in APP + PS1 transgenic mice
    Mol Ther (2008) 16, 1580-1586. PubMed  Europe PubMed DOI  PMC  EPMC
  32. Cerdeira,A.S., Bras-Silva,C. and Leite-Moreira,A.F.
    Endothelin-converting enzyme inhibitors: their application in cardiovascular diseases
    Rev Port Cardiol (2008) 27, 385-408. PubMed  Europe PubMed  I
  33. Lambert,L.A., Whyteside,A.R., Turner,A.J. and Usmani,B.A.
    Isoforms of endothelin-converting enzyme-1 (ECE-1) have opposing effects on prostate cancer cell invasion
    Br J Cancer (2008) 99, 1114-1120. PubMed  Europe PubMed DOI  PMC  EPMC
  34. Rayhman,O., Klipper,E., Muller,L., Davidson,B., Reich,R. and Meidan,R.
    Small interfering RNA molecules targeting endothelin-converting enzyme-1 inhibit endothelin-1 synthesis and the invasive phenotype of ovarian carcinoma cells
    Cancer Res (2008) 68, 9265-9273. PubMed  Europe PubMed DOI
  35. Roosterman,D., Kempkes,C., Cottrell,G.S., Padilla,B.E., Bunnett,N.W., Turck,C.W. and Steinhoff,M.
    Endothelin-converting enzyme-1 degrades internalized somatostatin-14
    Endocrinology (2008) 149, 2200-2207. PubMed  Europe PubMed DOI  PMC  EPMC
    36. 2007
  36. Banno,M., Hanada,H., Kamide,K., Kokubo,Y., Kada,A., Yang,J., Tanaka,C., Takiuchi,S., Horio,T., Matayoshi,T., Yasuda,H., Nagura,J., Tomoike,H., Kawano,Y. and Miyata,T.
    Association of genetic polymorphisms of endothelin-converting enzyme-1 gene with hypertension in a Japanese population and rare missense mutation in preproendothelin-1 in Japanese hypertensives
    Hypertens Res (2007) 30, 513-520. PubMed  Europe PubMed DOI  M
  37. Kuruppu,S., Reeve,S. and Ian Smith,A.
    Characterisation of endothelin converting enzyme-1 shedding from endothelial cells
    FEBS Lett (2007) 581, 4501-4506. PubMed  Europe PubMed DOI
  38. Padilla,B.E., Cottrell,G.S., Roosterman,D., Pikios,S., Muller,L., Steinhoff,M. and Bunnett,N.W.
    Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins
    J Cell Biol (2007) 179, 981-997. PubMed  Europe PubMed DOI  PMC  EPMC
  39. Roosterman,D., Cottrell,G.S., Padilla,B.E., Muller,L., Eckman,C.B., Bunnett,N.W. and Steinhoff,M.
    Endothelin-converting enzyme 1 degrades neuropeptides in endosomes to control receptor recycling
    Proc Natl Acad Sci U S A (2007) 104, 11838-11843. PubMed  Europe PubMed DOI  PMC  EPMC
    40. 2006
  40. [YEAR:23-5-2006]Choi,D.S., Wang,D., Yu,G.Q., Zhu,G., Kharazia,V.N., Paredes,J.P., Chang,W.S., Deitchman,J.K., Mucke,L. and Messing,R.O.
    PKCepsilon increases endothelin converting enzyme activity and reduces amyloid plaque pathology in transgenic mice
    Proc Natl Acad Sci U S A (23-5-2006) 103, 8215-8220. PubMed  Europe PubMed DOI  PMC  EPMC  U
  41. Dawson,L.A., Maitland,N.J., Berry,P., Turner,A.J. and Usmani,B.A.
    Expression and localization of endothelin-converting enzyme-1 in human prostate cancer
    Exp Biol Med (Maywood) (2006) 231, 1106-1110. PubMed  Europe PubMed  R
  42. [YEAR:14-8-2006]Eckman,E.A., Adams,S.K., Troendle,F.J., Stodola,B.A., Kahn,M.A., Fauq,A.H., Xiao,H.D., Bernstein,K.E. and Eckman,C.B.
    Regulation of steady-state beta-amyloid levels in the brain by neprilysin and endothelin-converting enzyme but not angiotensin-converting enzyme
    J Biol Chem (14-8-2006) 281, 30471-30478. PubMed  Europe PubMed DOI  K
  43. Fisk,L., Nalivaeva,N.N. and Turner,A.J.
    Regulation of endothelin-converting enzyme-1 expression in human neuroblastoma cells
    Exp Biol Med (Maywood) (2006) 231, 1048-1053. PubMed  Europe PubMed
  44. Gokhale,N.H. and Cowan,J.A.
    Metallopeptide-promoted inactivation of angiotensin-converting enzyme and endothelin-converting enzyme 1: Toward dual-action therapeutics
    J Biol Inorg Chem (2006) 11, 937-947. PubMed  Europe PubMed DOI  I
  45. Hunter,A.R. and Turner,A.J.
    Expression and localization of endothelin-converting enzyme-1 isoforms in human endothelial cells
    Exp Biol Med (Maywood) (2006) 231, 718-722. PubMed  Europe PubMed
  46. Jackson,C.D., Barnes,K., Homer-Vanniasinkam,S. and Turner,A.J.
    Expression and localization of human endothelin-converting enzyme-1 isoforms in symptomatic atherosclerotic disease and saphenous vein
    Exp Biol Med (Maywood) (2006) 231, 794-801. PubMed  Europe PubMed
  47. Jafri,F. and Ergul,A.
    Phosphorylation of endothelin converting enzyme-1 isoforms: relevance to subcellular localization
    Exp Biol Med (Maywood) (2006) 231, 713-717. PubMed  Europe PubMed
  48. Klipper,E., Levy,N., Gilboa,T., Muller,L. and Meidan,R.
    Identification of a novel alternatively spliced variant endothelin converting enzyme-1 lacking a transmembrane domain
    Exp Biol Med (Maywood) (2006) 231, 723-728. PubMed  Europe PubMed
  49. Navarrete,C. and Suguihara,C.
    Endothelin-converting enzyme inhibitors
    Curr Enzyme Inhib (2006) 2, 373-378. DOI  I
  50. Smith,A.I., Lew,R.A., Thomas,W.G. and Tochon-Danguy,N.
    Protein kinase C regulates the cell surface activity of endothelin-converting enzyme-1
    Int J Pept Res Ther (2006) 12, 291-295. PubMed  Europe PubMed DOI  PMC  EPMC
    51. 2005
  51. Battistini,B., Daull,P. and Jeng,A.Y.
    CGS 35601, a triple inhibitor of angiotensin converting enzyme, neutral endopeptidase and endothelin converting enzyme
    Cardiovasc Drug Rev (2005) 23, 317-330. PubMed  Europe PubMed  I
  52. [YEAR:27-1-2005]Berger,Y., Dehmlow,H., Blum-Kaelin,D., Kitas,E.A., Loffler,B.M., Aebi,J.D. and Juillerat-Jeanneret,L.
    Endothelin-converting enzyme-1 inhibition and growth of human glioblastoma cells
    J Med Chem (27-1-2005) 48, 483-498. PubMed  Europe PubMed DOI
  53. [YEAR:26-9-2005]Meidan,R., Klipper,E., Gilboa,T., Muller,L. and Levy,N.
    Endothelin-converting enzyme-1, abundance of isoforms a-d and identification of a novel alternatively spliced variant lacking a transmembrane domain
    J Biol Chem (26-9-2005) 280, 40867-40874. PubMed  Europe PubMed DOI  R
    54. 2004
  54. Ahn,K. and Johnson,G.D.
    Endothelin-converting enzyme 1
    [ISSN:0-12-079610-4] (2004) 2, 429-434.  V
  55. Chang,C.Z., Yen,C.P., Winadi,D., Wu,S.C., Howng,S.L., Lin,T.K., Jeng,A.Y., Kassell,N.F. and Kwan,A.L.
    Neuroprotective effect of CGS 26303, an endothelin-converting enzyme inhibitor, on transient middle cerebral artery occlusion in rats
    J Cardiovasc Pharmacol (2004) 44, S487-S489. PubMed  Europe PubMed DOI  I
  56. Funalot,B., Ouimet,T., Claperon,A., Fallet,C., Delacourte,A., Epelbaum,J., Subkowski,T., Leonard,N., Codron,V., David,J.P., Amouyel,P., Schwartz,J.C. and Helbecque,N.
    Endothelin-converting enzyme-1 is expressed in human cerebral cortex and protects against Alzheimer's disease
    Mol Psychiatry (2004) 9, 1122-1128. PubMed  Europe PubMed DOI
  57. Inguimbert,N., Poras,H., Dhotel,H., Beslot,F., Scalbert,E., Bennejean,C., Renard,P., Fournie-Zaluski,M.C. and Roques,B.P.
    In vivo properties of thiol inhibitors of the three vasopeptidases NEP, ACE and ECE are improved by introduction of a 7-azatryptophan in P2' position
    J Pept Res (2004) 63, 99-107. PubMed  Europe PubMed DOI  I
  58. Macours,N., Poels,J., Hens,K., Francis,C. and Huybrechts,R.
    Structure, evolutionary conservation, and functions of angiotensin- and endothelin-converting enzymes
    Int Rev Cytol (2004) 239, 47-97. PubMed  Europe PubMed DOI  V
  59. Trapani,A.J., Beil,M.E., Bruseo,C.W., Savage,P., Firooznia,F. and Jeng,A.Y.
    CGS 35601 and its orally active prodrug CGS 37808 as triple inhibitors of endothelin-converting enzyme-1, neutral endopeptidase 24.11, and angiotensin-converting enzyme
    J Cardiovasc Pharmacol (2004) 44 Suppl 1, S211-S215. PubMed  Europe PubMed DOI  I
    60. 2003
  60. Funke-Kaiser,H., Lemmer,J., Langsdorff,C.V., Thomas,A., Kovacevic,S.D., Strasdat,M., Behrouzi,T., Zollmann,F.S., Paul,M. and Orzechowski,H.D.
    Endothelin-converting enzyme-1 (ECE-1) is a downstream target of the homeobox transcription factor Nkx2-5
    FASEB J (2003) 17, 1487-1489. PubMed  Europe PubMed DOI
  61. Funke-Kaiser,H., Thomas,A., Bremer,J., Kovacevic,S.D., Scheuch,K., Bolbrinker,J., Theis,S., Lemmer,J., Zimmermann,A., Zollmann,F.S., Herrmann,S.M., Paul,M. and Orzechowski,H.D.
    Regulation of the major isoform of human endothelin-converting enzyme-1 by a strong housekeeping promoter modulated by polymorphic microsatellites
    J Hypertens (2003) 21, 2111-2124. PubMed  Europe PubMed DOI
  62. Gentile,M.T. and Lembo,G.
    Polymorphisms in human endothelin-converting enzyme (ECE-1) promoter can modulate ECE-1 gene expression
    J Hypertens (2003) 21, 2013-2014. PubMed  Europe PubMed DOI  M
  63. Isaka,D., Emoto,N., Raharjo,S.B., Yokoyama,M. and Matsuo,M.
    The effects of phosphoramidon on the expression of human endothelin-converting enzyme-1 (ECE-1) isoforms
    J Cardiovasc Pharmacol (2003) 42, 136-141. PubMed  Europe PubMed DOI  I
  64. Jeng,A.Y.
    Utility of endothelin-converting enzyme inhibitors for the treatment of cardiovascular diseases
    Curr Opin Investig Drugs (2003) 4, 1076-1081. PubMed  Europe PubMed  I
  65. [YEAR:3-1-2003]Muller,L., Barret,A., Etienne,E., Meidan,R., Valdenaire,O., Corvol,P. and Tougard,C.
    Heterodimerization of endothelin-converting enzyme-1 isoforms regulates the subcellular distribution of this metalloprotease
    J Biol Chem (3-1-2003) 278, 545-555. PubMed  Europe PubMed DOI
    66. 2002
  66. [YEAR:4-11-2002]Firooznia,F., Gude,C., Chan,K., Tan,J., Fink,C.A., Savage,P., Beil,M.E., Bruseo,C.W., Trapani,A.J. and Jeng,A.Y.
    Synthesis and biological activity of potent heterocyclic thiol-based inhibitors of endothelin-converting enzyme-1
    Bioorg Med Chem Lett (4-11-2002) 12, 3059-3062. PubMed  Europe PubMed DOI  I
  67. Jeng,A.Y., Mulder,P., Kwan,A.L. and Battistini,B.
    Nonpeptidic endothelin-converting enzyme inhibitors and their potential therapeutic applications
    Can J Physiol Pharmacol (2002) 80, 440-449. PubMed  Europe PubMed DOI  I
  68. [YEAR:15-2-2002]Johnson,G.D., Swenson,H.R., Ramage,R. and Ahn,K.
    Mapping the active site of endothelin-converting enzyme-1 through subsite specificity and mutagenesis studies: A comparison with neprilysin
    Arch Biochem Biophys (15-2-2002) 398, 240-248. PubMed  Europe PubMed DOI
  69. Kulathila,R., Clark,K., Savage,P., Bowen,B.R., Emoto,N., Yanagisawa,M. and Jeng,A.Y.
    Expression, purification and characterization of the monomeric and dimeric forms of soluble bovine endothelin converting enzyme-1a
    Clin Sci (Lond) (2002) 103 Suppl 48, 94S-97S. PubMed  Europe PubMed DOI
  70. [YEAR:6-5-2002]Yamazaki,K., Hasegawa,H., Umekawa,K., Ueki,Y., Ohashi,N. and Kanaoka,M.
    Design, synthesis and biological activity of novel non-peptidyl endothelin converting enzyme inhibitors, 1-phenyl-tetrazole-formazan analogues
    Bioorg Med Chem Lett (6-5-2002) 12, 1275-1278. PubMed  Europe PubMed DOI  I
    71. 2001
  71. Barker,S., Khan,N.Q., Wood,E.G. and Corder,R.
    Effect of an antisense oligodeoxynucleotide to endothelin-converting enzyme-1c (ECE-1c) on ECE-1c mRNA, ECE-1 protein and endothelin-1 synthesis in bovine pulmonary artery smooth muscle cells
    Mol Pharmacol (2001) 59, 163-169. PubMed  Europe PubMed
  72. Bur,D., Dale,G.E. and Oefner,C.
    A three-dimensional model of endothelin-converting enzyme (ECE) based on the X-ray structure of neutral endopeptidase 24.11 (NEP)
    Protein Eng (2001) 14, 337-341. PubMed  Europe PubMed  S  I
  73. [YEAR:6-7-2001]Eckman,E.A., Reed,D.K. and Eckman,C.B.
    Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme
    J Biol Chem (6-7-2001) 276, 24540-24548. PubMed  Europe PubMed DOI  I
  74. [YEAR:15-6-2001]Luciani,N., de Rocquigny,H., Turcaud,S., Romieu,A. and Roques,B.P.
    Highly sensitive and selective fluorescence assays for rapid screening of endothelin-converting enzyme inhibitors
    Biochem J (15-6-2001) 356, 813-819. PubMed  Europe PubMed DOI  PMC  EPMC  A
  75. [YEAR:17-8-2001]MacLeod,K.J., Fuller,R.S., Scholten,J.D. and Ahn,K.
    Conserved cysteine and tryptophan residues of the endothelin-converting enzyme-1 CXAW motif are critical for protein maturation and enzyme activity
    J Biol Chem (17-8-2001) 276, 30608-30614. PubMed  Europe PubMed DOI
  76. Uhlmann,D., Witzigmann,H., Senninger,N., Hauss,J. and Spiegel,H.U.
    Protective role of an endothelin-converting enzyme inhibitor (FR901533) in hepatic ischemia/reperfusion injury
    Microvasc Res (2001) 62, 43-54. PubMed  Europe PubMed DOI  I
  77. Uhlmann,D., Witzigmann,H., Senninger,N., Hauss,J. and Spiegel,H.
    Improvement of postischemic hepatic microhemodynamics by an endothelin converting enzyme inhibitor (FR 901533)
    Transplant Proc (2001) 33, 2549-2550. PubMed  Europe PubMed DOI  I
  78. Zhang,J., Leontovich,A. and Sarras,M.P., Jr.
    Molecular and functional evidence for early divergence of an endothelin-like system during metazoan evolution: analysis of the Cnidarian, hydra
    Development (2001) 128, 1607-1615. PubMed  Europe PubMed
    79. 2000
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