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Literature for peptidase M13.002: endothelin-converting enzyme 1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, R Splicing, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Ulku,I., Ansari,F.E., Hancock,M.A., Zhou,H., Cagnone,G., Joyal,J.S., Fisher,T.A.J., Kennedy,T.E., Liebsch,F. and Multhaup,G.<br>Characterization of endothelin-converting enzyme 1 as a key enzyme in the multienzyme Abeta degradation pathway<br>Proc Natl Acad Sci U S A (2025) 122, e2507450122-e2507450122. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Zhang,S., Yan,Z., Nurmamat,A., Zhuang,R., Zhou,Y., Xiu,M., Pang,Y., Li,D., Zhao,L., Liu,X. and Han,Y.<br>Exploring the evolutionary conservation and functional implications of Endothelin Converting Enzyme 1 (ECE1) in lamprey (Lethenteron reissneri)<br>Fish Physiol Biochem (2025) 51, 174-174. PubMed  Europe PubMed DOI
    3. 2024
  3. Adu-Gyamfi,M., Goettsch,C., Kamhieh-Milz,J., Chen,L., Pfefferkorn,A.M., Hofmann,A., Brunssen,C., Muller,G., Walther,T., Ashraf,M.I., Morawietz,H., Witowski,J. and Catar,R.<br>The Role of NOX2-Derived Reactive Oxygen Species in the Induction of Endothelin-Converting Enzyme-1 by Angiotensin II<br>Antioxidants (Basel) (2024) 13 PubMed  Europe PubMed DOI  PMC  EPMC
  4. Almarza,C., Villalobos-Nova,K., Toro,M.A., Gonzalez,M., Niechi,I., Brown-Brown,D.A., Lopez-Munoz,R.A., Silva-Pavez,E., Gaete-Ramirez,B., Varas-Godoy,M., Burzio,V.A., Jara,L., Aguayo,F. and Tapia,J.C.<br>Cisplatin-resistance and aggressiveness are enhanced by a highly stable endothelin-converting enzyme-1c in lung cancer cells<br>Biol Res (2024) 57, 74-74. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Chen,L., Lu,Y., Zhao,M., Xu,J., Wang,Y., Xu,Q., Cao,Y. and Liu,H.<br>A non-canonical role of endothelin converting enzyme 1 (ECE1) in promoting lung cancer development via directly targeting protein kinase B (AKT)<br>J Gene Med (2024) 26, e3612-e3612. PubMed  Europe PubMed DOI  K
  6. Zukowska,J., Moss,S.J., Subramanian,V. and Acharya,K.R.<br>Molecular basis of selective amyloid-beta degrading enzymes in Alzheimer's disease<br>FEBS J (2024) 291, 2999-3029. PubMed  Europe PubMed DOI  V
    7. 2023
  7. Zhu,Y., Saint-Pol,J., Nguyen,V., Rubinstein,E., Boucheix,C. and Greco,C.<br>The Tetraspanin Tspan8 Associates with Endothelin Converting Enzyme ECE1 and Regulates Its Activity<br>Cancers (Basel) (2023) 15 PubMed  Europe PubMed DOI  PMC  EPMC
    8. 2020
  8. Arfian,N., Suzuki,Y., Hartopo,A.B., Anggorowati,N., Nugrahaningsih,D.A.A. and Emoto,N.<br>Endothelin converting enzyme-1 (ECE-1) deletion in association with Endothelin-1 downregulation ameliorates kidney fibrosis in mice<br>Life Sci (2020) 258, 118223-118223. PubMed  Europe PubMed DOI  K
  9. Perez-Moreno,P., Indo,S., Niechi,I., Huerta,H., Cabello,P., Jara,L., Aguayo,F., Varas-Godoy,M., Burzio,V.A. and Tapia,J.C.<br>Endothelin-converting enzyme-1c promotes stem cell traits and aggressiveness in colorectal cancer cells<br>Mol Oncol (2020) 14, 347-362. PubMed  Europe PubMed DOI
  10. Perez-Moreno,P., Quezada-Meza,C., Chavez-Almarza,C., Niechi,I., Silva-Pavez,E., Trigo-Hidalgo,C., Aguayo,F., Jara,L., Caceres-Verschae,A., Varas-Godoy,M., Diaz,V.M., Garcia de Herreros,A., Burzio,V.A. and Tapia,J.C.<br>Phosphorylation of Endothelin-Converting Enzyme-1c at Serines 18 and 20 by CK2 Promotes Aggressiveness Traits in Colorectal Cancer Cells<br>Front Oncol (2020) 10, 1004-1004. PubMed  Europe PubMed DOI  PMC  EPMC
    11. 2019
  11. Tapia,J.C. and Niechi,I.<br>Endothelin-converting enzyme-1 in cancer aggressiveness<br>Cancer Lett (2019) 452, 152-157. PubMed  Europe PubMed DOI
    12. 2017
  12. Miners,J.S. and Love,S.<br>Endothelin-converting enzymes degrade alpha-synuclein and are reduced in dementia with Lewy bodies<br>J Neurochem (2017) 141, 275-286. PubMed  Europe PubMed DOI
    13. 2016
  13. Smith,A.I., Rajapakse,N.W., Kleifeld,O., Lomonte,B., Sikanyika,N.L., Spicer,A.J., Hodgson,W.C., Conroy,P.J., Small,D.H., Kaye,D.M., Parkington,H.C., Whisstock,J.C. and Kuruppu,S.<br>N-terminal domain of Bothrops asper myotoxin II enhances the activity of endothelin converting enzyme-1 and neprilysin<br>Sci Rep (2016) 6, 22413-22413. PubMed  Europe PubMed DOI  PMC  EPMC
    14. 2014
  14. Miners,J.S., Palmer,J.C., Tayler,H., Palmer,L.E., Ashby,E., Kehoe,P.G. and Love,S.<br>Abeta degradation or cerebral perfusion? Divergent effects of multifunctional enzymes<br>Front Aging Neurosci (2014) 6, 238-238. PubMed  Europe PubMed DOI  PMC  EPMC
    15. 2013
  15. Cattaruzza,F., Poole,D.P. and Bunnett,N.W.<br>Arresting inflammation: contributions of plasma membrane and endosomal signalling to neuropeptide-driven inflammatory disease<br>Biochem Soc Trans (2013) 41, 137-143. PubMed  Europe PubMed DOI
  16. Martinez-Miguel,P., Medrano-Andres,D., Lopes-Martin,V., Arribas-Gomez,I., Rodriguez-Puyol,M., Rodriguez-Puyol,D. and Lopez-Ongil,S.<br>Regulation of endothelin-converting enzyme-1 (ECE-1) by the calcimimetic R-568<br>Pharmacol Res (2013) 76, 106-118. PubMed  Europe PubMed DOI  I
  17. Tanneeru,K., Sahu,I. and Guruprasad,L.<br>Ligand-based drug design for human endothelin converting enzyme-1 inhibitors<br>Med Chem Res (2013) 22, 4401-4409. DOI  I
    18. 2012
  18. Kuruppu,S. and Smith,A.I.<br>Endothelin converting enzyme-1 phosphorylation and trafficking<br>FEBS Lett (2012) 586, 2212-2217. PubMed  Europe PubMed DOI
  19. Kuruppu,S., Tochon-Danguy,N. and Smith,A.I.<br>Protein kinase C recognition sites in the cytoplasmic domain of endothelin converting enzyme-1c<br>Biochem Biophys Res Commun (2012) 427, 606-610. PubMed  Europe PubMed DOI
  20. Nakayama,K., Emoto,N., Suzuki,Y., Vignon-Zellweger,N., Yagi,K. and Ken-Ichi,H.<br>Physiological relevance of hydrolysis of atrial natriuretic peptide by endothelin-converting enzyme-1<br>Kobe J Med Sci (2012) 58, E12-E18. PubMed  Europe PubMed
  21. Ul-Haq,Z., Iqbal,S. and Moin,S.T.<br>Dynamic changes in the secondary structure of ECE-1 and XCE account for their different substrate specificities<br>BMC Bioinformatics (2012) 13, 285-285. PubMed  Europe PubMed DOI  P
  22. Whyteside,A.R. and Turner,A.J.<br>Endothelin-converting enzyme 1 (ECE-1)<br>[ISSN:978-0-12-407744-7] (2012) 3, 624-631. DOI
    23. 2011
  23. Hong,Y., MacNab,S., Lambert,L.A., Turner,A.J., Whitehouse,A. and Usmani,B.A.<br>Herpesvirus saimiri-based endothelin-converting enzyme-1 shRNA expression decreases prostate cancer cell invasion and migration<br>Int J Cancer (2011) 129, 586-598. PubMed  Europe PubMed DOI  K
    24. 2010
  24. Jullien,N., Makritis,A., Georgiadis,D., Beau,F., Yiotakis,A. and Dive,V.<br>Phosphinic tripeptides as dual angiotensin-converting enzyme C-domain and endothelin-converting enzyme-1 inhibitors<br>J Med Chem (2010) 53, 208-220. PubMed  Europe PubMed DOI  I
  25. Kuruppu,S., Tochon-Danguy,N. and Smith,A.I.<br>Role of protein kinase C in endothelin converting enzyme-1 trafficking and shedding from endothelial cells<br>Biochem Biophys Res Commun (2010) 398, 173-177. PubMed  Europe PubMed DOI
  26. Whyteside,A.R., Hinsley,E.E., Lambert,L.A., McDermott,P.J. and Turner,A.J.<br>ECE-1 influences prostate cancer cell invasion via ET-1-mediated FAK phosphorylation and ET-1-independent mechanisms<br>Can J Physiol Pharmacol (2010) 88, 850-854. PubMed  Europe PubMed DOI
    27. 2009
  27. Cottrell,G.S., Padilla,B.E., Amadesi,S., Poole,D.P., Murphy,J.E., Hardt,M., Roosterman,D., Steinhoff,M. and Bunnett,N.W.<br>Endosomal endothelin-converting enzyme-1: a regulator of beta-arrestin-dependent ERK signaling<br>J Biol Chem (2009) 284, 22411-22425. PubMed  Europe PubMed DOI  PMC  EPMC
  28. Dive,V., Chang,C.F., Yiotakis,A. and Sturrock,E.D.<br>Inhibition of zinc metallopeptidases in cardiovascular disease - from unity to trinity, or duality?<br>Curr Pharm Des (2009) 15, 3606-3621. PubMed  Europe PubMed DOI  V  I
  29. Jin,Z., Luxiang,C., Huadong,Z., Zhiqiang,X., Lihua,H. and Huiyun,L.<br>C-338A polymorphism of the endothelin-converting enzyme-1 gene and the susceptibility to carotid atherosclerosis<br>Microvasc Res (2009) 78, 128-131. PubMed  Europe PubMed DOI  M
  30. Schulz,H., Dale,G.E., Karimi-Nejad,Y. and Oefner,C.<br>Structure of human endothelin-converting enzyme I complexed with phosphoramidon<br>J Mol Biol (2009) 385, 178-187. PubMed  Europe PubMed DOI  S  I
    31. 2008
  31. Carty,N.C., Nash,K., Lee,D., Mercer,M., Gottschall,P.E., Meyers,C., Muzyczka,N., Gordon,M.N. and Morgan,D.<br>Adeno-associated viral (AAV) serotype 5 vector mediated gene delivery of endothelin-converting enzyme reduces Abeta deposits in APP + PS1 transgenic mice<br>Mol Ther (2008) 16, 1580-1586. PubMed  Europe PubMed DOI  PMC  EPMC
  32. Cerdeira,A.S., Bras-Silva,C. and Leite-Moreira,A.F.<br>Endothelin-converting enzyme inhibitors: their application in cardiovascular diseases<br>Rev Port Cardiol (2008) 27, 385-408. PubMed  Europe PubMed  I
  33. Lambert,L.A., Whyteside,A.R., Turner,A.J. and Usmani,B.A.<br>Isoforms of endothelin-converting enzyme-1 (ECE-1) have opposing effects on prostate cancer cell invasion<br>Br J Cancer (2008) 99, 1114-1120. PubMed  Europe PubMed DOI  PMC  EPMC
  34. Rayhman,O., Klipper,E., Muller,L., Davidson,B., Reich,R. and Meidan,R.<br>Small interfering RNA molecules targeting endothelin-converting enzyme-1 inhibit endothelin-1 synthesis and the invasive phenotype of ovarian carcinoma cells<br>Cancer Res (2008) 68, 9265-9273. PubMed  Europe PubMed DOI
  35. Roosterman,D., Kempkes,C., Cottrell,G.S., Padilla,B.E., Bunnett,N.W., Turck,C.W. and Steinhoff,M.<br>Endothelin-converting enzyme-1 degrades internalized somatostatin-14<br>Endocrinology (2008) 149, 2200-2207. PubMed  Europe PubMed DOI  PMC  EPMC
    36. 2007
  36. Banno,M., Hanada,H., Kamide,K., Kokubo,Y., Kada,A., Yang,J., Tanaka,C., Takiuchi,S., Horio,T., Matayoshi,T., Yasuda,H., Nagura,J., Tomoike,H., Kawano,Y. and Miyata,T.<br>Association of genetic polymorphisms of endothelin-converting enzyme-1 gene with hypertension in a Japanese population and rare missense mutation in preproendothelin-1 in Japanese hypertensives<br>Hypertens Res (2007) 30, 513-520. PubMed  Europe PubMed DOI  M
  37. Kuruppu,S., Reeve,S. and Ian Smith,A.<br>Characterisation of endothelin converting enzyme-1 shedding from endothelial cells<br>FEBS Lett (2007) 581, 4501-4506. PubMed  Europe PubMed DOI
  38. Padilla,B.E., Cottrell,G.S., Roosterman,D., Pikios,S., Muller,L., Steinhoff,M. and Bunnett,N.W.<br>Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins<br>J Cell Biol (2007) 179, 981-997. PubMed  Europe PubMed DOI  PMC  EPMC
  39. Roosterman,D., Cottrell,G.S., Padilla,B.E., Muller,L., Eckman,C.B., Bunnett,N.W. and Steinhoff,M.<br>Endothelin-converting enzyme 1 degrades neuropeptides in endosomes to control receptor recycling<br>Proc Natl Acad Sci U S A (2007) 104, 11838-11843. PubMed  Europe PubMed DOI  PMC  EPMC
    40. 2006
  40. [YEAR:23-5-2006]Choi,D.S., Wang,D., Yu,G.Q., Zhu,G., Kharazia,V.N., Paredes,J.P., Chang,W.S., Deitchman,J.K., Mucke,L. and Messing,R.O.<br>PKCepsilon increases endothelin converting enzyme activity and reduces amyloid plaque pathology in transgenic mice<br>Proc Natl Acad Sci U S A (23-5-2006) 103, 8215-8220. PubMed  Europe PubMed DOI  PMC  EPMC  U
  41. Dawson,L.A., Maitland,N.J., Berry,P., Turner,A.J. and Usmani,B.A.<br>Expression and localization of endothelin-converting enzyme-1 in human prostate cancer<br>Exp Biol Med (Maywood) (2006) 231, 1106-1110. PubMed  Europe PubMed  R
  42. [YEAR:14-8-2006]Eckman,E.A., Adams,S.K., Troendle,F.J., Stodola,B.A., Kahn,M.A., Fauq,A.H., Xiao,H.D., Bernstein,K.E. and Eckman,C.B.<br>Regulation of steady-state beta-amyloid levels in the brain by neprilysin and endothelin-converting enzyme but not angiotensin-converting enzyme<br>J Biol Chem (14-8-2006) 281, 30471-30478. PubMed  Europe PubMed DOI  K
  43. Fisk,L., Nalivaeva,N.N. and Turner,A.J.<br>Regulation of endothelin-converting enzyme-1 expression in human neuroblastoma cells<br>Exp Biol Med (Maywood) (2006) 231, 1048-1053. PubMed  Europe PubMed
  44. Gokhale,N.H. and Cowan,J.A.<br>Metallopeptide-promoted inactivation of angiotensin-converting enzyme and endothelin-converting enzyme 1: Toward dual-action therapeutics<br>J Biol Inorg Chem (2006) 11, 937-947. PubMed  Europe PubMed DOI  I
  45. Hunter,A.R. and Turner,A.J.<br>Expression and localization of endothelin-converting enzyme-1 isoforms in human endothelial cells<br>Exp Biol Med (Maywood) (2006) 231, 718-722. PubMed  Europe PubMed
  46. Jackson,C.D., Barnes,K., Homer-Vanniasinkam,S. and Turner,A.J.<br>Expression and localization of human endothelin-converting enzyme-1 isoforms in symptomatic atherosclerotic disease and saphenous vein<br>Exp Biol Med (Maywood) (2006) 231, 794-801. PubMed  Europe PubMed
  47. Jafri,F. and Ergul,A.<br>Phosphorylation of endothelin converting enzyme-1 isoforms: relevance to subcellular localization<br>Exp Biol Med (Maywood) (2006) 231, 713-717. PubMed  Europe PubMed
  48. Klipper,E., Levy,N., Gilboa,T., Muller,L. and Meidan,R.<br>Identification of a novel alternatively spliced variant endothelin converting enzyme-1 lacking a transmembrane domain<br>Exp Biol Med (Maywood) (2006) 231, 723-728. PubMed  Europe PubMed
  49. Navarrete,C. and Suguihara,C.<br>Endothelin-converting enzyme inhibitors<br>Curr Enzyme Inhib (2006) 2, 373-378. DOI  I
  50. Smith,A.I., Lew,R.A., Thomas,W.G. and Tochon-Danguy,N.<br>Protein kinase C regulates the cell surface activity of endothelin-converting enzyme-1<br>Int J Pept Res Ther (2006) 12, 291-295. PubMed  Europe PubMed DOI  PMC  EPMC
    51. 2005
  51. Battistini,B., Daull,P. and Jeng,A.Y.<br>CGS 35601, a triple inhibitor of angiotensin converting enzyme, neutral endopeptidase and endothelin converting enzyme<br>Cardiovasc Drug Rev (2005) 23, 317-330. PubMed  Europe PubMed  I
  52. [YEAR:27-1-2005]Berger,Y., Dehmlow,H., Blum-Kaelin,D., Kitas,E.A., Loffler,B.M., Aebi,J.D. and Juillerat-Jeanneret,L.<br>Endothelin-converting enzyme-1 inhibition and growth of human glioblastoma cells<br>J Med Chem (27-1-2005) 48, 483-498. PubMed  Europe PubMed DOI
  53. [YEAR:26-9-2005]Meidan,R., Klipper,E., Gilboa,T., Muller,L. and Levy,N.<br>Endothelin-converting enzyme-1, abundance of isoforms a-d and identification of a novel alternatively spliced variant lacking a transmembrane domain<br>J Biol Chem (26-9-2005) 280, 40867-40874. PubMed  Europe PubMed DOI  R
    54. 2004
  54. Ahn,K. and Johnson,G.D.<br>Endothelin-converting enzyme 1<br>[ISSN:0-12-079610-4] (2004) 2, 429-434.  V
  55. Chang,C.Z., Yen,C.P., Winadi,D., Wu,S.C., Howng,S.L., Lin,T.K., Jeng,A.Y., Kassell,N.F. and Kwan,A.L.<br>Neuroprotective effect of CGS 26303, an endothelin-converting enzyme inhibitor, on transient middle cerebral artery occlusion in rats<br>J Cardiovasc Pharmacol (2004) 44, S487-S489. PubMed  Europe PubMed DOI  I
  56. Funalot,B., Ouimet,T., Claperon,A., Fallet,C., Delacourte,A., Epelbaum,J., Subkowski,T., Leonard,N., Codron,V., David,J.P., Amouyel,P., Schwartz,J.C. and Helbecque,N.<br>Endothelin-converting enzyme-1 is expressed in human cerebral cortex and protects against Alzheimer's disease<br>Mol Psychiatry (2004) 9, 1122-1128. PubMed  Europe PubMed DOI
  57. Inguimbert,N., Poras,H., Dhotel,H., Beslot,F., Scalbert,E., Bennejean,C., Renard,P., Fournie-Zaluski,M.C. and Roques,B.P.<br>In vivo properties of thiol inhibitors of the three vasopeptidases NEP, ACE and ECE are improved by introduction of a 7-azatryptophan in P2' position<br>J Pept Res (2004) 63, 99-107. PubMed  Europe PubMed DOI  I
  58. Macours,N., Poels,J., Hens,K., Francis,C. and Huybrechts,R.<br>Structure, evolutionary conservation, and functions of angiotensin- and endothelin-converting enzymes<br>Int Rev Cytol (2004) 239, 47-97. PubMed  Europe PubMed DOI  V
  59. Trapani,A.J., Beil,M.E., Bruseo,C.W., Savage,P., Firooznia,F. and Jeng,A.Y.<br>CGS 35601 and its orally active prodrug CGS 37808 as triple inhibitors of endothelin-converting enzyme-1, neutral endopeptidase 24.11, and angiotensin-converting enzyme<br>J Cardiovasc Pharmacol (2004) 44 Suppl 1, S211-S215. PubMed  Europe PubMed DOI  I
    60. 2003
  60. Funke-Kaiser,H., Lemmer,J., Langsdorff,C.V., Thomas,A., Kovacevic,S.D., Strasdat,M., Behrouzi,T., Zollmann,F.S., Paul,M. and Orzechowski,H.D.<br>Endothelin-converting enzyme-1 (ECE-1) is a downstream target of the homeobox transcription factor Nkx2-5<br>FASEB J (2003) 17, 1487-1489. PubMed  Europe PubMed DOI
  61. Funke-Kaiser,H., Thomas,A., Bremer,J., Kovacevic,S.D., Scheuch,K., Bolbrinker,J., Theis,S., Lemmer,J., Zimmermann,A., Zollmann,F.S., Herrmann,S.M., Paul,M. and Orzechowski,H.D.<br>Regulation of the major isoform of human endothelin-converting enzyme-1 by a strong housekeeping promoter modulated by polymorphic microsatellites<br>J Hypertens (2003) 21, 2111-2124. PubMed  Europe PubMed DOI
  62. Gentile,M.T. and Lembo,G.<br>Polymorphisms in human endothelin-converting enzyme (ECE-1) promoter can modulate ECE-1 gene expression<br>J Hypertens (2003) 21, 2013-2014. PubMed  Europe PubMed DOI  M
  63. Isaka,D., Emoto,N., Raharjo,S.B., Yokoyama,M. and Matsuo,M.<br>The effects of phosphoramidon on the expression of human endothelin-converting enzyme-1 (ECE-1) isoforms<br>J Cardiovasc Pharmacol (2003) 42, 136-141. PubMed  Europe PubMed DOI  I
  64. Jeng,A.Y.<br>Utility of endothelin-converting enzyme inhibitors for the treatment of cardiovascular diseases<br>Curr Opin Investig Drugs (2003) 4, 1076-1081. PubMed  Europe PubMed  I
  65. [YEAR:3-1-2003]Muller,L., Barret,A., Etienne,E., Meidan,R., Valdenaire,O., Corvol,P. and Tougard,C.<br>Heterodimerization of endothelin-converting enzyme-1 isoforms regulates the subcellular distribution of this metalloprotease<br>J Biol Chem (3-1-2003) 278, 545-555. PubMed  Europe PubMed DOI
    66. 2002
  66. [YEAR:4-11-2002]Firooznia,F., Gude,C., Chan,K., Tan,J., Fink,C.A., Savage,P., Beil,M.E., Bruseo,C.W., Trapani,A.J. and Jeng,A.Y.<br>Synthesis and biological activity of potent heterocyclic thiol-based inhibitors of endothelin-converting enzyme-1<br>Bioorg Med Chem Lett (4-11-2002) 12, 3059-3062. PubMed  Europe PubMed DOI  I
  67. Jeng,A.Y., Mulder,P., Kwan,A.L. and Battistini,B.<br>Nonpeptidic endothelin-converting enzyme inhibitors and their potential therapeutic applications<br>Can J Physiol Pharmacol (2002) 80, 440-449. PubMed  Europe PubMed DOI  I
  68. [YEAR:15-2-2002]Johnson,G.D., Swenson,H.R., Ramage,R. and Ahn,K.<br>Mapping the active site of endothelin-converting enzyme-1 through subsite specificity and mutagenesis studies: A comparison with neprilysin<br>Arch Biochem Biophys (15-2-2002) 398, 240-248. PubMed  Europe PubMed DOI
  69. Kulathila,R., Clark,K., Savage,P., Bowen,B.R., Emoto,N., Yanagisawa,M. and Jeng,A.Y.<br>Expression, purification and characterization of the monomeric and dimeric forms of soluble bovine endothelin converting enzyme-1a<br>Clin Sci (Lond) (2002) 103 Suppl 48, 94S-97S. PubMed  Europe PubMed DOI
  70. [YEAR:6-5-2002]Yamazaki,K., Hasegawa,H., Umekawa,K., Ueki,Y., Ohashi,N. and Kanaoka,M.<br>Design, synthesis and biological activity of novel non-peptidyl endothelin converting enzyme inhibitors, 1-phenyl-tetrazole-formazan analogues<br>Bioorg Med Chem Lett (6-5-2002) 12, 1275-1278. PubMed  Europe PubMed DOI  I
    71. 2001
  71. Barker,S., Khan,N.Q., Wood,E.G. and Corder,R.<br>Effect of an antisense oligodeoxynucleotide to endothelin-converting enzyme-1c (ECE-1c) on ECE-1c mRNA, ECE-1 protein and endothelin-1 synthesis in bovine pulmonary artery smooth muscle cells<br>Mol Pharmacol (2001) 59, 163-169. PubMed  Europe PubMed
  72. Bur,D., Dale,G.E. and Oefner,C.<br>A three-dimensional model of endothelin-converting enzyme (ECE) based on the X-ray structure of neutral endopeptidase 24.11 (NEP)<br>Protein Eng (2001) 14, 337-341. PubMed  Europe PubMed  S  I
  73. [YEAR:6-7-2001]Eckman,E.A., Reed,D.K. and Eckman,C.B.<br>Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme<br>J Biol Chem (6-7-2001) 276, 24540-24548. PubMed  Europe PubMed DOI  I
  74. [YEAR:15-6-2001]Luciani,N., de Rocquigny,H., Turcaud,S., Romieu,A. and Roques,B.P.<br>Highly sensitive and selective fluorescence assays for rapid screening of endothelin-converting enzyme inhibitors<br>Biochem J (15-6-2001) 356, 813-819. PubMed  Europe PubMed DOI  PMC  EPMC  A
  75. [YEAR:17-8-2001]MacLeod,K.J., Fuller,R.S., Scholten,J.D. and Ahn,K.<br>Conserved cysteine and tryptophan residues of the endothelin-converting enzyme-1 CXAW motif are critical for protein maturation and enzyme activity<br>J Biol Chem (17-8-2001) 276, 30608-30614. PubMed  Europe PubMed DOI
  76. Uhlmann,D., Witzigmann,H., Senninger,N., Hauss,J. and Spiegel,H.U.<br>Protective role of an endothelin-converting enzyme inhibitor (FR901533) in hepatic ischemia/reperfusion injury<br>Microvasc Res (2001) 62, 43-54. PubMed  Europe PubMed DOI  I
  77. Uhlmann,D., Witzigmann,H., Senninger,N., Hauss,J. and Spiegel,H.<br>Improvement of postischemic hepatic microhemodynamics by an endothelin converting enzyme inhibitor (FR 901533)<br>Transplant Proc (2001) 33, 2549-2550. PubMed  Europe PubMed DOI  I
  78. Zhang,J., Leontovich,A. and Sarras,M.P., Jr.<br>Molecular and functional evidence for early divergence of an endothelin-like system during metazoan evolution: analysis of the Cnidarian, hydra<br>Development (2001) 128, 1607-1615. PubMed  Europe PubMed
    79. 2000
  79. Brooks,S.C., Fernandez,L. and Ergul,A.<br>Secretion of endothelin converting enzyme-1a: The hydrophobic signal anchor domain alone is not sufficient to promote membrane localization<br>Mol Cell Biochem (2000) 208, 45-51. PubMed  Europe PubMed
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