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CHEBI:87635 - statin (synthetic)
| ChEBI ID | CHEBI:87635 |
| ChEBI Name | statin (synthetic) |
| Stars | |
| Definition | A statin which does not occur naturally and which is not obtained by chemical transformation of a naturally occurring statin. |
| Last Modified | 24 August 2015 |
| Submitter | Gareth Owen |
| Roles Classification |
|---|
| Biological Role: | EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor Any EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD+ or NADP+ acceptor) inhibitor that inhibits HMG-CoA reductases. Hydroxymethylglutaryl-CoA reductase inhibitors have been shown to lower directly cholesterol synthesis. The Enzyme Commission designation is EC 1.1.1.34 for the NADPH-dependent enzyme and EC 1.1.1.88 for an NADH-dependent enzyme. |
| Application: | anticholesteremic drug A substance used to lower plasma cholesterol levels. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| statin (synthetic) (CHEBI:87635) is a statin (CHEBI:87631) |
| Incoming Relation(s) |
| (3R,5S)-fluvastatin (CHEBI:38565) is a statin (synthetic) (CHEBI:87635) |
| (3R,5S)-fluvastatin sodium (CHEBI:77602) is a statin (synthetic) (CHEBI:87635) |
| (3S,5R)-fluvastatin (CHEBI:5136) is a statin (synthetic) (CHEBI:87635) |
| (3S,5R)-fluvastatin sodium (CHEBI:77603) is a statin (synthetic) (CHEBI:87635) |
| atorvastatin (CHEBI:39548) is a statin (synthetic) (CHEBI:87635) |
| atorvastatin calcium trihydrate (CHEBI:2911) is a statin (synthetic) (CHEBI:87635) |
| cerivastatin (CHEBI:3558) is a statin (synthetic) (CHEBI:87635) |
| cerivastatin sodium (CHEBI:3559) is a statin (synthetic) (CHEBI:87635) |
| fluvastatin (CHEBI:38561) is a statin (synthetic) (CHEBI:87635) |
| fluvastatin sodium (CHEBI:5137) is a statin (synthetic) (CHEBI:87635) |
| pitavastatin (CHEBI:32020) is a statin (synthetic) (CHEBI:87635) |
| pitavastatin calcium (CHEBI:71258) is a statin (synthetic) (CHEBI:87635) |
| rosuvastatin (CHEBI:38545) is a statin (synthetic) (CHEBI:87635) |
| Synonyms | Source |
|---|---|
| synthetic statin | ChEBI |
| synthetic statins | ChEBI |
| statins (synthetic) | ChEBI |
| Citations |
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