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CHEBI:77603 - (3S,5R)-fluvastatin sodium

ChEBI IDCHEBI:77603
ChEBI Name(3S,5R)-fluvastatin sodium
Stars
ASCII Name(3S,5R)-fluvastatin sodium
DefinitionAn organic sodium salt resulting from the replacement of the proton from the carboxy group of (3S,5R)-fluvastatin by a sodium ion.
Last Modified24 August 2015
SubmitterGareth Owen
DownloadsMolfile
FormulaC24H25FNO4.Na
Net Charge0
Average Mass433.455
Monoisotopic Mass433.16653
SMILESCC(C)n1c(/C=C/[C@H](O)C[C@H](O)CC(=O)[O-])c(-c2ccc(F)cc2)c2ccccc21.[Na+]
InChIInChI=1S/C24H26FNO4.Na/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30;/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30);/q;+1/p-1/b12-11+;/t18-,19-;/m0./s1
InChIKeyZGGHKIMDNBDHJB-RPQBTBOMSA-M
Roles Classification
Biological Role:
EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor  Any EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD+ or NADP+ acceptor) inhibitor that inhibits HMG-CoA reductases. Hydroxymethylglutaryl-CoA reductase inhibitors have been shown to lower directly cholesterol synthesis. The Enzyme Commission designation is EC 1.1.1.34 for the NADPH-dependent enzyme and EC 1.1.1.88 for an NADH-dependent enzyme.
Application:
anticholesteremic drug  A substance used to lower plasma cholesterol levels.
ChEBI Ontology
Outgoing Relation(s)
(3S,5R)-fluvastatin sodium (CHEBI:77603) has part (3S,5R)-fluvastatin(1−) (CHEBI:77601)
(3S,5R)-fluvastatin sodium (CHEBI:77603) is a organic sodium salt (CHEBI:38700)
(3S,5R)-fluvastatin sodium (CHEBI:77603) is a statin (synthetic) (CHEBI:87635)
(3S,5R)-fluvastatin sodium (CHEBI:77603) is enantiomer of (3R,5S)-fluvastatin sodium (CHEBI:77602)
Incoming Relation(s)
fluvastatin sodium (CHEBI:5137) has part (3S,5R)-fluvastatin sodium (CHEBI:77603)
(3R,5S)-fluvastatin sodium (CHEBI:77602) is enantiomer of (3S,5R)-fluvastatin sodium (CHEBI:77603)
IUPAC Name 
sodium (3S,5R,6E)-7-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoate
Synonyms  Source
(−)-(3S,5R)-fluvastatin sodiumChEBI
(3S,5R)-(−)-fluvastatin sodiumChEBI
(−)-fluvastatin sodiumChEBI
Registry NumbersSources
Reaxys:6630710Reaxys