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CHEBI:87631 - statin
| ChEBI ID | CHEBI:87631 |
| ChEBI Name | statin |
| Stars | |
| Definition | Any organooxygen compound whose structure is related to compactin (mevastatin) and which may be used as an anticholesteremic drug due its EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitory properties. |
| Last Modified | 28 January 2016 |
| Submitter | Gareth Owen |
| Wikipedia |
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| Roles Classification |
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| Biological Role: | EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor Any EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD+ or NADP+ acceptor) inhibitor that inhibits HMG-CoA reductases. Hydroxymethylglutaryl-CoA reductase inhibitors have been shown to lower directly cholesterol synthesis. The Enzyme Commission designation is EC 1.1.1.34 for the NADPH-dependent enzyme and EC 1.1.1.88 for an NADH-dependent enzyme. |
| Application: | anticholesteremic drug A substance used to lower plasma cholesterol levels. |
| ChEBI Ontology |
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| Outgoing Relation(s) |
| statin (CHEBI:87631) has role anticholesteremic drug (CHEBI:35821) |
| statin (CHEBI:87631) has role EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor (CHEBI:35664) |
| statin (CHEBI:87631) is a organooxygen compound (CHEBI:36963) |
| Incoming Relation(s) |
| statin (naturally occurring) (CHEBI:87632) is a statin (CHEBI:87631) |
| statin (semi-synthetic) (CHEBI:87633) is a statin (CHEBI:87631) |
| statin (synthetic) (CHEBI:87635) is a statin (CHEBI:87631) |
| Synonym | Source |
|---|---|
| statins | ChEBI |
| Manual Xrefs | Databases |
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| Statin | Wikipedia |
| Citations |
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