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CHEBI:5137 - fluvastatin sodium
| ChEBI ID | CHEBI:5137 |
| ChEBI Name | fluvastatin sodium |
| Stars | |
| Definition | A racemate that is the sodium salt of fluvastatin. An HMG-CoA reductase inhibitor, it is used to reduce triglycerides and LDL-cholesterol, and increase HDL-chloesterol, in the treatment of hyperlipidaemia. |
| Last Modified | 24 August 2015 |
| Roles Classification |
|---|
| Biological Roles: | EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor An EC 3.4.24.* (metalloendopeptidase) inhibitor that interferes with the action of anthrax lethal factor endopeptidase (EC 3.4.24.83). EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor Any EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD+ or NADP+ acceptor) inhibitor that inhibits HMG-CoA reductases. Hydroxymethylglutaryl-CoA reductase inhibitors have been shown to lower directly cholesterol synthesis. The Enzyme Commission designation is EC 1.1.1.34 for the NADPH-dependent enzyme and EC 1.1.1.88 for an NADH-dependent enzyme. |
| Applications: | antilipemic drug A substance used to treat hyperlipidemia (an excess of lipids in the blood). anticholesteremic drug A substance used to lower plasma cholesterol levels. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| fluvastatin sodium (CHEBI:5137) has part (3R,5S)-fluvastatin sodium (CHEBI:77602) |
| fluvastatin sodium (CHEBI:5137) has part (3S,5R)-fluvastatin sodium (CHEBI:77603) |
| fluvastatin sodium (CHEBI:5137) has role antilipemic drug (CHEBI:35679) |
| fluvastatin sodium (CHEBI:5137) has role EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor (CHEBI:77255) |
| fluvastatin sodium (CHEBI:5137) is a racemate (CHEBI:60911) |
| fluvastatin sodium (CHEBI:5137) is a statin (synthetic) (CHEBI:87635) |
| IUPAC Name |
|---|
| rac-sodium (3R,5S,6E)-7-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoate |
| Synonyms | Source |
|---|---|
| (±)-fluvastatin sodium | ChEBI |
| (±)-sodium (3R,5S,6E)-7-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoate | ChEBI |
| XU-62-320 | ChEBI |
| sodium (±)-(3R,5S,6E)-7-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoate | ChEBI |
| Brand Names | Source |
|---|---|
| Vastin | ChemIDplus |
| Lymetel | ChemIDplus |
| Primesin | ChemIDplus |
| Lescol | KEGG DRUG |
| Lipaxan | ChemIDplus |
| Locol | ChemIDplus |
| Registry Numbers | Sources |
|---|---|
| Reaxys:6630711 | Reaxys |
| CAS:93957-55-2 | ChemIDplus |
| CAS:93957-55-2 | KEGG DRUG |
| Citations |
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