$VAR1 = undef;

Summary for peptidase S09.004: acylaminoacyl-peptidase

Names
MEROPS Name	acylaminoacyl-peptidase
Other names	acylamino-acid-releasing enzyme, APEH g.p. (Homo sapiens), N-acylpeptide hydrolase, N-formylmethionine (fMet) aminopeptidase, oxidized protein hydrolase, OPH

Domain architecture

MEROPS Classification
Classification	Clan SC >> Subclan (none) >> Family S9 >> Subfamily C >> S09.004
Holotype	acylaminoacyl-peptidase (Homo sapiens), Uniprot accession P13798 (peptidase unit: 477-728), MERNUM MER0000408
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00369
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.19 (Omega peptidases) >> Peptidase 3.4.19.1
Enzymology	BRENDA database
Activity status	human: active (Manning, 2004) mouse: active (Kobayashi et al., 1987)
Other databases	TREEFAM	http://www.treefam.org/family/TF312937
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/fah-/-/-/- (based on 14 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	0	2	0	0	0	0	0
Pro	0	0	0	0	0	1	0	0
Ala	0	0	0	2	0	1	0	0
Val	0	1	2	0	0	0	0	1
Leu	0	1	0	0	0	0	1	1
Ile	0	0	0	0	0	0	0	0
Met	0	0	0	0	0	0	1	0
Phe	0	0	0	4	1	0	0	0
Tyr	1	0	0	0	1	0	0	0
Trp	0	0	0	0	0	0	0	0
Ser	0	0	0	1	0	1	0	0
Thr	0	0	0	0	0	0	0	0
Cys	0	0	0	0	0	0	0	0
Asn	0	0	0	0	0	0	0	0
Gln	0	0	0	0	1	1	0	0
Asp	0	0	0	0	0	0	0	1
Glu	1	1	0	1	1	0	1	1
Lys	1	0	0	0	0	1	1	0
Arg	0	0	0	0	0	0	0	1
His	0	0	1	2	1	0	0	0