Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase S09.004: acylaminoacyl-peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: P Specificity, I Inhibitor, V Review, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Hoernstein,S.N., Miniera,A.A. and Reski,R.
    Acylamino acid-releasing enzyme (AARE), a bifunctional protease with a potential role in aging
    J Exp Bot PubMed  Europe PubMed DOI
  2. Huang,L.Y., Wang,H., Zhang,Y.Y. and Liu,S.Y.
    An acylaminoacyl-peptide hydrolase-activated fluorescent probe for ultrasensitive detection of pesticide residue
    Spectrochim Acta A Mol Biomol Spectrosc338, 126152-126152. PubMed  Europe PubMed DOI
  3. Liu,S.Y., Wang,H., Zhang,Y.Y. and Huang,L.Y.
    Discovery of an Enzyme-Activated Fluorogenic Probe for In Vivo Profiling of Acylaminoacyl-Peptide Hydrolase
    Anal Chem97, 2204-2213. PubMed  Europe PubMed DOI
  4. Sundararaman,S.A., Miller,J.J., Daley,E.C., O'Brien,K.A., Kasak,P., Daniels,A.M., Edwards,R.L., Heidel,K.M., Bague,D.A., Wilson,M.A., Koelper,A.J., Kourtoglou,E.C., White,A.D., August,S.A., Apple,G.A., Rouamba,R.W., Durand,A.J., Esteb,J.J., Muller,F.L., Johnson,R.J., Hoops,G.C., Dowd,C.S. and Odom John,A.R.
    Prodrug activation in malaria parasites mediated by an imported erythrocyte esterase, acylpeptide hydrolase (APEH)
    Proc Natl Acad Sci U S A122, e2417682122-e2417682122. PubMed  Europe PubMed DOI
    5. 2022
  5. Covarrubias,A.A., Fuente-Ortega,E., Rossi,G., Cocca,E., Rossi,M., Palmieri,G. and Pancetti,F.C.
    Differential Distribution and Activity Profile of Acylpeptide Hydrolase in the Rat Seminiferous Epithelium
    Biomedicines10, PubMed  Europe PubMed DOI
  6. Fusco,C., Agrillo,B., Gogliettino,M., Palmieri,G. and Cocca,E.
    In Vitro Assays for the Bifunctional Acylpeptide Hydrolase (APEH) Enzyme from Antarctic Fish
    Methods Mol Biol2498, 413-424. PubMed  Europe PubMed DOI
    7. 2021
  7. Sandomenico,A., Gogliettino,M., Iaccarino,E., Fusco,C., Caporale,A., Ruvo,M., Palmieri,G. and Cocca,E.
    Oxidized Substrates of APEH as a Tool to Study the Endoprotease Activity of the Enzyme
    Int J Mol Sci23, PubMed  Europe PubMed DOI
  8. Tangri,A., Lighty,K., Loganathan,J., Mesmar,F., Podicheti,R., Zhang,C., Iwanicki,M., Drapkin,R., Nakshatri,H. and Mitra,S.
    Deubiquitinase UCHL1 Maintains Protein Homeostasis through the PSMA7-APEH-Proteasome Axis in High-grade Serous Ovarian Carcinoma
    Mol Cancer Res PubMed  Europe PubMed DOI
  9. Tyler,K., Geilman,S., Bell,D.M., Taylor,N., Honeycutt,S.C., Garrett,P.I., Hillhouse,T.M. and Covey,T.M.
    Acyl Peptide Enzyme Hydrolase (APEH) activity is inhibited by lipid metabolites and peroxidation products
    Chem Biol Interact348, 109639-109639. PubMed  Europe PubMed DOI
    10. 2018
  10. Zhu,J., Wang,Y., Li,X., Han,W. and Zhao,L.
    Understanding the interactions of different substrates with wild-type and mutant acylaminoacyl peptidase using molecular dynamics simulations
    J Biomol Struct Dyn36, 4285-4302. PubMed  Europe PubMed DOI
    11. 2017
  11. Garcia-Rojo,G., Gamiz,F., Ampuero,E., Rojas-Espina,D., Sandoval,R., Rozas,C., Morales,B., Wyneken,U. and Pancetti,F.
    In vivo sub-chronic treatment with dichlorvos in young rats promotes synaptic plasticity and learning by a mechanism that involves acylpeptide hydrolase instead of acetylcholinesterase inhibition. Correlation with endogenous beta-amyloid levels
    Front Pharmacol8, 483-483. PubMed  Europe PubMed DOI
  12. Zeng,Z., Rulten,S.L., Breslin,C., Zlatanou,A., Coulthard,V. and Caldecott,K.W.
    Acylpeptide hydrolase is a component of the cellular response to DNA damage
    DNA Repair (Amst)58, 52-61. PubMed  Europe PubMed DOI
    13. 2016
  13. Jin,H., Zhu,J., Dong,Y. and Han,W.
    Exploring the different ligand escape pathways in acylaminoacyl peptidase by random acceleration and steered molecular dynamics simulations
    RSC Adv6, 10987-10996. DOI
  14. Palumbo,R., Gogliettino,M., Cocca,E., Iannitti,R., Sandomenico,A., Ruvo,M., Balestrieri,M., Rossi,M. and Palmieri,G.
    APEH inhibition affects osteosarcoma cell viability via downregulation of the proteasome
    Int J Mol Sci17, PubMed  Europe PubMed DOI  I
  15. Wang,D., Jin,H., Wang,J., Guan,S., Zhang,Z. and Han,W.
    Exploration of the chlorpyrifos escape pathway from acylpeptide hydrolases using steered molecular dynamics simulations
    J Biomol Struct Dyn34, 749-761. PubMed  Europe PubMed DOI  I
    16. 2015
  16. Riccio,A., Gogliettino,M., Palmieri,G., Balestrieri,M., Facchiano,A., Rossi,M., Palumbo,S., Monti,G. and Cocca,E.
    A new APEH cluster with antioxidant functions in the antarctic hemoglobinless icefish Chionodraco hamatus
    PLoS ONE10, e0125594- PubMed  Europe PubMed DOI
    17. 2014
  17. Are,V.N., Ghosh,B., Kumar,A., Yadav,P., Bhatnagar,D., Jamdar,S.N. and Makde,R.D.
    Expression, purification, crystallization and preliminary X-ray diffraction analysis of acylpeptide hydrolase from Deinococcus radiodurans
    Acta Crystallogr F Struct Biol Commun70, 1292-1295. PubMed  Europe PubMed DOI
  18. Gogliettino,M., Riccio,A., Balestrieri,M., Cocca,E., Facchiano,A., D'Arco,T.M., Tesoro,C., Rossi,M. and Palmieri,G.
    A novel class of bifunctional acylpeptide hydrolases - potential role in the antioxidant defense systems of the antarctic fish Trematomus bernacchii
    FEBS J281, 401-415. PubMed  Europe PubMed DOI
  19. Lan,V.T., Ito,K., Ito,S. and Kawarasaki,Y.
    Trp-Arg-Xaa tripeptides act as uncompetitive-type inhibitors of human dipeptidyl peptidase IV
    Peptides54, 166-170. PubMed  Europe PubMed DOI  I
  20. McGoldrick,C.A., Jiang,Y.L., Paromov,V., Brannon,M., Krishnan,K. and Stone,W.L.
    Identification of oxidized protein hydrolase as a potential prodrug target in prostate cancer
    BMC Cancer14, 77-77. PubMed  Europe PubMed DOI
  21. Santhoshkumar,P., Xie,L., Raju,M., Reneker,L. and Sharma,K.K.
    Lens crystallin modifications and cataract in transgenic mice overexpressing acylpeptide hydrolase
    J Biol Chem289, 9039-9052. PubMed  Europe PubMed DOI
    22. 2012
  22. Abraham,C.R. and Nagle,M.W.
    Acylaminoacyl-peptidase
    [ISSN:978-0-12-407742-3]3, 3401-3403. DOI
  23. Nakai,A., Yamauchi,Y., Sumi,S. and Tanaka,K.
    Role of acylamino acid-releasing enzyme/oxidized protein hydrolase in sustaining homeostasis of the cytoplasmic antioxidative system
    Planta236, 427-436. PubMed  Europe PubMed DOI
    24. 2011
  24. Palmieri,G., Bergamo,P., Luini,A., Ruvo,M., Gogliettino,M., Langella,E., Saviano,M., Hegde,R.N., Sandomenico,A. and Rossi,M.
    Acylpeptide hydrolase inhibition as targeted strategy to induce proteasomal down-regulation
    PLoS ONE6, e25888-e25888. PubMed  Europe PubMed DOI  I
    25. 2010
  25. Kim,J.H., Stevens,R.C., Maccoss,M.J., Goodlett,D.R., Scherl,A., Richter,R.J., Suzuki,S.M. and Furlong,C.E.
    Identification and characterization of biomarkers of organophosphorus exposures in humans
    Adv Exp Med Biol660, 61-71. PubMed  Europe PubMed DOI
    26. 2009
  26. Olmos,C., Sandoval,R., Rozas,C., Navarro,S., Wyneken,U., Zeise,M., Morales,B. and Pancetti,F.
    Effect of short-term exposure to dichlorvos on synaptic plasticity of rat hippocampal slices: involvement of acylpeptide hydrolase and alpha(7) nicotinic receptors
    Toxicol Appl Pharmacol238, 37-46. PubMed  Europe PubMed DOI
  27. Yamin,R., Zhao,C., O'Connor,P.B., McKee,A.C. and Abraham,C.R.
    Acyl peptide hydrolase degrades monomeric and oligomeric amyloid-beta peptide
    Mol Neurodegener4, 33-33. PubMed  Europe PubMed DOI  P
    28. 2007
  28. Yamin,R., Bagchi,S., Hildebrant,R., Scaloni,A., Widom,R.L. and Abraham,C.R.
    Acyl peptide hydrolase, a serine proteinase isolated from conditioned medium of neuroblastoma cells, degrades the amyloid-beta peptide
    J Neurochem100, 458-467. PubMed  Europe PubMed DOI  U
    29. 2005
  29. Quistad,G.B., Klintenberg,R. and Casida,J.E.
    Blood acylpeptide hydrolase activity is a sensitive marker for exposure to some organophosphate toxicants
    Toxicol Sci86, 291-299. PubMed  Europe PubMed DOI
  30. [YEAR:1-10-2005]Wright,H., Kiss,A.L., Szeltner,Z., Polgar,L. and Fulop,V.
    Crystallization and preliminary crystallographic analysis of porcine acylaminoacyl peptidase
    Acta Crystallograph Sect F Struct Biol Cryst Commun61, 942-944. PubMed  Europe PubMed DOI
    31. 2004
  31. [YEAR:30-7-2004]Kiss,A.L., Szeltner,Z., Fulop,V. and Polgar,L.
    His507 of acylaminoacyl peptidase stabilizes the active site conformation, not the catalytic intermediate
    FEBS Lett571, 17-20. PubMed  Europe PubMed DOI
  32. Manning,J.M.
    Acylaminoacyl-peptidase
    [ISSN:0-12-079610-4]2, 1917-1919.  V
    33. 2003
  33. Durand,A., Villard,C., Giardina,T., Perrier,J., Juge,N. and Puigserver,A.
    Structural properties of porcine intestine acylpeptide hydrolase
    J Protein Chem22, 183-191. PubMed  Europe PubMed DOI
  34. Yamauchi,Y., Ejiri,Y., Toyoda,Y. and Tanaka,K.
    Identification and biochemical characterization of plant acylamino acid-releasing enzyme
    J Biochem134, 251-257. PubMed  Europe PubMed DOI
    35. 2001
  35. Senthilkumar,R., Reddy,P.N. and Sharma,K.K.
    Studies on trypsin-modified bovine and human lens acylpeptide hydrolase
    Exp Eye Res72, 301-310. PubMed  Europe PubMed DOI  I
    36. 2000
  36. [YEAR:16-3-2000]Fujino,T., Watanabe,K., Beppu,M., Kikugawa,K. and Yasuda,H.
    Identification of oxidized protein hydrolase of human erythrocytes as acylpeptide hydrolase
    Biochim Biophys Acta1478, 102-112. PubMed  Europe PubMed DOI  I
  37. Richards,P.G., Johnson,M.K. and Ray,D.E.
    Identification of acylpeptide hydrolase as a sensitive site for reaction with organophosphorus compounds and a potential target for cognitive enhancing drugs
    Mol Pharmacol58, 577-583. PubMed  Europe PubMed
    38. 1999
  38. Scaloni,A., Ingallinella,P., Andolfo,A., Jones,W., Marino,G. and Manning,J.M.
    Structural investigations on human erythrocyte acylpeptide hydrolase by mass spectrometric procedures
    J Protein Chem18, 349-360. PubMed  Europe PubMed DOI
  39. [YEAR:16-9-1999]Yamaguchi,M., Kambayashi,D., Toda,J., Sano,T., Toyoshima,S. and Hojo,H.
    Acetylleucine chloromethyl ketone, an inhibitor of acylpeptide hydrolase, induces apoptosis of U937 cells
    Biochem Biophys Res Commun263, 139-142. PubMed  Europe PubMed DOI  I
    40. 1998
  40. [YEAR:23-9-1998]Fujino,T., Ishikawa,T., Inoue,M., Beppu,M. and Kikugawa,K.
    Characterization of membrane-bound serine protease related to degradation of oxidatively damaged erythrocyte membrane proteins
    Biochim Biophys Acta1374, 47-55. PubMed  Europe PubMed DOI  I
  41. Fujino,T., Tada,T., Beppu,M. and Kikugawa,K.
    Purification and characterization of a serine protease in erythrocyte cytosol that is adherent to oxidized membranes and preferentially degrades proteins modified by oxidation and glycation
    J Biochem124, 1077-1085. PubMed  Europe PubMed
  42. Mitta,M., Miyagi,M., Kato,I. and Tsunasawa,S.
    Identification of the catalytic triad residues of porcine liver acylamino acid-releasing enzyme
    J Biochem123, 924-931. PubMed  Europe PubMed
    43. 1995
  43. Miyagi,M., Sakiyama,F., Kato,I. and Tsunasawa,S.
    Complete covalent structure of porcine liver acylamino acid-releasing enzyme and identification of its active site serine residue
    J Biochem118, 771-779. PubMed  Europe PubMed  I
    44. 1994
  44. [YEAR:27-5-1994]Scaloni,A., Barra,D., Jones,W.M. and Manning,J.M.
    Human acylpeptide hydrolase. Studies on its thiol groups and mechanism of action
    J Biol Chem269, 15076-15084. PubMed  Europe PubMed  I
  45. Sokolik,C.W., Liang,T.C. and Wold,F.
    Studies on the specificity of acetylaminoacyl-peptide hydrolase
    Protein Sci3, 126-131. PubMed  Europe PubMed DOI
    46. 1993
  46. [YEAR:5-10-1993]Feese,M., Scaloni,A., Jones,W.M., Manning,J.M. and Remington,S.J.
    Crystallization and preliminary X-ray studies of human erythrocyte acylpeptide hydrolase
    J Mol Biol233, 546-549. PubMed  Europe PubMed DOI
    47. 1992
  47. Barrett,A.J. and Rawlings,N.D.
    Oligopeptidases, and the emergence of the prolyl oligopeptidase family
    Biol Chem Hoppe Seyler373, 353-360. PubMed  Europe PubMed
  48. Scaloni,A., Jones,W.M., Barra,D., Pospischil,M., Sassa,S., Popowicz,A., Manning,L.R., Schneewind,O. and Manning,J.M.
    Acylpeptide hydrolase: inhibitors and some active site residues of the human enzyme
    J Biol Chem267, 3811-3818. PubMed  Europe PubMed  I
  49. Scaloni,A., Jones,W., Pospischil,M., Sassa,S., Schneewind,O., Popowicz,A.M., Bossa,F., Graziano,S.L. and Manning,J.M.
    Deficiency of acylpeptide hydrolase in small-cell lung carcinoma cell lines
    J Lab Clin Med120, 546-552. PubMed  Europe PubMed
  50. Sherriff,R.M., Broom,M.F. and Chadwick,V.S.
    Isolation and purification of N-formylmethionine aminopeptidase from rat intestine
    Biochim Biophys Acta1119, 275-280. PubMed  Europe PubMed DOI
    51. 1989
  51. Lin,L.W., Lee,F.J. and Smith,J.A.
    Structural organization of the rat acyl-peptide hydrolase gene
    Nucleic Acids Res17, 4397-4400. PubMed  Europe PubMed
  52. Mitta,M., Asada,K., Uchimura,Y., Kimizuka,F., Kato,I., Sakiyama,F. and Tsunasawa,S.
    The primary structure of porcine liver acylamino acid-releasing enzyme deduced from cDNA sequences
    J Biochem106, 548-551. PubMed  Europe PubMed
  53. [YEAR:5-7-1989]Radhakrishna,G. and Wold,F.
    Purification and characterization of an N-acylaminoacyl-peptide hydrolase from rabbit muscle
    J Biol Chem264, 11076-11081. PubMed  Europe PubMed
    54. 1988
  54. [YEAR:14-4-1988]Jones,W.M. and Manning,J.M.
    Substrate specificity of an acylaminopeptidase that catalyzes the cleavage of the blocked amino termini of peptides
    Biochim Biophys Acta953, 357-360. PubMed  Europe PubMed
    55. 1987
  55. Kobayashi,K. and Smith,J.A.
    Acyl-peptide hydrolase from rat liver. Characterization of enzyme reaction
    J Biol Chem262, 11435-11445. PubMed  Europe PubMed
    56. 1986
  56. [YEAR:29-8-1986]Jones,W.M., Manning,L.R. and Manning,J.M.
    Enzymic cleavage of the blocked amino terminal residues of peptides
    Biochem Biophys Res Commun139, 244-250. PubMed  Europe PubMed
    57. 1985
  57. [YEAR:31-1-1985]Jones,W.M. and Manning,J.M.
    Acylpeptide hydrolase activity from erythrocytes
    Biochem Biophys Res Commun126, 933-940. PubMed  Europe PubMed
    58. 1981
  58. Schonberger,O.L. and Tschesche,H.
    N-Acetylalanine aminopeptidase, a new enzyme from human erythrocytes
    Hoppe Seylers Z Physiol Chem362, 865-873. PubMed  Europe PubMed
    59. 1978
  59. [YEAR:25-7-1978]Gade,W. and Brown,J.L.
    Purification and partial characterization of alpha-N-acylpeptide hydrolase from bovine liver
    J Biol Chem253, 5012-5018. PubMed  Europe PubMed
    60. 1975
  60. Tsunasawa,S., Narita,K. and Ogata,K.
    Purification and properties of acylamino acid-releasing enzyme from rat liver
    J Biochem77, 89-102. PubMed  Europe PubMed

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use