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Literature for peptidase S09.004: acylaminoacyl-peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: P Specificity, I Inhibitor, V Review, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Hoernstein,S.N., Miniera,A.A. and Reski,R.<br>Acylamino acid-releasing enzyme (AARE), a bifunctional protease with a potential role in aging<br>J Exp Bot (2025) PubMed  Europe PubMed DOI
  2. Huang,L.Y., Wang,H., Zhang,Y.Y. and Liu,S.Y.<br>An acylaminoacyl-peptide hydrolase-activated fluorescent probe for ultrasensitive detection of pesticide residue<br>Spectrochim Acta A Mol Biomol Spectrosc (2025) 338, 126152-126152. PubMed  Europe PubMed DOI
  3. Liu,S.Y., Wang,H., Zhang,Y.Y. and Huang,L.Y.<br>Discovery of an Enzyme-Activated Fluorogenic Probe for In Vivo Profiling of Acylaminoacyl-Peptide Hydrolase<br>Anal Chem (2025) 97, 2204-2213. PubMed  Europe PubMed DOI
  4. Sundararaman,S.A., Miller,J.J., Daley,E.C., O'Brien,K.A., Kasak,P., Daniels,A.M., Edwards,R.L., Heidel,K.M., Bague,D.A., Wilson,M.A., Koelper,A.J., Kourtoglou,E.C., White,A.D., August,S.A., Apple,G.A., Rouamba,R.W., Durand,A.J., Esteb,J.J., Muller,F.L., Johnson,R.J., Hoops,G.C., Dowd,C.S. and Odom John,A.R.<br>Prodrug activation in malaria parasites mediated by an imported erythrocyte esterase, acylpeptide hydrolase (APEH)<br>Proc Natl Acad Sci U S A (2025) 122, e2417682122-e2417682122. PubMed  Europe PubMed DOI
    5. 2022
  5. Covarrubias,A.A., Fuente-Ortega,E., Rossi,G., Cocca,E., Rossi,M., Palmieri,G. and Pancetti,F.C.<br>Differential Distribution and Activity Profile of Acylpeptide Hydrolase in the Rat Seminiferous Epithelium<br>Biomedicines (2022) 10 PubMed  Europe PubMed DOI  PMC  EPMC
  6. Fusco,C., Agrillo,B., Gogliettino,M., Palmieri,G. and Cocca,E.<br>In Vitro Assays for the Bifunctional Acylpeptide Hydrolase (APEH) Enzyme from Antarctic Fish<br>Methods Mol Biol (2022) 2498, 413-424. PubMed  Europe PubMed DOI
    7. 2021
  7. Sandomenico,A., Gogliettino,M., Iaccarino,E., Fusco,C., Caporale,A., Ruvo,M., Palmieri,G. and Cocca,E.<br>Oxidized Substrates of APEH as a Tool to Study the Endoprotease Activity of the Enzyme<br>Int J Mol Sci (2021) 23 PubMed  Europe PubMed DOI  PMC  EPMC
  8. Tangri,A., Lighty,K., Loganathan,J., Mesmar,F., Podicheti,R., Zhang,C., Iwanicki,M., Drapkin,R., Nakshatri,H. and Mitra,S.<br>Deubiquitinase UCHL1 Maintains Protein Homeostasis through the PSMA7-APEH-Proteasome Axis in High-grade Serous Ovarian Carcinoma<br>Mol Cancer Res (2021) PubMed  Europe PubMed DOI
  9. Tyler,K., Geilman,S., Bell,D.M., Taylor,N., Honeycutt,S.C., Garrett,P.I., Hillhouse,T.M. and Covey,T.M.<br>Acyl Peptide Enzyme Hydrolase (APEH) activity is inhibited by lipid metabolites and peroxidation products<br>Chem Biol Interact (2021) 348, 109639-109639. PubMed  Europe PubMed DOI
    10. 2018
  10. Zhu,J., Wang,Y., Li,X., Han,W. and Zhao,L.<br>Understanding the interactions of different substrates with wild-type and mutant acylaminoacyl peptidase using molecular dynamics simulations<br>J Biomol Struct Dyn (2018) 36, 4285-4302. PubMed  Europe PubMed DOI
    11. 2017
  11. Garcia-Rojo,G., Gamiz,F., Ampuero,E., Rojas-Espina,D., Sandoval,R., Rozas,C., Morales,B., Wyneken,U. and Pancetti,F.<br>In vivo sub-chronic treatment with dichlorvos in young rats promotes synaptic plasticity and learning by a mechanism that involves acylpeptide hydrolase instead of acetylcholinesterase inhibition. Correlation with endogenous beta-amyloid levels<br>Front Pharmacol (2017) 8, 483-483. PubMed  Europe PubMed DOI  PMC  EPMC
  12. Zeng,Z., Rulten,S.L., Breslin,C., Zlatanou,A., Coulthard,V. and Caldecott,K.W.<br>Acylpeptide hydrolase is a component of the cellular response to DNA damage<br>DNA Repair (Amst) (2017) 58, 52-61. PubMed  Europe PubMed DOI
    13. 2016
  13. Jin,H., Zhu,J., Dong,Y. and Han,W.<br>Exploring the different ligand escape pathways in acylaminoacyl peptidase by random acceleration and steered molecular dynamics simulations<br>RSC Adv (2016) 6, 10987-10996. DOI
  14. Palumbo,R., Gogliettino,M., Cocca,E., Iannitti,R., Sandomenico,A., Ruvo,M., Balestrieri,M., Rossi,M. and Palmieri,G.<br>APEH inhibition affects osteosarcoma cell viability via downregulation of the proteasome<br>Int J Mol Sci (2016) 17 PubMed  Europe PubMed DOI  I
  15. Wang,D., Jin,H., Wang,J., Guan,S., Zhang,Z. and Han,W.<br>Exploration of the chlorpyrifos escape pathway from acylpeptide hydrolases using steered molecular dynamics simulations<br>J Biomol Struct Dyn (2016) 34, 749-761. PubMed  Europe PubMed DOI  I
    16. 2015
  16. Riccio,A., Gogliettino,M., Palmieri,G., Balestrieri,M., Facchiano,A., Rossi,M., Palumbo,S., Monti,G. and Cocca,E.<br>A new APEH cluster with antioxidant functions in the antarctic hemoglobinless icefish Chionodraco hamatus<br>PLoS ONE (2015) 10, e0125594- PubMed  Europe PubMed DOI  PMC  EPMC
    17. 2014
  17. Are,V.N., Ghosh,B., Kumar,A., Yadav,P., Bhatnagar,D., Jamdar,S.N. and Makde,R.D.<br>Expression, purification, crystallization and preliminary X-ray diffraction analysis of acylpeptide hydrolase from Deinococcus radiodurans<br>Acta Crystallogr F Struct Biol Commun (2014) 70, 1292-1295. PubMed  Europe PubMed DOI
  18. Gogliettino,M., Riccio,A., Balestrieri,M., Cocca,E., Facchiano,A., D'Arco,T.M., Tesoro,C., Rossi,M. and Palmieri,G.<br>A novel class of bifunctional acylpeptide hydrolases - potential role in the antioxidant defense systems of the antarctic fish Trematomus bernacchii<br>FEBS J (2014) 281, 401-415. PubMed  Europe PubMed DOI
  19. Lan,V.T., Ito,K., Ito,S. and Kawarasaki,Y.<br>Trp-Arg-Xaa tripeptides act as uncompetitive-type inhibitors of human dipeptidyl peptidase IV<br>Peptides (2014) 54, 166-170. PubMed  Europe PubMed DOI  I
  20. McGoldrick,C.A., Jiang,Y.L., Paromov,V., Brannon,M., Krishnan,K. and Stone,W.L.<br>Identification of oxidized protein hydrolase as a potential prodrug target in prostate cancer<br>BMC Cancer (2014) 14, 77-77. PubMed  Europe PubMed DOI  PMC  EPMC
  21. Santhoshkumar,P., Xie,L., Raju,M., Reneker,L. and Sharma,K.K.<br>Lens crystallin modifications and cataract in transgenic mice overexpressing acylpeptide hydrolase<br>J Biol Chem (2014) 289, 9039-9052. PubMed  Europe PubMed DOI
    22. 2012
  22. Abraham,C.R. and Nagle,M.W.<br>Acylaminoacyl-peptidase<br>[ISSN:978-0-12-407742-3] (2012) 3, 3401-3403. DOI
  23. Nakai,A., Yamauchi,Y., Sumi,S. and Tanaka,K.<br>Role of acylamino acid-releasing enzyme/oxidized protein hydrolase in sustaining homeostasis of the cytoplasmic antioxidative system<br>Planta (2012) 236, 427-436. PubMed  Europe PubMed DOI
    24. 2011
  24. Palmieri,G., Bergamo,P., Luini,A., Ruvo,M., Gogliettino,M., Langella,E., Saviano,M., Hegde,R.N., Sandomenico,A. and Rossi,M.<br>Acylpeptide hydrolase inhibition as targeted strategy to induce proteasomal down-regulation<br>PLoS ONE (2011) 6, e25888-e25888. PubMed  Europe PubMed DOI  PMC  EPMC  I
    25. 2010
  25. Kim,J.H., Stevens,R.C., Maccoss,M.J., Goodlett,D.R., Scherl,A., Richter,R.J., Suzuki,S.M. and Furlong,C.E.<br>Identification and characterization of biomarkers of organophosphorus exposures in humans<br>Adv Exp Med Biol (2010) 660, 61-71. PubMed  Europe PubMed DOI
    26. 2009
  26. Olmos,C., Sandoval,R., Rozas,C., Navarro,S., Wyneken,U., Zeise,M., Morales,B. and Pancetti,F.<br>Effect of short-term exposure to dichlorvos on synaptic plasticity of rat hippocampal slices: involvement of acylpeptide hydrolase and alpha(7) nicotinic receptors<br>Toxicol Appl Pharmacol (2009) 238, 37-46. PubMed  Europe PubMed DOI
  27. Yamin,R., Zhao,C., O'Connor,P.B., McKee,A.C. and Abraham,C.R.<br>Acyl peptide hydrolase degrades monomeric and oligomeric amyloid-beta peptide<br>Mol Neurodegener (2009) 4, 33-33. PubMed  Europe PubMed DOI  PMC  EPMC  P
    28. 2007
  28. Yamin,R., Bagchi,S., Hildebrant,R., Scaloni,A., Widom,R.L. and Abraham,C.R.<br>Acyl peptide hydrolase, a serine proteinase isolated from conditioned medium of neuroblastoma cells, degrades the amyloid-beta peptide<br>J Neurochem (2007) 100, 458-467. PubMed  Europe PubMed DOI  U
    29. 2005
  29. Quistad,G.B., Klintenberg,R. and Casida,J.E.<br>Blood acylpeptide hydrolase activity is a sensitive marker for exposure to some organophosphate toxicants<br>Toxicol Sci (2005) 86, 291-299. PubMed  Europe PubMed DOI
  30. [YEAR:1-10-2005]Wright,H., Kiss,A.L., Szeltner,Z., Polgar,L. and Fulop,V.<br>Crystallization and preliminary crystallographic analysis of porcine acylaminoacyl peptidase<br>Acta Crystallograph Sect F Struct Biol Cryst Commun (1-10-2005) 61, 942-944. PubMed  Europe PubMed DOI  PMC  EPMC
    31. 2004
  31. [YEAR:30-7-2004]Kiss,A.L., Szeltner,Z., Fulop,V. and Polgar,L.<br>His507 of acylaminoacyl peptidase stabilizes the active site conformation, not the catalytic intermediate<br>FEBS Lett (30-7-2004) 571, 17-20. PubMed  Europe PubMed DOI
  32. Manning,J.M.<br>Acylaminoacyl-peptidase<br>[ISSN:0-12-079610-4] (2004) 2, 1917-1919.  V
    33. 2003
  33. Durand,A., Villard,C., Giardina,T., Perrier,J., Juge,N. and Puigserver,A.<br>Structural properties of porcine intestine acylpeptide hydrolase<br>J Protein Chem (2003) 22, 183-191. PubMed  Europe PubMed DOI
  34. Yamauchi,Y., Ejiri,Y., Toyoda,Y. and Tanaka,K.<br>Identification and biochemical characterization of plant acylamino acid-releasing enzyme<br>J Biochem (2003) 134, 251-257. PubMed  Europe PubMed DOI
    35. 2001
  35. Senthilkumar,R., Reddy,P.N. and Sharma,K.K.<br>Studies on trypsin-modified bovine and human lens acylpeptide hydrolase<br>Exp Eye Res (2001) 72, 301-310. PubMed  Europe PubMed DOI  I
    36. 2000
  36. [YEAR:16-3-2000]Fujino,T., Watanabe,K., Beppu,M., Kikugawa,K. and Yasuda,H.<br>Identification of oxidized protein hydrolase of human erythrocytes as acylpeptide hydrolase<br>Biochim Biophys Acta (16-3-2000) 1478, 102-112. PubMed  Europe PubMed DOI  I
  37. Richards,P.G., Johnson,M.K. and Ray,D.E.<br>Identification of acylpeptide hydrolase as a sensitive site for reaction with organophosphorus compounds and a potential target for cognitive enhancing drugs<br>Mol Pharmacol (2000) 58, 577-583. PubMed  Europe PubMed
    38. 1999
  38. Scaloni,A., Ingallinella,P., Andolfo,A., Jones,W., Marino,G. and Manning,J.M.<br>Structural investigations on human erythrocyte acylpeptide hydrolase by mass spectrometric procedures<br>J Protein Chem (1999) 18, 349-360. PubMed  Europe PubMed DOI
  39. [YEAR:16-9-1999]Yamaguchi,M., Kambayashi,D., Toda,J., Sano,T., Toyoshima,S. and Hojo,H.<br>Acetylleucine chloromethyl ketone, an inhibitor of acylpeptide hydrolase, induces apoptosis of U937 cells<br>Biochem Biophys Res Commun (16-9-1999) 263, 139-142. PubMed  Europe PubMed DOI  I
    40. 1998
  40. Fujino,T., Tada,T., Beppu,M. and Kikugawa,K.<br>Purification and characterization of a serine protease in erythrocyte cytosol that is adherent to oxidized membranes and preferentially degrades proteins modified by oxidation and glycation<br>J Biochem (1998) 124, 1077-1085. PubMed  Europe PubMed
  41. [YEAR:23-9-1998]Fujino,T., Ishikawa,T., Inoue,M., Beppu,M. and Kikugawa,K.<br>Characterization of membrane-bound serine protease related to degradation of oxidatively damaged erythrocyte membrane proteins<br>Biochim Biophys Acta (23-9-1998) 1374, 47-55. PubMed  Europe PubMed DOI  I
  42. Mitta,M., Miyagi,M., Kato,I. and Tsunasawa,S.<br>Identification of the catalytic triad residues of porcine liver acylamino acid-releasing enzyme<br>J Biochem (1998) 123, 924-931. PubMed  Europe PubMed
    43. 1995
  43. Miyagi,M., Sakiyama,F., Kato,I. and Tsunasawa,S.<br>Complete covalent structure of porcine liver acylamino acid-releasing enzyme and identification of its active site serine residue<br>J Biochem (1995) 118, 771-779. PubMed  Europe PubMed  I
    44. 1994
  44. [YEAR:27-5-1994]Scaloni,A., Barra,D., Jones,W.M. and Manning,J.M.<br>Human acylpeptide hydrolase. Studies on its thiol groups and mechanism of action<br>J Biol Chem (27-5-1994) 269, 15076-15084. PubMed  Europe PubMed  I
  45. Sokolik,C.W., Liang,T.C. and Wold,F.<br>Studies on the specificity of acetylaminoacyl-peptide hydrolase<br>Protein Sci (1994) 3, 126-131. PubMed  Europe PubMed DOI  PMC  EPMC
    46. 1993
  46. [YEAR:5-10-1993]Feese,M., Scaloni,A., Jones,W.M., Manning,J.M. and Remington,S.J.<br>Crystallization and preliminary X-ray studies of human erythrocyte acylpeptide hydrolase<br>J Mol Biol (5-10-1993) 233, 546-549. PubMed  Europe PubMed DOI
    47. 1992
  47. Barrett,A.J. and Rawlings,N.D.<br>Oligopeptidases, and the emergence of the prolyl oligopeptidase family<br>Biol Chem Hoppe Seyler (1992) 373, 353-360. PubMed  Europe PubMed
  48. Scaloni,A., Jones,W., Pospischil,M., Sassa,S., Schneewind,O., Popowicz,A.M., Bossa,F., Graziano,S.L. and Manning,J.M.<br>Deficiency of acylpeptide hydrolase in small-cell lung carcinoma cell lines<br>J Lab Clin Med (1992) 120, 546-552. PubMed  Europe PubMed
  49. Scaloni,A., Jones,W.M., Barra,D., Pospischil,M., Sassa,S., Popowicz,A., Manning,L.R., Schneewind,O. and Manning,J.M.<br>Acylpeptide hydrolase: inhibitors and some active site residues of the human enzyme<br>J Biol Chem (1992) 267, 3811-3818. PubMed  Europe PubMed  I
  50. Sherriff,R.M., Broom,M.F. and Chadwick,V.S.<br>Isolation and purification of N-formylmethionine aminopeptidase from rat intestine<br>Biochim Biophys Acta (1992) 1119, 275-280. PubMed  Europe PubMed DOI
    51. 1989
  51. Lin,L.W., Lee,F.J. and Smith,J.A.<br>Structural organization of the rat acyl-peptide hydrolase gene<br>Nucleic Acids Res (1989) 17, 4397-4400. PubMed  Europe PubMed  PMC  EPMC
  52. Mitta,M., Asada,K., Uchimura,Y., Kimizuka,F., Kato,I., Sakiyama,F. and Tsunasawa,S.<br>The primary structure of porcine liver acylamino acid-releasing enzyme deduced from cDNA sequences<br>J Biochem (1989) 106, 548-551. PubMed  Europe PubMed
  53. [YEAR:5-7-1989]Radhakrishna,G. and Wold,F.<br>Purification and characterization of an N-acylaminoacyl-peptide hydrolase from rabbit muscle<br>J Biol Chem (5-7-1989) 264, 11076-11081. PubMed  Europe PubMed
    54. 1988
  54. [YEAR:14-4-1988]Jones,W.M. and Manning,J.M.<br>Substrate specificity of an acylaminopeptidase that catalyzes the cleavage of the blocked amino termini of peptides<br>Biochim Biophys Acta (14-4-1988) 953, 357-360. PubMed  Europe PubMed
    55. 1987
  55. Kobayashi,K. and Smith,J.A.<br>Acyl-peptide hydrolase from rat liver. Characterization of enzyme reaction<br>J Biol Chem (1987) 262, 11435-11445. PubMed  Europe PubMed
    56. 1986
  56. [YEAR:29-8-1986]Jones,W.M., Manning,L.R. and Manning,J.M.<br>Enzymic cleavage of the blocked amino terminal residues of peptides<br>Biochem Biophys Res Commun (29-8-1986) 139, 244-250. PubMed  Europe PubMed
    57. 1985
  57. [YEAR:31-1-1985]Jones,W.M. and Manning,J.M.<br>Acylpeptide hydrolase activity from erythrocytes<br>Biochem Biophys Res Commun (31-1-1985) 126, 933-940. PubMed  Europe PubMed
    58. 1981
  58. Schonberger,O.L. and Tschesche,H.<br>N-Acetylalanine aminopeptidase, a new enzyme from human erythrocytes<br>Hoppe Seylers Z Physiol Chem (1981) 362, 865-873. PubMed  Europe PubMed
    59. 1978
  59. [YEAR:25-7-1978]Gade,W. and Brown,J.L.<br>Purification and partial characterization of alpha-N-acylpeptide hydrolase from bovine liver<br>J Biol Chem (25-7-1978) 253, 5012-5018. PubMed  Europe PubMed
    60. 1975
  60. Tsunasawa,S., Narita,K. and Ogata,K.<br>Purification and properties of acylamino acid-releasing enzyme from rat liver<br>J Biochem (1975) 77, 89-102. PubMed  Europe PubMed

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