Substrates for peptidase S08.063: site-1 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
Abz-Asp-Ile-Tyr-Ile-Ser-Arg-Arg-Leu-Leu-Gly-Thr-Phe-Thr-Tyr(NO2)-Ala-CONH2			Abz-Asp-Ile-Tyr-Ile-Ser-Arg-Arg-Leu-Leu+Gly-Thr-Phe-Thr-Tyr(NO2)-Ala-CONH2	S		Arg	Arg	Leu	Leu	Gly	Thr	Phe	Thr	Seidah & Chretien, 2004
ac-Arg-Arg-Leu-NHPhNO2			ac-Arg-Arg-Leu+NHPhNO2	S		ac	Arg	Arg	Leu	NAN	-	-	-	Bodvard et al., 2007
AT3g16570/MGL6_2	Q9LUS7	1-138	peptide-Leu88+Ala-peptide	P	NT	Arg	Arg	Ile	Leu	Ala	Thr	Arg	Arg	Srivastava et al., 2009
brain-derived neurotrophic factor precursor	P23560	19-247	peptide-Thr57+Ser-peptide	P		Arg	Gly	Leu	Thr	Ser	Leu	Ala	Asp		4012
cAMP responsive element binding protein 3-like 3	Q91XE9	1-479	peptide-Ala321+Val-peptide	P		Thr	Cys	Ile	Ala	Val	Leu	Leu	Leu	Zhang et al., 2006	18333
Cyclic AMP-responsive element-binding protein 3	O43889	1-395	peptide-Arg291+Ala-peptide	P	-	Arg	Gln	Leu	Arg	Ala	Leu	Pro	Ser	Pasquato et al., 2006
Cyclic AMP-responsive element-binding protein 3-like protein 1	Q96BA8	1-519	peptide-Leu426+Phe-peptide	P	-	Arg	Ser	Leu	Leu	Phe	Tyr	Asp	Asp	Pasquato et al., 2006
Cyclic AMP-responsive element-binding protein 3-like protein 2	Q70SY1	1-520	peptide-Leu430+Ile-peptide	P	-	Arg	Asn	Leu	Leu	Ile	Tyr	Glu	Glu	Pasquato et al., 2006
Cyclic AMP-responsive element-binding protein 3-like protein 3	Q68CJ9	1-461	peptide-His364+Asn-peptide	P	-	Arg	Thr	Leu	His	Asn	Asp	Ala	Ala	Pasquato et al., 2006
Cyclic AMP-responsive element-binding protein 3-like protein 4	Q8TEY5	1-395	peptide-Leu338+Thr-peptide	P	-	Arg	Asn	Ile	Leu	Thr	His	Lys	Asp	Pasquato et al., 2006
envelope glycoprotein	P08669	2-491	peptide-Leu258+Gly-peptide	N		Arg	Arg	Leu	Leu	Gly	Thr	Phe	Thr	Seidah & Chretien, 2004	17544
envelope glycoprotein			peptide-Leu524+Ser-peptide	N		Arg	Arg	Leu	Leu	Ser	Glu	Glu	Ser	Seidah & Chretien, 2004
glycoprotein	Q8B113	2-481	peptide-Leu246+Ala-peptide	N	NT	Arg	Arg	Pro	Leu	Ala	Phe	Phe	Ser	Rojek et al., 2008
GP-C derived peptide	P08669	250-265	peptide-Leu259+Gly-peptide	N		Arg	Arg	Leu	Leu	Gly	Thr	Phe	Thr	Pasquato et al., 2006
oxidised protein response stress factor ATF6	P18850	1-670	peptide-Leu419+Gly-peptide	P		Arg	His	Leu	Leu	Gly	Phe	Ser	Ala	Chen et al., 2002	17869
pre-glycoprotein polyprotein GP complex	Q8AYW1	2-479	peptide-Leu245+Ala-peptide	N	NT	Arg	Lys	Pro	Leu	Ala	Phe	Phe	Ser	Rojek et al., 2008
pre-glycoprotein polyprotein GP complex	P26313	2-485	peptide-Lys251+Ala-peptide	N	NT	Arg	Ser	Leu	Lys	Ala	Phe	Phe	Ser	Rojek et al., 2008
pre-glycoprotein polyprotein GP complex	Q6IUF7	2-496	peptide-Lys262+Ala-peptide	N	NT	Arg	Ser	Leu	Lys	Ala	Phe	Phe	Ser	Rojek et al., 2008
pre-glycoprotein polyprotein GP complex	P03540	2-503	peptide-Leu273+Gly-peptide	N	NT	Arg	Lys	Leu	Leu	Gly	Phe	Phe	Thr	Rojek et al., 2008
pre-glycoprotein polyprotein GP complex	Q84168	2-518	peptide-Gln283+Ala-peptide	N	NT	Arg	Arg	Leu	Gln	Ala	Phe	Leu	Thr	Rojek et al., 2008
pre-glycoprotein polyprotein GP complex	P18141	2-495	peptide-Lys261+Ala-peptide	N	NT	Arg	Thr	Leu	Lys	Ala	Phe	Phe	Ser	Rojek et al., 2008
pre-glycoprotein polyprotein GP complex	P07399	2-498	peptide-Ser265+Gly-peptide	P	NT	Arg	Arg	Leu	Ser	Gly	Thr	Phe	Thr	Rojek et al., 2008
Pre-glycoprotein polyprotein GP complex	P09991	2-498	peptide-Ala265+Gly-peptide	P	-	Arg	Arg	Leu	Ala	Gly	Thr	Phe	Thr	Pasquato et al., 2006
site-1 peptidase		187-1052	peptide-Leu767+Ser-peptide	P		Gln	Lys	Leu	Leu	Ser	Ile	Asp	Leu	Seidah & Chretien, 2004	17546
site-1 peptidase precursor	Q14703	18-1052	peptide-Phe116+Arg-peptide	P		Arg	Lys	Val	Phe	Arg	Ser	Leu	Lys		17868
site-1 peptidase precursor	Q14703	18-1052	peptide-Lys120+Tyr-peptide	P		Arg	Ser	Leu	Lys	Tyr	Ala	Glu	Ser	Touré et al., 2000	17548
site-1 peptidase precursor	Q14703	18-1052	peptide-Leu169+Arg-peptide	P		Arg	Arg	Leu	Leu	Arg	Ala	Ile	Pro	Touré et al., 2000	17547
Somatostatin	P60042	89-116	peptide-Leu35+Gln-peptide	P	-	Arg	Gln	Phe	Leu	Gln	Lys	Ser	Leu	Pasquato et al., 2006
sterol regulatory element binding protein 1	P36956	1-1147	peptide-Leu530+Gly-peptide	P	-	Arg	Asn	Val	Leu	Gly	Thr	Glu	Ser	Pasquato et al., 2006
sterol regulatory element binding protein-2	Q60429	1-1139	peptide-Leu520+Ser-peptide	N		Arg	Ser	Val	Leu	Ser	Leu	Glu	Ser		17550
sterol regulatory element binding protein-2	Q12772	1-1141	peptide-Leu522+Ser-peptide	N		Arg	Ser	Val	Leu	Ser	Phe	Glu	Ser	Seidah et al., 1999	17551