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Literature for peptidase S08.063: site-1 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: A Assay, T Target, M Mutation, P Specificity, K Knockout, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Bullington,A.V., Micallo,I., Bajaj,B., Kumar,P., Schlamowitz,N., Silva,A., Hendrix,S., Zelcer,N. and Kober,D.L.
    Structural basis for substrate selectivity by site-one protease revealed by studies with a small-molecule inhibitor
    Proc Natl Acad Sci U S A122, e2426931122-e2426931122. PubMed  Europe PubMed DOI  I
    2. 2024
  2. Chen,J., Zhou,Y., Liu,Z., Lu,Y., Jiang,Y., Cao,K., Zhou,N., Wang,D., Zhang,C., Zhou,N., Shi,K., Zhang,L., Zhou,L., Wang,Z., Zhang,H., Tang,K., Ma,J., Lv,J. and Huang,B.
    Hepatic glycogenesis antagonizes lipogenesis by blocking S1P via UDPG
    Science383, eadi3332-eadi3332. PubMed  Europe PubMed DOI
  3. Hendrix,S., Tan,J.M.E., Ndoj,K., Kingma,J., Valiloo,M., Zijlstra,L.F., Ottenhoff,R., Seidah,N.G., Loregger,A., Kober,D.L. and Zelcer,N.
    SPRING is a Dedicated Licensing Factor for SREBP-Specific Activation by S1P
    Mol Cell Biol44, 123-137. PubMed  Europe PubMed DOI
  4. Santinelli,R., Benz,N., Guellec,J., Quinquis,F., Kocas,E., Thomas,J., Montier,T., Ka,C., Luczka-Majerus,E., Sage,E., Ferec,C., Coraux,C. and Trouve,P.
    The Inhibition of the Membrane-Bound Transcription Factor Site-1 Protease (MBTP1) Alleviates the p.Phe508del-Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Defects in Cystic Fibrosis Cells
    Cells13, PubMed  Europe PubMed DOI
    5. 2023
  5. Bost,C., Hartlaub,J., Pinho Dos Reis,V., Strecker,T., Seidah,N.G., Groschup,M.H., Diederich,S. and Fischer,K.
    The proprotein convertase SKI-1/S1P is a critical host factor for Nairobi sheep disease virus infectivity
    Virus Res329, 199099-199099. PubMed  Europe PubMed DOI
    6. 2022
  6. Chen,F., Ni,C., Wang,X., Cheng,R., Pan,C., Wang,Y., Liang,J., Zhang,J., Cheng,J., Chin,Y.E., Zhou,Y., Wang,Z., Guo,Y., Chen,S., Htun,S., Mathes,E.F., de Alba Campomanes,A.G., Slavotinek,A.M., Zhang,S., Li,M. and Yao,Z.
    S1P defects cause a new entity of cataract, alopecia, oral mucosal disorder, and psoriasis-like syndrome
    EMBO Mol Med14, e14904-e14904. PubMed  Europe PubMed DOI
  7. Hartal-Benishay,L.H., Saadi,E., Toubiana,S., Shaked,L., Lalzar,M., Abu Hatoum,O., Tal,S., Selig,S. and Barki-Harrington,L.
    MBTPS1 regulates proliferation of colorectal cancer primarily through its action on sterol regulatory element-binding proteins
    Front Oncol12, 1004014-1004014. PubMed  Europe PubMed DOI
  8. Yuan,Y., Zhou,Q., Wang,C., Zhou,W., Gu,W. and Zheng,B.
    Clinical and molecular characterization of a patient with MBTPS1 related spondyloepiphyseal dysplasia: Evidence of pathogenicity for a synonymous variant
    Front Pediatr10, 1056141-1056141. PubMed  Europe PubMed DOI  K
    9. 2021
  9. Chen,X., Zhang,J., Liu,P., Wei,Y., Wang,X., Xiao,J., Wang,C.C. and Wang,L.
    Proteolytic processing of secretory pathway kinase Fam20C by site-1 protease promotes biomineralization
    Proc Natl Acad Sci U S A118, PubMed  Europe PubMed DOI
  10. Danyukova,T., Schoneck,K. and Pohl,S.
    Site-1 and site-2 proteases: A team of two in regulated proteolysis
    Biochim Biophys Acta Mol Cell Res1869, 119138-119138. PubMed  Europe PubMed DOI  V
  11. Xiao,J., Xiong,Y., Yang,L.T., Wang,J.Q., Zhou,Z.M., Dong,L.W., Shi,X.J., Zhao,X., Luo,J. and Song,B.L.
    POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation
    Protein Cell12, 279-296. PubMed  Europe PubMed DOI
    12. 2020
  12. Bayraktar,E.C., La,K., Karpman,K., Unlu,G., Ozerdem,C., Ritter,D.J., Alwaseem,H., Molina,H., Hoffmann,H.H., Millner,A., Atilla-Gokcumen,G.E., Gamazon,E.R., Rushing,A.R., Knapik,E.W., Basu,S. and Birsoy,K.
    Metabolic coessentiality mapping identifies C12orf49 as a regulator of SREBP processing and cholesterol metabolism
    Nat Metab2, 487-498. PubMed  Europe PubMed DOI
  13. Feng,Y., Peng,K., Luo,R., Wang,F. and Yang,T.
    Site-1 Protease-Derived Soluble (Pro)Renin Receptor Contributes to Angiotensin II-Induced Hypertension in Mice
    HypertensionHYPERTENSIONAHA12015100-HYPERTENSIONAHA12015100. PubMed  Europe PubMed DOI
  14. Stuhrwohldt,N., Scholl,S., Lang,L., Katzenberger,J., Schumacher,K. and Schaller,A.
    The biogenesis of CLEL peptides involves several processing events in consecutive compartments of the secretory pathway
    elife9, PubMed  Europe PubMed DOI
    15. 2019
  15. Olaposi,O.I., Oyekanmi,N., Ojo,A.A. and Eniafe,G.O.
    Membrane-bound transcription factor site-1 protease in PF429242 bound state: computational kinetics and dynamics of reversible binding
    Drug Res (Stuttg)69, 643-649. PubMed  Europe PubMed DOI  I
  16. Schweitzer,G.G., Gan,C., Bucelli,R.C., Wegner,D., Schmidt,R.E., Shinawi,M., Finck,B.N. and Brookheart,R.T.
    A mutation in site-1 protease is associated with a complex phenotype that includes episodic hyperCKemia and focal myoedema
    Mol Genet Genomic Med7, e00733-e00733. PubMed  Europe PubMed DOI  M
    17. 2018
  17. Al-Maskari,M., Care,M.A., Robinson,E., Cocco,M., Tooze,R.M. and Doody,G.M.
    Site-1 protease function is essential for the generation of antibody secreting cells and reprogramming for secretory activity
    Sci Rep8, 14338-14338. PubMed  Europe PubMed DOI  I
  18. Kondo,Y., Fu,J., Wang,H., Hoover,C., McDaniel,J.M., Steet,R., Patra,D., Song,J., Pollard,L., Cathey,S., Yago,T., Wiley,G., Macwana,S., Guthridge,J., McGee,S., Li,S., Griffin,C., Furukawa,K., James,J.A., Ruan,C., McEver,R.P., Wierenga,K.J., Gaffney,P.M. and Xia,L.
    Site-1 protease deficiency causes human skeletal dysplasia due to defective inter-organelle protein trafficking
    JCI Insight3, PubMed  Europe PubMed DOI  M
  19. Patra,D., Delassus,E., Mueller,J., Abou-Ezzi,G. and Sandell,L.J.
    Site-1 protease regulates skeletal stem cell population and osteogenic differentiation in mice
    Biol Open7, PubMed  Europe PubMed DOI  K
  20. Urata,S., Uno,Y., Kurosaki,Y. and Yasuda,J.
    The cholesterol, fatty acid and triglyceride synthesis pathways regulated by site 1 protease (S1P) are required for efficient replication of severe fever with thrombocytopenia syndrome virus
    Biochem Biophys Res Commun503, 631-636. PubMed  Europe PubMed DOI  I
    21. 2017
  21. Caruana,B.T., Skoric,A., Brown,A.J. and Lutze-Mann,L.H.
    Site-1 protease, a novel metabolic target for glioblastoma
    Biochem Biophys Res Commun490, 760-766. PubMed  Europe PubMed DOI  I
  22. Hyrina,A., Meng,F., McArthur,S.J., Eivemark,S., Nabi,I.R. and Jean,F.
    Human subtilisin kexin isozyme-1 (SKI-1)/site-1 protease (S1P) regulates cytoplasmic lipid droplet abundance: a potential target for indirect-acting anti-dengue virus agents
    PLoS ONE12, e0174483-e0174483. PubMed  Europe PubMed DOI  I
  23. Iwata,Y., Ashida,M., Hasegawa,C., Tabara,K., Mishiba,K.I. and Koizumi,N.
    Activation of the Arabidopsis membrane-bound transcription factor bZIP28 is mediated by site-2 protease, but not site-1 protease
    Plant J91, 408-415. PubMed  Europe PubMed DOI
  24. Nakagawa,T., Suzuki-Nakagawa,C., Watanabe,A., Asami,E., Matsumoto,M., Nakano,M., Ebihara,A., Uddin,M.N. and Suzuki,F.
    Site-1 protease is required for the generation of soluble (pro)renin receptor
    J Biochem161, 369-379. PubMed  Europe PubMed DOI  I
  25. Stegmann,M., Monaghan,J., Smakowska-Luzan,E., Rovenich,H., Lehner,A., Holton,N., Belkhadir,Y. and Zipfel,C.
    The receptor kinase FER is a RALF-regulated scaffold controlling plant immune signaling
    Science355, 287-289. PubMed  Europe PubMed DOI
  26. Velho,R.V., De Pace,R., Klunder,S., Di Lorenzo,G., Schweizer,M., Braulke,T. and Pohl,S.
    Site-1 protease and lysosomal homeostasis
    Biochim Biophys Acta1864, 2162-2168. PubMed  Europe PubMed DOI  V
  27. Verhelst,S.H.L.
    Intramembrane proteases as drug targets
    FEBS J284, 1489-1502. PubMed  Europe PubMed DOI  I
    28. 2016
  28. da Palma,J.R., Cendron,L., Seidah,N.G., Pasquato,A. and Kunz,S.
    Mechanism of folding and activation of subtilisin kexin isozyme-1 (SKI-1)/site-1 protease (S1P)
    J Biol Chem291, 2055-2066. PubMed  Europe PubMed DOI
  29. Ghorbani,S., Hoogewijs,K., Pecenkova,T., Fernandez,A., Inze,A., Eeckhout,D., Kawa,D., De Jaeger,G., Beeckman,T., Madder,A., Van Breusegem,F. and Hilson,P.
    The SBT6.1 subtilase processes the GOLVEN1 peptide controlling cell elongation
    J Exp Bot67, 4877-4887. PubMed  Europe PubMed DOI
  30. Maluch,I., Walewska,A., Sikorska,E. and Prahl,A.
    [Proprotein convertases - family of serine proteases with a broad spectrum of physiological functions]
    Postepy Biochem62, 472-481. PubMed  Europe PubMed  V
    31. 2015
  31. Klunder,S., Heeren,J., Markmann,S., Santer,R., Braulke,T. and Pohl,S.
    Site-1 protease-activated formation of lysosomal targeting motifs is independent of the lipogenic transcription control
    J Lipid Res56, 1625-1632. PubMed  Europe PubMed DOI
  32. Sun,L., Zhang,S.S., Lu,S.J. and Liu,J.X.
    Site-1 protease cleavage site is important for the ER stress-induced activation of membrane-associated transcription factor bZIP28 in Arabidopsis
    Sci China Life Sci58, 270-275. PubMed  Europe PubMed DOI
  33. Velho,R.V., De Pace,R., Klunder,S., Sperb-Ludwig,F., Lourenco,C.M., Schwartz,I.V., Braulke,T. and Pohl,S.
    Analyses of disease-related GNPTAB mutations define a novel GlcNAc-1-phosphotransferase interaction domain and an alternative site-1 protease cleavage site
    Hum Mol Genet24, 3497-3505. PubMed  Europe PubMed DOI
    34. 2014
  34. da Palma,J.R., Burri,D.J., Oppliger,J., Salamina,M., Cendron,L., de Laureto,P.P., Seidah,N.G., Kunz,S. and Pasquato,A.
    Zymogen activation and subcellular activity of subtilisin kexin isozyme 1/site 1 protease
    J Biol Chem289, 35743-35756. PubMed  Europe PubMed DOI
  35. Patra,D., Delassus,E., Liang,G. and Sandell,L.J.
    Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIb procollagen and down-regulation of cholesterol and lipid homeostasis
    PLoS ONE9, e105674-e105674. PubMed  Europe PubMed DOI  K
    36. 2013

  36. Activating cathepsin K in osteoclasts stimulates bone formation through S1P
    Bonekey Rep2, 362-362. PubMed  Europe PubMed DOI  K
  37. Burri,D.J., Pasquato,A., Ramos da Palma,J., Igonet,S., Oldstone,M.B. and Kunz,S.
    The role of proteolytic processing and the stable signal peptide in expression of the Old World arenavirus envelope glycoprotein ectodomain
    Virology436, 127-133. PubMed  Europe PubMed DOI
  38. Burri,D.J., Ramos da Palma,J., Seidah,N.G., Zanotti,G., Cendron,L., Pasquato,A. and Kunz,S.
    Differential recognition of old world and new world arenavirus envelope glycoproteins by subtilisin kexin isozyme 1 (SKI-1)/site 1 protease (S1P)
    J Virol87, 6406-6414. PubMed  Europe PubMed DOI  P
  39. Morohashi,Y. and Tomita,T.
    Protein trafficking and maturation regulate intramembrane proteolysis
    Biochim Biophys Acta1828, 2855-2861. PubMed  Europe PubMed DOI  V
  40. Seidah,N.G., Sadr,M.S., Chretien,M. and Mbikay,M.
    The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions
    J Biol Chem288, 21473-21481. PubMed  Europe PubMed DOI  V
    41. 2012
  41. Burri,D.J., Pasqual,G., Rochat,C., Seidah,N.G., Pasquato,A. and Kunz,S.
    Molecular characterization of the processing of arenavirus envelope glycoprotein precursors by subtilisin kexin isozyme-1/site-1 protease
    J Virol86, 4935-4946. PubMed  Europe PubMed DOI
  42. Denard,B., Lee,C. and Ye,J.
    Doxorubicin blocks proliferation of cancer cells through proteolytic activation of CREB3L1
    elife1, e00090-e00090. PubMed  Europe PubMed DOI
  43. Olmstead,A.D., Knecht,W., Lazarov,I., Dixit,S.B. and Jean,F.
    Human subtilase SKI-1/S1P is a master regulator of the HCV lifecycle and a potential host cell target for developing indirect-acting antiviral agents
    PLoS Pathog8, e1002468-e1002468. PubMed  Europe PubMed DOI
  44. Rutschmann,S., Crozat,K., Li,X., Du,X., Hanselman,J.C., Shigeoka,A.A., Brandl,K., Popkin,D.L., McKay,D.B., Xia,Y., Moresco,E.M. and Beutler,B.
    Hypopigmentation and maternal-zygotic embryonic lethality caused by a hypomorphic mbtps1 mutation in mice
    G3 (Bethesda)2, 499-504. PubMed  Europe PubMed DOI  M
  45. Seidah,N.G.
    Site-1 protease
    [ISSN:978-0-12-407742-3]3, 3265-3270. DOI
  46. Seidah,N.G. and Prat,A.
    The biology and therapeutic targeting of the proprotein convertases
    Nat Rev Drug Discov11, 367-383. PubMed  Europe PubMed DOI  V
    47. 2011
  47. Howarth,D.L., Passeri,M. and Sadler,K.C.
    Drinks like a fish: using zebrafish to understand alcoholic liver disease
    Alcohol Clin Exp Res35, 826-829. PubMed  Europe PubMed DOI  M
  48. Lee,A.M., Pasquato,A. and Kunz,S.
    Novel approaches in anti-arenaviral drug development
    Virology411, 163-169. PubMed  Europe PubMed DOI  T
  49. Majumdar,S., Chen,A., Palmer-Smith,H. and Basak,A.
    Novel circular, cyclic and acyclic psi(CH(2)O) containing peptide inhibitors of SKI-1/S1P: synthesis, kinetic and biochemical evaluations
    Curr Med Chem18, 2770-2782. PubMed  Europe PubMed DOI  I
  50. Marschner,K., Kollmann,K., Schweizer,M., Braulke,T. and Pohl,S.
    A key enzyme in the biogenesis of lysosomes is a protease that regulates cholesterol metabolism
    Science333, 87-90. PubMed  Europe PubMed DOI  P
  51. Ozdemir,C. and Rawson,R.B.
    Other ways to skin a cat: activating SREBP without scap
    Fly (Austin)5, 3-6. PubMed  Europe PubMed  M  V
  52. Pasquato,A., Burri,D.J., Traba,E.G., Hanna-El-Daher,L., Seidah,N.G. and Kunz,S.
    Arenavirus envelope glycoproteins mimic autoprocessing sites of the cellular proprotein convertase subtilisin kexin isozyme-1/site-1 protease
    Virology417, 18-26. PubMed  Europe PubMed DOI
  53. Patra,D., Delassus,E., Hayashi,S. and Sandell,L.J.
    Site-1 protease is essential to growth plate maintenance and is a critical regulator of chondrocyte hypertrophic differentiation in postnatal mice
    J Biol Chem286, 29227-29240. PubMed  Europe PubMed DOI  K
  54. Popkin,D.L., Teijaro,J.R., Sullivan,B.M., Urata,S., Rutschmann,S., de la Torre,J.C., Kunz,S., Beutler,B. and Oldstone,M.
    Hypomorphic mutation in the site-1 protease mbtps1 endows resistance to persistent viral infection in a cell-specific manner
    Cell Host Microbe9, 212-222. PubMed  Europe PubMed DOI  M
  55. Seidah,N.G.
    The proprotein convertases, 20 years later
    Methods Mol Biol768, 23-57. PubMed  Europe PubMed DOI  V
  56. Seidah,N.G.
    What lies ahead for the proprotein convertases?
    Ann N Y Acad Sci1220, 149-161. PubMed  Europe PubMed DOI  V
  57. Urata,S., Yun,N., Pasquato,A., Paessler,S., Kunz,S. and de la Torre,J.C.
    Antiviral activity of a small-molecule inhibitor of arenavirus glycoprotein processing by the cellular site 1 protease
    J Virol85, 795-803. PubMed  Europe PubMed DOI  I
  58. Ye,J.
    Cell biology. Protease sets site-1 on lysosomes
    Science333, 50-51. PubMed  Europe PubMed DOI
    59. 2010
  59. Basak,A., Mitra,D., Das,A.K., Mohottalage,D. and Basak,A.
    C(2)-Symmetric azobenzene-amino acid conjugates and their inhibition of subtilisin kexin isozyme-1
    Bioorg Med Chem Lett20, 3977-3981. PubMed  Europe PubMed DOI  I
  60. Rojek,J.M., Pasqual,G., Sanchez,A.B., Nguyen,N.T., de la Torre,J.C. and Kunz,S.
    Targeting the proteolytic processing of the viral glycoprotein precursor is a promising novel antiviral strategy against arenaviruses
    J Virol84, 573-584. PubMed  Europe PubMed DOI  T  I
    61. 2009
  61. Gorski,J.P., Huffman,N.T., Cui,C., Henderson,E.P., Midura,R.J. and Seidah,N.G.
    Potential role of proprotein convertase SKI-1 in the mineralization of primary bone
    Cells Tissues Organs189, 25-32. PubMed  Europe PubMed DOI
  62. Maisa,A., Stroher,U., Klenk,H.D., Garten,W. and Strecker,T.
    Inhibition of Lassa virus glycoprotein cleavage and multicycle replication by site 1 protease-adapted alpha(1)-antitrypsin variants
    PLoS Negl Trop Dis3, e446-e446. PubMed  Europe PubMed DOI
  63. Srivastava,R., Liu,J.X., Guo,H., Yin,Y. and Howell,S.H.
    Regulation and processing of a plant peptide hormone, AtRALF23, in Arabidopsis
    Plant J59, 930-939. PubMed  Europe PubMed DOI
  64. Wolf,S., Rausch,T. and Greiner,S.
    The N-terminal pro region mediates retention of unprocessed type-I PME in the Golgi apparatus
    Plant J58, 361-375. PubMed  Europe PubMed DOI
    65. 2008
  65. Hawkins,J.L., Robbins,M.D., Warren,L.C., Xia,D., Petras,S.F., Valentine,J.J., Varghese,A.H., Wang,I.K., Subashi,T.A., Shelly,L.D., Hay,B.A., Landschulz,K.T., Geoghegan,K.F. and Harwood,H.J., Jr.
    Pharmacologic inhibition of site 1 protease activity inhibits sterol regulatory element-binding protein processing and reduces lipogenic enzyme gene expression and lipid synthesis in cultured cells and experimental animals
    J Pharmacol Exp Ther326, 801-808. PubMed  Europe PubMed DOI  I
  66. Rojek,J.M., Lee,A.M., Nguyen,N., Spiropoulou,C.F. and Kunz,S.
    Site 1 protease is required for proteolytic processing of the glycoproteins of the South American hemorrhagic fever viruses Junin, Machupo, and Guanarito
    J Virol82, 6045-6051. PubMed  Europe PubMed DOI
    67. 2007
  67. Bergeron,E., Vincent,M.J. and Nichol,S.T.
    Crimean-Congo hemorrhagic fever virus glycoprotein processing by the endoprotease SKI-1/S1P is critical for virus infectivity
    J Virol81, 13271-13276. PubMed  Europe PubMed DOI  T
  68. Bodvard,K., Mohlin,J. and Knecht,W.
    Recombinant expression, purification, and kinetic and inhibitor characterisation of human site-1-protease
    Protein Expr Purif51, 308-319. PubMed  Europe PubMed DOI  A  E
  69. De Windt,A., Rai,M., Bernier,L., Thelen,K., Soini,J., Lefebvre,C., Chintawar,S., Lavigne,J., Saarinen,L., Kytomaki,L., Munzer,J.S., Lutjohann,D., Pandolfo,M., Davignon,J., Seidah,N.G. and Laaksonen,R.
    Gene set enrichment analysis reveals several globally affected pathways due to SKI-1/S1P inhibition in HepG2 cells
    DNA Cell Biol26, 765-772. PubMed  Europe PubMed DOI
  70. Hay,B.A., Abrams,B., Zumbrunn,A.Y., Valentine,J.J., Warren,L.C., Petras,S.F., Shelly,L.D., Xia,A., Varghese,A.H., Hawkins,J.L., Van Camp,J.A., Robbins,M.D., Landschulz,K. and Harwood,H.J., Jr.
    Aminopyrrolidineamide inhibitors of site-1 protease
    Bioorg Med Chem Lett17, 4411-4414. PubMed  Europe PubMed DOI  I
  71. Liu,J.X., Srivastava,R., Che,P. and Howell,S.H.
    Salt stress responses in Arabidopsis utilize a signal transduction pathway related to endoplasmic reticulum stress signaling
    Plant J51, 897-909. PubMed  Europe PubMed DOI
  72. Patra,D., Xing,X., Davies,S., Bryan,J., Franz,C., Hunziker,E.B. and Sandell,L.J.
    Site-1 protease is essential for endochondral bone formation in mice
    J Cell Biol179, 687-700. PubMed  Europe PubMed DOI  K
  73. Pullikotil,P., Benjannet,S., Mayne,J. and Seidah,N.G.
    The proprotein convertase SKI-1/S1P: alternate translation and subcellular localization
    J Biol Chem282, 27402-27413. PubMed  Europe PubMed DOI
  74. Seidah,N.G. and Prat,A.
    The proprotein convertases are potential targets in the treatment of dyslipidemia
    J Mol Med (Berl)85, 685-696. PubMed  Europe PubMed DOI  V
    75. 2006
  75. Basak,S., Mohottalage,D. and Basak,A.
    Multibranch and pseudopeptide approach for design of novel inhibitors of subtilisin kexin isozyme-1
    Protein Pept Lett13, 863-876. PubMed  Europe PubMed DOI  I
  76. Murakami,T., Kondo,S., Ogata,M., Kanemoto,S., Saito,A., Wanaka,A. and Imaizumi,K.
    Cleavage of the membrane-bound transcription factor OASIS in response to endoplasmic reticulum stress
    J Neurochem96, 1090-1100. PubMed  Europe PubMed DOI
  77. [YEAR:21-6-2006]Pasquato,A., Pullikotil,P., Asselin,M.C., Vacatello,M., Paolillo,L., Ghezzo,F., Basso,F., Di Bello,C., Dettin,M. and Seidah,N.G.
    The proprotein convertase SKI-1/S1P. In vitro analysis of Lassa virus glycoprotein-derived substrates and ex vivo validation of irreversible peptide inhibitors
    J Biol Chem281, 23471-23481. PubMed  Europe PubMed DOI  I
  78. Patra,D., Davies, Bryan,J., Xing,X. and Sandell,L.J.
    Lack of endochondral ossification in site-1 protease knockout mice
    Eur Cells and Mater12, 8-  K
  79. Scamuffa,N., Calvo,F., Chretien,M., Seidah,N.G. and Khatib,A.M.
    Proprotein convertases: lessons from knockouts
    FASEB J20, 1954-1963. PubMed  Europe PubMed DOI  K  V
  80. Stirling,J. and O'Hare,P.
    CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P
    Mol Biol Cell17, 413-426. PubMed  Europe PubMed DOI
    81. 2004
  81. [YEAR:27-8-2004]Basak,S., Stewart,N.A., Chretien,M. and Basak,A.
    Aminoethyl benzenesulfonyl fluoride and its hexapeptide (Ac-VFRSLK) conjugate are both in vitro inhibitors of subtilisin kexin isozyme-1
    FEBS Lett573, 186-194. PubMed  Europe PubMed DOI  I
  82. Beatson,S. and Ponting,C.P.
    GIFT domains: linking eukaryotic intraflagellar transport and glycosylation to bacterial gliding
    Trends Biochem Sci29, 396-399. PubMed  Europe PubMed DOI
  83. [YEAR:15-8-2004]Mouchantaf,R., Watt,H.L., Sulea,T., Seidah,N.G., Alturaihi,H., Patel,Y.C. and Kumar,U.
    Prosomatostatin is proteolytically processed at the amino terminal segment by subtilase SKI-1
    Regul Pept120, 133-140. PubMed  Europe PubMed DOI
  84. [YEAR:16-2-2004]Pullikotil,P., Vincent,M., Nichol,S.T. and Seidah,N.G.
    Development of protein-based inhibitors of the proprotein of convertase SKI-1/S1P: processing of SREBP-2, ATF6, and a viral glycoprotein
    J Biol Chem279, 17338-17347. PubMed  Europe PubMed DOI
  85. Seidah,N.G. and Chretien,M.
    Proprotein convertase SKI-1/S1P
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