Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase S08.063: site-1 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: A Assay, T Target, M Mutation, P Specificity, K Knockout, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Bullington,A.V., Micallo,I., Bajaj,B., Kumar,P., Schlamowitz,N., Silva,A., Hendrix,S., Zelcer,N. and Kober,D.L.<br>Structural basis for substrate selectivity by site-one protease revealed by studies with a small-molecule inhibitor<br>Proc Natl Acad Sci U S A (2025) 122, e2426931122-e2426931122. PubMed  Europe PubMed DOI  I
  2. Miao,H., Tao,L., Dai,Y., Yuan,Z. and Qiu,J.<br>A novel brain-derived peptide inhibits microglial pyroptosis through MBTPS1 in neonatal hypoxic-ischemic brain damage<br>Brain Res Bull (2025) 233, 111664-111664. PubMed  Europe PubMed DOI
    3. 2024
  3. Chen,J., Zhou,Y., Liu,Z., Lu,Y., Jiang,Y., Cao,K., Zhou,N., Wang,D., Zhang,C., Zhou,N., Shi,K., Zhang,L., Zhou,L., Wang,Z., Zhang,H., Tang,K., Ma,J., Lv,J. and Huang,B.<br>Hepatic glycogenesis antagonizes lipogenesis by blocking S1P via UDPG<br>Science (2024) 383, eadi3332-eadi3332. PubMed  Europe PubMed DOI
  4. Hendrix,S., Tan,J.M.E., Ndoj,K., Kingma,J., Valiloo,M., Zijlstra,L.F., Ottenhoff,R., Seidah,N.G., Loregger,A., Kober,D.L. and Zelcer,N.<br>SPRING is a Dedicated Licensing Factor for SREBP-Specific Activation by S1P<br>Mol Cell Biol (2024) 44, 123-137. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Hendrix,S., Dartigue,V., Hall,H., Bawaria,S., Kingma,J., Bajaj,B., Zelcer,N. and Kober,D.L.<br>SPRING licenses S1P-mediated cleavage of SREBP2 by displacing an inhibitory pro-domain<br>Nat Commun (2024) 15, 5732-5732. PubMed  Europe PubMed DOI  PMC  EPMC
  6. Santinelli,R., Benz,N., Guellec,J., Quinquis,F., Kocas,E., Thomas,J., Montier,T., Ka,C., Luczka-Majerus,E., Sage,E., Ferec,C., Coraux,C. and Trouve,P.<br>The Inhibition of the Membrane-Bound Transcription Factor Site-1 Protease (MBTP1) Alleviates the p.Phe508del-Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Defects in Cystic Fibrosis Cells<br>Cells (2024) 13 PubMed  Europe PubMed DOI  PMC  EPMC
    7. 2023
  7. Bost,C., Hartlaub,J., Pinho Dos Reis,V., Strecker,T., Seidah,N.G., Groschup,M.H., Diederich,S. and Fischer,K.<br>The proprotein convertase SKI-1/S1P is a critical host factor for Nairobi sheep disease virus infectivity<br>Virus Res (2023) 329, 199099-199099. PubMed  Europe PubMed DOI  PMC  EPMC
    8. 2022
  8. Chen,F., Ni,C., Wang,X., Cheng,R., Pan,C., Wang,Y., Liang,J., Zhang,J., Cheng,J., Chin,Y.E., Zhou,Y., Wang,Z., Guo,Y., Chen,S., Htun,S., Mathes,E.F., de Alba Campomanes,A.G., Slavotinek,A.M., Zhang,S., Li,M. and Yao,Z.<br>S1P defects cause a new entity of cataract, alopecia, oral mucosal disorder, and psoriasis-like syndrome<br>EMBO Mol Med (2022) 14, e14904-e14904. PubMed  Europe PubMed DOI  PMC  EPMC
  9. Hartal-Benishay,L.H., Saadi,E., Toubiana,S., Shaked,L., Lalzar,M., Abu Hatoum,O., Tal,S., Selig,S. and Barki-Harrington,L.<br>MBTPS1 regulates proliferation of colorectal cancer primarily through its action on sterol regulatory element-binding proteins<br>Front Oncol (2022) 12, 1004014-1004014. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Yuan,Y., Zhou,Q., Wang,C., Zhou,W., Gu,W. and Zheng,B.<br>Clinical and molecular characterization of a patient with MBTPS1 related spondyloepiphyseal dysplasia: Evidence of pathogenicity for a synonymous variant<br>Front Pediatr (2022) 10, 1056141-1056141. PubMed  Europe PubMed DOI  PMC  EPMC  K
    11. 2021
  11. Chen,X., Zhang,J., Liu,P., Wei,Y., Wang,X., Xiao,J., Wang,C.C. and Wang,L.<br>Proteolytic processing of secretory pathway kinase Fam20C by site-1 protease promotes biomineralization<br>Proc Natl Acad Sci U S A (2021) 118 PubMed  Europe PubMed DOI
  12. Danyukova,T., Schoneck,K. and Pohl,S.<br>Site-1 and site-2 proteases: A team of two in regulated proteolysis<br>Biochim Biophys Acta Mol Cell Res (2021) 1869, 119138-119138. PubMed  Europe PubMed DOI  V
  13. Xiao,J., Xiong,Y., Yang,L.T., Wang,J.Q., Zhou,Z.M., Dong,L.W., Shi,X.J., Zhao,X., Luo,J. and Song,B.L.<br>POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation<br>Protein Cell (2021) 12, 279-296. PubMed  Europe PubMed DOI
    14. 2020
  14. Bayraktar,E.C., La,K., Karpman,K., Unlu,G., Ozerdem,C., Ritter,D.J., Alwaseem,H., Molina,H., Hoffmann,H.H., Millner,A., Atilla-Gokcumen,G.E., Gamazon,E.R., Rushing,A.R., Knapik,E.W., Basu,S. and Birsoy,K.<br>Metabolic coessentiality mapping identifies C12orf49 as a regulator of SREBP processing and cholesterol metabolism<br>Nat Metab (2020) 2, 487-498. PubMed  Europe PubMed DOI  PMC  EPMC
  15. Feng,Y., Peng,K., Luo,R., Wang,F. and Yang,T.<br>Site-1 Protease-Derived Soluble (Pro)Renin Receptor Contributes to Angiotensin II-Induced Hypertension in Mice<br>Hypertension (2020) , HYPERTENSIONAHA12015100-HYPERTENSIONAHA12015100. PubMed  Europe PubMed DOI
  16. Stuhrwohldt,N., Scholl,S., Lang,L., Katzenberger,J., Schumacher,K. and Schaller,A.<br>The biogenesis of CLEL peptides involves several processing events in consecutive compartments of the secretory pathway<br>elife (2020) 9 PubMed  Europe PubMed DOI  PMC  EPMC
    17. 2019
  17. Olaposi,O.I., Oyekanmi,N., Ojo,A.A. and Eniafe,G.O.<br>Membrane-bound transcription factor site-1 protease in PF429242 bound state: computational kinetics and dynamics of reversible binding<br>Drug Res (Stuttg) (2019) 69, 643-649. PubMed  Europe PubMed DOI  I
  18. Schweitzer,G.G., Gan,C., Bucelli,R.C., Wegner,D., Schmidt,R.E., Shinawi,M., Finck,B.N. and Brookheart,R.T.<br>A mutation in site-1 protease is associated with a complex phenotype that includes episodic hyperCKemia and focal myoedema<br>Mol Genet Genomic Med (2019) 7, e00733-e00733. PubMed  Europe PubMed DOI  M
    19. 2018
  19. Al-Maskari,M., Care,M.A., Robinson,E., Cocco,M., Tooze,R.M. and Doody,G.M.<br>Site-1 protease function is essential for the generation of antibody secreting cells and reprogramming for secretory activity<br>Sci Rep (2018) 8, 14338-14338. PubMed  Europe PubMed DOI  PMC  EPMC  I
  20. Kondo,Y., Fu,J., Wang,H., Hoover,C., McDaniel,J.M., Steet,R., Patra,D., Song,J., Pollard,L., Cathey,S., Yago,T., Wiley,G., Macwana,S., Guthridge,J., McGee,S., Li,S., Griffin,C., Furukawa,K., James,J.A., Ruan,C., McEver,R.P., Wierenga,K.J., Gaffney,P.M. and Xia,L.<br>Site-1 protease deficiency causes human skeletal dysplasia due to defective inter-organelle protein trafficking<br>JCI Insight (2018) 3 PubMed  Europe PubMed DOI  M
  21. Patra,D., Delassus,E., Mueller,J., Abou-Ezzi,G. and Sandell,L.J.<br>Site-1 protease regulates skeletal stem cell population and osteogenic differentiation in mice<br>Biol Open (2018) 7 PubMed  Europe PubMed DOI  K
  22. Urata,S., Uno,Y., Kurosaki,Y. and Yasuda,J.<br>The cholesterol, fatty acid and triglyceride synthesis pathways regulated by site 1 protease (S1P) are required for efficient replication of severe fever with thrombocytopenia syndrome virus<br>Biochem Biophys Res Commun (2018) 503, 631-636. PubMed  Europe PubMed DOI  I
    23. 2017
  23. Caruana,B.T., Skoric,A., Brown,A.J. and Lutze-Mann,L.H.<br>Site-1 protease, a novel metabolic target for glioblastoma<br>Biochem Biophys Res Commun (2017) 490, 760-766. PubMed  Europe PubMed DOI  I
  24. Hyrina,A., Meng,F., McArthur,S.J., Eivemark,S., Nabi,I.R. and Jean,F.<br>Human subtilisin kexin isozyme-1 (SKI-1)/site-1 protease (S1P) regulates cytoplasmic lipid droplet abundance: a potential target for indirect-acting anti-dengue virus agents<br>PLoS ONE (2017) 12, e0174483-e0174483. PubMed  Europe PubMed DOI  PMC  EPMC  I
  25. Iwata,Y., Ashida,M., Hasegawa,C., Tabara,K., Mishiba,K.I. and Koizumi,N.<br>Activation of the Arabidopsis membrane-bound transcription factor bZIP28 is mediated by site-2 protease, but not site-1 protease<br>Plant J (2017) 91, 408-415. PubMed  Europe PubMed DOI
  26. Nakagawa,T., Suzuki-Nakagawa,C., Watanabe,A., Asami,E., Matsumoto,M., Nakano,M., Ebihara,A., Uddin,M.N. and Suzuki,F.<br>Site-1 protease is required for the generation of soluble (pro)renin receptor<br>J Biochem (2017) 161, 369-379. PubMed  Europe PubMed DOI  I
  27. Stegmann,M., Monaghan,J., Smakowska-Luzan,E., Rovenich,H., Lehner,A., Holton,N., Belkhadir,Y. and Zipfel,C.<br>The receptor kinase FER is a RALF-regulated scaffold controlling plant immune signaling<br>Science (2017) 355, 287-289. PubMed  Europe PubMed DOI
  28. Velho,R.V., De Pace,R., Klunder,S., Di Lorenzo,G., Schweizer,M., Braulke,T. and Pohl,S.<br>Site-1 protease and lysosomal homeostasis<br>Biochim Biophys Acta (2017) 1864, 2162-2168. PubMed  Europe PubMed DOI  V
  29. Verhelst,S.H.L.<br>Intramembrane proteases as drug targets<br>FEBS J (2017) 284, 1489-1502. PubMed  Europe PubMed DOI  I
    30. 2016
  30. da Palma,J.R., Cendron,L., Seidah,N.G., Pasquato,A. and Kunz,S.<br>Mechanism of folding and activation of subtilisin kexin isozyme-1 (SKI-1)/site-1 protease (S1P)<br>J Biol Chem (2016) 291, 2055-2066. PubMed  Europe PubMed DOI
  31. Ghorbani,S., Hoogewijs,K., Pecenkova,T., Fernandez,A., Inze,A., Eeckhout,D., Kawa,D., De Jaeger,G., Beeckman,T., Madder,A., Van Breusegem,F. and Hilson,P.<br>The SBT6.1 subtilase processes the GOLVEN1 peptide controlling cell elongation<br>J Exp Bot (2016) 67, 4877-4887. PubMed  Europe PubMed DOI
  32. Maluch,I., Walewska,A., Sikorska,E. and Prahl,A.<br>[Proprotein convertases - family of serine proteases with a broad spectrum of physiological functions]<br>Postepy Biochem (2016) 62, 472-481. PubMed  Europe PubMed  V
    33. 2015
  33. Klunder,S., Heeren,J., Markmann,S., Santer,R., Braulke,T. and Pohl,S.<br>Site-1 protease-activated formation of lysosomal targeting motifs is independent of the lipogenic transcription control<br>J Lipid Res (2015) 56, 1625-1632. PubMed  Europe PubMed DOI
  34. Sun,L., Zhang,S.S., Lu,S.J. and Liu,J.X.<br>Site-1 protease cleavage site is important for the ER stress-induced activation of membrane-associated transcription factor bZIP28 in Arabidopsis<br>Sci China Life Sci (2015) 58, 270-275. PubMed  Europe PubMed DOI
  35. Velho,R.V., De Pace,R., Klunder,S., Sperb-Ludwig,F., Lourenco,C.M., Schwartz,I.V., Braulke,T. and Pohl,S.<br>Analyses of disease-related GNPTAB mutations define a novel GlcNAc-1-phosphotransferase interaction domain and an alternative site-1 protease cleavage site<br>Hum Mol Genet (2015) 24, 3497-3505. PubMed  Europe PubMed DOI
    36. 2014
  36. da Palma,J.R., Burri,D.J., Oppliger,J., Salamina,M., Cendron,L., de Laureto,P.P., Seidah,N.G., Kunz,S. and Pasquato,A.<br>Zymogen activation and subcellular activity of subtilisin kexin isozyme 1/site 1 protease<br>J Biol Chem (2014) 289, 35743-35756. PubMed  Europe PubMed DOI
  37. Patra,D., Delassus,E., Liang,G. and Sandell,L.J.<br>Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIb procollagen and down-regulation of cholesterol and lipid homeostasis<br>PLoS ONE (2014) 9, e105674-e105674. PubMed  Europe PubMed DOI  PMC  EPMC  K
    38. 2013
  38. <br>Activating cathepsin K in osteoclasts stimulates bone formation through S1P<br>Bonekey Rep (2013) 2, 362-362. PubMed  Europe PubMed DOI  PMC  EPMC  K
  39. Burri,D.J., Pasquato,A., Ramos da Palma,J., Igonet,S., Oldstone,M.B. and Kunz,S.<br>The role of proteolytic processing and the stable signal peptide in expression of the Old World arenavirus envelope glycoprotein ectodomain<br>Virology (2013) 436, 127-133. PubMed  Europe PubMed DOI
  40. Burri,D.J., Ramos da Palma,J., Seidah,N.G., Zanotti,G., Cendron,L., Pasquato,A. and Kunz,S.<br>Differential recognition of old world and new world arenavirus envelope glycoproteins by subtilisin kexin isozyme 1 (SKI-1)/site 1 protease (S1P)<br>J Virol (2013) 87, 6406-6414. PubMed  Europe PubMed DOI  P
  41. Morohashi,Y. and Tomita,T.<br>Protein trafficking and maturation regulate intramembrane proteolysis<br>Biochim Biophys Acta (2013) 1828, 2855-2861. PubMed  Europe PubMed DOI  V
  42. Seidah,N.G., Sadr,M.S., Chretien,M. and Mbikay,M.<br>The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions<br>J Biol Chem (2013) 288, 21473-21481. PubMed  Europe PubMed DOI  V
    43. 2012
  43. Burri,D.J., Pasqual,G., Rochat,C., Seidah,N.G., Pasquato,A. and Kunz,S.<br>Molecular characterization of the processing of arenavirus envelope glycoprotein precursors by subtilisin kexin isozyme-1/site-1 protease<br>J Virol (2012) 86, 4935-4946. PubMed  Europe PubMed DOI
  44. Denard,B., Lee,C. and Ye,J.<br>Doxorubicin blocks proliferation of cancer cells through proteolytic activation of CREB3L1<br>elife (2012) 1, e00090-e00090. PubMed  Europe PubMed DOI  PMC  EPMC
  45. Olmstead,A.D., Knecht,W., Lazarov,I., Dixit,S.B. and Jean,F.<br>Human subtilase SKI-1/S1P is a master regulator of the HCV lifecycle and a potential host cell target for developing indirect-acting antiviral agents<br>PLoS Pathog (2012) 8, e1002468-e1002468. PubMed  Europe PubMed DOI  PMC  EPMC
  46. Rutschmann,S., Crozat,K., Li,X., Du,X., Hanselman,J.C., Shigeoka,A.A., Brandl,K., Popkin,D.L., McKay,D.B., Xia,Y., Moresco,E.M. and Beutler,B.<br>Hypopigmentation and maternal-zygotic embryonic lethality caused by a hypomorphic mbtps1 mutation in mice<br>G3 (Bethesda) (2012) 2, 499-504. PubMed  Europe PubMed DOI  PMC  EPMC  M
  47. Seidah,N.G. and Prat,A.<br>The biology and therapeutic targeting of the proprotein convertases<br>Nat Rev Drug Discov (2012) 11, 367-383. PubMed  Europe PubMed DOI  V
  48. Seidah,N.G.<br>Site-1 protease<br>[ISSN:978-0-12-407742-3] (2012) 3, 3265-3270. DOI
    49. 2011
  49. Howarth,D.L., Passeri,M. and Sadler,K.C.<br>Drinks like a fish: using zebrafish to understand alcoholic liver disease<br>Alcohol Clin Exp Res (2011) 35, 826-829. PubMed  Europe PubMed DOI  M
  50. Lee,A.M., Pasquato,A. and Kunz,S.<br>Novel approaches in anti-arenaviral drug development<br>Virology (2011) 411, 163-169. PubMed  Europe PubMed DOI  T
  51. Majumdar,S., Chen,A., Palmer-Smith,H. and Basak,A.<br>Novel circular, cyclic and acyclic psi(CH(2)O) containing peptide inhibitors of SKI-1/S1P: synthesis, kinetic and biochemical evaluations<br>Curr Med Chem (2011) 18, 2770-2782. PubMed  Europe PubMed DOI  I
  52. Marschner,K., Kollmann,K., Schweizer,M., Braulke,T. and Pohl,S.<br>A key enzyme in the biogenesis of lysosomes is a protease that regulates cholesterol metabolism<br>Science (2011) 333, 87-90. PubMed  Europe PubMed DOI  P
  53. Ozdemir,C. and Rawson,R.B.<br>Other ways to skin a cat: activating SREBP without scap<br>Fly (Austin) (2011) 5, 3-6. PubMed  Europe PubMed  M  V
  54. Pasquato,A., Burri,D.J., Traba,E.G., Hanna-El-Daher,L., Seidah,N.G. and Kunz,S.<br>Arenavirus envelope glycoproteins mimic autoprocessing sites of the cellular proprotein convertase subtilisin kexin isozyme-1/site-1 protease<br>Virology (2011) 417, 18-26. PubMed  Europe PubMed DOI
  55. Patra,D., Delassus,E., Hayashi,S. and Sandell,L.J.<br>Site-1 protease is essential to growth plate maintenance and is a critical regulator of chondrocyte hypertrophic differentiation in postnatal mice<br>J Biol Chem (2011) 286, 29227-29240. PubMed  Europe PubMed DOI  K
  56. Popkin,D.L., Teijaro,J.R., Sullivan,B.M., Urata,S., Rutschmann,S., de la Torre,J.C., Kunz,S., Beutler,B. and Oldstone,M.<br>Hypomorphic mutation in the site-1 protease mbtps1 endows resistance to persistent viral infection in a cell-specific manner<br>Cell Host Microbe (2011) 9, 212-222. PubMed  Europe PubMed DOI  PMC  EPMC  M
  57. Seidah,N.G.<br>What lies ahead for the proprotein convertases?<br>Ann N Y Acad Sci (2011) 1220, 149-161. PubMed  Europe PubMed DOI  V
  58. Seidah,N.G.<br>The proprotein convertases, 20 years later<br>Methods Mol Biol (2011) 768, 23-57. PubMed  Europe PubMed DOI  V
  59. Urata,S., Yun,N., Pasquato,A., Paessler,S., Kunz,S. and de la Torre,J.C.<br>Antiviral activity of a small-molecule inhibitor of arenavirus glycoprotein processing by the cellular site 1 protease<br>J Virol (2011) 85, 795-803. PubMed  Europe PubMed DOI  I
  60. Ye,J.<br>Cell biology. Protease sets site-1 on lysosomes<br>Science (2011) 333, 50-51. PubMed  Europe PubMed DOI
    61. 2010
  61. Basak,A., Mitra,D., Das,A.K., Mohottalage,D. and Basak,A.<br>C(2)-Symmetric azobenzene-amino acid conjugates and their inhibition of subtilisin kexin isozyme-1<br>Bioorg Med Chem Lett (2010) 20, 3977-3981. PubMed  Europe PubMed DOI  I
  62. Rojek,J.M., Pasqual,G., Sanchez,A.B., Nguyen,N.T., de la Torre,J.C. and Kunz,S.<br>Targeting the proteolytic processing of the viral glycoprotein precursor is a promising novel antiviral strategy against arenaviruses<br>J Virol (2010) 84, 573-584. PubMed  Europe PubMed DOI  T  I
    63. 2009
  63. Gorski,J.P., Huffman,N.T., Cui,C., Henderson,E.P., Midura,R.J. and Seidah,N.G.<br>Potential role of proprotein convertase SKI-1 in the mineralization of primary bone<br>Cells Tissues Organs (2009) 189, 25-32. PubMed  Europe PubMed DOI
  64. Maisa,A., Stroher,U., Klenk,H.D., Garten,W. and Strecker,T.<br>Inhibition of Lassa virus glycoprotein cleavage and multicycle replication by site 1 protease-adapted alpha(1)-antitrypsin variants<br>PLoS Negl Trop Dis (2009) 3, e446-e446. PubMed  Europe PubMed DOI  PMC  EPMC
  65. Srivastava,R., Liu,J.X., Guo,H., Yin,Y. and Howell,S.H.<br>Regulation and processing of a plant peptide hormone, AtRALF23, in Arabidopsis<br>Plant J (2009) 59, 930-939. PubMed  Europe PubMed DOI
  66. Wolf,S., Rausch,T. and Greiner,S.<br>The N-terminal pro region mediates retention of unprocessed type-I PME in the Golgi apparatus<br>Plant J (2009) 58, 361-375. PubMed  Europe PubMed DOI
    67. 2008
  67. Hawkins,J.L., Robbins,M.D., Warren,L.C., Xia,D., Petras,S.F., Valentine,J.J., Varghese,A.H., Wang,I.K., Subashi,T.A., Shelly,L.D., Hay,B.A., Landschulz,K.T., Geoghegan,K.F. and Harwood,H.J., Jr.<br>Pharmacologic inhibition of site 1 protease activity inhibits sterol regulatory element-binding protein processing and reduces lipogenic enzyme gene expression and lipid synthesis in cultured cells and experimental animals<br>J Pharmacol Exp Ther (2008) 326, 801-808. PubMed  Europe PubMed DOI  I
  68. Rojek,J.M., Lee,A.M., Nguyen,N., Spiropoulou,C.F. and Kunz,S.<br>Site 1 protease is required for proteolytic processing of the glycoproteins of the South American hemorrhagic fever viruses Junin, Machupo, and Guanarito<br>J Virol (2008) 82, 6045-6051. PubMed  Europe PubMed DOI  PMC  EPMC
    69. 2007
  69. Bergeron,E., Vincent,M.J. and Nichol,S.T.<br>Crimean-Congo hemorrhagic fever virus glycoprotein processing by the endoprotease SKI-1/S1P is critical for virus infectivity<br>J Virol (2007) 81, 13271-13276. PubMed  Europe PubMed DOI  PMC  EPMC  T
  70. Bodvard,K., Mohlin,J. and Knecht,W.<br>Recombinant expression, purification, and kinetic and inhibitor characterisation of human site-1-protease<br>Protein Expr Purif (2007) 51, 308-319. PubMed  Europe PubMed DOI  A  E
  71. De Windt,A., Rai,M., Bernier,L., Thelen,K., Soini,J., Lefebvre,C., Chintawar,S., Lavigne,J., Saarinen,L., Kytomaki,L., Munzer,J.S., Lutjohann,D., Pandolfo,M., Davignon,J., Seidah,N.G. and Laaksonen,R.<br>Gene set enrichment analysis reveals several globally affected pathways due to SKI-1/S1P inhibition in HepG2 cells<br>DNA Cell Biol (2007) 26, 765-772. PubMed  Europe PubMed DOI
  72. Hay,B.A., Abrams,B., Zumbrunn,A.Y., Valentine,J.J., Warren,L.C., Petras,S.F., Shelly,L.D., Xia,A., Varghese,A.H., Hawkins,J.L., Van Camp,J.A., Robbins,M.D., Landschulz,K. and Harwood,H.J., Jr.<br>Aminopyrrolidineamide inhibitors of site-1 protease<br>Bioorg Med Chem Lett (2007) 17, 4411-4414. PubMed  Europe PubMed DOI  I
  73. Liu,J.X., Srivastava,R., Che,P. and Howell,S.H.<br>Salt stress responses in Arabidopsis utilize a signal transduction pathway related to endoplasmic reticulum stress signaling<br>Plant J (2007) 51, 897-909. PubMed  Europe PubMed DOI  PMC  EPMC
  74. Patra,D., Xing,X., Davies,S., Bryan,J., Franz,C., Hunziker,E.B. and Sandell,L.J.<br>Site-1 protease is essential for endochondral bone formation in mice<br>J Cell Biol (2007) 179, 687-700. PubMed  Europe PubMed DOI  PMC  EPMC  K
  75. Pullikotil,P., Benjannet,S., Mayne,J. and Seidah,N.G.<br>The proprotein convertase SKI-1/S1P: alternate translation and subcellular localization<br>J Biol Chem (2007) 282, 27402-27413. PubMed  Europe PubMed DOI
  76. Seidah,N.G. and Prat,A.<br>The proprotein convertases are potential targets in the treatment of dyslipidemia<br>J Mol Med (Berl) (2007) 85, 685-696. PubMed  Europe PubMed DOI  V
    77. 2006
  77. Basak,S., Mohottalage,D. and Basak,A.<br>Multibranch and pseudopeptide approach for design of novel inhibitors of subtilisin kexin isozyme-1<br>Protein Pept Lett (2006) 13, 863-876. PubMed  Europe PubMed DOI  I
  78. Murakami,T., Kondo,S., Ogata,M., Kanemoto,S., Saito,A., Wanaka,A. and Imaizumi,K.<br>Cleavage of the membrane-bound transcription factor OASIS in response to endoplasmic reticulum stress<br>J Neurochem (2006) 96, 1090-1100. PubMed  Europe PubMed DOI
  79. [YEAR:21-6-2006]Pasquato,A., Pullikotil,P., Asselin,M.C., Vacatello,M., Paolillo,L., Ghezzo,F., Basso,F., Di Bello,C., Dettin,M. and Seidah,N.G.<br>The proprotein convertase SKI-1/S1P. In vitro analysis of Lassa virus glycoprotein-derived substrates and ex vivo validation of irreversible peptide inhibitors<br>J Biol Chem (21-6-2006) 281, 23471-23481. PubMed  Europe PubMed DOI  I
  80. Patra,D., Davies, Bryan,J., Xing,X. and Sandell,L.J.<br>Lack of endochondral ossification in site-1 protease knockout mice<br>Eur Cells and Mater (2006) 12, 8-  K
  81. Scamuffa,N., Calvo,F., Chretien,M., Seidah,N.G. and Khatib,A.M.<br>Proprotein convertases: lessons from knockouts<br>FASEB J (2006) 20, 1954-1963. PubMed  Europe PubMed DOI  K  V
  82. Stirling,J. and O'Hare,P.<br>CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P<br>Mol Biol Cell (2006) 17, 413-426. PubMed  Europe PubMed DOI  PMC  EPMC
    83. 2004
  83. [YEAR:27-8-2004]Basak,S., Stewart,N.A., Chretien,M. and Basak,A.<br>Aminoethyl benzenesulfonyl fluoride and its hexapeptide (Ac-VFRSLK) conjugate are both in vitro inhibitors of subtilisin kexin isozyme-1<br>FEBS Lett (27-8-2004) 573, 186-194. PubMed  Europe PubMed DOI  I
  84. Beatson,S. and Ponting,C.P.<br>GIFT domains: linking eukaryotic intraflagellar transport and glycosylation to bacterial gliding<br>Trends Biochem Sci (2004) 29, 396-399. PubMed  Europe PubMed DOI
  85. [YEAR:15-8-2004]Mouchantaf,R., Watt,H.L., Sulea,T., Seidah,N.G., Alturaihi,H., Patel,Y.C. and Kumar,U.<br>Prosomatostatin is proteolytically processed at the amino terminal segment by subtilase SKI-1<br>Regul Pept (15-8-2004) 120, 133-140. PubMed  Europe PubMed DOI
  86. [YEAR:16-2-2004]Pullikotil,P., Vincent,M., Nichol,S.T. and Seidah,N.G.<br>Development of protein-based inhibitors of the proprotein of convertase SKI-1/S1P: processing of SREBP-2, ATF6, and a viral glycoprotein<br>J Biol Chem (16-2-2004) 279, 17338-17347. PubMed  Europe PubMed DOI
  87. Seidah,N.G. and Chretien,M.<br>Proprotein convertase SKI-1/S1P<br>[ISSN:0-12-079610-4] (2004) 2, 1845-1847.  V
  88. [YEAR:6-8-2004]Shen,J. and Prywes,R.<br>Dependence of site-2 protease cleavage of ATF6 on prior site-1 protease digestion is determined by the size of the luminal domain of ATF6<br>J Biol Chem (6-8-2004) 279, 43046-43051. PubMed  Europe PubMed DOI
    89. 2003
  89. Beyer,W.R., Popplau,D., Garten,W., von Laer,D. and Lenz,O.<br>Endoproteolytic processing of the lymphocytic choriomeningitis virus glycoprotein by the subtilase SKI-1/S1P<br>J Virol (2003) 77, 2866-2872. PubMed  Europe PubMed DOI  PMC  EPMC
  90. Kunz,S., Edelmann,K.H., de la Torre,J.C., Gorney,R. and Oldstone,M.B.<br>Mechanisms for lymphocytic choriomeningitis virus glycoprotein cleavage, transport, and incorporation into virions<br>Virology (2003) 314, 168-178. PubMed  Europe PubMed DOI
  91. Okada,T., Haze,K., Nadanaka,S., Yoshida,H., Seidah,N.G., Hirano,Y., Sato,R., Negishi,M. and Mori,K.<br>A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6<br>J Biol Chem (2003) 278, 31024-31032. PubMed  Europe PubMed DOI  I
  92. [YEAR:25-11-2003]Schlombs,K., Wagner,T. and Scheel,J.<br>Site-1 protease is required for cartilage development in zebrafish<br>Proc Natl Acad Sci U S A (25-11-2003) 100, 14024-14029. PubMed  Europe PubMed DOI  PMC  EPMC  K
  93. Vincent,M.J., Sanchez,A.J., Erickson,B.R., Basak,A., Chretien,M., Seidah,N.G. and Nichol,S.T.<br>Crimean-Congo hemorrhagic fever virus glycoprotein proteolytic processing by subtilase SKI-1<br>J Virol (2003) 77, 8640-8649. PubMed  Europe PubMed DOI  PMC  EPMC
    94. 2002
  94. [YEAR:13-3-2002]Basak,A., Chretien,M. and Seidah,N.G.<br>A rapid fluorometric assay for the proteolytic activity of SKI-1/S1P based on the surface glycoprotein of the hemorrhagic fever Lassa virus<br>FEBS Lett (13-3-2002) 514, 333-339. PubMed  Europe PubMed DOI  A
  95. [YEAR:29-3-2002]Elagoz,A., Benjannet,S., Mammarbassi,A., Wickham,L. and Seidah,N.G.<br>Biosynthesis and cellular trafficking of the convertase SKI-1/S1P: ectodomain shedding requires SKI-1 activity<br>J Biol Chem (29-3-2002) 277, 11265-11275. PubMed  Europe PubMed DOI
  96. [YEAR:15-1-2002]Goldstein,J.L., Rawson,R.B. and Brown,M.S.<br>Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis<br>Arch Biochem Biophys (15-1-2002) 397, 139-148. PubMed  Europe PubMed DOI
  97. Raggo,C., Rapin,N., Stirling,J., Gobeil,P., Smith-Windsor,E., O'Hare,P. and Misra,V.<br>Luman, the cellular counterpart of herpes simplex virus VP16, is processed by regulated intramembrane proteolysis<br>Mol Cell Biol (2002) 22, 5639-5649. PubMed  Europe PubMed DOI  PMC  EPMC
  98. Seegmiller,A.C., Dobrosotskaya,I., Goldstein,J.L., Ho,Y.K., Brown,M.S. and Rawson,R.B.<br>The SREBP pathway in Drosophila: regulation by palmitate, not sterols<br>Dev Cell (2002) 2, 229-238. PubMed  Europe PubMed DOI
    99. 2001
  99. Caron,M., Auclair,R., Vigouroux,C., Glorian,M., Forest,C. and Capeau,J.<br>The HIV protease inhibitor indinavir impairs sterol regulatory element-binding protein-1 intranuclear localization, inhibits preadipocyte differentiation, and induces insulin resistance<br>Diabetes (2001) 50, 1378-1388. PubMed  Europe PubMed  I
  100. [YEAR:23-10-2001]Lenz,O., Ter Meulen,J., Klenk,H.D., Seidah,N.G. and Garten,W.<br>The Lassa virus glycoprotein precursor GP-C is proteolytically processed by subtilase SKI-1/S1P<br>Proc Natl Acad Sci U S A (23-10-2001) 98, 12701-12705. PubMed  Europe PubMed DOI  PMC  EPMC
  101. [YEAR:20-11-2001]Yang,J., Goldstein,J.L., Hammer,R.E., Moon,Y.A., Brown,M.S. and Horton,J.D.<br>Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene<br>Proc Natl Acad Sci U S A (20-11-2001) 98, 13607-13612. PubMed  Europe PubMed DOI  PMC  EPMC  K
    102. 2000
  102. Nakajima,T., Iwaki,K., Kodama,T., Inazawa,J. and Emi,M.<br>Genomic structure and chromosomal mapping of the human Site-1 protease (S1P) gene<br>J Hum Genet (2000) 45, 212-217. PubMed  Europe PubMed DOI
  103. Toure,B.B., Munzer,J.S., Basak,A., Benjannet,S., Rochemont,J., Lazure,C., Chretien,M. and Seidah,N.G.<br>Biosynthesis and enzymatic characterization of human SKI-1/S1P and the processing of its inhibitory prosegment<br>J Biol Chem (2000) 275, 2349-2358. PubMed  Europe PubMed DOI
  104. Ye,J., Rawson,R.B., Komuro,R., Chen,X., Dave,U.P., Prywes,R., Brown,M.S. and Goldstein,J.L.<br>ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs<br>Mol Cell (2000) 6, 1355-1364. PubMed  Europe PubMed DOI
    105. 1999
  105. [YEAR:28-9-1999]Brown,M.S. and Goldstein,J.L.<br>A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood<br>Proc Natl Acad Sci U S A (28-9-1999) 96, 11041-11048. PubMed  Europe PubMed DOI  PMC  EPMC
  106. [YEAR:6-8-1999]Cheng,D., Espenshade,P.J., Slaughter,C.A., Jaen,J.C., Brown,M.S. and Goldstein,J.L.<br>Secreted site-1 protease cleaves peptides corresponding to luminal loop of sterol regulatory element-binding proteins<br>J Biol Chem (6-8-1999) 274, 22805-22812. PubMed  Europe PubMed DOI
  107. [YEAR:23-12-1999]DeBose-Boyd,R.A., Brown,M.S., Li,W.P., Nohturfft,A., Goldstein,J.L. and Espenshade,P.J.<br>Transport-dependent proteolysis of SREBP: Relocation of Site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi<br>Cell (23-12-1999) 99, 703-712. PubMed  Europe PubMed
  108. [YEAR:6-8-1999]Espenshade,P.J., Cheng,D., Goldstein,J.L. and Brown,M.S.<br>Autocatalytic processing of site-1 protease removes propeptide and permits cleavage of sterol regulatory element-binding proteins<br>J Biol Chem (6-8-1999) 274, 22795-22804. PubMed  Europe PubMed DOI
  109. Seidah,N.G., Benjannet,S., Hamelin,J., Mamarbachi,A.M., Basak,A., Marcinkiewicz,J., Mbikay,M., Chretien,M. and Marcinkiewicz,M.<br>The subtilisin/kexin family of precursor convertases. Emphasis on PC1, PC2/7B2, POMC and the novel enzyme SKI-1<br>Ann N Y Acad Sci (1999) 885, 57-74. PubMed  Europe PubMed
  110. [YEAR:16-2-1999]Seidah,N.G., Mowla,S.J., Hamelin,J., Mamarbachi,A.M., Benjannet,S., Toure,B.B., Basak,A., Munzer,J.S., Marcinkiewicz,J., Zhong,M., Barale,J.C., Lazure,C., Murphy,R.A., Chretien,M. and Marcinkiewicz,M.<br>Mammalian subtilisin/kexin isozyme SKI-1: a widely expressed proprotein convertase with a unique cleavage specificity and cellular localization<br>Proc Natl Acad Sci U S A (16-2-1999) 96, 1321-1326. PubMed  Europe PubMed DOI  PMC  EPMC
    111. 1998
  111. Sakai,J., Rawson,R.B., Espenshade,P.J., Cheng,D., Seegmiller,A.C., Goldstein,J.L. and Brown,M.S.<br>Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells<br>Mol Cell (1998) 2, 505-514. PubMed  Europe PubMed
    112. 1996
  112. [YEAR:28-6-1996]Sakai,J., Duncan,E.A., Rawson,R.B., Hua,X., Brown,M.S. and Goldstein,J.L.<br>Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment<br>Cell (28-6-1996) 85, 1037-1046. PubMed  Europe PubMed DOI

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use