$VAR1 = undef;

Summary for peptidase S08.063: site-1 peptidase

Names
MEROPS Name	site-1 peptidase
Other names	AtS1P (Arabidopsis thaliana), AtSBT6.1 (Arabidopsis thaliana), KIAA0091 putative peptidase, mammalian subtilisin/kexin isozyme 1, MBTPS1 g.p. (Homo sapiens), membrane-bound transcription factor peptidase site 1, proprotein convertase SKI-1, PS1, SKI-1 (Mus musculus), S1P protease, sterol regulatory element-binding protein site 1 protease, site-1 protease, SREBP S1 protease

Domain architecture

MEROPS Classification
Classification	Clan SB >> Subclan (none) >> Family S8 >> Subfamily A >> S08.063
Holotype	site-1 peptidase (Cricetulus griseus), Uniprot accession Q9Z2A8 (peptidase unit: 179-473), MERNUM MER0004988
History	Identifier created: MEROPS 3.1 (22 December 1998)

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00356
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.112
Enzymology	BRENDA database
Proteolytic events	CutDB database (10 cleavages)
Activity status	human: active (Seidah & Chretien, 2004) mouse: active (by similarity) (Cheng et al., 1999)
Other databases	TREEFAM	http://www.treefam.org/family/TF324501
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	R/rsk/L/Lags/ft/fe/st (based on 31 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	1	0	0	8	0	0	0
Pro	0	0	2	0	0	0	1	1
Ala	0	0	0	2	8	2	2	2
Val	0	0	4	0	1	0	0	0
Leu	0	0	20	19	0	4	3	3
Ile	0	0	3	0	1	1	1	0
Met	0	0	0	0	0	0	0	0
Phe	0	0	1	1	1	9	11	0
Tyr	0	0	0	0	1	2	0	0
Trp	0	0	0	0	0	0	0	0
Ser	0	6	0	1	5	1	2	11
Thr	1	2	0	1	1	7	0	7
Cys	0	1	0	0	0	0	0	0
Asn	0	3	0	0	1	0	0	0
Gln	1	2	0	1	1	0	0	0
Asp	0	0	0	0	0	1	2	3
Glu	0	0	0	0	0	1	6	1
Lys	0	4	0	4	0	1	1	1
Arg	28	11	1	1	2	0	1	1
His	0	1	0	1	0	1	0	0