Substrates for peptidase S08.039: PCSK9 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
proprotein convertase 9	Q80W65	35-694	peptide-Met86+Glu-peptide	P	Val	Val	Leu	Met	Glu	Glu	Thr	Gln	Seidah et al., 2003
proprotein convertase 9 precursor	Q8NBP7	31-692	peptide-Leu82+Lys-peptide	P	Val	Val	Val	Leu	Lys	Glu	Glu	Thr	Seidah et al., 2003	4051
proprotein convertase 9 precursor	Q8NBP7	31-692	peptide-Gln152+Ser-peptide	P	Val	Phe	Ala	Gln	Ser	Ile	Pro	Trp	Benjannet et al., 2004	20647