Sequence features for peptidase S08.039: PCSK9 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

 

MERNUM Species Sequence length Peptidase unit Active site residues Source
MER0298521 Alligator sinensis 709 167-613 D209, H249, N340, S409 GENBANK:XP_006025909
MER0686266 Aptenodytes forsteri 596 69-518 D111, H151, N242, S311, GENBANK:XP_009285775
MER0685680 Aquila chrysaetos 657 130-571 D172, H212, N303, S372 GENBANK:XP_011570448
MER0556482 Astatotilapia burtoni 639 103-522 D148, H188, N279, S348 GENBANK:XP_005923322
MER0362335 Astyanax mexicanus 675 135-570 D177, H217, N308, S377 UNIPROT:W5L1M5
MER0362335 Astyanax mexicanus 675 135-570 D177, H217, N308, S377 UNIPROT:W5L1M5
MER0384864 Balaenoptera acutorostrata 659 84-538 D126, H166, N257, S326 GENBANK:XP_007164449
MER0498750 butyrate-producing bacterium SSC/2 558 89-546 D103, H171, N286, S491 GENBANK:YP_007788851
MER0401635 Callithrix jacchus 690 189-413 D184, H224, D319, S384 UNIPROT:A8T688
MER0401635 Callithrix jacchus 690 189-413 D184, H224, D319, S384 UNIPROT:A8T688
MER0677427 Camelus dromedarius 684 136-590 D178, H218, N309, S378 GENBANK:XP_010982926
MER0335507 Camelus ferus 651 103-557 D145, H185, N276, S345 GENBANK:XP_006180212
MER0103883 Cavia porcellus 688 142-594 D184, H224, N315, S384 GENBANK:XP_003464101
MER0541471 Ceratotherium simum 689 140-594 D186, H226, N317, S386 GENBANK:XP_004438688
MER0591243 Chelonia mydas 679 136-589 D178, H218, N309, S378 UNIPROT:M7BNK4
MER0591243 Chelonia mydas 679 136-589 D178, H218, N309, S378 UNIPROT:M7BNK4
MER0583855 Chinchilla lanigera 690 144-596 D186, H226, N317, S386 GENBANK:XP_005398562
MER0577978 Chrysemys picta 679 136-589 D178, H218, N309, S378 GENBANK:XP_005284930
MER0574572 Chrysochloris asiatica 687 143-597 D185, H225, N316, S385 GENBANK:XP_006839877
MER0221802 Clostridium saccharolyticum 566 91-549 D105, H173, N288, S496 UNIPROT:D9R956
MER0221802 Clostridium saccharolyticum 566 91-549 D105, H173, N288, S496 UNIPROT:D9R956
MER0401652 Cricetulus griseus 658 114-568 D156, H196, N287, S356 GENBANK:XP_007624971
MER0664986 Cuculus canorus 546 124-541 D166, H206, N302, S371 GENBANK:XP_009558988
MER0567040 Cynoglossus semilaevis 663 133-579 D178, H218, N307, S376 GENBANK:XP_008305323
MER0171403 Danio rerio 667 135-586 D177, H217, N308, S377 GENBANK:XP_001922940
MER0605417 Dasypus novemcinctus 730 141-595 D183, H223, N314, S383 GENBANK:XP_004468035
MER0664489 Egretta garzetta 588 61-510 D103, H143, N234, S303 GENBANK:XP_009634473
MER0564469 Elephantulus edwardii 688 140-594 D182, H222, N313, S382 GENBANK:XP_006879886
MER0198245 Eubacterium rectale 530 79-522 D90, H146, N261, S467 UNIPROT:C4ZHC4
MER0198245 Eubacterium rectale 530 79-522 D90, H146, N261, S467 UNIPROT:C4ZHC4
MER0560649 Falco cherrug 602 76-524 D118, H157, N248, S317 GENBANK:XP_005440485
MER0657029 Fukomys damarensis 596 48-500 D90, H130, N221, S290 GENBANK:XP_010608727
MER0557792 Galeopterus variegatus 689 141-595 D183, H223, N314, S383 GENBANK:XP_008568363
MER0401657 Gallus gallus 815 284-737 D326, H366, N457, S526 GENBANK:XP_003641739
MER0652387 Haliaeetus leucocephalus 656 129-578 D171, H211, N302, S371 GENBANK:XP_010580996
MER0401645 Heterocephalus glaber 564 140-556 D182, H222, N313, S382 GENBANK:XP_004869694
MER0022416 Homo sapiens 692 143-597 D186, H226, N317, S386 GENBANK:ACN81318
MER0022416 Homo sapiens 692 143-597 D186, H226, N317, S386 GENBANK:ACN81318
MER0022416 Homo sapiens 692 143-597 D186, H226, N317, S386 GENBANK:ACN81318
MER0022416 Homo sapiens 692 143-597 D186, H226, N317, S386 GENBANK:ACN81318
MER0022416 Homo sapiens 692 143-597 D186, H226, N317, S386 GENBANK:ACN81318
MER0414236 Latimeria chalumnae 672 134-583 D176, H216, N307, S376 GENBANK:XP_006005563
MER0554290 Lepisosteus oculatus 636 103-514 D145, H185, N276, S345 GENBANK:XP_006635074
MER0548542 Lipotes vexillifer 659 84-538 D126, H166, N257, S326 GENBANK:XP_007471195
MER0062545 Loktanella vestfoldensis 741 1-547 D128, H156, N258, S339 UNIPROT:A3V738
MER0062545 Loktanella vestfoldensis 741 1-547 D128, H156, N258, S339 UNIPROT:A3V738
MER0161661 Macaca mulatta 692 144-598 D186, H226, N317, S386 GENBANK:NP_001106130
MER0161661 Macaca mulatta 692 144-598 D186, H226, N317, S386 GENBANK:NP_001106130
MER0161661 Macaca mulatta 692 144-598 D186, H226, N317, S386 GENBANK:NP_001106130
MER0161661 Macaca mulatta 692 144-598 D186, H226, N317, S386 GENBANK:NP_001106130
MER0647614 Manacus vitellinus 630 106-552 D148, H188, N279, S348 GENBANK:XP_008923471
MER0543741 Maylandia zebra 670 133-553 D178, H218, N309, S378 GENBANK:XP_004557251
MER0401658 Meleagris gallopavo 569 19-468 D61, H101, N192, S261 GENBANK:XP_003208913
MER0544037 Mesocricetus auratus 663 146-567 D192, H232, N323, S392 GENBANK:XP_005072304
MER0538063 Microtus ochrogaster 746 210-652 D252, H292, P374, S440 GENBANK:XP_005353682
MER0022415 Mus musculus 694 147-601 D189, H229, N320, S389 GENBANK:BAC31452
MER0022415 Mus musculus 694 147-601 D189, H229, N320, S389 GENBANK:BAC31452
MER0640681 Nannospalax galili 693 145-599 D187, H227, N318, S387 GENBANK:XP_008831203
MER0535306 Neolamprologus brichardi 663 159-546 D172, H212, N303, S372 GENBANK:XP_006790216
MER0256955 Nomascus leucogenys 693 145-599 D187, H227, N318, S387 UNIPROT:G1RWX5
MER0256955 Nomascus leucogenys 693 145-599 D187, H227, N318, S387 UNIPROT:G1RWX5
MER0635291 Notothenia coriiceps 661 133-574 D178, H218, N309, S378 GENBANK:XP_010778919
MER0532479 Octodon degus 686 140-592 D182, H222, N313, S382 GENBANK:XP_004642652
MER0529611 Orcinus orca 692 143-597 D185, H225, N316, S385 GENBANK:XP_004273850
MER0401663 Oreochromis niloticus 669 133-552 D178, H218, N309, S378 UNIPROT:I3J3V1
MER0401663 Oreochromis niloticus 669 133-552 D178, H218, N309, S378 UNIPROT:I3J3V1
MER0528541 Orycteropus afer 686 145-596 D187, H227, N318, S387 GENBANK:XP_007954479
MER0605204 Oryctolagus cuniculus 697 146-603 D193, H233, N324, S393 GENBANK:XP_008263420
MER0401640 Otolemur garnettii 670 144-598 D186, H226, N317, S386 GENBANK:XP_003793200
MER0401639 Pan paniscus 811 263-717 D305, H345, N436, S505 GENBANK:XP_003815030
MER0071709 Pan troglodytes 692 144-598 D186, H226, N317, S386 GENBANK:NP_001104592
MER0071709 Pan troglodytes 692 144-598 D186, H226, N317, S386 GENBANK:NP_001104592
MER0071709 Pan troglodytes 692 144-598 D186, H226, N317, S386 GENBANK:NP_001104592
MER0071709 Pan troglodytes 692 144-598 D186, H226, N317, S386 GENBANK:NP_001104592
MER0525172 Pelodiscus sinensis 679 137-590 D179, H219, N310, S379 GENBANK:XP_006133549
MER0521063 Physeter catodon 693 144-598 D186, H226, N317, S386 GENBANK:XP_007110136
MER0629804 Picoides pubescens 542 85-504 D127, H167, N258, S327 GENBANK:XP_009900496
MER0514312 Poecilia reticulata 671 136-568 D181, H221, N312, S381 GENBANK:XP_008405611
MER0401643 Pongo abelii 809 261-715 D303, H343, N434, S503 GENBANK:XP_002810823
MER0014057 Rattus norvegicus 691 143-597 D185, H225, N316, S385 UNIPROT:P59996
MER0014057 Rattus norvegicus 691 143-597 D185, H225, N316, S385 UNIPROT:P59996
MER0014057 Rattus norvegicus 691 143-597 D185, H225, N316, S385 UNIPROT:P59996
MER0133802 Rhizobium leguminosarum 792 241-624 D247, H279, N391, S545 UNIPROT:B6A3T9
MER0133802 Rhizobium leguminosarum 792 241-624 D247, H279, N391, S545 UNIPROT:B6A3T9
MER0508703 Roseburia intestinalis 561 61-548 D102, H170, N285, S493 GENBANK:YP_007833406
MER0509957 Ruminococcus obeum 562 91-550 D102, H168, N283, S495 GENBANK:YP_007805532
MER0509721 Ruminococcus sp. SR1/5 603 82-600 D123, H213, N328, S536 GENBANK:YP_007785040
MER0512717 Saimiri boliviensis 691 143-597 D185, H225, N316, S385 GENBANK:XP_003921563
MER0401649 Sarcophilus harrisii 704 158-611 D200, H240, N331, S400 GENBANK:XP_003767361
MER0401646 Sus scrofa 704 142-609 D197, H237, N328, S397 GENBANK:XP_005653495
MER0409648 synthetic construct 692 144-598 D186, H226, N317, S386 GENBANK:AAI66619
MER0172533 Taeniopygia guttata 589 2-247 A16, H49, N140, S209 GENBANK:XP_002194239
MER0596558 Tarsius syrichta 679 132-586 D174, H214, N305, S374 GENBANK:XP_008063625
MER0166219 Tetraodon nigroviridis 465 73-445 D109, H148, N239, S339 UNIPROT:Q4RL06
MER0166219 Tetraodon nigroviridis 465 73-445 D109, H148, N239, S339 UNIPROT:Q4RL06
MER0486543 Trichechus manatus 690 142-596 D184, H224, N315, S384 GENBANK:XP_004371755
MER0597854 Tupaia chinensis 737 142-589 D184, H224, G308, S377 GENBANK:XP_006146165
MER0616977 Vicugna pacos 695 141-601 D183, H223, N314, S383 GENBANK:XP_006200643
MER0172800 Xenopus laevis 676 135-588 D177, H217, N308, S377 GENBANK:NP_001088613
MER0401650 Xenopus tropicalis 676 135-588 D177, H217, N308, S377 GENBANK:XP_002931479