Sequence features for peptidase S08.039: PCSK9 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

 

MERNUM Species Sequence length Peptidase unit Active site residues Source
MER0298521 Alligator sinensis 709 167-613 D209, H249, N340, S409 GENBANK:XP_006025909
MER0686266 Aptenodytes forsteri 596 69-518 D111, H151, N242, S311, GENBANK:XP_009285775
MER0685680 Aquila chrysaetos 657 130-571 D172, H212, N303, S372 GENBANK:XP_011570448
MER0556482 Astatotilapia burtoni 639 103-522 D148, H188, N279, S348 GENBANK:XP_005923322
MER0362335 Astyanax mexicanus 675 135-570 D177, H217, N308, S377 UNIPROT:W5L1M5
MER0362335 Astyanax mexicanus 675 135-570 D177, H217, N308, S377 UNIPROT:W5L1M5
MER0384864 Balaenoptera acutorostrata 659 84-538 D126, H166, N257, S326 GENBANK:XP_007164449
MER0498750 butyrate-producing bacterium SSC/2 558 89-546 D103, H171, N286, S491 GENBANK:YP_007788851
MER0401635 Callithrix jacchus 690 189-413 D184, H224, D319, S384 UNIPROT:A8T688
MER0401635 Callithrix jacchus 690 189-413 D184, H224, D319, S384 UNIPROT:A8T688
MER0677427 Camelus dromedarius 684 136-590 D178, H218, N309, S378 GENBANK:XP_010982926
MER0335507 Camelus ferus 651 103-557 D145, H185, N276, S345 GENBANK:XP_006180212
MER0103883 Cavia porcellus 688 142-594 D184, H224, N315, S384 GENBANK:XP_003464101
MER0541471 Ceratotherium simum 689 140-594 D186, H226, N317, S386 GENBANK:XP_004438688
MER0591243 Chelonia mydas 679 136-589 D178, H218, N309, S378 UNIPROT:M7BNK4
MER0591243 Chelonia mydas 679 136-589 D178, H218, N309, S378 UNIPROT:M7BNK4
MER0583855 Chinchilla lanigera 690 144-596 D186, H226, N317, S386 GENBANK:XP_005398562
MER0577978 Chrysemys picta 679 136-589 D178, H218, N309, S378 GENBANK:XP_005284930
MER0574572 Chrysochloris asiatica 687 143-597 D185, H225, N316, S385 GENBANK:XP_006839877
MER0221802 Clostridium saccharolyticum 566 91-549 D105, H173, N288, S496 UNIPROT:D9R956
MER0221802 Clostridium saccharolyticum 566 91-549 D105, H173, N288, S496 UNIPROT:D9R956
MER0401652 Cricetulus griseus 658 114-568 D156, H196, N287, S356 GENBANK:XP_007624971
MER0664986 Cuculus canorus 546 124-541 D166, H206, N302, S371 GENBANK:XP_009558988
MER0567040 Cynoglossus semilaevis 663 133-579 D178, H218, N307, S376 GENBANK:XP_008305323
MER0171403 Danio rerio 667 135-586 D177, H217, N308, S377 GENBANK:XP_001922940
MER0605417 Dasypus novemcinctus 730 141-595 D183, H223, N314, S383 GENBANK:XP_004468035
MER0664489 Egretta garzetta 588 61-510 D103, H143, N234, S303 GENBANK:XP_009634473
MER0564469 Elephantulus edwardii 688 140-594 D182, H222, N313, S382 GENBANK:XP_006879886
MER0198245 Eubacterium rectale 530 79-522 D90, H146, N261, S467 UNIPROT:C4ZHC4
MER0198245 Eubacterium rectale 530 79-522 D90, H146, N261, S467 UNIPROT:C4ZHC4
MER0560649 Falco cherrug 602 76-524 D118, H157, N248, S317 GENBANK:XP_005440485
MER0657029 Fukomys damarensis 596 48-500 D90, H130, N221, S290 GENBANK:XP_010608727
MER0557792 Galeopterus variegatus 689 141-595 D183, H223, N314, S383 GENBANK:XP_008568363
MER0401657 Gallus gallus 815 284-737 D326, H366, N457, S526 GENBANK:XP_003641739
MER0652387 Haliaeetus leucocephalus 656 129-578 D171, H211, N302, S371 GENBANK:XP_010580996
MER0401645 Heterocephalus glaber 564 140-556 D182, H222, N313, S382 GENBANK:XP_004869694
MER0022416 Homo sapiens 692 143-597 D186, H226, N317, S386 GENBANK:ACN81318
MER0022416 Homo sapiens 692 143-597 D186, H226, N317, S386 GENBANK:ACN81318
MER0022416 Homo sapiens 692 143-597 D186, H226, N317, S386 GENBANK:ACN81318
MER0022416 Homo sapiens 692 143-597 D186, H226, N317, S386 GENBANK:ACN81318
MER0022416 Homo sapiens 692 143-597 D186, H226, N317, S386 GENBANK:ACN81318
MER0414236 Latimeria chalumnae 672 134-583 D176, H216, N307, S376 GENBANK:XP_006005563
MER0554290 Lepisosteus oculatus 636 103-514 D145, H185, N276, S345 GENBANK:XP_006635074
MER0548542 Lipotes vexillifer 659 84-538 D126, H166, N257, S326 GENBANK:XP_007471195
MER0062545 Loktanella vestfoldensis 741 1-547 D128, H156, N258, S339 UNIPROT:A3V738
MER0062545 Loktanella vestfoldensis 741 1-547 D128, H156, N258, S339 UNIPROT:A3V738
MER0161661 Macaca mulatta 692 144-598 D186, H226, N317, S386 GENBANK:NP_001106130
MER0161661 Macaca mulatta 692 144-598 D186, H226, N317, S386 GENBANK:NP_001106130
MER0161661 Macaca mulatta 692 144-598 D186, H226, N317, S386 GENBANK:NP_001106130
MER0161661 Macaca mulatta 692 144-598 D186, H226, N317, S386 GENBANK:NP_001106130
MER0647614 Manacus vitellinus 630 106-552 D148, H188, N279, S348 GENBANK:XP_008923471
MER0543741 Maylandia zebra 670 133-553 D178, H218, N309, S378 GENBANK:XP_004557251
MER0401658 Meleagris gallopavo 569 19-468 D61, H101, N192, S261 GENBANK:XP_003208913
MER0544037 Mesocricetus auratus 663 146-567 D192, H232, N323, S392 GENBANK:XP_005072304
MER0538063 Microtus ochrogaster 746 210-652 D252, H292, P374, S440 GENBANK:XP_005353682
MER0022415 Mus musculus 694 147-601 D189, H229, N320, S389 GENBANK:BAC31452
MER0022415 Mus musculus 694 147-601 D189, H229, N320, S389 GENBANK:BAC31452
MER0640681 Nannospalax galili 693 145-599 D187, H227, N318, S387 GENBANK:XP_008831203
MER0535306 Neolamprologus brichardi 663 159-546 D172, H212, N303, S372 GENBANK:XP_006790216
MER0256955 Nomascus leucogenys 693 145-599 D187, H227, N318, S387 UNIPROT:G1RWX5
MER0256955 Nomascus leucogenys 693 145-599 D187, H227, N318, S387 UNIPROT:G1RWX5
MER0635291 Notothenia coriiceps 661 133-574 D178, H218, N309, S378 GENBANK:XP_010778919
MER0532479 Octodon degus 686 140-592 D182, H222, N313, S382 GENBANK:XP_004642652
MER0529611 Orcinus orca 692 143-597 D185, H225, N316, S385 GENBANK:XP_004273850
MER0401663 Oreochromis niloticus 669 133-552 D178, H218, N309, S378 UNIPROT:I3J3V1
MER0401663 Oreochromis niloticus 669 133-552 D178, H218, N309, S378 UNIPROT:I3J3V1
MER0528541 Orycteropus afer 686 145-596 D187, H227, N318, S387 GENBANK:XP_007954479
MER0605204 Oryctolagus cuniculus 697 146-603 D193, H233, N324, S393 GENBANK:XP_008263420
MER0401640 Otolemur garnettii 670 144-598 D186, H226, N317, S386 GENBANK:XP_003793200
MER0401639 Pan paniscus 811 263-717 D305, H345, N436, S505 GENBANK:XP_003815030
MER0071709 Pan troglodytes 692 144-598 D186, H226, N317, S386 GENBANK:NP_001104592
MER0071709 Pan troglodytes 692 144-598 D186, H226, N317, S386 GENBANK:NP_001104592
MER0071709 Pan troglodytes 692 144-598 D186, H226, N317, S386 GENBANK:NP_001104592
MER0071709 Pan troglodytes 692 144-598 D186, H226, N317, S386 GENBANK:NP_001104592
MER0525172 Pelodiscus sinensis 679 137-590 D179, H219, N310, S379 GENBANK:XP_006133549
MER0521063 Physeter catodon 693 144-598 D186, H226, N317, S386 GENBANK:XP_007110136
MER0629804 Picoides pubescens 542 85-504 D127, H167, N258, S327 GENBANK:XP_009900496
MER0514312 Poecilia reticulata 671 136-568 D181, H221, N312, S381 GENBANK:XP_008405611
MER0401643 Pongo abelii 809 261-715 D303, H343, N434, S503 GENBANK:XP_002810823
MER0014057 Rattus norvegicus 691 143-597 D185, H225, N316, S385 UNIPROT:P59996
MER0014057 Rattus norvegicus 691 143-597 D185, H225, N316, S385 UNIPROT:P59996
MER0014057 Rattus norvegicus 691 143-597 D185, H225, N316, S385 UNIPROT:P59996
MER0133802 Rhizobium leguminosarum 792 241-624 D247, H279, N391, S545 UNIPROT:B6A3T9
MER0133802 Rhizobium leguminosarum 792 241-624 D247, H279, N391, S545 UNIPROT:B6A3T9
MER0508703 Roseburia intestinalis 561 61-548 D102, H170, N285, S493 GENBANK:YP_007833406
MER0509957 Ruminococcus obeum 562 91-550 D102, H168, N283, S495 GENBANK:YP_007805532
MER0509721 Ruminococcus sp. SR1/5 603 82-600 D123, H213, N328, S536 GENBANK:YP_007785040
MER0512717 Saimiri boliviensis 691 143-597 D185, H225, N316, S385 GENBANK:XP_003921563
MER0401649 Sarcophilus harrisii 704 158-611 D200, H240, N331, S400 GENBANK:XP_003767361
MER0401646 Sus scrofa 704 142-609 D197, H237, N328, S397 GENBANK:XP_005653495
MER0409648 synthetic construct 692 144-598 D186, H226, N317, S386 GENBANK:AAI66619
MER0172533 Taeniopygia guttata 589 2-247 A16, H49, N140, S209 GENBANK:XP_002194239
MER0596558 Tarsius syrichta 679 132-586 D174, H214, N305, S374 GENBANK:XP_008063625
MER0166219 Tetraodon nigroviridis 465 73-445 D109, H148, N239, S339 UNIPROT:Q4RL06
MER0166219 Tetraodon nigroviridis 465 73-445 D109, H148, N239, S339 UNIPROT:Q4RL06
MER0486543 Trichechus manatus 690 142-596 D184, H224, N315, S384 GENBANK:XP_004371755
MER0597854 Tupaia chinensis 737 142-589 D184, H224, G308, S377 GENBANK:XP_006146165
MER0616977 Vicugna pacos 695 141-601 D183, H223, N314, S383 GENBANK:XP_006200643
MER0172800 Xenopus laevis 676 135-588 D177, H217, N308, S377 GENBANK:NP_001088613
MER0401650 Xenopus tropicalis 676 135-588 D177, H217, N308, S377 GENBANK:XP_002931479