Structure for peptidase S08.039: PCSK9 peptidase

PDB	Organism	Resolution	Comment
2P4E_P	Homo sapiens	1.98 Å	mature
The catalytic residues are shown in ball-and-stick representation: Asp186 in pink, His226 in purple, Asn317 in dark pink and Ser386 in orange. The propeptide is shown in grey ribbon representation.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Homo sapiens
mature peptidase	1.98 Å	2P4E	2P4E	2P4E	2P4E	2P4E	2P4E	Cunningham et al., 2007
mature peptidase	2.30 Å	2PMW	2PMW	2PMW	2PMW	2PMW	2PMW	Piper et al., 2007
the crystal structure of pcsk9 at 1.9 angstroms resolution reveals structural homology to resistin within the c- terminal domain	1.90 Å	2QTW	2QTW	2QTW	2QTW	2QTW	2QTW	Hampton et al., 2007
wt pcsk9-deltac bound to wt egf-a of ldlr	2.40 Å	2W2M	2W2M	2W2M	2W2M	2W2M	2W2M	Bottomley et al., 2009
wt pcsk9-deltac bound to egf-a h306y mutant of ldlr	2.30 Å	2W2N	2W2N	2W2N	2W2N	2W2N	2W2N	Bottomley et al., 2009
pcsk9-deltac d374y mutant bound to wt egf-a of ldlr	2.62 Å	2W2O	2W2O	2W2O	2W2O	2W2O	2W2O	Bottomley et al., 2009
pcsk9-deltac d374a mutant bound to wt egf-a of ldlr	2.62 Å	2W2P	2W2P	2W2P	2W2P	2W2P	2W2P	Bottomley et al., 2009
pcsk9-deltac d374h mutant bound to wt egf-a of ldlr	2.33 Å	2W2Q	2W2Q	2W2Q	2W2Q	2W2Q	2W2Q	Bottomley et al., 2009
pcsk9:egf-a complex	2.41 Å	3BPS	3BPS	3BPS	3BPS	3BPS	3BPS	Kwon et al., 2008
pcsk9:egfa(h306y)	2.70 Å	3GCW	3GCW	3GCW	3GCW	3GCW	3GCW
pcsk9:egfa (ph 7.4)	2.70 Å	3GCX	3GCX	3GCX	3GCX	3GCX	3GCX
complex with FAB from ldlr competitive antibody	2.30 Å	3H42	3H42	3H42	3H42	3H42	3H42	Chan et al., 2009