Summary for peptidase S08.039: PCSK9 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma


MEROPS NamePCSK9 peptidase
Other namesMername-AA185 peptidase, NARC-1, neural apoptosis-regulated convertase 1, PC9, PCSK9 g.p. (Homo sapiens), proprotein convertase 9, proprotein convertase subtilisin/kexin 9
Domain architecture
MEROPS Classification
Classification Clan SB >> Subclan (none) >> Family S8 >> Subfamily A >> S08.039
HolotypePCSK9 peptidase (Mus musculus), Uniprot accession Q80W65 (peptidase unit: 147-601), MERNUM MER0022415
History Identifier created: MEROPS 6.1 (10 January 2003)
Catalytic typeSerine
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (2 cleavages)
Activity statushuman: putative (Naureckiene etal, 2003)
mouse: putative
KnockoutMutations in proprotein convertase 9 have been associated with autosomal dominant hypercholesterolemia (Abifadel et al., 2003; Maxwell & Breslow, 2005).
Other databases TREEFAM
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
PCSK9 1p32.2 ENSG00000169174 255738 PCSK9
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Pcsk9 4:C7 ENSMUSG00000044254 100102 MGI:2140260