Summary for peptidase S08.039: PCSK9 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

 

Names
MEROPS NamePCSK9 peptidase
Other namesMername-AA185 peptidase, NARC-1, neural apoptosis-regulated convertase 1, PC9, PCSK9 g.p. (Homo sapiens), proprotein convertase 9, proprotein convertase subtilisin/kexin 9
Domain architecture
MEROPS Classification
Classification Clan SB >> Subclan (none) >> Family S8 >> Subfamily A >> S08.039
HolotypePCSK9 peptidase (Mus musculus), Uniprot accession Q80W65 (peptidase unit: 147-601), MERNUM MER0022415
History Identifier created: MEROPS 6.1 (10 January 2003)
Activity
Catalytic typeSerine
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (2 cleavages)
Activity statushuman: putative (Naureckiene etal, 2003)
mouse: putative
KnockoutMutations in proprotein convertase 9 have been associated with autosomal dominant hypercholesterolemia (Abifadel et al., 2003; Maxwell & Breslow, 2005).
Other databases TREEFAMhttp://www.treefam.org/family/TF106271
PANTHERhttp://www.pantherdb.org/panther/familyList.do?searchType=basic&fieldName=all&listType=6&fieldValue=PTHR43806:SF21
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
PCSK9 1p32.2 ENSG00000169174 255738 PCSK9
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Pcsk9 4:C7 ENSMUSG00000044254 100102 MGI:2140260