$VAR1 = undef;

Summary for peptidase S08.024: dentilisin

Names
MEROPS Name	dentilisin
Other names	CTLP, membrane-associated chymotrypsin-like protease, PrtP g.p. (Treponema denticola), trepolisin

Domain architecture

MEROPS Classification
Classification	Clan SB >> Subclan (none) >> Family S8 >> Subfamily A >> S08.024
Holotype	dentilisin (Treponema denticola) (peptidase unit: 161-640), MERNUM MER0002739
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00348
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (2 cleavages)
Physiology	Thought to contribute to pathogenesis of periodontal disease caused by the organism.
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	akq/a/p/fg/l/-/- (based on 17 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	1	2	0	0	4	0	0	0
Pro	0	0	5	0	0	2	0	0
Ala	4	6	2	2	0	0	0	0
Val	0	1	2	1	0	0	1	0
Leu	1	0	0	1	0	3	1	1
Ile	1	1	2	2	0	2	1	1
Met	0	0	0	0	0	0	2	0
Phe	0	0	2	7	1	1	1	1
Tyr	0	0	1	0	0	0	0	0
Trp	0	0	0	0	0	0	0	0
Ser	0	0	0	0	0	0	0	1
Thr	0	0	0	0	0	0	0	0
Cys	0	0	0	0	0	0	0	0
Asn	0	0	0	0	0	0	0	0
Gln	3	2	0	1	1	0	0	1
Asp	0	0	1	0	1	0	0	0
Glu	0	2	0	0	0	0	1	0
Lys	3	0	1	2	0	1	2	1
Arg	2	2	0	1	2	2	1	1
His	0	1	0	0	2	0	0	1