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Literature for peptidase S07.001: flavivirin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, P Specificity, I Inhibitor, E Expression, L Localization, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2023
  1. Agback,T., Lesovoy,D., Han,X., Lomzov,A., Sun,R., Sandalova,T., Orekhov,V.Y., Achour,A. and Agback,P. \<br\>Combined NMR and molecular dynamics conformational filter identifies unambiguously dynamic ensembles of Dengue protease NS2B/NS3pro\<br\>Commun Biol (2023) 6, 1193. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Akram,M., Hameed,S., Hassan,A. and Khan,K. \<br\>Development in the Inhibition of Dengue Proteases as Drug Targets\<br\>Curr Med Chem (2023) PubMed  Europe PubMed DOI  V
  3. Coronado,M.A., Gering,I., Sevenich,M., Olivier,D.S., Mastalipour,M., Amaral,M.S., Willbold,D. and Eberle,R.J. \<br\>The Importance of Epigallocatechin as a Scaffold for Drug Development against Flaviviruses\<br\>Pharmaceutics (2023) 15, PubMed  Europe PubMed DOI  PMC  EPMC
  4. Gandhi,L., Maisnam,D., Rathore,D., Chauhan,P., Bonagiri,A. and Venkataramana,M. \<br\>Differential localization of dengue virus protease affects cell homeostasis and triggers to thrombocytopenia\<br\>iScience (2023) 26, 107024. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Incicco,J.J., Cababie,L.A., Sarto,C., Adler,N.S., Amrein,F., Mikkelsen,E., Arrar,M. and Kaufman,S.B. \<br\>Thermodynamic and mechanistic analysis of the functional properties of dengue virus NS3 helicase\<br\>Biophys Rev (2023) 15, 591-600. PubMed  Europe PubMed DOI  PMC  EPMC  V
  6. Maus,H., Hinze,G., Hammerschmidt,S.J., Basche,T. and Schirmeister,T. \<br\>A competition smFRET assay to study ligand-induced conformational changes of the dengue virus protease\<br\>Protein Sci (2023) 32, e4526. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Misra,R., Maity,A., Kundu,S., Bhunia,M., Nanda,B., Maiti,N.C. and Pal,U. \<br\>Loop Dynamics and Conformational Flexibility in Dengue Serine Protease Activity: Noninvasive Perturbation by Solvent Exchange\<br\>J Chem Inf Model (2023) 63, 2122-2132. PubMed  Europe PubMed DOI
  8. Teramoto,T. \<br\>Dengue virus serotypic replacement of NS3 protease or helicase domain causes chimeric viral attenuation but can be recovered by a compensated mutation at helicase domain or NS2B, respectively\<br\>J Virol (2023) 97, e0085423. PubMed  Europe PubMed DOI  PMC  EPMC
  9. Wang,S.H., Kuo,B.J., Ho,T.C., Wan,S.W., Yen,K.L., Huang,P.H., Perng,O.G.C., Chen,P.L., Chien,Y.W. and Lo,Y.C. \<br\>Lambda-free light chain: A serum marker of dengue disease via NS3 protease-mediated antibody cleavage\<br\>Virulence (2023) 14, 2279355. PubMed  Europe PubMed DOI  PMC  EPMC
    10. 2022
  10. Bagga,T., Tulsian,N.K., Mok,Y.K., Kini,R.M. and Sivaraman,J. \<br\>Mapping of molecular interactions between human E3 ligase TRIM69 and Dengue virus NS3 protease using hydrogen-deuterium exchange mass spectrometry\<br\>Cell Mol Life Sci (2022) 79, 233. PubMed  Europe PubMed DOI
  11. Cheng,J., Feng,S., Zhang,Y., Ding,T., Jiang,H., Zhang,Z., Wang,J., Wang,X. and Cheng,M. \<br\>Discovery of highly potent DENV NS2B-NS3 covalent inhibitors containing a phenoxymethylphenyl residue\<br\>Biochem Biophys Res Commun (2022) 627, 214-219. PubMed  Europe PubMed DOI  I
  12. Dang,M., Lim,L., Roy,A. and Song,J. \<br\>Myricetin Allosterically Inhibits the Dengue NS2B-NS3 Protease by Disrupting the Active and Locking the Inactive Conformations\<br\>ACS Omega (2022) 7, 2798-2808. PubMed  Europe PubMed DOI  PMC  EPMC  I
  13. Hao,J., Li,J., Zhang,Z., Yang,Y., Zhou,Q., Wu,T., Chen,T., Wu,Z., Zhang,P., Cui,J. and Li,Y.P. \<br\>NLRC5 restricts dengue virus infection by promoting the autophagic degradation of viral NS3 through E3 ligase CUL2 (cullin 2)\<br\>Autophagy (2022) 1-16. PubMed  Europe PubMed DOI
  14. Hasan,M., Mia,M.M., Munna,S.U., Talha,M.M.H. and Das,K. \<br\>Seawater fungi-derived compound screening to identify novel small molecules against dengue virus NS5 methyltransferase and NS2B/NS3 protease\<br\>Inform Med Unlocked (2022) 30, 100932. PubMed  Europe PubMed DOI  PMC  EPMC
    15. 2021
  15. Kai,Y., Lilan,X. and Yaoming,L. \<br\>Monoclonal Antibody That Inhibits Cleavage Activity of Japanese Encephalitis Virus NS3\<br\>Monoclon Antib Immunodiagn Immunother (2021) 40, 28-32. PubMed  Europe PubMed DOI
  16. Kuhl,N., Leuthold,M.M., Behnam,M.A.M. and Klein,C.D. \<br\>Beyond Basicity: Discovery of Nonbasic DENV-2 Protease Inhibitors with Potent Activity in Cell Culture\<br\>J Med Chem (2021) 64, 4567-4587. PubMed  Europe PubMed DOI  I
  17. Murtuja,S., Shilkar,D., Sarkar,B., Sinha,B.N. and Jayaprakash,V. \<br\>A short survey of dengue protease inhibitor development in the past 6 years (2015-2020) with an emphasis on similarities between DENV and SARS-CoV-2 proteases\<br\>Bioorg Med Chem (2021) 49, 116415. PubMed  Europe PubMed DOI  PMC  EPMC  V
  18. Wahaab,A., Liu,K., Hameed,M., Anwar,M.N., Kang,L., Li,C., Ma,X., Wajid,A., Yang,Y., Khan,U.H., Wei,J., Li,B., Shao,D., Qiu,Y. and Ma,Z. \<br\>Identification of Cleavage Sites Proteolytically Processed by NS2B-NS3 Protease in Polyprotein of Japanese Encephalitis Virus\<br\>Pathogens (2021) 10, PubMed  Europe PubMed DOI
    19. 2020
  19. Agback,P., Woestenenk,E. and Agback,T. \<br\>Probing contacts of inhibitor locked in transition states in the catalytic triad of DENV2 type serine protease and its mutants by 1H, 19F and 15 N NMR spectroscopy\<br\>BMC Mol Cell Biol (2020) 21, 38. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
  20. Arias-Arias,J.L., MacPherson,D.J., Hill,M.E., Hardy,J.A. and Mora-Rodriguez,R. \<br\>A fluorescence-activatable reporter of flavivirus NS2B-NS3 protease activity enables live imaging of infection in single cells and viral plaques\<br\>J Biol Chem (2020) 295, 2212-2226. PubMed  Europe PubMed DOI  A  L
  21. Drazic,T., Kopf,S., Corridan,J., Leuthold,M.M., Bertosa,B. and Klein,C.D. \<br\>Peptide-beta-lactam inhibitors of dengue and West Nile virus NS2B-NS3 protease display two distinct binding modes\<br\>J Med Chem (2020) 63, 140-156. PubMed  Europe PubMed DOI  I
  22. Drazic,T., Kopf,S., Corridan,J., Leuthold,M.M., Bertosa,B. and Klein,C.D. \<br\>Correction to Peptide-beta-lactam Inhibitors of Dengue and West Nile Virus NS2B-NS3 Protease Display Two Distinct Binding Modes\<br\>J Med Chem (2020) 63, 10530. PubMed  Europe PubMed DOI
  23. Dwivedi,V.D., Bharadwaj,S., Afroz,S., Khan,N., Ansari,M.A., Yadava,U., Tripathi,R.C., Tripathi,I.P., Mishra,S.K. and Kang,S.G. \<br\>Anti-dengue infectivity evaluation of bioflavonoid from Azadirachta indica by dengue virus serine protease inhibition\<br\>J Biomol Struct Dyn (2020) 1-14. PubMed  Europe PubMed DOI  I
  24. Gandikota,C., Gandhi,L., Maisnam,D., Kesavulu,M.M., Billoria,A., Prasad,V. and Venkataramana,M. \<br\>A novel anti-NS2BNS3pro antibody-based indirect ELISA test for the diagnosis of dengue virus infections\<br\>J Med Virol (2020) PubMed  Europe PubMed DOI
  25. Hamdani,S.S., Khan,B.A., Hameed,S., Batool,F., Saleem,H.N., Mughal,E.U. and Saeed,M. \<br\>Synthesis and evaluation of novel S-benzyl- and S-alkylphthalimide- oxadiazole -benzenesulfonamide hybrids as inhibitors of dengue virus protease\<br\>Bioorg Chem (2020) 96, 103567. PubMed  Europe PubMed DOI  I
  26. Holt,B.A. and Kwong,G.A. \<br\>Protease circuits for processing biological information\<br\>Nat Commun (2020) 11, 5021. PubMed  Europe PubMed DOI  PMC  EPMC
  27. Kuhl,N., Graf,D., Bock,J., Behnam,M.A.M., Leuthold,M.M. and Klein,C.D. \<br\>A New Class of Dengue and West Nile Virus Protease Inhibitors with Submicromolar Activity in Reporter Gene DENV-2 Protease and Viral Replication Assays\<br\>J Med Chem (2020) PubMed  Europe PubMed DOI
  28. Li,Q. and Kang,C. \<br\>Insights into structures and dynamics of flavivirus proteases from NMR studies\<br\>Int J Mol Sci (2020) 21, PubMed  Europe PubMed DOI  S
  29. Noske,G.D., Gawriljuk,V.O., Fernandes,R.S., Furtado,N.D., Bonaldo,M.C., Oliva,G. and Godoy,A.S. \<br\>Structural characterization and polymorphism analysis of the NS2B-NS3 protease from the 2017 Brazilian circulating strain of Yellow Fever virus\<br\>Biochim Biophys Acta Gen Subj (2020) 1864, 129521. PubMed  Europe PubMed DOI  S
  30. Phoo,W.W., El Sahili,A., Zhang,Z., Chen,M.W., Liew,C.W., Lescar,J., Vasudevan,S.G. and Luo,D. \<br\>Crystal structures of full length DENV4 NS2B-NS3 reveal the dynamic interaction between NS2B and NS3\<br\>Antiviral Res (2020) 182, 104900. PubMed  Europe PubMed DOI
  31. Rut,W., Groborz,K., Zhang,L., Modrzycka,S., Poreba,M., Hilgenfeld,R. and Drag,M. \<br\>Profiling of flaviviral NS2B-NS3 protease specificity provides a structural basis for the development of selective chemical tools that differentiate Dengue from Zika and West Nile viruses\<br\>Antiviral Res (2020) 175, 104731. PubMed  Europe PubMed DOI  P
  32. Shanmugam,A., Ramakrishnan,C., Velmurugan,D. and Gromiha,M.M. \<br\>Identification of potential inhibitors for targets involved in Dengue fever\<br\>Curr Top Med Chem (2020) PubMed  Europe PubMed DOI
  33. Stanley,J.T., Gilchrist,A.R., Stabell,A.C., Allen,M.A., Sawyer,S.L. and Dowell,R.D. \<br\>Two-stage ML classifier for identifying host protein targets of the dengue protease\<br\>Pac Symp Biocomput (2020) 25, 487-498. PubMed  Europe PubMed
    34. 2019
  34. Abdulrahman,A.Y., Rothan,H.A., Khazali,A.S., Teoh,T.C., Daher,A.M. and Yusof,R. \<br\>Synthetic peptide optimization improves the inhibition of dengue NS2B-NS3 protease and dengue replication in vitro\<br\>Acta Virol (2019) 63, 278-285. PubMed  Europe PubMed DOI  I
  35. Chiramel,A.I., Meyerson,N.R., McNally,K.L., Broeckel,R.M., Montoya,V.R., Mendez-Solis,O., Robertson,S.J., Sturdevant,G.L., Lubick,K.J., Nair,V., Youseff,B.H., Ireland,R.M., Bosio,C.M., Kim,K., Luban,J., Hirsch,V.M., Taylor,R.T., Bouamr,F., Sawyer,S.L. and Best,S.M. \<br\>TRIM5alpha Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation\<br\>Cell Rep (2019) 27, 3269-3283. PubMed  Europe PubMed DOI
  36. da Silva-Junior,E.F. and de Araujo-Junior,J.X. \<br\>Peptide derivatives as inhibitors of NS2B-NS3 protease from Dengue, West Nile, and Zika flaviviruses\<br\>Bioorg Med Chem (2019) 27, 3963-3978. PubMed  Europe PubMed DOI  I
  37. de Oliveira,A.S., Gazolla,P.A.R., Oliveira,A.F.C.D.S., Pereira,W.L., de S Viol,L.C., Maia,A.F.D.S., Santos,E.G., da Silva,I.E.P., Mendes,T.A.O., da Silva,A.M., Dias,R.S., da Silva,C.C., Poleto,M.D., Teixeira,R.R. and de Paula,S.O. \<br\>Discovery of novel West Nile virus protease inhibitor based on isobenzonafuranone and triazolic derivatives of eugenol and indan-1,3-dione scaffolds\<br\>PLoS ONE (2019) 14, e0223017. PubMed  Europe PubMed DOI  I
  38. Hariono,M., Choi,S.B., Roslim,R.F., Nawi,M.S., Tan,M.L., Kamarulzaman,E.E., Mohamed,N., Yusof,R., Othman,S., Abd Rahman,N., Othman,R. and Wahab,H.A. \<br\>Thioguanine-based DENV-2 NS2B/NS3 protease inhibitors: virtual screening, synthesis, biological evaluation and molecular modelling\<br\>PLoS ONE (2019) 14, e0210869. PubMed  Europe PubMed DOI  PMC  EPMC  I
  39. Hill,M.E., Yildiz,M. and Hardy,J.A. \<br\>Cysteine disulfide traps reveal distinct conformational ensembles in dengue virus NS2B-NS3 protease\<br\>Biochemistry (2019) 58, 776-787. PubMed  Europe PubMed DOI  S
  40. Jakob,A.K.M.H., Sundermann,T.R. and Klein,C.D. \<br\>Backbone modifications in peptidic inhibitors of flaviviral proteases\<br\>Bioorg Med Chem Lett (2019) 29, 1913-1917. PubMed  Europe PubMed DOI  I
  41. Ji,M., Zhu,T., Xing,M., Luan,N., Mwangi,J., Yan,X., Mo,G., Rong,M., Li,B., Lai,R. and Jin,L. \<br\>An antiviral peptide from Alopecosa nagpag spider targets NS2B-NS3 protease of flaviviruses\<br\>Toxins (Basel) (2019) 11, PubMed  Europe PubMed DOI  I
  42. Lim,L., Gupta,G., Roy,A., Kang,J., Srivastava,S., Shi,J. and Song,J. \<br\>Structurally- and dynamically-driven allostery of the chymotrypsin-like proteases of SARS, Dengue and Zika viruses\<br\>Prog Biophys Mol Biol (2019) 143, 52-66. PubMed  Europe PubMed DOI  S
  43. Majerova,T., Novotny,P., Krysova,E. and Konvalinka,J. \<br\>Exploiting the unique features of Zika and Dengue proteases for inhibitor design\<br\>Biochimie (2019) 166, 132-141. PubMed  Europe PubMed DOI  I
  44. Millies,B., von Hammerstein,F., Gellert,A., Hammerschmidt,S., Barthels,F., Goppel,U., Immerheiser,M., Elgner,F., Jung,N., Basic,M., Kersten,C., Kiefer,W., Bodem,J., Hildt,E., Windbergs,M., Hellmich,U.A. and Schirmeister,T. \<br\>Proline-based allosteric inhibitors of Zika and Dengue virus NS2B/NS3 proteases\<br\>J Med Chem (2019) 62, 11359-11382. PubMed  Europe PubMed DOI  I
  45. Nitsche,C. \<br\>Proteases from dengue, West Nile and Zika viruses as drug targets\<br\>Biophys Rev (2019) 11, 157-165. PubMed  Europe PubMed DOI  I
  46. Saw,W.G., Pan,A., Subramanian Manimekalai,M.S., Gruber,A. and Gruber,G. \<br\>Structure and flexibility of non-structural proteins 3 and -5 of Dengue- and Zika viruses in solution\<br\>Prog Biophys Mol Biol (2019) 143, 67-77. PubMed  Europe PubMed DOI
  47. Sundermann,T.R., Benzin,C.V., Drazic,T. and Klein,C.D. \<br\>Synthesis and structure-activity relationships of small-molecular di-basic esters, amides and carbamates as flaviviral protease inhibitors\<br\>Eur J Med Chem (2019) 176, 187-194. PubMed  Europe PubMed DOI  I
  48. Vishvakarma,V.K., Shukla,N., Reetu, Kumari,K., Patel,R. and Singh,P. \<br\>A model to study the inhibition of nsP2B-nsP3 protease of dengue virus with imidazole, oxazole, triazole thiadiazole, and thiazolidine based scaffolds\<br\>Heliyon (2019) 5, e02124. PubMed  Europe PubMed DOI  PMC  EPMC  I
  49. Yao,Y., Huo,T., Lin,Y.L., Nie,S., Wu,F., Hua,Y., Wu,J., Kneubehl,A.R., Vogt,M.B., Rico-Hesse,R. and Song,Y. \<br\>Discovery, X-ray crystallography and antiviral activity of allosteric inhibitors of flavivirus NS2B-NS3 protease\<br\>J Am Chem Soc (2019) 141, 6832-6836. PubMed  Europe PubMed DOI  I
    50. 2018
  50. Agback,P. and Agback,T. \<br\>Direct evidence of a low barrier hydrogen bond in the catalytic triad of a serine protease\<br\>Sci Rep (2018) 8, 10078. PubMed  Europe PubMed DOI  PMC  EPMC  S
  51. Beesetti,H., Tyagi,P., Medapi,B., Krishna,V.S., Sriram,D., Khanna,N. and Swaminathan,S. \<br\>A quinoline compound inhibits the replication of dengue virus serotypes 1-4 in Vero cells\<br\>Antivir Ther (2018) 23, 385-394. PubMed  Europe PubMed DOI  I
  52. Chen,J., Jiang,H., Li,F., Hu,B., Wang,Y., Wang,M., Wang,J. and Cheng,M. \<br\>Computational insight into dengue virus NS2B-NS3 protease inhibition: a combined ligand- and structure-based approach\<br\>Comput Biol Chem (2018) 77, 261-271. PubMed  Europe PubMed DOI  I
  53. Constant,D.A., Mateo,R., Nagamine,C.M. and Kirkegaard,K. \<br\>Targeting intramolecular proteinase NS2B/3 cleavages for trans-dominant inhibition of dengue virus\<br\>Proc Natl Acad Sci U S A (2018) 115, 10136-10141. PubMed  Europe PubMed DOI  I
  54. Gibbs,A.C., Steele,R., Liu,G., Tounge,B.A. and Montelione,G.T. \<br\>Inhibitor bound dengue NS2B-NS3pro reveals multiple dynamic binding modes\<br\>Biochemistry (2018) 57, 1591-1602. PubMed  Europe PubMed DOI  I
  55. Leonel,C.A., Lima,W.G., Dos Santos,M., Ferraz,A.C., Taranto,A.G., de Magalhaes,J.C., Dos Santos,L.L. and Ferreira,J.M.S. \<br\>Pharmacophoric characteristics of dengue virus NS2B/NS3pro inhibitors: a systematic review of the most promising compounds\<br\>Arch Virol (2018) 163, 575-586. PubMed  Europe PubMed DOI  I
  56. Martinez,A.A., Espinosa,B.A., Adamek,R.N., Thomas,B.A., Chau,J., Gonzalez,E., Keppetipola,N. and Salzameda,N.T. \<br\>Breathing new life into West Nile virus therapeutics; discovery and study of zafirlukast as an NS2B-NS3 protease inhibitor\<br\>Eur J Med Chem (2018) 157, 1202-1213. PubMed  Europe PubMed DOI  I
  57. O'Rourke,A., Kremb,S., Duggan,B.M., Sioud,S., Kharbatia,N., Raji,M., Emwas,A.H., Gerwick,W.H. and Voolstra,C.R. \<br\>Identification of a 3-alkylpyridinium compound from the Red Sea sponge Amphimedon chloros with in vitro inhibitory activity against the West Nile virus NS3 protease\<br\>Molecules (2018) 23, PubMed  Europe PubMed DOI  I
  58. Oliveira,A.F.C.D.S., de Souza,A.P.M., de Oliveira,A.S., Da Silva,M.L., de Oliveira,F.M., Santos,E.G., da Silva,I.E.P., Ferreira,R.S., Villela,F.S., Martins,F.T., Leal,D.H.S., Vaz,B.G., Teixeira,R.R. and de Paula,S.O. \<br\>Zirconium catalyzed synthesis of 2-arylidene Indan-1,3-diones and evaluation of their inhibitory activity against NS2B-NS3 WNV protease\<br\>Eur J Med Chem (2018) 149, 98-109. PubMed  Europe PubMed DOI  I
  59. Padmapriya,P., Gracy Fathima,S., Ramanathan,G., V,Y., A,K.S., Kaveri,K., Gunasekaran,P., Tirichurapalli Sivagnanam,U. and Thennarasu,S. \<br\>Development of antiviral inhibitor against dengue 2 targeting Ns3 protein: In vitro and in silico significant studies\<br\>Acta Trop (2018) 188, 1-8. PubMed  Europe PubMed DOI  I
  60. Pinkham,A.M., Yu,Z. and Cowan,J.A. \<br\>Broad-spectrum catalytic metallopeptide inactivators of Zika and West Nile virus NS2B/NS3 proteases\<br\>Chem Commun (Camb) (2018) 54, 12357-12360. PubMed  Europe PubMed DOI  I
  61. Sarwar,M.W., Riaz,A., Dilshad,S.M.R., al-Qahtani,A., Nawaz-Ul-Rehman,M.S. and Mubin,M. \<br\>Structure activity relationship (SAR) and quantitative structure activity relationship (QSAR) studies showed plant flavonoids as potential inhibitors of dengue NS2B-NS3 protease\<br\>BMC Struct Biol (2018) 18, 6. PubMed  Europe PubMed DOI  PMC  EPMC  I
  62. Stabell,A.C., Meyerson,N.R., Gullberg,R.C., Gilchrist,A.R., Webb,K.J., Old,W.M., Perera,R. and Sawyer,S.L. \<br\>Dengue viruses cleave STING in humans but not in nonhuman primates, their presumed natural reservoir\<br\>elife (2018) 7, PubMed  Europe PubMed DOI  PMC  EPMC  P
  63. Yusufzai,S.K., Osman,H., Khan,M.S., Abd Razik,B.M., Ezzat,M.O., Mohamad,S., Sulaiman,O., Gansau,J.A. and Parumasivam,T. \<br\>4-Thiazolidinone coumarin derivatives as two-component NS2B/NS3 DENV flavivirus serine protease inhibitors: synthesis, molecular docking, biological evaluation and structure-activity relationship studies\<br\>Chem Cent J (2018) 12, 69. PubMed  Europe PubMed DOI  I
    64. 2017
  64. Aguilera-Pesantes,D., Robayo,L.E., Mendez,P.E., Mollocana,D., Marrero-Ponce,Y., Torres,F.J. and Mendez,M.A. \<br\>Discovering key residues of dengue virus NS2b-NS3-protease: new binding sites for antiviral inhibitors design\<br\>Biochem Biophys Res Commun (2017) 492, 631-642. PubMed  Europe PubMed DOI  I
  65. Aguirre,S., Luthra,P., Sanchez-Aparicio,M.T., Maestre,A.M., Patel,J., Lamothe,F., Fredericks,A.C., Tripathi,S., Zhu,T., Pintado-Silva,J., Webb,L.G., Bernal-Rubio,D., Solovyov,A., Greenbaum,B., Simon,V., Basler,C.F., Mulder,L.C., Garcia-Sastre,A. and Fernandez-Sesma,A. \<br\>Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection\<br\>Nat Microbiol (2017) 2, 17037. PubMed  Europe PubMed DOI
  66. Hsieh,M.S., Chen,M.Y., Hsieh,C.H., Pan,C.H., Yu,G.Y. and Chen,H.W. \<br\>Detection and quantification of dengue virus using a novel biosensor system based on dengue NS3 protease activity\<br\>PLoS ONE (2017) 12, e0188170. PubMed  Europe PubMed DOI  PMC  EPMC  A
  67. Li,Z., Sakamuru,S., Huang,R., Brecher,M., Koetzner,C.A., Zhang,J., Chen,H., Qin,C.F., Zhang,Q.Y., Zhou,J., Kramer,L.D., Xia,M. and Li,H. \<br\>Erythrosin B is a potent and broad-spectrum orthosteric inhibitor of the flavivirus NS2B-NS3 protease\<br\>Antiviral Res (2017) 150, 217-225. PubMed  Europe PubMed DOI  I
  68. Lin,K.H., Ali,A., Rusere,L., Soumana,D.I., Yilmaz,N.K. and Schiffer,C.A. \<br\>Dengue virus NS2B/NS3 protease inhibitors exploiting the prime side\<br\>J Virol (2017) PubMed  Europe PubMed DOI  I
  69. Liu,H., Zhang,L., Sun,J., Chen,W., Li,S., Wang,Q., Yu,H., Xia,Z., Jin,X. and Wang,C. \<br\>ER protein SCAP inhibits Dengue virus NS2B3 protease by suppressing its K27-linked polyubiquitylation\<br\>J Virol (2017) PubMed  Europe PubMed DOI
  70. Mirza,S.B., Lee,R.C.H., Chu,J.J.H., Salmas,R.E., Mavromoustakos,T. and Durdagi,S. \<br\>Discovery of selective dengue virus inhibitors using combination of molecular fingerprint-based virtual screening protocols, structure-based pharmacophore model development, molecular dynamics simulations and in vitro studies\<br\>J Mol Graph Model (2017) 79, 88-102. PubMed  Europe PubMed DOI  I
  71. Nitsche,C., Zhang,L., Weigel,L.F., Schilz,J., Graf,D., Bartenschlager,R., Hilgenfeld,R. and Klein,C.D. \<br\>Peptide-boronic acid inhibitors of flaviviral proteases: medicinal chemistry and structural biology\<br\>J Med Chem (2017) 60, 511-516. PubMed  Europe PubMed DOI  I
  72. Osman,H., Idris,N.H., Kamarulzaman,E.E., Wahab,H.A. and Hassan,M.Z. \<br\>3,5-Bis(arylidene)-4-piperidones as potential dengue protease inhibitors\<br\>Acta Pharm Sin B (2017) 7, 479-484. PubMed  Europe PubMed DOI  PMC  EPMC  A  I
  73. Pan,A., Saw,W.G., Subramanian Manimekalai,M.S., Gruber,A., Joon,S., Matsui,T., Weiss,T.M. and Gruber,G. \<br\>Structural features of NS3 of Dengue virus serotypes 2 and 4 in solution and insight into RNA binding and the inhibitory role of quercetin\<br\>Acta Crystallogr D Struct Biol (2017) 73, 402-419. PubMed  Europe PubMed DOI  S
  74. Pathak,N., Lai,M.L., Chen,W.Y., Hsieh,B.W., Yu,G.Y. and Yang,J.M. \<br\>Pharmacophore anchor models of flaviviral NS3 proteases lead to drug repurposing for DENV infection\<br\>BMC Bioinformatics (2017) 18, 548. PubMed  Europe PubMed DOI  PMC  EPMC  I
  75. Qamar,M.T., Ashfaq,U.A., Tusleem,K., Mumtaz,A., Tariq,Q., Goheer,A. and Ahmed,B. \<br\>In-silico identification and evaluation of plant flavonoids as dengue NS2B/NS3 protease inhibitors using molecular docking and simulation approach\<br\>Pak J Pharm Sci (2017) 30, 2119-2137. PubMed  Europe PubMed  I
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