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Literature for peptidase S07.001: flavivirin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, P Specificity, I Inhibitor, E Expression, L Localization, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Bhattacharya,M., Bhowmik,D. and Yin,Q.
    In Vitro Cleavage Assay to Characterize DENV NS2B3 Antagonism of cGAS
    Methods Mol Biol (2025) 2854, 153-170. PubMed  Europe PubMed DOI
  2. Bhunia,M., Misra,R., Maity,A., Mohid,S.A., Kundu,S., Bhunia,A., Maiti,N.C. and Pal,U.
    Dynamic claw of dengue protease unveils druggability potential with high affinity allosteric inhibitors
    PNAS Nexus (2025) 4, af276-af276. PubMed  Europe PubMed DOI  PMC  EPMC
  3. Blazquez,A.B., Saiz,J.C., Herrero,L., Sanchez-Cespedes,J., Vazquez,A., Cisneros,J.M., Martin-Acebes,M.A. and Jimenez de Oya,N.
    Fluorescence-based biosensors for West Nile virus detection
    Virulence (2025) 16, 2597663-2597663. PubMed  Europe PubMed DOI  PMC  EPMC
  4. Bonardi,A.
    Computational approaches for designing viral protease inhibitors
    Enzymes (2025) 58, 59-91. PubMed  Europe PubMed DOI
  5. Cavina,L., Alocen Portillo,A., Balmer,M.P.A., Dammer,J.C., Schillemans,D., Hamdani,S.H., Ackerschott,B., Dieteren,C.E.J., Martina,B.E.E., van Buuren,B.N.M., Rockstroh,A., Ulbert,S., Hermkens,P.H.H., Llinas Brunet,M., Girones,D., Feiters,M.C. and Rutjes,F.P.J.T.
    Development of Lipopeptides as Orthoflavivirin Inhibitors with Low Micromolar Broad-Spectrum Antiorthoflaviviral Activity
    J Med Chem (2025) PubMed  Europe PubMed DOI  I
  6. Corliss,L., Petit,C.M. and Lennemann,N.J.
    Subcellular determinants of orthoflavivirus protease activity
    bioRxiv (2025) PubMed  Europe PubMed DOI  PMC  EPMC
  7. Kumar,A.
    Differentially labeled flaviviral protease-cofactor complex for NMR spectroscopic applications
    Protein Expr Purif (2025) 229, 106684-106684. PubMed  Europe PubMed DOI
  8. Murtuja,S., Das,S., Jana,I.D., Shilkar,D., Rakshit,G., Sarkar,B., Sinha,B.N., Dewangan,R.P., Mondal,A. and Jayaprakash,V.
    Identification of novel thiazole derivatives as flaviviral protease inhibitors effective against Dengue (DENV2) and Japanese encephalitis viruses
    Antimicrob Agents Chemother (2025) , e0165124-e0165124. PubMed  Europe PubMed DOI
  9. Starvaggi,J., Di Chio,C., Lang,J., Belgiovine,V., Trisciuzzi,D., Previti,S., Klein,C., Nicolotti,O., Di Maro,S., Zappala,M. and Ettari,R.
    Development of Novel Proline- and Pipecolic Acid-Based Allosteric Inhibitors of Dengue and Zika Virus NS2B/NS3 Protease
    Pharmaceuticals (Basel) (2025) 19 PubMed  Europe PubMed DOI  PMC  EPMC
  10. Zammarchi,L., Chechi,F., Spinicci,M. and Bartoloni,A.
    Flaviviruses proteases
    Enzymes (2025) 58, 251-278. PubMed  Europe PubMed DOI
  11. Zhu,X., Gao,X., Wu,Y., Lu,J., Chen,X., Zhao,C., Li,H., Zhang,Z., Liu,S., Xiao,G. and Pan,X.
    Eltrombopag, an FDA-approved drug, inhibits dengue virus type 2 by targeting NS2B-NS3 protease
    Virol Sin (2025) PubMed  Europe PubMed DOI
    12. 2024
  12. Akram,M., Hameed,S., Hassan,A. and Khan,K.
    Development in the Inhibition of Dengue Proteases as Drug Targets
    Curr Med Chem (2024) 31, 2195-2233. PubMed  Europe PubMed DOI  V
  13. Behnam,M.A.M. and Klein,C.D.
    Alternate recognition by dengue protease: Proteolytic and binding assays provide functional evidence beyond an induced-fit
    Biochimie (2024) 227, 15-27. PubMed  Europe PubMed DOI
  14. Cavina,L., Bouma,M.J., Girones,D. and Feiters,M.C.
    Orthoflaviviral Inhibitors in Clinical Trials, Preclinical In Vivo Efficacy Targeting NS2B-NS3 and Cellular Antiviral Activity via Competitive Protease Inhibition
    Molecules (2024) 29 PubMed  Europe PubMed DOI  PMC  EPMC  V  I
  15. Chongjun,Y., Nasr,A.M.S., Latif,M.A.M., Rahman,M.B.A., Marlisah,E. and Tejo,B.A.
    Predicting repurposed drugs targeting the NS3 protease of dengue virus using machine learning-based QSAR, molecular docking, and molecular dynamics simulations
    SAR QSAR Environ Res (2024) , 1-22. PubMed  Europe PubMed DOI
  16. Jitonnom,J., Meelua,W., Tue-Nguen,P., Saparpakorn,P., Hannongbua,S. and Chotpatiwetchkul,W.
    3D-QSAR and molecular docking studies of peptide-hybrids as dengue virus NS2B/NS3 protease inhibitors
    Chem Biol Interact (2024) 396, 111040-111040. PubMed  Europe PubMed DOI
  17. Khalili,N.S.D., Khawory,M.H., Salin,N.H., Zakaria,I.I., Hariono,M., Mikhaylov,A.A., Kamarulzaman,E.E., Wahab,A., Supratman,U. and Nurul Azmi,M.
    Synthesis and biological activity of imidazole phenazine derivatives as potential inhibitors for NS2B-NS3 dengue protease
    Heliyon (2024) 10, e24202-e24202. PubMed  Europe PubMed DOI  PMC  EPMC  I
  18. Lin,Y.F., Lai,H.C., Lin,C.S., Hung,P.Y., Kan,J.Y., Chiu,S.W., Lu,C.H., Petrova,S.F., Baltina,L. and Lin,C.W.
    Discovery of Potent Dengue Virus NS2B-NS3 Protease Inhibitors Among Glycyrrhizic Acid Conjugates with Amino Acids and Dipeptides Esters
    Viruses (2024) 16 PubMed  Europe PubMed DOI  PMC  EPMC
  19. Mushtaq,M., Siddiqui,A.R., Shafeeq,S., Khalid,A. and Ul-Haq,Z.
    Shifting paradigms: The promise of allosteric inhibitors against dengue virus protease
    Int J Biol Macromol (2024) 282, 137056-137056. PubMed  Europe PubMed DOI  V
  20. Mustafa,N.F., Cheng,K.K., Nadri,M.H., Razali,S.A., Zakaria,I.I., Salin,N.H. and Amran,S.I.
    Discovery of azaleatin as a potential allosteric inhibitor for dengue NS2B-NS3 protease using in vitro and in silico studies
    J Biomol Struct Dyn (2024) , 1-12. PubMed  Europe PubMed DOI  I
  21. Serafim,M.S.M., Kronenberger,T., Rocha,R.E.O., Rosa,A.D.R.A., Mello,T.L.G., Poso,A., Ferreira,R.S., Abrahao,J.S., Kroon,E.G., Mota,B.E.F. and Maltarollo,V.G.
    Aminopyrimidine Derivatives as Multiflavivirus Antiviral Compounds Identified from a Consensus Virtual Screening Approach
    J Chem Inf Model (2024) 64, 393-411. PubMed  Europe PubMed DOI
  22. Souza,B., Pontes,M., de,O.C., Sousa,F.d., Tizziani,T., Pollo,E., Dambros,B.P., Scotti,M.T., Steindel,M., Braga,A.L., Schirmeister,T., Assis,F.d. and Sandjo,L.P.
    Inhibitory Effects of Mangifera indica Secondary Metabolites and Their Synthetic Derivatives against SARS-CoV-2 M(pro) and NS2B/NS3 (ZIKV and DENV-2)
    ACS Omega (2024) 9, 44624-44638. PubMed  Europe PubMed DOI  PMC  EPMC
  23. Stalin,A., Han,J., Daniel Reegan,A., Ignacimuthu,S., Liu,S., Yao,X. and Zou,Q.
    Exploring the antiviral inhibitory activity of Niloticin against the NS2B/NS3 protease of Dengue virus (DENV2)
    Int J Biol Macromol (2024) , 133791-133791. PubMed  Europe PubMed DOI  I
  24. Starvaggi,J., Previti,S., Zappala,M. and Ettari,R.
    The Inhibition of NS2B/NS3 Protease: A New Therapeutic Opportunity to Treat Dengue and Zika Virus Infection
    Int J Mol Sci (2024) 25 PubMed  Europe PubMed DOI  PMC  EPMC
    25. 2023
  25. Agback,T., Lesovoy,D., Han,X., Lomzov,A., Sun,R., Sandalova,T., Orekhov,V.Y., Achour,A. and Agback,P.
    Combined NMR and molecular dynamics conformational filter identifies unambiguously dynamic ensembles of Dengue protease NS2B/NS3pro
    Commun Biol (2023) 6, 1193-1193. PubMed  Europe PubMed DOI  PMC  EPMC
  26. Coronado,M.A., Gering,I., Sevenich,M., Olivier,D.S., Mastalipour,M., Amaral,M.S., Willbold,D. and Eberle,R.J.
    The Importance of Epigallocatechin as a Scaffold for Drug Development against Flaviviruses
    Pharmaceutics (2023) 15 PubMed  Europe PubMed DOI  PMC  EPMC
  27. Gandhi,L., Maisnam,D., Rathore,D., Chauhan,P., Bonagiri,A. and Venkataramana,M.
    Differential localization of dengue virus protease affects cell homeostasis and triggers to thrombocytopenia
    iScience (2023) 26, 107024-107024. PubMed  Europe PubMed DOI  PMC  EPMC
  28. Incicco,J.J., Cababie,L.A., Sarto,C., Adler,N.S., Amrein,F., Mikkelsen,E., Arrar,M. and Kaufman,S.B.
    Thermodynamic and mechanistic analysis of the functional properties of dengue virus NS3 helicase
    Biophys Rev (2023) 15, 591-600. PubMed  Europe PubMed DOI  PMC  EPMC  V
  29. Maus,H., Hinze,G., Hammerschmidt,S.J., Basche,T. and Schirmeister,T.
    A competition smFRET assay to study ligand-induced conformational changes of the dengue virus protease
    Protein Sci (2023) 32, e4526-e4526. PubMed  Europe PubMed DOI  PMC  EPMC
  30. Misra,R., Maity,A., Kundu,S., Bhunia,M., Nanda,B., Maiti,N.C. and Pal,U.
    Loop Dynamics and Conformational Flexibility in Dengue Serine Protease Activity: Noninvasive Perturbation by Solvent Exchange
    J Chem Inf Model (2023) 63, 2122-2132. PubMed  Europe PubMed DOI
  31. Teramoto,T.
    Dengue virus serotypic replacement of NS3 protease or helicase domain causes chimeric viral attenuation but can be recovered by a compensated mutation at helicase domain or NS2B, respectively
    J Virol (2023) 97, e0085423-e0085423. PubMed  Europe PubMed DOI  PMC  EPMC
  32. Wang,S.H., Kuo,B.J., Ho,T.C., Wan,S.W., Yen,K.L., Huang,P.H., Perng,O.G.C., Chen,P.L., Chien,Y.W. and Lo,Y.C.
    Lambda-free light chain: A serum marker of dengue disease via NS3 protease-mediated antibody cleavage
    Virulence (2023) 14, 2279355-2279355. PubMed  Europe PubMed DOI  PMC  EPMC
    33. 2022
  33. Bagga,T., Tulsian,N.K., Mok,Y.K., Kini,R.M. and Sivaraman,J.
    Mapping of molecular interactions between human E3 ligase TRIM69 and Dengue virus NS3 protease using hydrogen-deuterium exchange mass spectrometry
    Cell Mol Life Sci (2022) 79, 233-233. PubMed  Europe PubMed DOI
  34. Cheng,J., Feng,S., Zhang,Y., Ding,T., Jiang,H., Zhang,Z., Wang,J., Wang,X. and Cheng,M.
    Discovery of highly potent DENV NS2B-NS3 covalent inhibitors containing a phenoxymethylphenyl residue
    Biochem Biophys Res Commun (2022) 627, 214-219. PubMed  Europe PubMed DOI  I
  35. Dang,M., Lim,L., Roy,A. and Song,J.
    Myricetin Allosterically Inhibits the Dengue NS2B-NS3 Protease by Disrupting the Active and Locking the Inactive Conformations
    ACS Omega (2022) 7, 2798-2808. PubMed  Europe PubMed DOI  PMC  EPMC  I
  36. Hao,J., Li,J., Zhang,Z., Yang,Y., Zhou,Q., Wu,T., Chen,T., Wu,Z., Zhang,P., Cui,J. and Li,Y.P.
    NLRC5 restricts dengue virus infection by promoting the autophagic degradation of viral NS3 through E3 ligase CUL2 (cullin 2)
    Autophagy (2022) , 1-16. PubMed  Europe PubMed DOI
  37. Hasan,M., Mia,M.M., Munna,S.U., Talha,M.M.H. and Das,K.
    Seawater fungi-derived compound screening to identify novel small molecules against dengue virus NS5 methyltransferase and NS2B/NS3 protease
    Inform Med Unlocked (2022) 30, 100932-100932. PubMed  Europe PubMed DOI  PMC  EPMC
  38. Samrat,S.K., Xu,J., Li,Z., Zhou,J. and Li,H.
    Antiviral Agents against Flavivirus Protease: Prospect and Future Direction
    Pathogens (2022) 11 PubMed  Europe PubMed DOI  PMC  EPMC  V
    39. 2021
  39. Kai,Y., Lilan,X. and Yaoming,L.
    Monoclonal Antibody That Inhibits Cleavage Activity of Japanese Encephalitis Virus NS3
    Monoclon Antib Immunodiagn Immunother (2021) 40, 28-32. PubMed  Europe PubMed DOI
  40. Kuhl,N., Leuthold,M.M., Behnam,M.A.M. and Klein,C.D.
    Beyond Basicity: Discovery of Nonbasic DENV-2 Protease Inhibitors with Potent Activity in Cell Culture
    J Med Chem (2021) 64, 4567-4587. PubMed  Europe PubMed DOI  I
  41. Murtuja,S., Shilkar,D., Sarkar,B., Sinha,B.N. and Jayaprakash,V.
    A short survey of dengue protease inhibitor development in the past 6 years (2015-2020) with an emphasis on similarities between DENV and SARS-CoV-2 proteases
    Bioorg Med Chem (2021) 49, 116415-116415. PubMed  Europe PubMed DOI  PMC  EPMC  V
  42. Wahaab,A., Liu,K., Hameed,M., Anwar,M.N., Kang,L., Li,C., Ma,X., Wajid,A., Yang,Y., Khan,U.H., Wei,J., Li,B., Shao,D., Qiu,Y. and Ma,Z.
    Identification of Cleavage Sites Proteolytically Processed by NS2B-NS3 Protease in Polyprotein of Japanese Encephalitis Virus
    Pathogens (2021) 10 PubMed  Europe PubMed DOI
    43. 2020
  43. Agback,P., Woestenenk,E. and Agback,T.
    Probing contacts of inhibitor locked in transition states in the catalytic triad of DENV2 type serine protease and its mutants by 1H, 19F and 15 N NMR spectroscopy
    BMC Mol Cell Biol (2020) 21, 38-38. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
  44. Arias-Arias,J.L., MacPherson,D.J., Hill,M.E., Hardy,J.A. and Mora-Rodriguez,R.
    A fluorescence-activatable reporter of flavivirus NS2B-NS3 protease activity enables live imaging of infection in single cells and viral plaques
    J Biol Chem (2020) 295, 2212-2226. PubMed  Europe PubMed DOI  A  L
  45. Drazic,T., Kopf,S., Corridan,J., Leuthold,M.M., Bertosa,B. and Klein,C.D.
    Peptide-beta-lactam inhibitors of dengue and West Nile virus NS2B-NS3 protease display two distinct binding modes
    J Med Chem (2020) 63, 140-156. PubMed  Europe PubMed DOI  I
  46. Drazic,T., Kopf,S., Corridan,J., Leuthold,M.M., Bertosa,B. and Klein,C.D.
    Correction to Peptide-beta-lactam Inhibitors of Dengue and West Nile Virus NS2B-NS3 Protease Display Two Distinct Binding Modes
    J Med Chem (2020) 63, 10530-10530. PubMed  Europe PubMed DOI
  47. Dwivedi,V.D., Bharadwaj,S., Afroz,S., Khan,N., Ansari,M.A., Yadava,U., Tripathi,R.C., Tripathi,I.P., Mishra,S.K. and Kang,S.G.
    Anti-dengue infectivity evaluation of bioflavonoid from Azadirachta indica by dengue virus serine protease inhibition
    J Biomol Struct Dyn (2020) , 1-14. PubMed  Europe PubMed DOI  I
  48. Gandikota,C., Gandhi,L., Maisnam,D., Kesavulu,M.M., Billoria,A., Prasad,V. and Venkataramana,M.
    A novel anti-NS2BNS3pro antibody-based indirect ELISA test for the diagnosis of dengue virus infections
    J Med Virol (2020) PubMed  Europe PubMed DOI
  49. Hamdani,S.S., Khan,B.A., Hameed,S., Batool,F., Saleem,H.N., Mughal,E.U. and Saeed,M.
    Synthesis and evaluation of novel S-benzyl- and S-alkylphthalimide- oxadiazole -benzenesulfonamide hybrids as inhibitors of dengue virus protease
    Bioorg Chem (2020) 96, 103567-103567. PubMed  Europe PubMed DOI  I
  50. Holt,B.A. and Kwong,G.A.
    Protease circuits for processing biological information
    Nat Commun (2020) 11, 5021-5021. PubMed  Europe PubMed DOI  PMC  EPMC
  51. Kuhl,N., Graf,D., Bock,J., Behnam,M.A.M., Leuthold,M.M. and Klein,C.D.
    A New Class of Dengue and West Nile Virus Protease Inhibitors with Submicromolar Activity in Reporter Gene DENV-2 Protease and Viral Replication Assays
    J Med Chem (2020) PubMed  Europe PubMed DOI
  52. Li,Q. and Kang,C.
    Insights into structures and dynamics of flavivirus proteases from NMR studies
    Int J Mol Sci (2020) 21 PubMed  Europe PubMed DOI  S
  53. Noske,G.D., Gawriljuk,V.O., Fernandes,R.S., Furtado,N.D., Bonaldo,M.C., Oliva,G. and Godoy,A.S.
    Structural characterization and polymorphism analysis of the NS2B-NS3 protease from the 2017 Brazilian circulating strain of Yellow Fever virus
    Biochim Biophys Acta Gen Subj (2020) 1864, 129521-129521. PubMed  Europe PubMed DOI  S
  54. Phoo,W.W., El Sahili,A., Zhang,Z., Chen,M.W., Liew,C.W., Lescar,J., Vasudevan,S.G. and Luo,D.
    Crystal structures of full length DENV4 NS2B-NS3 reveal the dynamic interaction between NS2B and NS3
    Antiviral Res (2020) 182, 104900-104900. PubMed  Europe PubMed DOI
  55. Rut,W., Groborz,K., Zhang,L., Modrzycka,S., Poreba,M., Hilgenfeld,R. and Drag,M.
    Profiling of flaviviral NS2B-NS3 protease specificity provides a structural basis for the development of selective chemical tools that differentiate Dengue from Zika and West Nile viruses
    Antiviral Res (2020) 175, 104731-104731. PubMed  Europe PubMed DOI  P
  56. Shanmugam,A., Ramakrishnan,C., Velmurugan,D. and Gromiha,M.M.
    Identification of potential inhibitors for targets involved in Dengue fever
    Curr Top Med Chem (2020) 20, 1742-1760. PubMed  Europe PubMed DOI
  57. Stanley,J.T., Gilchrist,A.R., Stabell,A.C., Allen,M.A., Sawyer,S.L. and Dowell,R.D.
    Two-stage ML classifier for identifying host protein targets of the dengue protease
    Pac Symp Biocomput (2020) 25, 487-498. PubMed  Europe PubMed
    58. 2019
  58. Abdulrahman,A.Y., Rothan,H.A., Khazali,A.S., Teoh,T.C., Daher,A.M. and Yusof,R.
    Synthetic peptide optimization improves the inhibition of dengue NS2B-NS3 protease and dengue replication in vitro
    Acta Virol (2019) 63, 278-285. PubMed  Europe PubMed DOI  I
  59. Chiramel,A.I., Meyerson,N.R., McNally,K.L., Broeckel,R.M., Montoya,V.R., Mendez-Solis,O., Robertson,S.J., Sturdevant,G.L., Lubick,K.J., Nair,V., Youseff,B.H., Ireland,R.M., Bosio,C.M., Kim,K., Luban,J., Hirsch,V.M., Taylor,R.T., Bouamr,F., Sawyer,S.L. and Best,S.M.
    TRIM5alpha Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation
    Cell Rep (2019) 27, 3269-3283. PubMed  Europe PubMed DOI
  60. da Silva-Junior,E.F. and de Araujo-Junior,J.X.
    Peptide derivatives as inhibitors of NS2B-NS3 protease from Dengue, West Nile, and Zika flaviviruses
    Bioorg Med Chem (2019) 27, 3963-3978. PubMed  Europe PubMed DOI  I
  61. de Oliveira,A.S., Gazolla,P.A.R., Oliveira,A.F.C.D.S., Pereira,W.L., de S Viol,L.C., Maia,A.F.D.S., Santos,E.G., da Silva,I.E.P., Mendes,T.A.O., da Silva,A.M., Dias,R.S., da Silva,C.C., Poleto,M.D., Teixeira,R.R. and de Paula,S.O.
    Discovery of novel West Nile virus protease inhibitor based on isobenzonafuranone and triazolic derivatives of eugenol and indan-1,3-dione scaffolds
    PLoS ONE (2019) 14, e0223017-e0223017. PubMed  Europe PubMed DOI  I
  62. Hariono,M., Choi,S.B., Roslim,R.F., Nawi,M.S., Tan,M.L., Kamarulzaman,E.E., Mohamed,N., Yusof,R., Othman,S., Abd Rahman,N., Othman,R. and Wahab,H.A.
    Thioguanine-based DENV-2 NS2B/NS3 protease inhibitors: virtual screening, synthesis, biological evaluation and molecular modelling
    PLoS ONE (2019) 14, e0210869-e0210869. PubMed  Europe PubMed DOI  PMC  EPMC  I
  63. Hill,M.E., Yildiz,M. and Hardy,J.A.
    Cysteine disulfide traps reveal distinct conformational ensembles in dengue virus NS2B-NS3 protease
    Biochemistry (2019) 58, 776-787. PubMed  Europe PubMed DOI  S
  64. Jakob,A.K.M.H., Sundermann,T.R. and Klein,C.D.
    Backbone modifications in peptidic inhibitors of flaviviral proteases
    Bioorg Med Chem Lett (2019) 29, 1913-1917. PubMed  Europe PubMed DOI  I
  65. Ji,M., Zhu,T., Xing,M., Luan,N., Mwangi,J., Yan,X., Mo,G., Rong,M., Li,B., Lai,R. and Jin,L.
    An antiviral peptide from Alopecosa nagpag spider targets NS2B-NS3 protease of flaviviruses
    Toxins (Basel) (2019) 11 PubMed  Europe PubMed DOI  I
  66. Lim,L., Gupta,G., Roy,A., Kang,J., Srivastava,S., Shi,J. and Song,J.
    Structurally- and dynamically-driven allostery of the chymotrypsin-like proteases of SARS, Dengue and Zika viruses
    Prog Biophys Mol Biol (2019) 143, 52-66. PubMed  Europe PubMed DOI  S
  67. Majerova,T., Novotny,P., Krysova,E. and Konvalinka,J.
    Exploiting the unique features of Zika and Dengue proteases for inhibitor design
    Biochimie (2019) 166, 132-141. PubMed  Europe PubMed DOI  I
  68. Millies,B., von Hammerstein,F., Gellert,A., Hammerschmidt,S., Barthels,F., Goppel,U., Immerheiser,M., Elgner,F., Jung,N., Basic,M., Kersten,C., Kiefer,W., Bodem,J., Hildt,E., Windbergs,M., Hellmich,U.A. and Schirmeister,T.
    Proline-based allosteric inhibitors of Zika and Dengue virus NS2B/NS3 proteases
    J Med Chem (2019) 62, 11359-11382. PubMed  Europe PubMed DOI  I
  69. Nitsche,C.
    Proteases from dengue, West Nile and Zika viruses as drug targets
    Biophys Rev (2019) 11, 157-165. PubMed  Europe PubMed DOI  I
  70. Saw,W.G., Pan,A., Subramanian Manimekalai,M.S., Gruber,A. and Gruber,G.
    Structure and flexibility of non-structural proteins 3 and -5 of Dengue- and Zika viruses in solution
    Prog Biophys Mol Biol (2019) 143, 67-77. PubMed  Europe PubMed DOI
  71. Sundermann,T.R., Benzin,C.V., Drazic,T. and Klein,C.D.
    Synthesis and structure-activity relationships of small-molecular di-basic esters, amides and carbamates as flaviviral protease inhibitors
    Eur J Med Chem (2019) 176, 187-194. PubMed  Europe PubMed DOI  I
  72. Vishvakarma,V.K., Shukla,N., Reetu, Kumari,K., Patel,R. and Singh,P.
    A model to study the inhibition of nsP2B-nsP3 protease of dengue virus with imidazole, oxazole, triazole thiadiazole, and thiazolidine based scaffolds
    Heliyon (2019) 5, e02124-e02124. PubMed  Europe PubMed DOI  PMC  EPMC  I
  73. Yao,Y., Huo,T., Lin,Y.L., Nie,S., Wu,F., Hua,Y., Wu,J., Kneubehl,A.R., Vogt,M.B., Rico-Hesse,R. and Song,Y.
    Discovery, X-ray crystallography and antiviral activity of allosteric inhibitors of flavivirus NS2B-NS3 protease
    J Am Chem Soc (2019) 141, 6832-6836. PubMed  Europe PubMed DOI  I
    74. 2018
  74. Agback,P. and Agback,T.
    Direct evidence of a low barrier hydrogen bond in the catalytic triad of a serine protease
    Sci Rep (2018) 8, 10078-10078. PubMed  Europe PubMed DOI  PMC  EPMC  S
  75. Beesetti,H., Tyagi,P., Medapi,B., Krishna,V.S., Sriram,D., Khanna,N. and Swaminathan,S.
    A quinoline compound inhibits the replication of dengue virus serotypes 1-4 in Vero cells
    Antivir Ther (2018) 23, 385-394. PubMed  Europe PubMed DOI  I
  76. Chen,J., Jiang,H., Li,F., Hu,B., Wang,Y., Wang,M., Wang,J. and Cheng,M.
    Computational insight into dengue virus NS2B-NS3 protease inhibition: a combined ligand- and structure-based approach
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