Substrates for peptidase S01.211: coagulation factor XIIa

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
Boc-Gln-Gly-Arg-NHMec			Boc-Gln-Gly-Arg+NHMec	S	Boc	Gln	Gly	Arg	AMC	-	-	-
coagulation factor VII	P08709	21-466	peptide-Arg194+Ile-peptide	P	Pro	Gln	Gly	Arg	Ile	Val	Gly	Gly	Ratnoff, 2004	17342
coagulation factor XI	P03951	19-625	peptide-Arg369+Ile-peptide	P	Ile	Lys	Pro	Arg	Ile	Val	Gly	Gly	Ratnoff, 2004	17343
coagulation factor XII	P00748	20-615	peptide-Arg353+Val-peptide	P	Ser	Met	Thr	Arg	Val	Val	Gly	Gly	Ratnoff, 2004	17344
D-Pro-Phe-Arg-NHPhNO2			D-Pro-Phe-Arg+NHPhNO2	S	-	DPr	Phe	Arg	NAN	-	-	-	Ratnoff, 2004
plasma kallikrein precursor	P03952	20-638	peptide-Arg371+Ile-peptide	P	Thr	Ser	Thr	Arg	Ile	Val	Gly	Gly	Chung et al., 1986	17345
renin precursor	P00797	24-406	peptide-Arg66+Leu-peptide	P	Pro	Met	Lys	Arg	Leu	Thr	Leu	Gly	Ratnoff, 2004	17346