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Literature for peptidase S01.211: coagulation factor XIIa

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, K Knockout, E Expression, V Review, M Mutation, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Elwakiel,A., Gupta,D., Rana,R., Manoharan,J., Al-Dabet,M.M., Ambreen,S., Fatima,S., Zimmermann,S., Mathew,A., Li,Z., Singh,K., Gupta,A., Pal,S., Sulaj,A., Kopf,S., Schwab,C., Baber,R., Geffers,R., Gotze,T., Alo,B., Lamers,C., Kluge,P., Kuenze,G., Kohli,S., Renne,T., Shahzad,K. and Isermann,B.<br>Author Correction: Factor XII signaling via uPAR-integrin beta1 axis promotes tubular senescence in diabetic kidney disease<br>Nat Commun (2026) 17, 540-540. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Krajewska,K., Pawlus,J., Ptaszynska,K. and Lisowska,A.<br>Factor XII-A New Therapeutic Target? A Systematic Review<br>Int J Mol Sci (2026) 27 PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2025
  3. Bundgaard,E., Pedersen,M.K., Bor,P. and Bor,M.V.<br>Revisiting the Link Between Factor XII and Recurrent Pregnancy Loss: A Scoping Review<br>Am J Reprod Immunol (2025) 94, e70127-e70127. PubMed  Europe PubMed DOI  PMC  EPMC
  4. Haj,A.K., Paul,D.S., Jurgens,S.J., Eswaran,H., Weng,L.C., Ryu,J., Rodriguez Espada,A., Chaudhry,S., Feingold,L.M., Burke,K., Koyama,S., Wang,X., Francis,J., Choi,S.H., Mackman,N., Bergmeier,W., Burgin,A., Ramo,J.T., Ellinor,P.T., Grover,S.P. and Bendapudi,P.K.<br>Coagulation factor XII haploinsufficiency is protective against venous thromboembolism in a population-scale multidimensional analysis<br>Nat Commun (2025) 16, 8176-8176. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Lira,A.L., Liu,T., Aslan,J.E., Puy,C. and McCarty,O.J.T.<br>Lipopolysaccharide supramolecular organization regulates the activation of coagulation factor XII<br>Biochim Biophys Acta Biomembr (2025) 1867, 184415-184415. PubMed  Europe PubMed DOI
  6. Lira,A.L., Drew,K.C., Puy,C., Shatzel,J.J. and McCarty,O.J.T.<br>Lipopolysaccharide and Coagulation Factor XII: Biophysics of Contact Activation in Infection<br>Semin Thromb Hemost (2025) PubMed  Europe PubMed DOI
  7. Liu,H., Yang,K., Wang,S. and Ge,J.<br>Advancements in research on the thrombo-inflammation mechanisms mediated by factor XII in ischemic stroke<br>J Thromb Thrombolysis (2025) PubMed  Europe PubMed DOI  V
  8. Lopez-Lera,A., Corvillo,F., Gonzalez-Sanchez,L., Melgosa,M. and Sanchez-Corral,P.<br>Relevance of the interactions between the complement and contact coagulation systems on renal pathology<br>Nefrologia (Engl Ed) (2025) , 501347-501347. PubMed  Europe PubMed DOI
  9. Nickel,K.F., Jamsa,A., Konrath,S., Papareddy,P., Butler,L.M., Stavrou,E.X., Frye,M., Gelderblom,M., Nieswandt,B., Hammerschmidt,S., Herwald,H. and Renne,T.<br>Factor XII-driven coagulation traps bacterial infections<br>J Exp Med (2025) 222 PubMed  Europe PubMed DOI  PMC  EPMC
  10. Satpathy,C., Mishra,T.K. and Jha,A.K.<br>Factor XI and XII inhibitors-Dawn of a new era<br>Indian Heart J (2025) PubMed  Europe PubMed DOI  V
  11. Yang,A., Zhang,Y., Sun,Y., Jiang,M., Lu,Y., Han,Y., Wu,D., Luo,Z. and Wu,Y.<br>Thiol isomerase ERp46 catalyzes the disulfide formation of coagulation factor XII enhancing its activity<br>J Thromb Haemost (2025) PubMed  Europe PubMed DOI
    12. 2024
  12. Al-Horani,R.A.<br>Revisiting the effect of cholesteryl sulfate on clotting and fibrinolysis: Inhibition of human thrombin and other human blood proteases<br>Heliyon (2024) 10, e28017-e28017. PubMed  Europe PubMed DOI  PMC  EPMC  I
  13. He,X., Zhao,Y., Guang,H., Chen,K., She,Z., Cao,M., Bai,M., Yang,Y., Su,M., Zhao,W., Liu,Y., Liu,S., Sun,H. and Gao,J.<br>Qinghaienin, a novel anticoagulation protein from the hard tick Haemaphysalis qinghaiensis, inhibits the activation of factor XII by competing for anionic surfaces<br>Int J Biol Macromol (2024) 290, 139120-139120. PubMed  Europe PubMed DOI
  14. Natorska,J., Zabczyk,M., Mastalerz,L. and Undas,A.<br>Increased factor XI but not factor XII is associated with enhanced inflammation and impaired fibrin clot properties in patients with eosinophilic granulomatosis with polyangiitis<br>Clin Exp Rheumatol (2024) 42, 822-827. PubMed  Europe PubMed DOI
  15. Shamanaev,A., Litvak,M., Ivanov,I., Srivastava,P., Sun,M.F., Dickeson,S.K., Kumar,S., He,T.Z. and Gailani,D.<br>Factor XII Structure-Function Relationships<br>Semin Thromb Hemost (2024) 50, 937-952. PubMed  Europe PubMed DOI  V
  16. Silbak,S. and Schmaier,A.H.<br>The enigma of factor XII surface binding<br>J Thromb Haemost (2024) 22, 2422-2425. PubMed  Europe PubMed DOI
  17. Xu,P., Zhang,Y., Guo,J., Li,H., Konrath,S., Zhou,P., Cai,L., Rao,H., Chen,H., Lin,J., Cui,Z., Ji,B., Wang,J., Li,N., Liu,D.P., Renne,T. and Wang,M.<br>A single-domain antibody targeting factor XII inhibits both thrombosis and inflammation<br>Nat Commun (2024) 15, 7898-7898. PubMed  Europe PubMed DOI  PMC  EPMC
    18. 2023
  18. Davoine,C., Traina,A., Evrard,J., Lanners,S., Fillet,M. and Pochet,L.<br>Coumarins as factor XIIa inhibitors: Potency and selectivity improvements using a fragment-based strategy<br>Eur J Med Chem (2023) 259, 115636-115636. PubMed  Europe PubMed DOI
  19. Ilin,I., Podoplelova,N., Sulimov,A., Kutov,D., Tashchilova,A., Panteleev,M., Shikhaliev,K., Krysin,M., Stolpovskaya,N., Potapov,A. and Sulimov,V.<br>Experimentally Validated Novel Factor XIIa Inhibitors Identified by Docking and Quantum Chemical Post-processing<br>Mol Inform (2023) 42, e2200205-e2200205. PubMed  Europe PubMed DOI  I
  20. Umei,N., Shin,S., Lai,A., Miller,J., Roberts,K., Strelkova,D., Chaudhary,N., Ichiba,S., Sakamoto,A., Whitehead,K. and Cook,K.<br>Factor XII Silencing Using siRNA Prevents Thrombus Formation in a Rat Model of Extracorporeal Life Support<br>ASAIO J (2023) 69, 527-532. PubMed  Europe PubMed DOI
    21. 2022
  21. Jiang,S., Jia,Z., Zheng,Y., Zhang,J., Li,Z., Yu,X., Zhang,K., Bai,Y., Guo,W., Kong,Y. and Li,Q.<br>Bifunctional fusion protein targeting both FXIIa and FXIa displays potent anticoagulation effects<br>Life Sci (2022) 309, 121021-121021. PubMed  Europe PubMed DOI
  22. Kilinc,E., Can Timucin,A., Selim Cinaroglu,S. and Timucin,E.<br>Modeling and dynamical analysis of the full-length structure of factor XII with zinc<br>J Mol Model (2022) 28, 129-129. PubMed  Europe PubMed DOI
  23. Mailer,R.K., Rangaswamy,C., Konrath,S., Emsley,J. and Renne,T.<br>An update on factor XII-driven vascular inflammation<br>Biochim Biophys Acta Mol Cell Res (2022) 1869, 119166-119166. PubMed  Europe PubMed DOI  V
  24. Mohammed,B.M., Cheng,Q. and Gailani,D.<br>A demonstration of factor XI contributing to hemostasis in the absence of factor XII<br>Res Pract Thromb Haemost (2022) 6, e12841-e12841. PubMed  Europe PubMed DOI  PMC  EPMC
  25. Shamanaev,A., Litvak,M. and Gailani,D.<br>Recent advances in factor XII structure and function<br>Curr Opin Hematol (2022) 29, 233-243. PubMed  Europe PubMed DOI  PMC  EPMC  V
  26. Shamanaev,A., Ivanov,I., Sun,M.F., Litvak,M., Srivastava,P., Mohammed,B.M., Shaban,R., Maddur,A., Verhamme,I.M., McCarty,O.J.T., Law,R.H.P. and Gailani,D.<br>A Model for Surface-Dependent Factor XII Activation: The Roles of Factor XII Heavy Chain Domains<br>Blood Adv (2022) PubMed  Europe PubMed DOI
  27. Sohaei,D., Hollenberg,M., Janket,S.J., Diamandis,E.P., Poda,G. and Prassas,I.<br>The therapeutic relevance of the Kallikrein-Kinin axis in SARS-cov-2-induced vascular pathology<br>Crit Rev Clin Lab Sci (2022) , 1-16. PubMed  Europe PubMed DOI  V
  28. Tashchilova,A., Podoplelova,N., Sulimov,A., Kutov,D., Ilin,I., Panteleev,M., Shikhaliev,K., Medvedeva,S., Novichikhina,N., Potapov,A. and Sulimov,V.<br>New Blood Coagulation Factor XIIa Inhibitors: Molecular Modeling, Synthesis, and Experimental Confirmation<br>Molecules (2022) 27 PubMed  Europe PubMed DOI  PMC  EPMC
    29. 2021
  29. Davoine,C., Fillet,M. and Pochet,L.<br>Capillary electrophoresis as a fragment screening tool to cross-validate hits from chromogenic assay: Application to FXIIa<br>Talanta (2021) 226, 122163-122163. PubMed  Europe PubMed DOI
  30. Heestermans,M., Naudin,C., Mailer,R.K., Konrath,S., Klaetschke,K., Jamsa,A., Frye,M., Deppermann,C., Pula,G., Kuta,P., Friese,M.A., Gelderblom,M., Sickmann,A., Preston,R.J.S., Nofer,J.R., Rose-John,S., Butler,L.M., Salomon,O., Stavrou,E.X. and Renne,T.<br>Identification of the factor XII contact activation site enables sensitive coagulation diagnostics<br>Nat Commun (2021) 12, 5596-5596. PubMed  Europe PubMed DOI  PMC  EPMC
  31. Kalinin,D.V.<br>Factor XII(a) inhibitors: a review of the patent literature<br>Expert Opin Ther Pat (2021) PubMed  Europe PubMed DOI
  32. Murray,N.P., Guzman,E. and Del Prado,M.<br>Transient acquired Factor XII deficiency associated with moderately severe Covid-19 pneumonia<br>Hematol Transfus Cell Ther (2021) PubMed  Europe PubMed DOI  PMC  EPMC
  33. Pawaskar,D., Chen,X., Glassman,F., May,F., Roberts,A., Biondo,M., McKenzie,A., Nolte,M.W., Jusko,W.J. and Tortorici,M.<br>Pharmacokinetic/pharmacodynamic modeling for dose selection for the first-in-human trial of the activated Factor XII inhibitor garadacimab (CSL312)<br>Clin Transl Sci (2021) PubMed  Europe PubMed DOI
  34. Stetter,C., Lopez-Caperuchipi,S., Hopp-Kramer,S., Bieber,M., Kleinschnitz,C., Siren,A.L. and Albert-Weissenberger,C.<br>Amelioration of Cognitive and Behavioral Deficits after Traumatic Brain Injury in Coagulation Factor XII Deficient Mice<br>Int J Mol Sci (2021) 22 PubMed  Europe PubMed DOI  PMC  EPMC
  35. Xiao,B., Liu,F., Jin,Y.H., Wang,M.X., Zhang,J., Lu,J.C. and Yang,X.C.<br>Two Novel Mutations (G774A and A1685G) Causing Coagulation Factor XII Deficiency in a Patient with Acute Inferior Myocardial Infarction<br>Ann Clin Lab Sci (2021) 51, 426-429. PubMed  Europe PubMed
    36. 2020
  36. Chaudhry,S.A., Serrata,M., Tomczak,L., Higgins,S., Ryu,J., Laprise,D., Enjyoji,K., Bekendam,R., Kaushik,V., Flaumenhaft,R. and Bendapudi,P.K.<br>Cationic Zinc is Required for Factor XII Recruitment and Activation by Stimulated Platelets and for Thrombus Formation in vivo<br>J Thromb Haemost (2020) PubMed  Europe PubMed DOI
  37. Cheng,X., Yang,L., Xin,Y., Zhu,L., Su,M. and Hao,X.<br>[Analysis of a pedigree affected with hereditary coagulation factor XII deficiency due to a homozygous 252delAsn deletion of F12 gene]<br>Zhonghua Yi Xue Yi Chuan Xue Za Zhi (2020) 37, 755-758. PubMed  Europe PubMed DOI
  38. Davoine,C., Bouckaert,C., Fillet,M. and Pochet,L.<br>Factor XII/XIIa inhibitors: Their discovery, development, and potential indications<br>Eur J Med Chem (2020) 208, 112753-112753. PubMed  Europe PubMed DOI  V
  39. Fang,C. and Schmaier,A.H.<br>Novel anti-thrombotic mechanisms mediated by Mas receptor as result of balanced activities between the kallikrein/kinin and the renin-angiotensin systems<br>Pharmacol Res (2020) 160, 105096-105096. PubMed  Europe PubMed DOI  PMC  EPMC  V
  40. Hofman,Z.L.M., Clark,C.C., Sanrattana,W., Nosairi,A., Parr,N.M.J., Zivkovic,M., Krause,K., Mahnke,N.A., Scheffel,J., Hack,C.E., Maurer,M., de Maat,S. and Maas,C.<br>A mutation in the kringle domain of human factor XII that causes autoinflammation, disturbs zymogen quiescence, and accelerates activation<br>J Biol Chem (2020) 295, 363-374. PubMed  Europe PubMed DOI  M
  41. Juang,L.J., Mazinani,N., Novakowski,S.K., Prowse,E.N.P., Haulena,M., Gailani,D., Lavkulich,L.M. and Kastrup,C.J.<br>Coagulation factor XII contributes to hemostasis when activated by soil in wounds<br>Blood Adv (2020) 4, 1737-1745. PubMed  Europe PubMed DOI  PMC  EPMC
  42. Kaira,B.G., Slater,A., McCrae,K.R., Dreveny,I., Sumya,U.M., Mutch,N.J., Searle,M. and Emsley,J.<br>Factor XII and kininogen asymmetric assembly with gC1qR/C1QBP/P32 is governed by allostery<br>Blood (2020) PubMed  Europe PubMed DOI
  43. L Venkatraman,K., A Syed,A., Indumathi,P. and Mehta,A.<br>VITPOR AI, a coagulation factor XIIa inhibitor from Porphyra yezoensis: in vivo mode of action and assessment of platelet function analysis<br>Protein Pept Lett (2020) 27, 243-250. PubMed  Europe PubMed DOI
  44. Marceau,F., Rivard,G.E., Gauthier,J.M., Binkley,K.E., Bonnefoy,A., Boccon-Gibod,I., Bouillet,L., Picard,M., Levesque,G., Elfassy,H.L., Bachelard,H., Hebert,J. and Bork,K.<br>Measurement of Bradykinin Formation and Degradation in Blood Plasma: Relevance for Acquired Angioedema Associated With Angiotensin Converting Enzyme Inhibition and for Hereditary Angioedema Due to Factor XII or Plasminogen Gene Variants<br>Front Med (Lausanne) (2020) 7, 358-358. PubMed  Europe PubMed DOI  PMC  EPMC  I
  45. Meini,S., Zanichelli,A., Sbrojavacca,R., Iuri,F., Roberts,A.T., Suffritti,C. and Tascini,C.<br>Understanding the Pathophysiology of COVID-19: Could the Contact System Be the Key?<br>Front Immunol (2020) 11, 2014-2014. PubMed  Europe PubMed DOI  PMC  EPMC
  46. Nakayama,M., Miyagawa,H., Kuranami,Y., Tsunooka-Ota,M., Yamaguchi,Y. and Kojima-Aikawa,K.<br>Annexin A4 inhibits sulfatide-induced activation of coagulation factor XII<br>J Thromb Haemost (2020) 18, 1357-1369. PubMed  Europe PubMed DOI
  47. Rohmann,J.L., Huo,S., Sperber,P.S., Piper,S.K., Rosendaal,F.R., Heuschmann,P.U., Endres,M., Liman,T.G. and Siegerink,B.<br>Coagulation factor XII, XI, and VIII activity levels and secondary events after first ischemic stroke<br>J Thromb Haemost (2020) PubMed  Europe PubMed DOI
  48. Sipka,S., Toth,A. and Sipka S Jr<br>Age-dependent possible role of contact-activated blood coagulation factor XII as a potential contributor to the "bradykinin storm" in COVID-19 patients<br>Orv Hetil (2020) 161, 2099-2103. PubMed  Europe PubMed DOI  V
  49. Srivastava,P. and Gailani,D.<br>The rebirth of the contact pathway: a new therapeutic target<br>Curr Opin Hematol (2020) 27, 311-319. PubMed  Europe PubMed DOI
  50. Takeyama,M., Nogami,K., Matsumoto,T., Noguchi-Sasaki,M., Kitazawa,T. and Shima,M.<br>An anti-factor IXa/factor X bispecific antibody, emicizumab, improves ex vivo coagulant potentials in plasma from patients with acquired hemophilia A<br>J Thromb Haemost (2020) 18, 825-833. PubMed  Europe PubMed DOI
  51. Thangaraj,S.S., Christiansen,S.H., Graversen,J.H., Sidelmann,J.J., Hansen,S.W.K., Bygum,A., Gram,J.B. and Palarasah,Y.<br>Contact activation-induced complex formation between complement factor H and coagulation factor XIIa<br>J Thromb Haemost (2020) 18, 876-884. PubMed  Europe PubMed DOI
  52. Xu,D., Xue,G., Peng,B., Feng,Z., Lu,H. and Gong,L.<br>High-Throughput Docking and Molecular Dynamics Simulations towards the Identification of Potential Inhibitors against Human Coagulation Factor XIIa<br>Comput Math Methods Med (2020) 2020, 2852051-2852051. PubMed  Europe PubMed DOI  PMC  EPMC  I
  53. Yoshida,K., Tanaka,S., Sato,Y., Watanabe,K., Muramatsu,K. and Murakawa,M.<br>Global cerebral infarction after aortic arch replacement surgery in a patient with postoperatively revealed factor XII deficiency: a case report<br>J Med Case Rep (2020) 14, 150-150. PubMed  Europe PubMed DOI  PMC  EPMC
    54. 2019
  54. Chaudhry,L.A., El-Sadek,W.Y.M., Chaudhry,G.A. and Al-Atawi,F.E.<br>Factor XII (Hageman factor) deficiency: a rare harbinger of life threatening complications<br>Pan Afr Med J (2019) 33, 39-39. PubMed  Europe PubMed DOI  PMC  EPMC  M
  55. de Maat,S., Clark,C.C., Boertien,M., Parr,N., Sanrattana,W., Hofman,Z.L.M. and Maas,C.<br>Factor XII truncation accelerates activation in solution<br>J Thromb Haemost (2019) 17, 183-194. PubMed  Europe PubMed DOI
  56. Maruyama,H., Brooks,M.B., Stablein,A. and Frye,A.<br>Factor XII deficiency is common in domestic cats and associated with two high frequency F12 mutations<br>Gene (2019) 706, 6-12. PubMed  Europe PubMed DOI  M
  57. Pathak,M., Manna,R., Li,C., Kaira,B.G., Hamad,B.K., Belviso,B.D., Bonturi,C.R., Dreveny,I., Fischer,P.M., Dekker,L.V., Oliva,M.L.V. and Emsley,J.<br>Crystal structures of the recombinant beta-factor XIIa protease with bound Thr-Arg and Pro-Arg substrate mimetics<br>Acta Crystallogr D Struct Biol (2019) 75, 578-591. PubMed  Europe PubMed DOI  S
  58. Peng,B., Xue,G., Xu,D., Feng,Z., Chen,J., Huang,M., Lu,H. and Gong,L.<br>Expression and purification of recombinant serine protease domain of human coagulation factor XII in Pichia pastoris<br>Biosci Biotechnol Biochem (2019) 83, 1815-1821. PubMed  Europe PubMed DOI  E
  59. Renne,T. and Stavrou,E.X.<br>Roles of factor XII in innate immunity<br>Front Immunol (2019) 10, 2011-2011. PubMed  Europe PubMed DOI  PMC  EPMC
  60. Sato,Y., Sugi,T. and Sakai,R.<br>Anti-factor XII autoantibodies in patients with recurrent pregnancy loss recognize the second epidermal growth factor-like domain<br>TH Open (2019) 3, e263-e263. PubMed  Europe PubMed DOI  PMC  EPMC
  61. Schmaier,A.H. and Stavrou,E.X.<br>Factor XII - what's important but not commonly thought about<br>Res Pract Thromb Haemost (2019) 3, 599-606. PubMed  Europe PubMed DOI  PMC  EPMC
  62. Zhang,H., Liu,S., Lin,C., Luo,S., Yang,L., Jin,Y., Zhu,L. and Wang,M.<br>Compound heterozygous mutations Glu502Lys and Met527Thr of the FXII gene in a patient with factor XII deficiency<br>Hematology (2019) 24, 420-425. PubMed  Europe PubMed DOI  M
    63. 2018
  63. Cao,H., Biondo,M., Lioe,H., Busfield,S., Rayzman,V., Nieswandt,B., Bork,K., Harrison,L.C., Auyeung,P., Farkas,H., Csuka,D., Pelzing,M., Dower,S., Wilson,M.J., Nash,A., Nolte,M.W. and Panousis,C.<br>Antibody-mediated inhibition of FXIIa blocks downstream bradykinin generation<br>J Allergy Clin Immunol (2018) 142, 1355-1358. PubMed  Europe PubMed DOI
  64. Dementiev,A., Silva,A., Yee,C., Li,Z., Flavin,M.T., Sham,H. and Partridge,J.R.<br>Structures of human plasma beta-factor XIIa cocrystallized with potent inhibitors<br>Blood Adv (2018) 2, 549-558. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
  65. Didiasova,M., Wujak,L., Schaefer,L. and Wygrecka,M.<br>Factor XII in coagulation, inflammation and beyond<br>Cell Signal (2018) 51, 257-265. PubMed  Europe PubMed DOI  V
  66. Fernandes,H.D., Newton,S. and Rodrigues,J.M.<br>Factor XII deficiency mimicking bleeding diathesis: a unique presentation and diagnostic pitfall<br>Cureus (2018) 10, e2817-e2817. PubMed  Europe PubMed DOI  PMC  EPMC  M
  67. Maas,C. and Renne,T.<br>Coagulation factor XII in thrombosis and inflammation<br>Blood (2018) 131, 1903-1909. PubMed  Europe PubMed DOI
  68. Mohammed,B.M., Ivanov,I., Matafonov,A., Emsley,J. and Gailani,D.<br>Activity of factor XII-Locarno<br>Res Pract Thromb Haemost (2018) 2, 168-173. PubMed  Europe PubMed DOI  PMC  EPMC  M
  69. Stavrou,E.X.<br>Factor XII in inflammation and wound healing<br>Curr Opin Hematol (2018) 25, 403-409. PubMed  Europe PubMed DOI
  70. Wilmot,H.V., Hockley,J., Rigsby,P. and Gray,E.<br>Establishment of the World Health Organization First International Standard for factor XII, plasma, human<br>Front Med (Lausanne) (2018) 5, 46-46. PubMed  Europe PubMed DOI  PMC  EPMC  A
  71. Yang,L., Jin,S., Ji,W., Cheng,X., Li,X., Jin,Y. and Wang,M.<br>[Analysis of a consanguineous pedigree affected with hereditary coagulation factor XII deficiency caused by homozygous Gly341Arg mutation]<br>Zhonghua Yi Xue Yi Chuan Xue Za Zhi (2018) 35, 69-73. PubMed  Europe PubMed DOI  M
  72. Zou,A., Wang,M., Jin,Y., Cheng,X., Su,K. and Yang,L.<br>Genetic analysis of a novel missense mutation (Gly542Ser) with factor XII deficiency in a Chinese patient of consanguineous marriage<br>Int J Hematol (2018) 107, 436-441. PubMed  Europe PubMed DOI  M
    73. 2017
  73. Bender,L., Weidmann,H., Rose-John,S., Renne,T. and Long,A.T.<br>Factor XII-driven inflammatory reactions with implications for anaphylaxis<br>Front Immunol (2017) 8, 1115-1115. PubMed  Europe PubMed DOI  PMC  EPMC
  74. Hamad,B.K., Pathak,M., Manna,R., Fischer,P.M., Emsley,J. and Dekker,L.V.<br>Assessment of the protein interaction between coagulation factor XII and corn trypsin inhibitor by molecular docking and biochemical validation<br>J Thromb Haemost (2017) 15, 1818-1828. PubMed  Europe PubMed DOI
  75. Ivanov,I., Matafonov,A., Sun,M.F., Cheng,Q., Dickeson,S.K., Verhamme,I.M., Emsley,J. and Gailani,D.<br>Proteolytic properties of single-chain factor XII: a mechanism for triggering contact activation<br>Blood (2017) 129, 1527-1537. PubMed  Europe PubMed DOI
  76. Ivanov,I., Matafonov,A. and Gailani,D.<br>Single-chain factor XII: a new form of activated factor XII<br>Curr Opin Hematol (2017) 24, 411-418. PubMed  Europe PubMed DOI
  77. Maruyama,H., Hosoe,H., Nagamatsu,K., Kano,R. and Kamata,H.<br>A novel missense mutation in the factor XII gene in a litter of cats with factor XII deficiency<br>J Vet Med Sci (2017) 79, 822-826. PubMed  Europe PubMed DOI  M
  78. Naudin,C., Burillo,E., Blankenberg,S., Butler,L. and Renne,T.<br>Factor XII contact activation<br>Semin Thromb Hemost (2017) 43, 814-826. PubMed  Europe PubMed DOI
  79. Nickel,K.F., Long,A.T., Fuchs,T.A., Butler,L.M. and Renne,T.<br>Factor XII as a therapeutic target in thromboembolic and inflammatory diseases<br>Arterioscler Thromb Vasc Biol (2017) 37, 13-20. PubMed  Europe PubMed DOI  T
  80. Simao,F., Ustunkaya,T., Clermont,A.C. and Feener,E.P.<br>Plasma kallikrein mediates brain hemorrhage and edema caused by tissue plasminogen activator therapy in mice after stroke<br>Blood (2017) 129, 2280-2290. PubMed  Europe PubMed DOI
  81. Wujak,L., Hesse,C., Sewald,K., Jonigk,D., Braubach,P., Warnecke,G., Fieguth,H.G., Braun,A., Lochnit,G., Markart,P., Schaefer,L. and Wygrecka,M.<br>FXII promotes proteolytic processing of the LRP1 ectodomain<br>Biochim Biophys Acta (2017) 1861, 2088-2098. PubMed  Europe PubMed DOI
  82. Yang,A., Chen,F., He,C., Zhou,J., Lu,Y., Dai,J., Birge,R.B. and Wu,Y.<br>The procoagulant activity of apoptotic cells is mediated by interaction with factor XII<br>Front Immunol (2017) 8, 1188-1188. PubMed  Europe PubMed DOI  PMC  EPMC
    83. 2016
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