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Literature for peptidase S01.211: coagulation factor XIIa

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

(Topics flags: A Assay, S Structure, T Target, K Knockout, E Expression, V Review, M Mutation, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Elwakiel,A., Gupta,D., Rana,R., Manoharan,J., Al-Dabet,M.M., Ambreen,S., Fatima,S., Zimmermann,S., Mathew,A., Li,Z., Singh,K., Gupta,A., Pal,S., Sulaj,A., Kopf,S., Schwab,C., Baber,R., Geffers,R., Gotze,T., Alo,B., Lamers,C., Kluge,P., Kuenze,G., Kohli,S., Renne,T., Shahzad,K. and Isermann,B.
    Author Correction: Factor XII signaling via uPAR-integrin beta1 axis promotes tubular senescence in diabetic kidney disease
    Nat Commun (2026) 17, 540-540. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Krajewska,K., Pawlus,J., Ptaszynska,K. and Lisowska,A.
    Factor XII-A New Therapeutic Target? A Systematic Review
    Int J Mol Sci (2026) 27 PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2025
  3. Bundgaard,E., Pedersen,M.K., Bor,P. and Bor,M.V.
    Revisiting the Link Between Factor XII and Recurrent Pregnancy Loss: A Scoping Review
    Am J Reprod Immunol (2025) 94, e70127-e70127. PubMed  Europe PubMed DOI  PMC  EPMC
  4. Haj,A.K., Paul,D.S., Jurgens,S.J., Eswaran,H., Weng,L.C., Ryu,J., Rodriguez Espada,A., Chaudhry,S., Feingold,L.M., Burke,K., Koyama,S., Wang,X., Francis,J., Choi,S.H., Mackman,N., Bergmeier,W., Burgin,A., Ramo,J.T., Ellinor,P.T., Grover,S.P. and Bendapudi,P.K.
    Coagulation factor XII haploinsufficiency is protective against venous thromboembolism in a population-scale multidimensional analysis
    Nat Commun (2025) 16, 8176-8176. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Lira,A.L., Liu,T., Aslan,J.E., Puy,C. and McCarty,O.J.T.
    Lipopolysaccharide supramolecular organization regulates the activation of coagulation factor XII
    Biochim Biophys Acta Biomembr (2025) 1867, 184415-184415. PubMed  Europe PubMed DOI
  6. Lira,A.L., Drew,K.C., Puy,C., Shatzel,J.J. and McCarty,O.J.T.
    Lipopolysaccharide and Coagulation Factor XII: Biophysics of Contact Activation in Infection
    Semin Thromb Hemost (2025) PubMed  Europe PubMed DOI
  7. Liu,H., Yang,K., Wang,S. and Ge,J.
    Advancements in research on the thrombo-inflammation mechanisms mediated by factor XII in ischemic stroke
    J Thromb Thrombolysis (2025) PubMed  Europe PubMed DOI  V
  8. Lopez-Lera,A., Corvillo,F., Gonzalez-Sanchez,L., Melgosa,M. and Sanchez-Corral,P.
    Relevance of the interactions between the complement and contact coagulation systems on renal pathology
    Nefrologia (Engl Ed) (2025) , 501347-501347. PubMed  Europe PubMed DOI
  9. Nickel,K.F., Jamsa,A., Konrath,S., Papareddy,P., Butler,L.M., Stavrou,E.X., Frye,M., Gelderblom,M., Nieswandt,B., Hammerschmidt,S., Herwald,H. and Renne,T.
    Factor XII-driven coagulation traps bacterial infections
    J Exp Med (2025) 222 PubMed  Europe PubMed DOI  PMC  EPMC
  10. Satpathy,C., Mishra,T.K. and Jha,A.K.
    Factor XI and XII inhibitors-Dawn of a new era
    Indian Heart J (2025) PubMed  Europe PubMed DOI  V
  11. Yang,A., Zhang,Y., Sun,Y., Jiang,M., Lu,Y., Han,Y., Wu,D., Luo,Z. and Wu,Y.
    Thiol isomerase ERp46 catalyzes the disulfide formation of coagulation factor XII enhancing its activity
    J Thromb Haemost (2025) PubMed  Europe PubMed DOI
    12. 2024
  12. Al-Horani,R.A.
    Revisiting the effect of cholesteryl sulfate on clotting and fibrinolysis: Inhibition of human thrombin and other human blood proteases
    Heliyon (2024) 10, e28017-e28017. PubMed  Europe PubMed DOI  PMC  EPMC  I
  13. He,X., Zhao,Y., Guang,H., Chen,K., She,Z., Cao,M., Bai,M., Yang,Y., Su,M., Zhao,W., Liu,Y., Liu,S., Sun,H. and Gao,J.
    Qinghaienin, a novel anticoagulation protein from the hard tick Haemaphysalis qinghaiensis, inhibits the activation of factor XII by competing for anionic surfaces
    Int J Biol Macromol (2024) 290, 139120-139120. PubMed  Europe PubMed DOI
  14. Natorska,J., Zabczyk,M., Mastalerz,L. and Undas,A.
    Increased factor XI but not factor XII is associated with enhanced inflammation and impaired fibrin clot properties in patients with eosinophilic granulomatosis with polyangiitis
    Clin Exp Rheumatol (2024) 42, 822-827. PubMed  Europe PubMed DOI
  15. Shamanaev,A., Litvak,M., Ivanov,I., Srivastava,P., Sun,M.F., Dickeson,S.K., Kumar,S., He,T.Z. and Gailani,D.
    Factor XII Structure-Function Relationships
    Semin Thromb Hemost (2024) 50, 937-952. PubMed  Europe PubMed DOI  V
  16. Silbak,S. and Schmaier,A.H.
    The enigma of factor XII surface binding
    J Thromb Haemost (2024) 22, 2422-2425. PubMed  Europe PubMed DOI
  17. Xu,P., Zhang,Y., Guo,J., Li,H., Konrath,S., Zhou,P., Cai,L., Rao,H., Chen,H., Lin,J., Cui,Z., Ji,B., Wang,J., Li,N., Liu,D.P., Renne,T. and Wang,M.
    A single-domain antibody targeting factor XII inhibits both thrombosis and inflammation
    Nat Commun (2024) 15, 7898-7898. PubMed  Europe PubMed DOI  PMC  EPMC
    18. 2023
  18. Davoine,C., Traina,A., Evrard,J., Lanners,S., Fillet,M. and Pochet,L.
    Coumarins as factor XIIa inhibitors: Potency and selectivity improvements using a fragment-based strategy
    Eur J Med Chem (2023) 259, 115636-115636. PubMed  Europe PubMed DOI
  19. Ilin,I., Podoplelova,N., Sulimov,A., Kutov,D., Tashchilova,A., Panteleev,M., Shikhaliev,K., Krysin,M., Stolpovskaya,N., Potapov,A. and Sulimov,V.
    Experimentally Validated Novel Factor XIIa Inhibitors Identified by Docking and Quantum Chemical Post-processing
    Mol Inform (2023) 42, e2200205-e2200205. PubMed  Europe PubMed DOI  I
  20. Umei,N., Shin,S., Lai,A., Miller,J., Roberts,K., Strelkova,D., Chaudhary,N., Ichiba,S., Sakamoto,A., Whitehead,K. and Cook,K.
    Factor XII Silencing Using siRNA Prevents Thrombus Formation in a Rat Model of Extracorporeal Life Support
    ASAIO J (2023) 69, 527-532. PubMed  Europe PubMed DOI
    21. 2022
  21. Jiang,S., Jia,Z., Zheng,Y., Zhang,J., Li,Z., Yu,X., Zhang,K., Bai,Y., Guo,W., Kong,Y. and Li,Q.
    Bifunctional fusion protein targeting both FXIIa and FXIa displays potent anticoagulation effects
    Life Sci (2022) 309, 121021-121021. PubMed  Europe PubMed DOI
  22. Kilinc,E., Can Timucin,A., Selim Cinaroglu,S. and Timucin,E.
    Modeling and dynamical analysis of the full-length structure of factor XII with zinc
    J Mol Model (2022) 28, 129-129. PubMed  Europe PubMed DOI
  23. Mailer,R.K., Rangaswamy,C., Konrath,S., Emsley,J. and Renne,T.
    An update on factor XII-driven vascular inflammation
    Biochim Biophys Acta Mol Cell Res (2022) 1869, 119166-119166. PubMed  Europe PubMed DOI  V
  24. Mohammed,B.M., Cheng,Q. and Gailani,D.
    A demonstration of factor XI contributing to hemostasis in the absence of factor XII
    Res Pract Thromb Haemost (2022) 6, e12841-e12841. PubMed  Europe PubMed DOI  PMC  EPMC
  25. Shamanaev,A., Litvak,M. and Gailani,D.
    Recent advances in factor XII structure and function
    Curr Opin Hematol (2022) 29, 233-243. PubMed  Europe PubMed DOI  PMC  EPMC  V
  26. Shamanaev,A., Ivanov,I., Sun,M.F., Litvak,M., Srivastava,P., Mohammed,B.M., Shaban,R., Maddur,A., Verhamme,I.M., McCarty,O.J.T., Law,R.H.P. and Gailani,D.
    A Model for Surface-Dependent Factor XII Activation: The Roles of Factor XII Heavy Chain Domains
    Blood Adv (2022) PubMed  Europe PubMed DOI
  27. Sohaei,D., Hollenberg,M., Janket,S.J., Diamandis,E.P., Poda,G. and Prassas,I.
    The therapeutic relevance of the Kallikrein-Kinin axis in SARS-cov-2-induced vascular pathology
    Crit Rev Clin Lab Sci (2022) , 1-16. PubMed  Europe PubMed DOI  V
  28. Tashchilova,A., Podoplelova,N., Sulimov,A., Kutov,D., Ilin,I., Panteleev,M., Shikhaliev,K., Medvedeva,S., Novichikhina,N., Potapov,A. and Sulimov,V.
    New Blood Coagulation Factor XIIa Inhibitors: Molecular Modeling, Synthesis, and Experimental Confirmation
    Molecules (2022) 27 PubMed  Europe PubMed DOI  PMC  EPMC
    29. 2021
  29. Davoine,C., Fillet,M. and Pochet,L.
    Capillary electrophoresis as a fragment screening tool to cross-validate hits from chromogenic assay: Application to FXIIa
    Talanta (2021) 226, 122163-122163. PubMed  Europe PubMed DOI
  30. Heestermans,M., Naudin,C., Mailer,R.K., Konrath,S., Klaetschke,K., Jamsa,A., Frye,M., Deppermann,C., Pula,G., Kuta,P., Friese,M.A., Gelderblom,M., Sickmann,A., Preston,R.J.S., Nofer,J.R., Rose-John,S., Butler,L.M., Salomon,O., Stavrou,E.X. and Renne,T.
    Identification of the factor XII contact activation site enables sensitive coagulation diagnostics
    Nat Commun (2021) 12, 5596-5596. PubMed  Europe PubMed DOI  PMC  EPMC
  31. Kalinin,D.V.
    Factor XII(a) inhibitors: a review of the patent literature
    Expert Opin Ther Pat (2021) PubMed  Europe PubMed DOI
  32. Murray,N.P., Guzman,E. and Del Prado,M.
    Transient acquired Factor XII deficiency associated with moderately severe Covid-19 pneumonia
    Hematol Transfus Cell Ther (2021) PubMed  Europe PubMed DOI  PMC  EPMC
  33. Pawaskar,D., Chen,X., Glassman,F., May,F., Roberts,A., Biondo,M., McKenzie,A., Nolte,M.W., Jusko,W.J. and Tortorici,M.
    Pharmacokinetic/pharmacodynamic modeling for dose selection for the first-in-human trial of the activated Factor XII inhibitor garadacimab (CSL312)
    Clin Transl Sci (2021) PubMed  Europe PubMed DOI
  34. Stetter,C., Lopez-Caperuchipi,S., Hopp-Kramer,S., Bieber,M., Kleinschnitz,C., Siren,A.L. and Albert-Weissenberger,C.
    Amelioration of Cognitive and Behavioral Deficits after Traumatic Brain Injury in Coagulation Factor XII Deficient Mice
    Int J Mol Sci (2021) 22 PubMed  Europe PubMed DOI  PMC  EPMC
  35. Xiao,B., Liu,F., Jin,Y.H., Wang,M.X., Zhang,J., Lu,J.C. and Yang,X.C.
    Two Novel Mutations (G774A and A1685G) Causing Coagulation Factor XII Deficiency in a Patient with Acute Inferior Myocardial Infarction
    Ann Clin Lab Sci (2021) 51, 426-429. PubMed  Europe PubMed
    36. 2020
  36. Chaudhry,S.A., Serrata,M., Tomczak,L., Higgins,S., Ryu,J., Laprise,D., Enjyoji,K., Bekendam,R., Kaushik,V., Flaumenhaft,R. and Bendapudi,P.K.
    Cationic Zinc is Required for Factor XII Recruitment and Activation by Stimulated Platelets and for Thrombus Formation in vivo
    J Thromb Haemost (2020) PubMed  Europe PubMed DOI
  37. Cheng,X., Yang,L., Xin,Y., Zhu,L., Su,M. and Hao,X.
    [Analysis of a pedigree affected with hereditary coagulation factor XII deficiency due to a homozygous 252delAsn deletion of F12 gene]
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi (2020) 37, 755-758. PubMed  Europe PubMed DOI
  38. Davoine,C., Bouckaert,C., Fillet,M. and Pochet,L.
    Factor XII/XIIa inhibitors: Their discovery, development, and potential indications
    Eur J Med Chem (2020) 208, 112753-112753. PubMed  Europe PubMed DOI  V
  39. Fang,C. and Schmaier,A.H.
    Novel anti-thrombotic mechanisms mediated by Mas receptor as result of balanced activities between the kallikrein/kinin and the renin-angiotensin systems
    Pharmacol Res (2020) 160, 105096-105096. PubMed  Europe PubMed DOI  PMC  EPMC  V
  40. Hofman,Z.L.M., Clark,C.C., Sanrattana,W., Nosairi,A., Parr,N.M.J., Zivkovic,M., Krause,K., Mahnke,N.A., Scheffel,J., Hack,C.E., Maurer,M., de Maat,S. and Maas,C.
    A mutation in the kringle domain of human factor XII that causes autoinflammation, disturbs zymogen quiescence, and accelerates activation
    J Biol Chem (2020) 295, 363-374. PubMed  Europe PubMed DOI  M
  41. Juang,L.J., Mazinani,N., Novakowski,S.K., Prowse,E.N.P., Haulena,M., Gailani,D., Lavkulich,L.M. and Kastrup,C.J.
    Coagulation factor XII contributes to hemostasis when activated by soil in wounds
    Blood Adv (2020) 4, 1737-1745. PubMed  Europe PubMed DOI  PMC  EPMC
  42. Kaira,B.G., Slater,A., McCrae,K.R., Dreveny,I., Sumya,U.M., Mutch,N.J., Searle,M. and Emsley,J.
    Factor XII and kininogen asymmetric assembly with gC1qR/C1QBP/P32 is governed by allostery
    Blood (2020) PubMed  Europe PubMed DOI
  43. L Venkatraman,K., A Syed,A., Indumathi,P. and Mehta,A.
    VITPOR AI, a coagulation factor XIIa inhibitor from Porphyra yezoensis: in vivo mode of action and assessment of platelet function analysis
    Protein Pept Lett (2020) 27, 243-250. PubMed  Europe PubMed DOI
  44. Marceau,F., Rivard,G.E., Gauthier,J.M., Binkley,K.E., Bonnefoy,A., Boccon-Gibod,I., Bouillet,L., Picard,M., Levesque,G., Elfassy,H.L., Bachelard,H., Hebert,J. and Bork,K.
    Measurement of Bradykinin Formation and Degradation in Blood Plasma: Relevance for Acquired Angioedema Associated With Angiotensin Converting Enzyme Inhibition and for Hereditary Angioedema Due to Factor XII or Plasminogen Gene Variants
    Front Med (Lausanne) (2020) 7, 358-358. PubMed  Europe PubMed DOI  PMC  EPMC  I
  45. Meini,S., Zanichelli,A., Sbrojavacca,R., Iuri,F., Roberts,A.T., Suffritti,C. and Tascini,C.
    Understanding the Pathophysiology of COVID-19: Could the Contact System Be the Key?
    Front Immunol (2020) 11, 2014-2014. PubMed  Europe PubMed DOI  PMC  EPMC
  46. Nakayama,M., Miyagawa,H., Kuranami,Y., Tsunooka-Ota,M., Yamaguchi,Y. and Kojima-Aikawa,K.
    Annexin A4 inhibits sulfatide-induced activation of coagulation factor XII
    J Thromb Haemost (2020) 18, 1357-1369. PubMed  Europe PubMed DOI
  47. Rohmann,J.L., Huo,S., Sperber,P.S., Piper,S.K., Rosendaal,F.R., Heuschmann,P.U., Endres,M., Liman,T.G. and Siegerink,B.
    Coagulation factor XII, XI, and VIII activity levels and secondary events after first ischemic stroke
    J Thromb Haemost (2020) PubMed  Europe PubMed DOI
  48. Sipka,S., Toth,A. and Sipka S Jr
    Age-dependent possible role of contact-activated blood coagulation factor XII as a potential contributor to the "bradykinin storm" in COVID-19 patients
    Orv Hetil (2020) 161, 2099-2103. PubMed  Europe PubMed DOI  V
  49. Srivastava,P. and Gailani,D.
    The rebirth of the contact pathway: a new therapeutic target
    Curr Opin Hematol (2020) 27, 311-319. PubMed  Europe PubMed DOI
  50. Takeyama,M., Nogami,K., Matsumoto,T., Noguchi-Sasaki,M., Kitazawa,T. and Shima,M.
    An anti-factor IXa/factor X bispecific antibody, emicizumab, improves ex vivo coagulant potentials in plasma from patients with acquired hemophilia A
    J Thromb Haemost (2020) 18, 825-833. PubMed  Europe PubMed DOI
  51. Thangaraj,S.S., Christiansen,S.H., Graversen,J.H., Sidelmann,J.J., Hansen,S.W.K., Bygum,A., Gram,J.B. and Palarasah,Y.
    Contact activation-induced complex formation between complement factor H and coagulation factor XIIa
    J Thromb Haemost (2020) 18, 876-884. PubMed  Europe PubMed DOI
  52. Xu,D., Xue,G., Peng,B., Feng,Z., Lu,H. and Gong,L.
    High-Throughput Docking and Molecular Dynamics Simulations towards the Identification of Potential Inhibitors against Human Coagulation Factor XIIa
    Comput Math Methods Med (2020) 2020, 2852051-2852051. PubMed  Europe PubMed DOI  PMC  EPMC  I
  53. Yoshida,K., Tanaka,S., Sato,Y., Watanabe,K., Muramatsu,K. and Murakawa,M.
    Global cerebral infarction after aortic arch replacement surgery in a patient with postoperatively revealed factor XII deficiency: a case report
    J Med Case Rep (2020) 14, 150-150. PubMed  Europe PubMed DOI  PMC  EPMC
    54. 2019
  54. Chaudhry,L.A., El-Sadek,W.Y.M., Chaudhry,G.A. and Al-Atawi,F.E.
    Factor XII (Hageman factor) deficiency: a rare harbinger of life threatening complications
    Pan Afr Med J (2019) 33, 39-39. PubMed  Europe PubMed DOI  PMC  EPMC  M
  55. de Maat,S., Clark,C.C., Boertien,M., Parr,N., Sanrattana,W., Hofman,Z.L.M. and Maas,C.
    Factor XII truncation accelerates activation in solution
    J Thromb Haemost (2019) 17, 183-194. PubMed  Europe PubMed DOI
  56. Maruyama,H., Brooks,M.B., Stablein,A. and Frye,A.
    Factor XII deficiency is common in domestic cats and associated with two high frequency F12 mutations
    Gene (2019) 706, 6-12. PubMed  Europe PubMed DOI  M
  57. Pathak,M., Manna,R., Li,C., Kaira,B.G., Hamad,B.K., Belviso,B.D., Bonturi,C.R., Dreveny,I., Fischer,P.M., Dekker,L.V., Oliva,M.L.V. and Emsley,J.
    Crystal structures of the recombinant beta-factor XIIa protease with bound Thr-Arg and Pro-Arg substrate mimetics
    Acta Crystallogr D Struct Biol (2019) 75, 578-591. PubMed  Europe PubMed DOI  S
  58. Peng,B., Xue,G., Xu,D., Feng,Z., Chen,J., Huang,M., Lu,H. and Gong,L.
    Expression and purification of recombinant serine protease domain of human coagulation factor XII in Pichia pastoris
    Biosci Biotechnol Biochem (2019) 83, 1815-1821. PubMed  Europe PubMed DOI  E
  59. Renne,T. and Stavrou,E.X.
    Roles of factor XII in innate immunity
    Front Immunol (2019) 10, 2011-2011. PubMed  Europe PubMed DOI  PMC  EPMC
  60. Sato,Y., Sugi,T. and Sakai,R.
    Anti-factor XII autoantibodies in patients with recurrent pregnancy loss recognize the second epidermal growth factor-like domain
    TH Open (2019) 3, e263-e263. PubMed  Europe PubMed DOI  PMC  EPMC
  61. Schmaier,A.H. and Stavrou,E.X.
    Factor XII - what's important but not commonly thought about
    Res Pract Thromb Haemost (2019) 3, 599-606. PubMed  Europe PubMed DOI  PMC  EPMC
  62. Zhang,H., Liu,S., Lin,C., Luo,S., Yang,L., Jin,Y., Zhu,L. and Wang,M.
    Compound heterozygous mutations Glu502Lys and Met527Thr of the FXII gene in a patient with factor XII deficiency
    Hematology (2019) 24, 420-425. PubMed  Europe PubMed DOI  M
    63. 2018
  63. Cao,H., Biondo,M., Lioe,H., Busfield,S., Rayzman,V., Nieswandt,B., Bork,K., Harrison,L.C., Auyeung,P., Farkas,H., Csuka,D., Pelzing,M., Dower,S., Wilson,M.J., Nash,A., Nolte,M.W. and Panousis,C.
    Antibody-mediated inhibition of FXIIa blocks downstream bradykinin generation
    J Allergy Clin Immunol (2018) 142, 1355-1358. PubMed  Europe PubMed DOI
  64. Dementiev,A., Silva,A., Yee,C., Li,Z., Flavin,M.T., Sham,H. and Partridge,J.R.
    Structures of human plasma beta-factor XIIa cocrystallized with potent inhibitors
    Blood Adv (2018) 2, 549-558. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
  65. Didiasova,M., Wujak,L., Schaefer,L. and Wygrecka,M.
    Factor XII in coagulation, inflammation and beyond
    Cell Signal (2018) 51, 257-265. PubMed  Europe PubMed DOI  V
  66. Fernandes,H.D., Newton,S. and Rodrigues,J.M.
    Factor XII deficiency mimicking bleeding diathesis: a unique presentation and diagnostic pitfall
    Cureus (2018) 10, e2817-e2817. PubMed  Europe PubMed DOI  PMC  EPMC  M
  67. Maas,C. and Renne,T.
    Coagulation factor XII in thrombosis and inflammation
    Blood (2018) 131, 1903-1909. PubMed  Europe PubMed DOI
  68. Mohammed,B.M., Ivanov,I., Matafonov,A., Emsley,J. and Gailani,D.
    Activity of factor XII-Locarno
    Res Pract Thromb Haemost (2018) 2, 168-173. PubMed  Europe PubMed DOI  PMC  EPMC  M
  69. Stavrou,E.X.
    Factor XII in inflammation and wound healing
    Curr Opin Hematol (2018) 25, 403-409. PubMed  Europe PubMed DOI
  70. Wilmot,H.V., Hockley,J., Rigsby,P. and Gray,E.
    Establishment of the World Health Organization First International Standard for factor XII, plasma, human
    Front Med (Lausanne) (2018) 5, 46-46. PubMed  Europe PubMed DOI  PMC  EPMC  A
  71. Yang,L., Jin,S., Ji,W., Cheng,X., Li,X., Jin,Y. and Wang,M.
    [Analysis of a consanguineous pedigree affected with hereditary coagulation factor XII deficiency caused by homozygous Gly341Arg mutation]
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi (2018) 35, 69-73. PubMed  Europe PubMed DOI  M
  72. Zou,A., Wang,M., Jin,Y., Cheng,X., Su,K. and Yang,L.
    Genetic analysis of a novel missense mutation (Gly542Ser) with factor XII deficiency in a Chinese patient of consanguineous marriage
    Int J Hematol (2018) 107, 436-441. PubMed  Europe PubMed DOI  M
    73. 2017
  73. Bender,L., Weidmann,H., Rose-John,S., Renne,T. and Long,A.T.
    Factor XII-driven inflammatory reactions with implications for anaphylaxis
    Front Immunol (2017) 8, 1115-1115. PubMed  Europe PubMed DOI  PMC  EPMC
  74. Hamad,B.K., Pathak,M., Manna,R., Fischer,P.M., Emsley,J. and Dekker,L.V.
    Assessment of the protein interaction between coagulation factor XII and corn trypsin inhibitor by molecular docking and biochemical validation
    J Thromb Haemost (2017) 15, 1818-1828. PubMed  Europe PubMed DOI
  75. Ivanov,I., Matafonov,A., Sun,M.F., Cheng,Q., Dickeson,S.K., Verhamme,I.M., Emsley,J. and Gailani,D.
    Proteolytic properties of single-chain factor XII: a mechanism for triggering contact activation
    Blood (2017) 129, 1527-1537. PubMed  Europe PubMed DOI
  76. Ivanov,I., Matafonov,A. and Gailani,D.
    Single-chain factor XII: a new form of activated factor XII
    Curr Opin Hematol (2017) 24, 411-418. PubMed  Europe PubMed DOI
  77. Maruyama,H., Hosoe,H., Nagamatsu,K., Kano,R. and Kamata,H.
    A novel missense mutation in the factor XII gene in a litter of cats with factor XII deficiency
    J Vet Med Sci (2017) 79, 822-826. PubMed  Europe PubMed DOI  M
  78. Naudin,C., Burillo,E., Blankenberg,S., Butler,L. and Renne,T.
    Factor XII contact activation
    Semin Thromb Hemost (2017) 43, 814-826. PubMed  Europe PubMed DOI
  79. Nickel,K.F., Long,A.T., Fuchs,T.A., Butler,L.M. and Renne,T.
    Factor XII as a therapeutic target in thromboembolic and inflammatory diseases
    Arterioscler Thromb Vasc Biol (2017) 37, 13-20. PubMed  Europe PubMed DOI  T
  80. Simao,F., Ustunkaya,T., Clermont,A.C. and Feener,E.P.
    Plasma kallikrein mediates brain hemorrhage and edema caused by tissue plasminogen activator therapy in mice after stroke
    Blood (2017) 129, 2280-2290. PubMed  Europe PubMed DOI
  81. Wujak,L., Hesse,C., Sewald,K., Jonigk,D., Braubach,P., Warnecke,G., Fieguth,H.G., Braun,A., Lochnit,G., Markart,P., Schaefer,L. and Wygrecka,M.
    FXII promotes proteolytic processing of the LRP1 ectodomain
    Biochim Biophys Acta (2017) 1861, 2088-2098. PubMed  Europe PubMed DOI
  82. Yang,A., Chen,F., He,C., Zhou,J., Lu,Y., Dai,J., Birge,R.B. and Wu,Y.
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