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Literature for peptidase S01.211: coagulation factor XIIa

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, K Knockout, E Expression, V Review, M Mutation, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Lira,A.L., Liu,T., Aslan,J.E., Puy,C. and McCarty,O.J.T.
    Lipopolysaccharide supramolecular organization regulates the activation of coagulation factor XII
    Biochim Biophys Acta Biomembr1867, 184415-184415. PubMed  Europe PubMed DOI
  2. Liu,H., Yang,K., Wang,S. and Ge,J.
    Advancements in research on the thrombo-inflammation mechanisms mediated by factor XII in ischemic stroke
    J Thromb Thrombolysis PubMed  Europe PubMed DOI  V
  3. Nickel,K.F., Jamsa,A., Konrath,S., Papareddy,P., Butler,L.M., Stavrou,E.X., Frye,M., Gelderblom,M., Nieswandt,B., Hammerschmidt,S., Herwald,H. and Renne,T.
    Factor XII-driven coagulation traps bacterial infections
    J Exp Med222, PubMed  Europe PubMed DOI
    4. 2024
  4. Al-Horani,R.A.
    Revisiting the effect of cholesteryl sulfate on clotting and fibrinolysis: Inhibition of human thrombin and other human blood proteases
    Heliyon10, e28017-e28017. PubMed  Europe PubMed DOI  I
  5. He,X., Zhao,Y., Guang,H., Chen,K., She,Z., Cao,M., Bai,M., Yang,Y., Su,M., Zhao,W., Liu,Y., Liu,S., Sun,H. and Gao,J.
    Qinghaienin, a novel anticoagulation protein from the hard tick Haemaphysalis qinghaiensis, inhibits the activation of factor XII by competing for anionic surfaces
    Int J Biol Macromol290, 139120-139120. PubMed  Europe PubMed DOI
  6. Natorska,J., Zabczyk,M., Mastalerz,L. and Undas,A.
    Increased factor XI but not factor XII is associated with enhanced inflammation and impaired fibrin clot properties in patients with eosinophilic granulomatosis with polyangiitis
    Clin Exp Rheumatol42, 822-827. PubMed  Europe PubMed DOI
  7. Shamanaev,A., Litvak,M., Ivanov,I., Srivastava,P., Sun,M.F., Dickeson,S.K., Kumar,S., He,T.Z. and Gailani,D.
    Factor XII Structure-Function Relationships
    Semin Thromb Hemost50, 937-952. PubMed  Europe PubMed DOI  V
  8. Silbak,S. and Schmaier,A.H.
    The enigma of factor XII surface binding
    J Thromb Haemost22, 2422-2425. PubMed  Europe PubMed DOI
  9. Xu,P., Zhang,Y., Guo,J., Li,H., Konrath,S., Zhou,P., Cai,L., Rao,H., Chen,H., Lin,J., Cui,Z., Ji,B., Wang,J., Li,N., Liu,D.P., Renne,T. and Wang,M.
    A single-domain antibody targeting factor XII inhibits both thrombosis and inflammation
    Nat Commun15, 7898-7898. PubMed  Europe PubMed DOI
    10. 2023
  10. Davoine,C., Traina,A., Evrard,J., Lanners,S., Fillet,M. and Pochet,L.
    Coumarins as factor XIIa inhibitors: Potency and selectivity improvements using a fragment-based strategy
    Eur J Med Chem259, 115636-115636. PubMed  Europe PubMed DOI
  11. Ilin,I., Podoplelova,N., Sulimov,A., Kutov,D., Tashchilova,A., Panteleev,M., Shikhaliev,K., Krysin,M., Stolpovskaya,N., Potapov,A. and Sulimov,V.
    Experimentally Validated Novel Factor XIIa Inhibitors Identified by Docking and Quantum Chemical Post-processing
    Mol Inform42, e2200205-e2200205. PubMed  Europe PubMed DOI  I
  12. Umei,N., Shin,S., Lai,A., Miller,J., Roberts,K., Strelkova,D., Chaudhary,N., Ichiba,S., Sakamoto,A., Whitehead,K. and Cook,K.
    Factor XII Silencing Using siRNA Prevents Thrombus Formation in a Rat Model of Extracorporeal Life Support
    ASAIO J69, 527-532. PubMed  Europe PubMed DOI
    13. 2022
  13. Jiang,S., Jia,Z., Zheng,Y., Zhang,J., Li,Z., Yu,X., Zhang,K., Bai,Y., Guo,W., Kong,Y. and Li,Q.
    Bifunctional fusion protein targeting both FXIIa and FXIa displays potent anticoagulation effects
    Life Sci309, 121021-121021. PubMed  Europe PubMed DOI
  14. Kilinc,E., Can Timucin,A., Selim Cinaroglu,S. and Timucin,E.
    Modeling and dynamical analysis of the full-length structure of factor XII with zinc
    J Mol Model28, 129-129. PubMed  Europe PubMed DOI
  15. Mailer,R.K., Rangaswamy,C., Konrath,S., Emsley,J. and Renne,T.
    An update on factor XII-driven vascular inflammation
    Biochim Biophys Acta Mol Cell Res1869, 119166-119166. PubMed  Europe PubMed DOI  V
  16. Mohammed,B.M., Cheng,Q. and Gailani,D.
    A demonstration of factor XI contributing to hemostasis in the absence of factor XII
    Res Pract Thromb Haemost6, e12841-e12841. PubMed  Europe PubMed DOI
  17. Shamanaev,A., Ivanov,I., Sun,M.F., Litvak,M., Srivastava,P., Mohammed,B.M., Shaban,R., Maddur,A., Verhamme,I.M., McCarty,O.J.T., Law,R.H.P. and Gailani,D.
    A Model for Surface-Dependent Factor XII Activation: The Roles of Factor XII Heavy Chain Domains
    Blood Adv PubMed  Europe PubMed DOI
  18. Shamanaev,A., Litvak,M. and Gailani,D.
    Recent advances in factor XII structure and function
    Curr Opin Hematol29, 233-243. PubMed  Europe PubMed DOI  V
  19. Sohaei,D., Hollenberg,M., Janket,S.J., Diamandis,E.P., Poda,G. and Prassas,I.
    The therapeutic relevance of the Kallikrein-Kinin axis in SARS-cov-2-induced vascular pathology
    Crit Rev Clin Lab Sci1-16. PubMed  Europe PubMed DOI  V
  20. Tashchilova,A., Podoplelova,N., Sulimov,A., Kutov,D., Ilin,I., Panteleev,M., Shikhaliev,K., Medvedeva,S., Novichikhina,N., Potapov,A. and Sulimov,V.
    New Blood Coagulation Factor XIIa Inhibitors: Molecular Modeling, Synthesis, and Experimental Confirmation
    Molecules27, PubMed  Europe PubMed DOI
    21. 2021
  21. Davoine,C., Fillet,M. and Pochet,L.
    Capillary electrophoresis as a fragment screening tool to cross-validate hits from chromogenic assay: Application to FXIIa
    Talanta226, 122163-122163. PubMed  Europe PubMed DOI
  22. Heestermans,M., Naudin,C., Mailer,R.K., Konrath,S., Klaetschke,K., Jamsa,A., Frye,M., Deppermann,C., Pula,G., Kuta,P., Friese,M.A., Gelderblom,M., Sickmann,A., Preston,R.J.S., Nofer,J.R., Rose-John,S., Butler,L.M., Salomon,O., Stavrou,E.X. and Renne,T.
    Identification of the factor XII contact activation site enables sensitive coagulation diagnostics
    Nat Commun12, 5596-5596. PubMed  Europe PubMed DOI
  23. Kalinin,D.V.
    Factor XII(a) inhibitors: a review of the patent literature
    Expert Opin Ther Pat PubMed  Europe PubMed DOI
  24. Murray,N.P., Guzman,E. and Del Prado,M.
    Transient acquired Factor XII deficiency associated with moderately severe Covid-19 pneumonia
    Hematol Transfus Cell Ther PubMed  Europe PubMed DOI
  25. Pawaskar,D., Chen,X., Glassman,F., May,F., Roberts,A., Biondo,M., McKenzie,A., Nolte,M.W., Jusko,W.J. and Tortorici,M.
    Pharmacokinetic/pharmacodynamic modeling for dose selection for the first-in-human trial of the activated Factor XII inhibitor garadacimab (CSL312)
    Clin Transl Sci PubMed  Europe PubMed DOI
  26. Stetter,C., Lopez-Caperuchipi,S., Hopp-Kramer,S., Bieber,M., Kleinschnitz,C., Siren,A.L. and Albert-Weissenberger,C.
    Amelioration of Cognitive and Behavioral Deficits after Traumatic Brain Injury in Coagulation Factor XII Deficient Mice
    Int J Mol Sci22, PubMed  Europe PubMed DOI
  27. Xiao,B., Liu,F., Jin,Y.H., Wang,M.X., Zhang,J., Lu,J.C. and Yang,X.C.
    Two Novel Mutations (G774A and A1685G) Causing Coagulation Factor XII Deficiency in a Patient with Acute Inferior Myocardial Infarction
    Ann Clin Lab Sci51, 426-429. PubMed  Europe PubMed
    28. 2020
  28. Chaudhry,S.A., Serrata,M., Tomczak,L., Higgins,S., Ryu,J., Laprise,D., Enjyoji,K., Bekendam,R., Kaushik,V., Flaumenhaft,R. and Bendapudi,P.K.
    Cationic Zinc is Required for Factor XII Recruitment and Activation by Stimulated Platelets and for Thrombus Formation in vivo
    J Thromb Haemost PubMed  Europe PubMed DOI
  29. Cheng,X., Yang,L., Xin,Y., Zhu,L., Su,M. and Hao,X.
    [Analysis of a pedigree affected with hereditary coagulation factor XII deficiency due to a homozygous 252delAsn deletion of F12 gene]
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi37, 755-758. PubMed  Europe PubMed DOI
  30. Davoine,C., Bouckaert,C., Fillet,M. and Pochet,L.
    Factor XII/XIIa inhibitors: Their discovery, development, and potential indications
    Eur J Med Chem208, 112753-112753. PubMed  Europe PubMed DOI  V
  31. Fang,C. and Schmaier,A.H.
    Novel anti-thrombotic mechanisms mediated by Mas receptor as result of balanced activities between the kallikrein/kinin and the renin-angiotensin systems
    Pharmacol Res160, 105096-105096. PubMed  Europe PubMed DOI  V
  32. Hofman,Z.L.M., Clark,C.C., Sanrattana,W., Nosairi,A., Parr,N.M.J., Zivkovic,M., Krause,K., Mahnke,N.A., Scheffel,J., Hack,C.E., Maurer,M., de Maat,S. and Maas,C.
    A mutation in the kringle domain of human factor XII that causes autoinflammation, disturbs zymogen quiescence, and accelerates activation
    J Biol Chem295, 363-374. PubMed  Europe PubMed DOI  M
  33. Juang,L.J., Mazinani,N., Novakowski,S.K., Prowse,E.N.P., Haulena,M., Gailani,D., Lavkulich,L.M. and Kastrup,C.J.
    Coagulation factor XII contributes to hemostasis when activated by soil in wounds
    Blood Adv4, 1737-1745. PubMed  Europe PubMed DOI
  34. Kaira,B.G., Slater,A., McCrae,K.R., Dreveny,I., Sumya,U.M., Mutch,N.J., Searle,M. and Emsley,J.
    Factor XII and kininogen asymmetric assembly with gC1qR/C1QBP/P32 is governed by allostery
    Blood PubMed  Europe PubMed DOI
  35. L Venkatraman,K., A Syed,A., Indumathi,P. and Mehta,A.
    VITPOR AI, a coagulation factor XIIa inhibitor from Porphyra yezoensis: in vivo mode of action and assessment of platelet function analysis
    Protein Pept Lett27, 243-250. PubMed  Europe PubMed DOI
  36. Marceau,F., Rivard,G.E., Gauthier,J.M., Binkley,K.E., Bonnefoy,A., Boccon-Gibod,I., Bouillet,L., Picard,M., Levesque,G., Elfassy,H.L., Bachelard,H., Hebert,J. and Bork,K.
    Measurement of Bradykinin Formation and Degradation in Blood Plasma: Relevance for Acquired Angioedema Associated With Angiotensin Converting Enzyme Inhibition and for Hereditary Angioedema Due to Factor XII or Plasminogen Gene Variants
    Front Med (Lausanne)7, 358-358. PubMed  Europe PubMed DOI  I
  37. Meini,S., Zanichelli,A., Sbrojavacca,R., Iuri,F., Roberts,A.T., Suffritti,C. and Tascini,C.
    Understanding the Pathophysiology of COVID-19: Could the Contact System Be the Key?
    Front Immunol11, 2014-2014. PubMed  Europe PubMed DOI
  38. Nakayama,M., Miyagawa,H., Kuranami,Y., Tsunooka-Ota,M., Yamaguchi,Y. and Kojima-Aikawa,K.
    Annexin A4 inhibits sulfatide-induced activation of coagulation factor XII
    J Thromb Haemost18, 1357-1369. PubMed  Europe PubMed DOI
  39. Rohmann,J.L., Huo,S., Sperber,P.S., Piper,S.K., Rosendaal,F.R., Heuschmann,P.U., Endres,M., Liman,T.G. and Siegerink,B.
    Coagulation factor XII, XI, and VIII activity levels and secondary events after first ischemic stroke
    J Thromb Haemost PubMed  Europe PubMed DOI
  40. Sipka,S., Toth,A. and Sipka S Jr
    Age-dependent possible role of contact-activated blood coagulation factor XII as a potential contributor to the "bradykinin storm" in COVID-19 patients
    Orv Hetil161, 2099-2103. PubMed  Europe PubMed DOI  V
  41. Srivastava,P. and Gailani,D.
    The rebirth of the contact pathway: a new therapeutic target
    Curr Opin Hematol27, 311-319. PubMed  Europe PubMed DOI
  42. Takeyama,M., Nogami,K., Matsumoto,T., Noguchi-Sasaki,M., Kitazawa,T. and Shima,M.
    An anti-factor IXa/factor X bispecific antibody, emicizumab, improves ex vivo coagulant potentials in plasma from patients with acquired hemophilia A
    J Thromb Haemost18, 825-833. PubMed  Europe PubMed DOI
  43. Thangaraj,S.S., Christiansen,S.H., Graversen,J.H., Sidelmann,J.J., Hansen,S.W.K., Bygum,A., Gram,J.B. and Palarasah,Y.
    Contact activation-induced complex formation between complement factor H and coagulation factor XIIa
    J Thromb Haemost18, 876-884. PubMed  Europe PubMed DOI
  44. Xu,D., Xue,G., Peng,B., Feng,Z., Lu,H. and Gong,L.
    High-Throughput Docking and Molecular Dynamics Simulations towards the Identification of Potential Inhibitors against Human Coagulation Factor XIIa
    Comput Math Methods Med2020, 2852051-2852051. PubMed  Europe PubMed DOI  I
  45. Yoshida,K., Tanaka,S., Sato,Y., Watanabe,K., Muramatsu,K. and Murakawa,M.
    Global cerebral infarction after aortic arch replacement surgery in a patient with postoperatively revealed factor XII deficiency: a case report
    J Med Case Rep14, 150-150. PubMed  Europe PubMed DOI
    46. 2019
  46. Chaudhry,L.A., El-Sadek,W.Y.M., Chaudhry,G.A. and Al-Atawi,F.E.
    Factor XII (Hageman factor) deficiency: a rare harbinger of life threatening complications
    Pan Afr Med J33, 39-39. PubMed  Europe PubMed DOI  M
  47. de Maat,S., Clark,C.C., Boertien,M., Parr,N., Sanrattana,W., Hofman,Z.L.M. and Maas,C.
    Factor XII truncation accelerates activation in solution
    J Thromb Haemost17, 183-194. PubMed  Europe PubMed DOI
  48. Maruyama,H., Brooks,M.B., Stablein,A. and Frye,A.
    Factor XII deficiency is common in domestic cats and associated with two high frequency F12 mutations
    Gene706, 6-12. PubMed  Europe PubMed DOI  M
  49. Pathak,M., Manna,R., Li,C., Kaira,B.G., Hamad,B.K., Belviso,B.D., Bonturi,C.R., Dreveny,I., Fischer,P.M., Dekker,L.V., Oliva,M.L.V. and Emsley,J.
    Crystal structures of the recombinant beta-factor XIIa protease with bound Thr-Arg and Pro-Arg substrate mimetics
    Acta Crystallogr D Struct Biol75, 578-591. PubMed  Europe PubMed DOI  S
  50. Peng,B., Xue,G., Xu,D., Feng,Z., Chen,J., Huang,M., Lu,H. and Gong,L.
    Expression and purification of recombinant serine protease domain of human coagulation factor XII in Pichia pastoris
    Biosci Biotechnol Biochem83, 1815-1821. PubMed  Europe PubMed DOI  E
  51. Renne,T. and Stavrou,E.X.
    Roles of factor XII in innate immunity
    Front Immunol10, 2011-2011. PubMed  Europe PubMed DOI
  52. Sato,Y., Sugi,T. and Sakai,R.
    Anti-factor XII autoantibodies in patients with recurrent pregnancy loss recognize the second epidermal growth factor-like domain
    TH Open3, e263-e263. PubMed  Europe PubMed DOI
  53. Schmaier,A.H. and Stavrou,E.X.
    Factor XII - what's important but not commonly thought about
    Res Pract Thromb Haemost3, 599-606. PubMed  Europe PubMed DOI
  54. Zhang,H., Liu,S., Lin,C., Luo,S., Yang,L., Jin,Y., Zhu,L. and Wang,M.
    Compound heterozygous mutations Glu502Lys and Met527Thr of the FXII gene in a patient with factor XII deficiency
    Hematology24, 420-425. PubMed  Europe PubMed DOI  M
    55. 2018
  55. Cao,H., Biondo,M., Lioe,H., Busfield,S., Rayzman,V., Nieswandt,B., Bork,K., Harrison,L.C., Auyeung,P., Farkas,H., Csuka,D., Pelzing,M., Dower,S., Wilson,M.J., Nash,A., Nolte,M.W. and Panousis,C.
    Antibody-mediated inhibition of FXIIa blocks downstream bradykinin generation
    J Allergy Clin Immunol142, 1355-1358. PubMed  Europe PubMed DOI
  56. Dementiev,A., Silva,A., Yee,C., Li,Z., Flavin,M.T., Sham,H. and Partridge,J.R.
    Structures of human plasma beta-factor XIIa cocrystallized with potent inhibitors
    Blood Adv2, 549-558. PubMed  Europe PubMed DOI  S  I
  57. Didiasova,M., Wujak,L., Schaefer,L. and Wygrecka,M.
    Factor XII in coagulation, inflammation and beyond
    Cell Signal51, 257-265. PubMed  Europe PubMed DOI  V
  58. Fernandes,H.D., Newton,S. and Rodrigues,J.M.
    Factor XII deficiency mimicking bleeding diathesis: a unique presentation and diagnostic pitfall
    Cureus10, e2817-e2817. PubMed  Europe PubMed DOI  M
  59. Maas,C. and Renne,T.
    Coagulation factor XII in thrombosis and inflammation
    Blood131, 1903-1909. PubMed  Europe PubMed DOI
  60. Mohammed,B.M., Ivanov,I., Matafonov,A., Emsley,J. and Gailani,D.
    Activity of factor XII-Locarno
    Res Pract Thromb Haemost2, 168-173. PubMed  Europe PubMed DOI  M
  61. Stavrou,E.X.
    Factor XII in inflammation and wound healing
    Curr Opin Hematol25, 403-409. PubMed  Europe PubMed DOI
  62. Wilmot,H.V., Hockley,J., Rigsby,P. and Gray,E.
    Establishment of the World Health Organization First International Standard for factor XII, plasma, human
    Front Med (Lausanne)5, 46-46. PubMed  Europe PubMed DOI  A
  63. Yang,L., Jin,S., Ji,W., Cheng,X., Li,X., Jin,Y. and Wang,M.
    [Analysis of a consanguineous pedigree affected with hereditary coagulation factor XII deficiency caused by homozygous Gly341Arg mutation]
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi35, 69-73. PubMed  Europe PubMed DOI  M
  64. Zou,A., Wang,M., Jin,Y., Cheng,X., Su,K. and Yang,L.
    Genetic analysis of a novel missense mutation (Gly542Ser) with factor XII deficiency in a Chinese patient of consanguineous marriage
    Int J Hematol107, 436-441. PubMed  Europe PubMed DOI  M
    65. 2017
  65. Bender,L., Weidmann,H., Rose-John,S., Renne,T. and Long,A.T.
    Factor XII-driven inflammatory reactions with implications for anaphylaxis
    Front Immunol8, 1115-1115. PubMed  Europe PubMed DOI
  66. Hamad,B.K., Pathak,M., Manna,R., Fischer,P.M., Emsley,J. and Dekker,L.V.
    Assessment of the protein interaction between coagulation factor XII and corn trypsin inhibitor by molecular docking and biochemical validation
    J Thromb Haemost15, 1818-1828. PubMed  Europe PubMed DOI
  67. Ivanov,I., Matafonov,A. and Gailani,D.
    Single-chain factor XII: a new form of activated factor XII
    Curr Opin Hematol24, 411-418. PubMed  Europe PubMed DOI
  68. Ivanov,I., Matafonov,A., Sun,M.F., Cheng,Q., Dickeson,S.K., Verhamme,I.M., Emsley,J. and Gailani,D.
    Proteolytic properties of single-chain factor XII: a mechanism for triggering contact activation
    Blood129, 1527-1537. PubMed  Europe PubMed DOI
  69. Maruyama,H., Hosoe,H., Nagamatsu,K., Kano,R. and Kamata,H.
    A novel missense mutation in the factor XII gene in a litter of cats with factor XII deficiency
    J Vet Med Sci79, 822-826. PubMed  Europe PubMed DOI  M
  70. Naudin,C., Burillo,E., Blankenberg,S., Butler,L. and Renne,T.
    Factor XII contact activation
    Semin Thromb Hemost43, 814-826. PubMed  Europe PubMed DOI
  71. Nickel,K.F., Long,A.T., Fuchs,T.A., Butler,L.M. and Renne,T.
    Factor XII as a therapeutic target in thromboembolic and inflammatory diseases
    Arterioscler Thromb Vasc Biol37, 13-20. PubMed  Europe PubMed DOI  T
  72. Simao,F., Ustunkaya,T., Clermont,A.C. and Feener,E.P.
    Plasma kallikrein mediates brain hemorrhage and edema caused by tissue plasminogen activator therapy in mice after stroke
    Blood129, 2280-2290. PubMed  Europe PubMed DOI
  73. Wujak,L., Hesse,C., Sewald,K., Jonigk,D., Braubach,P., Warnecke,G., Fieguth,H.G., Braun,A., Lochnit,G., Markart,P., Schaefer,L. and Wygrecka,M.
    FXII promotes proteolytic processing of the LRP1 ectodomain
    Biochim Biophys Acta1861, 2088-2098. PubMed  Europe PubMed DOI
  74. Yang,A., Chen,F., He,C., Zhou,J., Lu,Y., Dai,J., Birge,R.B. and Wu,Y.
    The procoagulant activity of apoptotic cells is mediated by interaction with factor XII
    Front Immunol8, 1188-1188. PubMed  Europe PubMed DOI
    75. 2016
  75. Bouckaert,C., Serra,S., Rondelet,G., Dolusic,E., Wouters,J., Dogne,J.M., Frederick,R. and Pochet,L.
    Synthesis, evaluation and structure-activity relationship of new 3-carboxamide coumarins as FXIIa inhibitors
    Eur J Med Chem110, 181-194. PubMed  Europe PubMed DOI  I
  76. Danese,E., Montagnana,M. and Lippi,G.
    Factor XII in hemostasis and thrombosis: active player or (innocent) bystander?
    Semin Thromb Hemost42, 682-688. PubMed  Europe PubMed DOI  V
  77. de Maat,S. and Maas,C.
    Factor XII: form determines Function
    J Thromb Haemost14, 1498-1506. PubMed  Europe PubMed DOI
  78. Fyfe,I.
    Traumatic brain injury: factor XII inhibition is neuroprotective after traumatic brain injury in mice
    Nat Rev Neurol12, 250-251. PubMed  Europe PubMed DOI  I
  79. Gobel,K., Pankratz,S., Asaridou,C.M., Herrmann,A.M., Bittner,S., Merker,M., Ruck,T., Glumm,S., Langhauser,F., Kraft,P., Krug,T.F., Breuer,J., Herold,M., Gross,C.C., Beckmann,D., Korb-Pap,A., Schuhmann,M.K., Kuerten,S., Mitroulis,I., Ruppert,C., Nolte,M.W., Panousis,C., Klotz,L., Kehrel,B., Korn,T., Langer,H.F., Pap,T., Nieswandt,B., Wiendl,H., Chavakis,T., Kleinschnitz,C. and Meuth,S.G.
    Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells
    Nat Commun7, 11626-11626. PubMed  Europe PubMed DOI
  80. Grumach,A.S., Stieber,C., Veronez,C.L., Cagini,N., Constantino-Silva,R.N., Cordeiro,E., Nothen,M.M., Pesquero,J.B. and Cichon,S.
    Homozygosity for a factor XII mutation in one female and one male patient with hereditary angio-oedema
    Allergy71, 119-123. PubMed  Europe PubMed DOI  M
  81. Hopp,S., Albert-Weissenberger,C., Mencl,S., Bieber,M., Schuhmann,M.K., Stetter,C., Nieswandt,B., Schmidt,P.M., Monoranu,C.M., Alafuzoff,I., Marklund,N., Nolte,M.W., Siren,A.L. and Kleinschnitz,C.
    Targeting coagulation factor XII as a novel therapeutic option in brain trauma
    Ann Neurol79, 970-982. PubMed  Europe PubMed DOI
  82. Jin,P., Jiang,W., Yan,H., Liu,L., Gu,S., Wang,X., Shen,L. and Mo,X.
    Novel mutations in congenital factor XII deficiency
    Front Biosci (Landmark Ed)21, 419-429. PubMed  Europe PubMed  M
  83. Kokoye,Y., Ivanov,I., Cheng,Q., Matafonov,A., Dickeson,S.K., Mason,S., Sexton,D.J., Renne,T., McCrae,K., Feener,E.P. and Gailani,D.
    A comparison of the effects of factor XII deficiency and prekallikrein deficiency on thrombus formation
    Thromb Res140, 118-124. PubMed  Europe PubMed DOI  M
  84. Swedberg,J.E., Mahatmanto,T., Abdul Ghani,H., de Veer,S.J., Schroeder,C.I., Harris,J.M. and Craik,D.J.
    Substrate-guided design of selective FXIIa inhibitors based on the plant-derived Momordica cochinchinensis trypsin inhibitor-II (MCoTI-II) scaffold
    J Med Chem59, 7287-7292. PubMed  Europe PubMed DOI
  85. Yang,L., Li,Y., Bhattacharya,A. and Zhang,Y.
    A plasma proteolysis pathway comprising blood coagulation proteases
    Oncotarget7, 40919-40938. PubMed  Europe PubMed DOI
  86. Zamolodchikov,D., Renne,T. and Strickland,S.
    The Alzheimer's disease peptide beta-amyloid promotes thrombin generation through activation of coagulation factor XII
    J Thromb Haemost14, 995-1007. PubMed  Europe PubMed DOI
    87. 2015
  87. Baeriswyl,V., Calzavarini,S., Chen,S., Zorzi,A., Bologna,L., Angelillo-Scherrer,A. and Heinis,C.
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