$VAR1 = undef;

Summary for peptidase S01.211: coagulation factor XIIa

Names
MEROPS Name	coagulation factor XIIa
Other names	F12 g.p. (Homo sapiens) (activated), Hageman factor (activated)

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.211
Holotype	coagulation factor XIIa (Homo sapiens), Uniprot accession P00748 (peptidase unit: 373-615), MERNUM MER0000187
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00305
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.38
Enzymology	BRENDA database
Proteolytic events	CutDB database (5 cleavages)
Activity status	human: active (Ratnoff, 2004) mouse: active (by similarity to human) (Shan et al., 2003)
Inhibitors	Not trapped by alpha-2-macroglobulin (Barrett 1981).
Physiology	First component of intrinsic pathway of blood coagulation in mammals.
Knockout	Mice with a targetted gene deletion for coagulation factor XII showed no factor XII plasma activity and had a markedly prolonged activated partial thromboplastin time (Pauer et al., 2004). Hereditary deficiency of coagulation factor XII causes the Hagemann trait (Pixley & Colman, 1993). A common form of Sotos syndrome is a "contiguous gene syndrome" incorporating deficiency of plasma coagulation factor XII (Kurotaki et al.,2005).
Pathways	KEGG	Complement and coagulation cascades
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/Coagulation_factor_XIIa