Substrates for peptidase S01.198: mannan-binding lectin-associated serine peptidase 1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
Bz-Arg-NHPhNO2 (BAPNA)			Bz-Arg+NHPhNO2	S		-	-	Bz	Arg	NAN	-	-	-	Chen & Wallis, 2004
C4b complement component 4B	P01029	20-1738	peptide-Arg753+Asn-peptide	P		His	Leu	Ala	Arg	Asn	Asn	His	Asn	Ogata et al., 1995	21713
complement component 3	P01027	25-1663	peptide-Arg748+Ser-peptide	P		Gly	Leu	Ala	Arg	Ser	Glu	Leu	Glu	Ogata et al., 1995	21714
complement component C2	P06681	21-752	peptide-Arg223+Lys224-peptide	P		Ser	Leu	Gly	Arg	Lys	Ile	Gln	Ile	Schwaeble et al., 2004	17331
complement component C4	P0C0L4	20-1744	peptide-Arg76+Ala77-peptide	P		Gly	Leu	Gln	Arg	Ala	Leu	Glu	Ile	Ogata et al., 1995	21712
mannan-binding lectin-associated serine peptidase 1	P48740	299-699	peptide-Arg504+Asp-peptide	P		Pro	Thr	Leu	Arg	Asp	Ser	Asp	Leu	Ambrus et al., 2003	20375
mannan-binding lectin-associated serine peptidase 1	P48740	299-699	peptide-Arg448+Ile-peptide	P	NT	Leu	Met	Ala	Arg	Ile	Phe	Asn	Gly	Ambrus et al., 2003
Z-Gly-Arg-SBzl			Z-Gly-Arg+SBzl	S		-	Z	Gly	Arg	SBz	-	-	-	Rossi et al., 2001