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Literature for peptidase S01.198: mannan-binding lectin-associated serine peptidase 1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, M Mutation, K Knockout, I Inhibitor, R Splicing, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2022
  1. Golomingi,M., Kohler,J., Jenny,L., Hardy,E.T., Dobo,J., Gal,P., Pal,G., Kiss,B., Lam,W.A. and Schroeder,V.
    Complement lectin pathway components MBL and MASP-1 promote haemostasis upon vessel injury in a microvascular bleeding model
    Front Immunol13, 948190-948190. PubMed  Europe PubMed DOI
  2. Nagy,Z.A., Heja,D., Bencze,D., Kiss,B., Boros,E., Szakacs,D., Fodor,K., Wilmanns,M., Kocsis,A., Dobo,J., Gal,P., Harmat,V. and Pal,G.
    Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation
    J Biol Chem298, 101985-101985. PubMed  Europe PubMed DOI
    3. 2021
  3. Rosbjerg,A., Wurzner,R., Garred,P. and Skjoedt,M.O.
    MASP-1 and MASP-3 Bind Directly to Aspergillus fumigatus and Promote Complement Activation and Phagocytosis
    J Innate Immun1-14. PubMed  Europe PubMed DOI
    4. 2020
  4. Cedzynski,M. and Swierzko,A.S.
    Components of the Lectin Pathway of Complement in Haematologic Malignancies
    Cancers (Basel)12, PubMed  Europe PubMed DOI
  5. Fuentes-Prior,P.
    Priming of SARS-CoV-2 S protein by several membrane-bound serine proteinases could explain enhanced viral infectivity and systemic COVID-19 infection
    J Biol Chem PubMed  Europe PubMed DOI  V
  6. Gajek,G., Swierzko,A.S. and Cedzynski,M.
    Association of Polymorphisms of MASP1/3, COLEC10, and COLEC11 Genes with 3MC Syndrome
    Int J Mol Sci21, PubMed  Europe PubMed DOI
    7. 2019
  7. Debreczeni,M.L., Nemeth,Z., Kajdacsi,E., Schwaner,E., Mako,V., Masszi,A., Doleschall,Z., Rigo,J., Walter,F.R., Deli,M.A., Pal,G., Dobo,J., Gal,P. and Cervenak,L.
    MASP-1 Increases endothelial permeability
    Front Immunol10, 991-991. PubMed  Europe PubMed DOI
    8. 2018
  8. Parej,K., Kocsis,A., Enyingi,C., Dani,R., Oroszlan,G., Beinrohr,L., Dobo,J., Zavodszky,P., Pal,G. and Gal,P.
    Cutting edge: a new player in the alternative complement pathway, MASP-1 is essential for LPS-induced, but not for Zymosan-induced, alternative pathway activation
    J Immunol200, 2247-2252. PubMed  Europe PubMed DOI
    9. 2016
  9. Banda,N.K., Acharya,S., Scheinman,R.I., Mehta,G., Coulombe,M., Takahashi,M., Sekine,H., Thiel,S., Fujita,T. and Holers,V.M.
    Mannan-binding lectin-associated serine protease 1/3 cleavage of pro-factor D into factor D in vivo and attenuation of collagen antibody-induced arthritis through their targeted inhibition by RNA interference-mediated gene silencing
    J Immunol197, 3680-3694. PubMed  Europe PubMed DOI
  10. Dobo,J., Pal,G., Cervenak,L. and Gal,P.
    The emerging roles of mannose-binding lectin-associated serine proteases (MASPs) in the lectin pathway of complement and beyond
    Immunol Rev274, 98-111. PubMed  Europe PubMed DOI
    11. 2015
  11. Jenny,L., Dobo,J., Gal,P. and Schroeder,V.
    MASP-1 of the complement system promotes clotting via prothrombin activation
    Mol Immunol65, 398-405. PubMed  Europe PubMed DOI
  12. Jenny,L., Dobo,J., Gal,P. and Schroeder,V.
    MASP-1 induced clotting - the first model of prothrombin activation by MASP-1
    PLoS ONE10, e0144633-e0144633. PubMed  Europe PubMed DOI
    13. 2014
  13. Rosbjerg,A., Munthe-Fog,L., Garred,P. and Skjoedt,M.O.
    Heterocomplex formation between MBL/ficolin/CL-11-associated serine protease-1 and -3 and MBL/ficolin/CL-11-associated protein-1
    J Immunol192, 4352-4360. PubMed  Europe PubMed DOI
    14. 2013
  14. Degn,S.E., Thiel,S. and Jensenius,J.C.
    Recombinant expression of the autocatalytic complement protease MASP-1 is crucially dependent on co-expression with its inhibitor, C1 inhibitor
    Protein Expr Purif88, 173-182. PubMed  Europe PubMed DOI  E
    15. 2012
  15. Heja,D., Harmat,V., Fodor,K., Wilmanns,M., Dobo,J., Kekesi,K.A., Zavodszky,P., Gal,P. and Pal,G.
    Monospecific inhibitors show that both mannan-binding lectin-associated serine protease-1 (MASP-1) and -2 are essential for lectin pathway activation and reveal structural plasticity of MASP-2
    J Biol Chem287, 20290-20300. PubMed  Europe PubMed DOI
  16. La Bonte,L.R., Pavlov,V.I., Tan,Y.S., Takahashi,K., Takahashi,M., Banda,N.K., Zou,C., Fujita,T. and Stahl,G.L.
    Mannose-binding lectin-associated serine protease-1 is a significant contributor to coagulation in a murine model of occlusive thrombosis
    J Immunol188, 885-891. PubMed  Europe PubMed DOI
  17. Schwaeble,W.J., Lynch,N.J., Gal,P. and Zavodszky,P.
    Mannan-binding lectin-associated serine proteases
    [ISSN:978-0-12-407742-3]3, 2857-2863. DOI
  18. Yongqing,T., Drentin,N., Duncan,R.C., Wijeyewickrema,L.C. and Pike,R.N.
    Mannose-binding lectin serine proteases and associated proteins of the lectin pathway of complement: two genes, five proteins and many functions?
    Biochim Biophys Acta1824, 253-262. PubMed  Europe PubMed DOI  V  R
    19. 2011
  19. Banda,N.K., Takahashi,M., Takahashi,K., Stahl,G.L., Hyatt,S., Glogowska,M., Wiles,T.A., Endo,Y., Fujita,T., Michael Holers,V. and Arend,W.P.
    Mechanisms of mannose-binding lectin-associated serine proteases-1/3 activation of the alternative pathway of complement
    Mol Immunol49, 281-289. PubMed  Europe PubMed DOI
  20. Dobo,J., Major,B., Kekesi,K.A., Szabo,I., Megyeri,M., Hajela,K., Juhasz,G., Zavodszky,P. and Gal,P.
    Cleavage of kininogen and subsequent bradykinin release by the complement component: mannose-binding lectin-associated serine protease (MASP)-1
    PLoS ONE6, e20036-e20036. PubMed  Europe PubMed DOI
  21. Gingras,A.R., Girija,U.V., Keeble,A.H., Panchal,R., Mitchell,D.A., Moody,P.C. and Wallis,R.
    Structural basis of mannan-binding lectin recognition by its associated serine protease MASP-1: implications for complement activation
    Structure19, 1635-1643. PubMed  Europe PubMed DOI  S
  22. Takahashi,K., Chang,W.C., Takahashi,M., Pavlov,V., Ishida,Y., La Bonte,L., Shi,L., Fujita,T., Stahl,G.L. and Van Cott,E.M.
    Mannose-binding lectin and its associated proteases (MASPs) mediate coagulation and its deficiency is a risk factor in developing complications from infection, including disseminated intravascular coagulation
    Immunobiology216, 96-102. PubMed  Europe PubMed DOI
    23. 2010
  23. Degn,S.E., Jensen,L., Gal,P., Dobo,J., Holmvad,S.H., Jensenius,J.C. and Thiel,S.
    Biological variations of MASP-3 and MAp44, two splice products of the MASP1 gene involved in regulation of the complement system
    J Immunol Methods361, 37-50. PubMed  Europe PubMed DOI  R
  24. Gulla,K.C., Gupta,K., Krarup,A., Gal,P., Schwaeble,W.J., Sim,R.B., O'Connor,C.D. and Hajela,K.
    Activation of mannan-binding lectin-associated serine proteases leads to generation of a fibrin clot
    Immunology129, 482-495. PubMed  Europe PubMed DOI
  25. Kocsis,A., Kekesi,K.A., Szasz,R., Vegh,B.M., Balczer,J., Dobo,J., Zavodszky,P., Gal,P. and Pal,G.
    Selective inhibition of the lectin pathway of complement with phage display selected peptides against mannose-binding lectin-associated serine protease (MASP)-1 and -2: significant contribution of MASP-1 to lectin pathway activation
    J Immunol185, 4169-4178. PubMed  Europe PubMed DOI  I
  26. Skjoedt,M.O., Hummelshoj,T., Palarasah,Y., Honore,C., Koch,C., Skjodt,K. and Garred,P.
    A novel mannose-binding lectin/ficolin-associated protein is highly expressed in heart and skeletal muscle tissues and inhibits complement activation
    J Biol Chem285, 8234-8243. PubMed  Europe PubMed DOI
  27. Takahashi,M., Ishida,Y., Iwaki,D., Kanno,K., Suzuki,T., Endo,Y., Homma,Y. and Fujita,T.
    Essential role of mannose-binding lectin-associated serine protease-1 in activation of the complement factor D
    J Exp Med207, 29-37. PubMed  Europe PubMed DOI  K
    28. 2009
  28. Degn,S.E., Hansen,A.G., Steffensen,R., Jacobsen,C., Jensenius,J.C. and Thiel,S.
    MAp44, a human protein associated with pattern recognition molecules of the complement system and regulating the lectin pathway of complement activation
    J Immunol183, 7371-7378. PubMed  Europe PubMed DOI
  29. Dobo,J., Harmat,V., Beinrohr,L., Sebestyen,E., Zavodszky,P. and Gal,P.
    MASP-1, a promiscuous complement protease: structure of its catalytic region reveals the basis of its broad specificity
    J Immunol183, 1207-1214. PubMed  Europe PubMed DOI  S
  30. Gal,P., Dobo,J., Zavodszky,P. and Sim,R.B.
    Early complement proteases: C1r, C1s and MASPs. A structural insight into activation and functions
    Mol Immunol46, 2745-2752. PubMed  Europe PubMed DOI  V
  31. Megyeri,M., Mako,V., Beinrohr,L., Doleschall,Z., Prohaszka,Z., Cervenak,L., Zavodszky,P. and Gal,P.
    Complement protease MASP-1 activates human endothelial cells: PAR4 activation is a link between complement and endothelial function
    J Immunol183, 3409-3416. PubMed  Europe PubMed DOI
    32. 2008
  32. Dobo,J., Harmat,V., Sebestyen,E., Beinrohr,L., Zavodszky,P. and Gal,P.
    Purification, crystallization and preliminary X-ray analysis of human mannose-binding lectin-associated serine protease-1 (MASP-1) catalytic region
    Acta Crystallograph Sect F Struct Biol Cryst Commun64, 781-784. PubMed  Europe PubMed DOI
  33. Krarup,A., Gulla,K.C., Gal,P., Hajela,K. and Sim,R.B.
    The action of MBL-associated serine protease 1 (MASP1) on factor XIII and fibrinogen
    Biochim Biophys Acta1784, 1294-1300. PubMed  Europe PubMed DOI
  34. Takahashi,M., Iwaki,D., Kanno,K., Ishida,Y., Xiong,J., Matsushita,M., Endo,Y., Miura,S., Ishii,N., Sugamura,K. and Fujita,T.
    Mannose-Binding Lectin (MBL)-Associated Serine Protease (MASP)-1 Contributes to Activation of the Lectin Complement Pathway
    J Immunol180, 6132-6138. PubMed  Europe PubMed  K
  35. Teillet,F., Gaboriaud,C., Lacroix,M., Martin,L., Arlaud,G.J. and Thielens,N.M.
    Crystal structure of the CUB1-EGF-CUB2 domain of human MASP-1/3 and identification of its interaction sites with mannan-binding lectin and ficolins
    J Biol Chem283, 25715-25724. PubMed  Europe PubMed DOI  S
    36. 2007
  36. Gal,P., Barna,L., Kocsis,A. and Zavodszky,P.
    Serine proteases of the classical and lectin pathways: similarities and differences
    Immunobiology212, 267-277. PubMed  Europe PubMed DOI  V
  37. Kang,H.J., Lee,S.M., Lee,H.H., Kim,J.Y., Lee,B.C., Yum,J.S., Moon,H.M. and Lee,B.L.
    Mannose-binding lectin without the aid of its associated serine proteases alters lipopolysaccharide-mediated cytokine/chemokine secretion from human endothelial cells
    Immunology122, 335-342. PubMed  Europe PubMed DOI
  38. Moller-Kristensen,M., Thiel,S., Sjoholm,A., Matsushita,M. and Jensenius,J.C.
    Cooperation between MASP-1 and MASP-2 in the generation of C3 convertase through the MBL pathway
    Int Immunol19, 141-149. PubMed  Europe PubMed DOI
  39. Takahashi,M., Mori,S., Shigeta,S. and Fujita,T.
    Role of MBL-associated serine protease (MASP) on activation of the lectin complement pathway
    Adv Exp Med Biol598, 93-104. PubMed  Europe PubMed DOI  V
  40. Weiss,G., Madsen,H.O. and Garred,P.
    A novel mannose-binding lectin-associated serine protease 1/3 gene variant
    Scand J Immunol65, 430-434. PubMed  Europe PubMed DOI  M
    41. 2006
  41. Selander,B., Martensson,U., Weintraub,A., Holmstrom,E., Matsushita,M., Thiel,S., Jensenius,J.C., Truedsson,L. and Sjoholm,A.G.
    Mannan-binding lectin activates C3 and the alternative complement pathway without involvement of C2
    J Clin Invest116, 1425-1434. PubMed  Europe PubMed DOI
    42. 2005
  42. [YEAR:15-4-2005]Lynch,N.J., Khan,S.U., Stover,C.M., Sandrini,S.M., Marston,D., Presanis,J.S. and Schwaeble,W.J.
    Composition of the lectin pathway of complement in Gallus gallus: absence of mannan-binding lectin-associated serine protease-1 in birds
    J Immunol174, 4998-5006. PubMed  Europe PubMed
  43. Song,L., Takamune,K., Sugawara,Y. and Fujii,T.
    cDNA cloning of a mannose-binding lectin-associated serine protease (MASP) gene from hagfish (Eptatretus burgeri)
    Zoolog Sci22, 897-904. PubMed  Europe PubMed DOI
    44. 2004
  44. [YEAR:18-6-2004]Chen,C.B. and Wallis,R.
    Two mechanisms for mannose-binding protein modulation of the activity of its associated serine proteases
    J Biol Chem279, 26058-26065. PubMed  Europe PubMed DOI
  45. Presanis,J.S., Hajela,K., Ambrus,G., Gal,P. and Sim,R.B.
    Differential substrate and inhibitor profiles for human MASP-1 and MASP-2
    Mol Immunol40, 921-929. PubMed  Europe PubMed DOI
  46. Schwaeble,W.J., Stover,C. and Reid,K.B.M.
    Mannan-binding lectin-associated serine proteases
    [ISSN:0-12-079610-4]2, 1623-1627.  V
  47. Wallis,R., Shaw,J.M., Uitdehaag,J., Chen,C.B., Torgersen,D. and Drickamer,K.
    Localization of the serine protease-binding sites in the collagen-like domain of mannose-binding protein: indirect effects of naturally occurring mutations on protease binding and activation
    J Biol Chem279, 14065-14073. PubMed  Europe PubMed DOI
    48. 2003
  48. [YEAR:1-2-2003]Ambrus,G., Gal,P., Kojima,M., Szilagyi,K., Balczer,J., Antal,J., Graf,L., Laich,A., Moffatt,B.E., Schwaeble,W., Sim,R.B. and Zavodszky,P.
    Natural substrates and inhibitors of mannan-binding lectin-associated serine protease-1 and -2: a study on recombinant catalytic fragments
    J Immunol170, 1374-1382. PubMed  Europe PubMed
  49. [YEAR:1-5-2003]Endo,Y., Nonaka,M., Saiga,H., Kakinuma,Y., Matsushita,A., Takahashi,M., Matsushita,M. and Fujita,T.
    Origin of mannose-binding lectin-associated serine protease (MASP)-1 and MASP-3 involved in the lectin complement pathway traced back to the invertebrate, amphioxus
    J Immunol170, 4701-4707. PubMed  Europe PubMed
  50. Presanis,J.S., Kojima,M. and Sim,R.B.
    Biochemistry and genetics of mannan-binding lectin (MBL)
    Biochem Soc Trans31, 748-752. PubMed  Europe PubMed DOI
    51. 2002
  51. [YEAR:15-11-2002]Cseh,S., Vera,L., Matsushita,M., Fujita,T., Arlaud,G.J. and Thielens,N.M.
    Characterization of the interaction between L-ficolin/p35 and mannan-binding lectin-associated serine proteases-1 and -2
    J Immunol169, 5735-5743. PubMed  Europe PubMed
  52. Endo,Y., Takahashi,M., Kuraya,M., Matsushita,M., Stover,C.M., Schwaeble,W.J. and Fujita,T.
    Functional characterization of human mannose-binding lectin-associated serine protease (MASP)-1/3 and MASP-2 promoters, and comparison with the C1s promoter
    Int Immunol14, 1193-1201. PubMed  Europe PubMed
  53. Fujita,T.
    Evolution of the lectin-complement pathway and its role in innate immunity
    Nat Rev Immunol2, 346-353. PubMed  Europe PubMed DOI
  54. Hajela,K., Kojima,M., Ambrus,G., Wong,K.H., Moffatt,B.E., Ferluga,J., Hajela,S., Gal,P. and Sim,R.B.
    The biological functions of MBL-associated serine proteases (MASPs)
    Immunobiology205, 467-475. PubMed  Europe PubMed
  55. Nonaka,M. and Miyazawa,S.
    Evolution of the initiating enzymes of the complement system
    Genome Biol3, REVIEWS1001-REVIEWS1001. PubMed  Europe PubMed
  56. Schwaeble,W., Dahl,M.R., Thiel,S., Stover,C. and Jensenius,J.C.
    The mannan-binding lectin-associated serine proteases (MASPs) and MAp19: four components of the lectin pathway activation complex encoded by two genes
    Immunobiology205, 455-466. PubMed  Europe PubMed DOI  R
    57. 2001
  57. [YEAR:13-7-2001]Chen,C.B. and Wallis,R.
    Stoichiometry of complexes between mannose-binding protein and its associated serine proteases. Defining functional units for complement activation
    J Biol Chem276, 25894-25902. PubMed  Europe PubMed DOI
  58. [YEAR:2-11-2001]Rossi,V., Cseh,S., Bally,I., Thielens,N.M., Jensenius,J.C. and Arlaud,G.J.
    Substrate specificities of recombinant mannan-binding lectin-associated serine proteases-1 and-2
    J Biol Chem276, 40880-40887. PubMed  Europe PubMed DOI
  59. [YEAR:15-4-2001]Thielens,N.M., Cseh,S., Thiel,S., Vorup-Jensen,T., Rossi,V., Jensenius,J.C. and Arlaud,G.J.
    Interaction properties of human mannan-binding lectin (MBL)-associated serine proteases-1 and -2, MBL-associated protein 19, and MBL
    J Immunol166, 5068-5077. PubMed  Europe PubMed
    60. 2000
  60. [YEAR:1-9-2000]Matsushita,M., Thiel,S., Jensenius,J.C., Terai,I. and Fujita,T.
    Proteolytic activities of two types of mannose-binding lectin-associated serine protease
    J Immunol165, 2637-2642. PubMed  Europe PubMed
  61. [YEAR:1-3-2000]Matsushita,M., Endo,Y. and Fujita,T.
    Cutting edge: Complement-activating complex of ficolin and mannose-binding lectin-associated serine protease
    J Immunol164, 2281-2284. PubMed  Europe PubMed
  62. Sim,R.B. and Laich,A.
    Serine proteases of the complement system
    Biochem Soc Trans28, 545-550. PubMed  Europe PubMed
  63. [YEAR:6-10-2000]Wallis,R. and Dodd,R.B.
    Interaction of mannose-binding protein with associated serine proteases: effects of naturally occurring mutations
    J Biol Chem275, 30962-30969. PubMed  Europe PubMed DOI
    64. 1999
  64. Takayama,Y., Takada,F., Nowatari,M., Kawakami,M. and Matsu-ura,N.
    Gene structure of the P100 serine-protease component of the human Ra-reactive factor
    Mol Immunol36, 505-514. PubMed  Europe PubMed DOI
  65. Wong,N.K., Kojima,M., Dobo,J., Ambrus,G. and Sim,R.B.
    Activities of the MBL-associated serine proteases (MASPs) and their regulation by natural inhibitors
    Mol Immunol36, 853-861. PubMed  Europe PubMed DOI
    66. 1998
  66. Matsushita,M., Endo,Y. and Fujita,T.
    MASP1 (MBL-associated serine protease 1)
    Immunobiology199, 340-347. PubMed  Europe PubMed DOI
  67. Matsushita,M., Endo,Y., Nonaka,M. and Fujita,T.
    Complement-related serine proteases in tunicates and vertebrates
    Curr Opin Immunol10, 29-35. PubMed  Europe PubMed DOI
    68. 1997
  68. Ji,X., Azumi,K., Sasaki,M. and Nonaka,M.
    Ancient origin of the complement lectin pathway revealed by molecular cloning of mannan binding protein-associated serine protease from a urochordate, the Japanese ascidian, Halocynthia roretzi
    Proc Natl Acad Sci U S A94, 6340-6345. PubMed  Europe PubMed DOI
  69. Knittel,T., Fellmer,P., Neubauer,K., Kawakami,M., Grundmann,A. and Ramadori,G.
    The complement-activating protease P100 is expressed by hepatocytes and is induced by IL-6 in vitro and during the acute phase reaction in vivo
    Lab Invest77, 221-230. PubMed  Europe PubMed
    70. 1996
  70. Endo,Y., Sato,T., Matsushita,M. and Fujita,T.
    Exon structure of the gene encoding the human mannose-binding protein-associated serine protease light chain: Comparison with complement C1r and C1s genes
    Int Immunol8, 1355-1358. PubMed  Europe PubMed
  71. Tan,S.M., Chung,M.C., Kon,O.L., Thiel,S., Lee,S.H. and Lu,J.
    Improvements on the purification of mannan-binding lectin and demonstration of its Ca(2+)-independent association with a C1s-like serine protease
    Biochem J319, 329-332. PubMed  Europe PubMed
    72. 1995
  72. Ogata,R.T., Low,P.J. and Kawakami,M.
    Substrate specificities of the protease of mouse serum Ra-reactive factor
    J Immunol154, 2351-2357. PubMed  Europe PubMed
  73. Terai,I., Kobayashi,K., Matsushita,M., Fujita,T. and Matsuno,K.
    alpha2-Macroglobulin binds to and inhibits mannose-binding protein-associated serine protease
    Int Immunol7, 1579-1584. PubMed  Europe PubMed
    74. 1994
  74. Sato,T., Endo,Y., Matsushita,M. and Fujita,T.
    Molecular characterization of a novel serine protease involved in activation of the complement system by mannose-binding protein
    Int Immunol6, 665-669. PubMed  Europe PubMed
  75. Takayama,Y., Takada,F., Takahashi,A. and Kawakami,M.
    A 100-kDa protein in the C4-activating component of Ra-reactive factor is a new serine protease having module organization similar to C1r and C1s
    J Immunol152, 2308-2316. PubMed  Europe PubMed
    76. 1993
  76. Ji,Y.H., Fujita,T., Hatsuse,H., Takahashi,A., Matsushita,M. and Kawakami,M.
    Activation of the C4 and C2 components of complement by a proteinase in serum bactericidal factor, Ra reactive factor
    J Immunol150, 571-578. PubMed  Europe PubMed
    77. 1992
  77. Matsushita,M. and Fujita,T.
    Activation of the classical complement pathway by mannose-binding protein in association with a novel C1s-like serine protease
    J Exp Med176, 1497-1502. PubMed  Europe PubMed DOI

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