$VAR1 = undef;

Summary for peptidase S01.198: mannan-binding lectin-associated serine peptidase 1

Names
MEROPS Name	mannan-binding lectin-associated serine peptidase 1
Other names	mannan-binding lectin-associated serine protease 1, MBP-associated serine protease, P100, Ra-reactive factor, MASP1 g.p. (Homo sapiens)

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.198
Holotype	mannan-binding lectin-associated serine peptidase 1 (Homo sapiens), Uniprot accession P48740 (peptidase unit: 449-698), MERNUM MER0000244
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00303
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (5 cleavages)
Activity status	human: active (Schwaeble et al., 2004) mouse: active (Ogata et al., 1995)
Physiology	Role in activation of the complement system in innate immunity.
Pathways	KEGG	Complement and coagulation cascades
	KEGG	Staphylococcus aureus infection
Other databases	TREEFAM	http://www.treefam.org/family/TF330373