$VAR1 = undef;

Summary for peptidase S01.156: enteropeptidase

Names
MEROPS Name	enteropeptidase
Other names	enterokinase, PRSS7 g.p. (Homo sapiens), TMPRSS15

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.156
Holotype	enteropeptidase (Bos taurus), Uniprot accession P98072 (peptidase unit: 801-1035), MERNUM MER0000207
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00286
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.9
Enzymology	BRENDA database
Proteolytic events	CutDB database (1 cleavage)
Activity status	human: active (Sadler, 2004) mouse: active (Yuan et al., 1998)
Biotechnology	Reagent for cleavage of recombinant fusion proteins.
Inhibitors	Not trapped by alpha-2-macroglobulin (Barrett 1981).
Physiology	Activates trypsinogen and other pancreatic proenzymes in intestine.
Knockout	Human enteropeptidase deficiency is a rare hereditary condition first described in 1969 (Mann & Mann, 1994).
Pharmaceutical relevance	Possible role in acute pancreatitis.
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/Enteropeptidase
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	ds/dg/Dey/RK-/glv/G/gs (based on 21 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	1	4	0	0	1	5	14	8
Pro	0	0	0	0	0	0	0	1
Ala	1	0	1	0	3	2	1	0
Val	2	1	0	0	0	4	1	0
Leu	0	1	0	0	0	4	0	0
Ile	0	0	0	0	3	0	0	0
Met	0	0	0	0	5	2	0	0
Phe	0	0	0	0	1	0	0	0
Tyr	0	1	3	0	0	0	0	0
Trp	1	0	0	0	2	1	0	1
Ser	6	2	1	0	1	0	1	7
Thr	0	0	0	0	0	0	0	0
Cys	0	0	0	0	2	0	2	0
Asn	0	2	0	0	0	0	0	0
Gln	1	0	0	0	1	0	1	1
Asp	6	8	11	0	0	0	0	1
Glu	1	2	5	0	0	0	0	1
Lys	0	0	0	7	0	1	0	0
Arg	1	0	0	14	1	1	0	0
His	1	0	0	0	0	0	0	0