Substrates for peptidase S01.127: cationic trypsin (Homo sapiens-type)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
carboxypeptidase B	P15086	16-417	peptide-Arg110+Ala-peptide	N	CS	Ser	Arg	Val	Arg	Ala	Thr	Gly	His	Yamamoto et al., 1992	3634
cationic trypsin	P07477	82-247	peptide-Arg122+Val-peptide	P	NT	Ile	Asn	Ala	Arg	Val	Ser	Thr	Ile	Szmola & Sahin-Toth, 2007	20900
MEP1A	Q8TDC9	1-746	peptide-Arg65+Asn-peptide	P		Gln	Lys	Ser	Arg	Asn	Gly	Leu	Arg	Rösmann et al., 2002	3637
meprin alpha subunit	P28825	1-747	peptide-Arg77+Asn-peptide	P		Pro	Arg	Thr	Arg	Asn	Ala	Met	Arg	Johnson & Bond, 1997	20472
pancreatic secretory trypsin inhibitor	P00995	24-79	peptide-Lys41+Ile-peptide	P		Gly	Cys	Thr	Lys	Ile	Tyr	Asp	Pro	Witt et al., 2000	3635
proteinase-activated receptor 2	P55085	26-397	peptide-Arg36+Ser-peptide	P		Ser	Lys	Gly	Arg	Ser	Leu	Ile	Gly	Bohm et al., 1996	18992
REG3A	Q53S56	1-175	peptide-Arg37+Ile-peptide	P		Pro	Ser	Ala	Arg	Ile	Arg	Cys	Pro	Graf et al., 2001	3636
Z-Gly-Pro-Arg-NHPhNO2			Z-Gly-Pro-Arg+NHPhNO2	S		Z	Gly	Pro	Arg	NAN	-	-	-	Chen & Ferec, 2004