$VAR1 = undef;
Summary for peptidase S01.127: cationic trypsin (Homo sapiens-type)
| Names | |
|---|---|
| MEROPS Name | cationic trypsin (Homo sapiens-type) |
| Other names | PRSS1 g.p. (Homo sapiens), trypsin 1 (Homo sapiens) |
| Domain architecture |
|---|
| MEROPS Classification | |
|---|---|
| Classification | Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.127 |
| Holotype | cationic trypsin (Homo sapiens-type), Uniprot accession P07477 (peptidase unit: 24-246), MERNUM MER0000020 |
| History | Identifier created: MEROPS 5.8 (19 March 2002) |
| Activity | |||
|---|---|---|---|
| Catalytic type | Serine | ||
| NC-IUBMB | Not yet included in IUBMB recommendations. | ||
| Proteolytic events | CutDB database (7 cleavages) | ||
| Knockout | Human hereditary pancreatitis (HP) is a rare, early-onset genetic disorder characterized by epigastric pain and often more serious complications. It is caused by mutations in the gene for cationic trypsinogen. Several different mutations have been detected, and they are associated with variants of the disease (Whitcomb et al., 1996; Gorry et al., 1997; Nishimori et al., 1999). | ||
| Pathways | KEGG | Influenza A | |
| KEGG | Neuroactive ligand-receptor interaction | ||
| KEGG | Pancreatic secretion | ||
| KEGG | Protein digestion and absorption | ||
| Other databases | TREEFAM | http://www.treefam.org/family/TF331065 | |
| Human genetics | ||||||
|---|---|---|---|---|---|---|
| Gene symbol | Locus | Megabases | Ensembl | Entrez gene | Gene Cards | OMIM |
| PRSS1 | 7q35 | ENSG00000173636 | 5644 | PRSS1 | 276000 | |
