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Literature for peptidase S01.127: cationic trypsin (Homo sapiens-type)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, K Knockout, P Specificity, E Expression, V Review, M Mutation, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. [YEAR:27-3-2025]Whitcomb,D.C.
    PRSS1-Related Hereditary Pancreatitis
     PubMed  Europe PubMed
    2. 2023
  2. Masson,E., Zou,W.B., Pu,N., Rebours,V., Genin,E., Wu,H., Lin,J.H., Wang,Y.C., Abrantes,A., Aguilera Munoz,L., Albouys,J., Alric,L., Amiot,X., Archambeaud,I., Audiau,S., Bastide,L., Baudon,J., Bellaiche,G., Bellon,S., Bertrand,V., Bideau,K., Billiemaz,K., Billioud,C., Bonnefoy,S., Borderon,C., Bournet,B., Breton,E., Brugel,M., Buscail,L., Cadiot,G., Camus,M., Causse,X., Chamouard,P., Chaput,U., Cholet,F., Ciocan,D.M., Clavel,C., Coffin,B., Coimet-Berger,L., Creveaux,I., Culetto,A., Daboussi,O., Mestier,L., Degand,T., D'engremont,C., Denis,B., Dermine,S., Desgrippes,R., D'Aubigny,A.D., Enaud,R., Fabre,A., Gargot,D., Gelsi,E., Gentilcore,E., Gincul,R., Ginglinger-Favre,E., Giovannini,M., Gomercic,C., Gondran,H., Grainville,T., Grandval,P., Grasset,D., Grimaldi,S., Grimbert,S., Hagege,H., Heissat,S., Hentic,O., Herber-Mayne,A., Hervouet,M., Hoibian,S., Jacques,J., Jais,B., Kaassis,M., Koch,S., Lacaze,E., Lacroute,J., Lamireau,T., Laurent,L., Guillou,X.L., Rhun,M.L., Leblanc,S., Levy,P., Lievre,A., Lorenzo,D., Maire,F., Marcel,K., Matias,C., Mauillon,J., Morgant,S., Moussata,D., Muller,N., Nambot,S., Napoleon,B., Olivier,A., Pagenault,M., Pelletier,A.L., Pennec,O., Pinard,F., Pioche,M., Prost,B., Queneherve,L., Rebours,V., Reboux,N., Rekik,S., Riachi,G., Rohmer,B., Roquelaure,B., Hezode,I.R., Rostain,F., Saurin,J.C., Servais,L., Stan-Iuga,R., Subtil,C., Texier,C., Thomassin,L., Tougeron,D., Tsakiris,L., Valats,J.C., Vuitton,L., Wallenhorst,T., Wangerme,M., Zanaldi,H. and Zerbib,F.
    Classification of PRSS1 variants responsible for chronic pancreatitis: An expert perspective from the Franco-Chinese GREPAN study group
    Pancreatology23, 491-506. PubMed  Europe PubMed DOI
    3. 2022
  3. Girodon,E., Rebours,V., Chen,J.M., Pagin,A., Levy,P., Ferec,C. and Bienvenu,T.
    Clinical interpretation of PRSS1 gene variants in patients with pancreatitis
    Clin Res Hepatol Gastroenterol46, 101531-101531. PubMed  Europe PubMed DOI  V
  4. Thiel,F., Reiser,M. and Weiss,F.U.
    A rare PRSS1 p.S127C mutation is associated with chronic pancreatitis and causes misfolding-induced ER-stress
    Pancreatology22, 1112-1119. PubMed  Europe PubMed DOI
    5. 2021
  5. Akhmedov,V.A. and Gaus,O.V.
    [Inflammatory diseases of the pancreas: what new do we know about the mechanisms of their development in the 21st century?]
    Ter Arkh93, 66-70. PubMed  Europe PubMed DOI
    6. 2020
  6. Dong,Z.M., Cheng,L., Zhang,P. and Zhao,G.C.
    Label-free analytical performances of a peptide-based QCM biosensor for trypsin
    Analyst145, 3329-3338. PubMed  Europe PubMed DOI  A
  7. Gui,F., Zhang,Y., Wan,J., Zhan,X., Yao,Y., Li,Y., Haddock,A.N., Shi,J., Guo,J., Chen,J., Zhu,X., Edenfield,B.H., Zhuang,L., Hu,C., Wang,Y., Mukhopadhyay,D., Radisky,E.S., Zhang,L., Lugea,A., Pandol,S.J., Bi,Y. and Ji,B.
    Trypsin activity governs increased susceptibility to pancreatitis in mice expressing human PRSS1R122H
    J Clin Invest130, 189-202. PubMed  Europe PubMed DOI
  8. Jancso,Z. and Sahin-Toth,M.
    Mutation that promotes activation of trypsinogen increases severity of secretagogue-induced pancreatitis in mice
    Gastroenterology158, 1083-1094. PubMed  Europe PubMed DOI
  9. Klaassen,K., Stankovic,B., Zukic,B., Kotur,N., Gasic,V., Pavlovic,S. and Stojiljkovic,M.
    Functional prediction and comparative population analysis of variants in genes for proteases and innate immunity related to SARS-CoV-2 infection
    Infect Genet Evol84, 104498-104498. PubMed  Europe PubMed DOI
  10. Li,G., Wei,H., Bi,J., Ding,X., Li,L., Xu,S., Yang,G. and Ren,W.
    Insights into dietary switch in cetaceans: evidence from molecular evolution of proteinases and lipases
    J Mol Evol PubMed  Europe PubMed DOI
  11. Li,X., Peng,Y., Liu,H., Xu,Y., Wang,X., Zhang,C. and Ma,X.
    Comparative studies on the interaction of nine flavonoids with trypsin
    Spectrochim Acta A Mol Biomol Spectrosc238, 118440-118440. PubMed  Europe PubMed DOI  I
  12. Malthouse,J.P.G.
    Kinetic studies of the effect of pH on the trypsin-catalyzed hydrolysis of N-alpha-benzyloxycarbonyl-l-lysine-p-nitroanilide: mechanism of trypsin catalysis
    ACS Omega5, 4915-4923. PubMed  Europe PubMed DOI
  13. Mosztbacher,D., Demcsak,A. and Sahin-Toth,M.
    Measuring digestive protease activation in the mouse pancreas
    Pancreatology20, 288-292. PubMed  Europe PubMed DOI  A
  14. Ni Chonchubhair,H.M., Duggan,S.N., Egan,S.M., Kenyon,M., O'Toole,D., McManus,R. and Conlon,K.C.
    A high prevalence of genetic polymorphisms in idiopathic and alcohol-associated chronic pancreatitis patients in Ireland
    HPB (Oxford) PubMed  Europe PubMed DOI
    15. 2019
  15. Demcsak,A., Geisz,A. and Sahin-Toth,M.
    Engineering mouse cationic trypsinogen for rapid and selective activation by cathepsin B
    Sci Rep9, 9188-9188. PubMed  Europe PubMed DOI
  16. Jancso,Z., Oracz,G., Kujko,A.A., Kolodziejczyk,E., Radisky,E.S., Rygiel,A.M. and Sahin-Toth,M.
    Novel pathogenic PRSS1 variant p.Glu190Lys in a case of chronic pancreatitis
    Front Genet10, 46-46. PubMed  Europe PubMed DOI  M
  17. Malicki,S., Ksiazek,M., Majewski,P., Pecak,A., Mydel,P., Grudnik,P. and Dubin,G.
    Development of a novel, high-affinity ssDNA trypsin inhibitor
    J Enzyme Inhib Med Chem34, 638-643. PubMed  Europe PubMed DOI  I
  18. Zhou,Z., Liu,W., Wang,Y., Ding,F., Liu,X., Zhao,Q., Zou,P., Wang,X. and Rao,H.
    A fluorometric and colorimetric method for determination of trypsin by exploiting the gold nanocluster-induced aggregation of hemoglobin-coated gold nanoparticles
    Mikrochim Acta186, 272-272. PubMed  Europe PubMed DOI  A
    19. 2018
  19. Schilling,O., Biniossek,M.L., Mayer,B., Elsasser,B., Brandstetter,H., Goettig,P., Stenman,U.H. and Koistinen,H.
    Specificity profiling of human trypsin-isoenzymes
    Biol Chem399, 997-1007. PubMed  Europe PubMed DOI  P
  20. Sendler,M., Weiss,F.U., Golchert,J., Homuth,G., van den Brandt,C., Mahajan,U.M., Partecke,L.I., Doring,P., Gukovsky,I., Gukovskaya,A.S., Wagh,P.R., Lerch,M.M. and Mayerle,J.
    Cathepsin B-mediated activation of trypsinogen in endocytosing macrophages increases severity of pancreatitis in mice
    Gastroenterology154, 704-718. PubMed  Europe PubMed DOI
    21. 2017
  21. Masuda,Y., Yamaotsu,N. and Hirono,S.
    Gibbs free energy of hydrolytic water molecule in acyl-enzyme intermediates of a serine protease: a potential application for computer-aided discovery of mechanism-based reversible covalent inhibitors
    Chem Pharm Bull (Tokyo)65, 889-892. PubMed  Europe PubMed DOI
    22. 2016
  22. Brandl,T., Simic,O., Skaanderup,P.R., Namoto,K., Berst,F., Ehrhardt,C., Schiering,N., Mueller,I. and Woelcke,J.
    Trypsin inhibitors for the treatment of pancreatitis
    Bioorg Med Chem Lett26, 4340-4344. PubMed  Europe PubMed DOI  I
  23. Kayode,O., Wang,R., Pendlebury,D.F., Cohen,I., Henin,R.D., Hockla,A., Soares,A.S., Papo,N., Caulfield,T.R. and Radisky,E.S.
    An acrobatic substrate metamorphosis reveals a requirement for substrate conformational dynamics in trypsin proteolysis
    J Biol Chem291, 26304-26319. PubMed  Europe PubMed DOI  S
  24. Yi,Q., Dong,F., Lin,L., Liu,Q., Chen,S., Gao,F. and He,Q.
    PRSS1 mutations and the proteinase/antiproteinase imbalance in the pathogenesis of pancreatic cancer
    Tumour Biol37, 5805-5810. PubMed  Europe PubMed DOI  M
  25. Zhuo,C.X., Wang,L.H., Feng,J.J. and Zhang,Y.D.
    Label-free fluorescent detection of trypsin activity based on DNA-stabilized silver nanocluster-peptide conjugates
    Sensors (Basel)16, PubMed  Europe PubMed DOI  A
    26. 2015
  26. Alloy,A.P., Kayode,O., Wang,R., Hockla,A., Soares,A.S. and Radisky,E.S.
    Mesotrypsin has evolved four unique residues to cleave trypsin inhibitors as substrates
    J Biol Chem290, 21523-21535. PubMed  Europe PubMed DOI
    27. 2014
  27. Chang,M.C., Jan,I.S., Liang,P.C., Jeng,Y.M., Yang,C.Y., Tien,Y.W., Wong,J.M. and Chang,Y.T.
    Human cationic trypsinogen but not serine peptidase inhibitor, Kazal type 1 variants increase the risk of type 1 autoimmune pancreatitis
    J Gastroenterol Hepatol29, 2038-2042. PubMed  Europe PubMed DOI  M
  28. Chen,Q., Xue,H., Chen,M., Gao,F., Xu,J., Liu,Q., Yang,X., Zheng,L. and Chen,H.
    High serum trypsin levels and the -409 T/T genotype of PRSS1 gene are susceptible to neonatal sepsis
    Inflammation37, 1751-1756. PubMed  Europe PubMed DOI  M
  29. Haerteis,S., Krappitz,A., Krappitz,M., Murphy,J.E., Bertog,M., Krueger,B., Nacken,R., Chung,H., Hollenberg,M.D., Knecht,W., Bunnett,N.W. and Korbmacher,C.
    Proteolytic activation of the human epithelial sodium channel by trypsin IV and trypsin I involves distinct cleavage sites
    J Biol Chem289, 19067-19078. PubMed  Europe PubMed DOI  P
  30. Hegyi,E., Cierna,I., Vavrova,L., Ilencikova,D., Konecny,M. and Kovacs,L.
    Chronic pancreatitis associated with the p.G208A variant of PRSS1 gene in a European patient
    JOP15, 49-52. PubMed  Europe PubMed  M
  31. Masamune,A.
    Genetics of pancreatitis: the 2014 update
    Tohoku J Exp Med232, 69-77. PubMed  Europe PubMed DOI  M
  32. Nemeth,B.C. and Sahin-Toth,M.
    Human cationic trypsinogen (PRSS1) variants and chronic pancreatitis
    Am J Physiol Gastrointest Liver Physiol306, G466-G473. PubMed  Europe PubMed DOI  M
  33. Ravi Kanth,V. and Nageshwar Reddy,D.
    Genetics of acute and chronic pancreatitis: an update
    World J Gastrointest Pathophysiol5, 427-437. PubMed  Europe PubMed DOI  M
  34. Szabo,A., Radisky,E.S. and Sahin-Toth,M.
    Zymogen activation confers thermodynamic stability on a key peptide bond and protects human cationic trypsin from degradation
    J Biol Chem289, 4753-4761. PubMed  Europe PubMed DOI
  35. Szabo,A., Salameh,M.A., Ludwig,M., Radisky,E.S. and Sahin-Toth,M.
    Tyrosine sulfation of human trypsin steers S2' subsite selectivity towards basic amino acids
    PLoS ONE9, e102063-e102063. PubMed  Europe PubMed DOI  P
    36. 2013
  36. Gao,F., Li,Y.M., Hong,G.L., Xu,Z.F., Liu,Q.C., He,Q.L., Lin,L.Q. and Weng,S.H.
    PRSS1_p.Leu81Met mutation results in autoimmune pancreatitis
    World J Gastroenterol19, 3332-3338. PubMed  Europe PubMed DOI  M
  37. Geisz,A., Hegyi,P. and Sahin-Toth,M.
    Robust autoactivation, chymotrypsin C independence and diminished secretion define a subset of hereditary pancreatitis-associated cationic trypsinogen mutants
    FEBS J280, 2888-2899. PubMed  Europe PubMed DOI  M
  38. Miao,P., Liu,T., Li,X., Ning,L., Yin,J. and Han,K.
    Highly sensitive, label-free colorimetric assay of trypsin using silver nanoparticles
    Biosens Bioelectron49, 20-24. PubMed  Europe PubMed DOI  A
    39. 2012
  39. Chen,J.M. and Ferec,C.
    Cationic trypsin (human)
    [ISSN:978-0-12-407742-3]3, 2609-2614. DOI
  40. Chen,J.M., Radisky,E.S. and Ferec,C.
    Human trypsins
    [ISSN:978-0-12-407742-3]3, 2600-2609. DOI
  41. Karstad,R., Isaksen,G., Wynendaele,E., Guttormsen,Y., De Spiegeleer,B., Brandsdal,B.O., Svendsen,J.S. and Svenson,J.
    Targeting the S1 and S3 subsite of trypsin with unnatural cationic amino acids generates antimicrobial peptides with potential for oral administration
    J Med Chem55, 6294-6305. PubMed  Europe PubMed DOI  I
  42. Orlichenko,L., Stolz,D.B., Noel,P., Behari,J., Liu,S. and Singh,V.P.
    ADP-ribosylation factor 1 protein regulates trypsinogen activation via organellar trafficking of procathepsin B protein and autophagic maturation in acute pancreatitis
    J Biol Chem287, 24284-24293. PubMed  Europe PubMed DOI
  43. Petronella,N. and Drouin,G.
    Strong purifying selection against gene conversions in the trypsin genes of primates
    Hum Genet131, 1739-1749. PubMed  Europe PubMed DOI
  44. Szabo,A. and Sahin-Toth,M.
    Determinants of chymotrypsin C cleavage specificity in the calcium-binding loop of human cationic trypsinogen
    FEBS J279, 4283-4292. PubMed  Europe PubMed DOI
  45. Szabo,A. and Sahin-Toth,M.
    Increased activation of hereditary pancreatitis-associated human cationic trypsinogen mutants in presence of chymotrypsin C
    J Biol Chem287, 20701-20710. PubMed  Europe PubMed DOI  M
    46. 2008
  46. Felderbauer,P., Schnekenburger,J., Lebert,R., Bulut,K., Parry,M., Meister,T., Schick,V., Schmitz,F., Domschke,W. and Schmidt,W.E.
    A novel A121T mutation in human cationic trypsinogen associated with hereditary pancreatitis: functional data indicating a loss-of-function mutation influencing the R122 trypsin cleavage site
    J Med Genet45, 507-512. PubMed  Europe PubMed DOI  M
  47. Liu,Q.C., Gao,F., Cheng,Z.J. and Ou,Q.S.
    Multisite mutations of the PRSS1 gene in a Chinese patient with chronic pancreatitis
    Hepatobiliary Pancreat Dis Int7, 331-332. PubMed  Europe PubMed  M
  48. Teich,N. and Mossner,J.
    Hereditary chronic pancreatitis
    Best Pract Res Clin Gastroenterol22, 115-130. PubMed  Europe PubMed DOI  V
    49. 2007
  49. Lee,T.Y., Oh,H.C., Kim,M.H., Kwon,S., Lee,S.S., Seo,D.W. and Lee,S.K.
    [Three cases of hereditary pancreatitis in two households in the same family associated with R122H mutation in cationic trypsinogen gene]
    Korean J Gastroenterol49, 395-399. PubMed  Europe PubMed  M
  50. Liu,Q.C., Cheng,Z.J., Yang,Y. and Ou,Q.S.
    [A novel mutation of PRSS1 gene in a Chinese hereditary pancreatitis family]
    Yi Chuan29, 1067-1070. PubMed  Europe PubMed  M
  51. Tzetis,M., Kaliakatsos,M., Fotoulaki,M., Papatheodorou,A., Doudounakis,S., Tsezou,A., Makrythanasis,P., Kanavakis,E. and Nousia-Arvanitakis,S.
    Contribution of the CFTR gene, the pancreatic secretory trypsin inhibitor gene (SPINK1) and the cationic trypsinogen gene (PRSS1) to the etiology of recurrent pancreatitis
    Clin Genet71, 451-457. PubMed  Europe PubMed DOI  M
    52. 2006
  52. Kiraly,O., Guan,L., Szepessy,E., Toth,M., Kukor,Z. and Sahin-Toth,M.
    Expression of human cationic trypsinogen with an authentic N terminus using intein-mediated splicing in aminopeptidase P deficient Escherichia coli
    Protein Expr Purif48, 104-111. PubMed  Europe PubMed DOI  E
    53. 2005
  53. [YEAR:21-3-2005]Pho-Iam,T., Thongnoppakhun,W., Yenchitsomanus,P.T. and Limwongse,C.
    A Thai family with hereditary pancreatitis and increased cancer risk due to a mutation in PRSS1 gene
    World J Gastroenterol11, 1634-1638. PubMed  Europe PubMed  M
  54. Teich,N., Nemoda,Z., Kohler,H., Heinritz,W., Mossner,J., Keim,V. and Sahin-Toth,M.
    Gene conversion between functional trypsinogen genes PRSS1 and PRSS2 associated with chronic pancreatitis in a six-year-old girl
    Hum Mutat25, 343-347. PubMed  Europe PubMed DOI  M
    55. 2004
  55. Chandak,G.R., Idris,M.M., Reddy,D.N., Mani,K.R., Bhaskar,S., Rao,G.V. and Singh,L.
    Absence of PRSS1 mutations and association of SPINK1 trypsin inhibitor mutations in hereditary and non-hereditary chronic pancreatitis
    Gut53, 723-728. PubMed  Europe PubMed DOI
  56. Chen,J.M. and Ferec,C.
    Human trypsins
    [ISSN:0-12-079610-4]2, 1489-1493.  V
  57. [YEAR:8-4-2004]Hohenblum,H., Vorauer-Uhl,K., Katinger,H. and Mattanovich,D.
    Bacterial expression and refolding of human trypsinogen
    J Biotechnol109, 3-11. PubMed  Europe PubMed DOI
  58. Teich,N., Le Marechal,C., Kukor,Z., Caca,K., Witzigmann,H., Chen,J.M., Toth,M., Mossner,J., Keim,V., Ferec,C. and Sahin-Toth,M.
    Interaction between trypsinogen isoforms in genetically determined pancreatitis: mutation E79K in cationic trypsin (PRSS1) causes increased transactivation of anionic trypsinogen (PRSS2)
    Hum Mutat23, 22-31. PubMed  Europe PubMed DOI
    59. 2002
  59. [YEAR:22-2-2002]Kukor,Z., Toth,M., Pal,G. and Sahin-Toth,M.
    Human cationic trypsinogen. Arg(117) is the reactive site of an inhibitory surface loop that controls spontaneous zymogen activation
    J Biol Chem277, 6111-6117. PubMed  Europe PubMed DOI
  60. Pfutzer,R., Myers,E., Applebaum-Shapiro,S., Finch,R., Ellis,I., Neoptolemos,J., Kant,J.A. and Whitcomb,D.C.
    Novel cationic trypsinogen (PRSS1) N29T and R122C mutations cause autosomal dominant hereditary pancreatitis
    Gut50, 271-272. PubMed  Europe PubMed DOI
  61. [YEAR:15-2-2002]Simon,P., Weiss,F.U., Sahin-Toth,M., Parry,M., Nayler,O., Lenfers,B., Schnekenburger,J., Mayerle,J., Domschke,W. and Lerch,M.M.
    Hereditary pancreatitis caused by a novel PRSS1 mutation (Arg-122 - > Cys) that alters autoactivation and autodegradation of cationic trypsinogen
    J Biol Chem277, 5404-5410. PubMed  Europe PubMed DOI  M
  62. Teich,N., Bauer,N., Mossner,J. and Keim,V.
    Mutational screening of patients with nonalcoholic chronic pancreatitis: Identification of further trypsinogen variants
    Am J Gastroenterol97, 341-346. PubMed  Europe PubMed DOI
    63. 2001
  63. Chen,J.M., Montier,T. and Ferec,C.
    Molecular pathology and evolutionary and physiological implications of pancreatitis-associated cationic trypsinogen mutations
    Hum Genet109, 245-252. PubMed  Europe PubMed DOI  M
  64. Crawford,S.E., Mukherjee,S.K., Estes,M.K., Lawton,J.A., Shaw,A.L., Ramig,R.F. and Prasad,B.V.V.
    Trypsin cleavage stabilizes the rotavirus VP4 spike
    J Virol75, 6052-6061. PubMed  Europe PubMed DOI
  65. [YEAR:1-12-2001]Keim,V., Bauer,N., Teich,N., Simon,P., Lerch,M.M. and Mossner,J.
    Clinical characterization of patients with hereditary pancreatitis and mutations in the cationic trypsinogen gene
    Am J Med111, 622-626. PubMed  Europe PubMed DOI
  66. [YEAR:6-7-2001]Szilagyi,L., Kenesi,E., Katona,G., Kaslik,G., Juhasz,G. and Graf,L.
    Comparative in vitro studies on native and recombinant human cationic trypsins. Cathepsin B is a possible pathological activator of trypsinogen in pancreatitis
    J Biol Chem276, 24574-24580. PubMed  Europe PubMed DOI
  67. Tautermann,G., Ruebsamen,H., Beck,M., Dertinger,S., Drexel,H. and Lohse,P.
    R116C mutation of cationic trypsinogen in a Turkish family with recurrent pancreatitis illustrates genetic microheterogeneity of hereditary pancreatitis
    Digestion64, 226-232. PubMed  Europe PubMed DOI
  68. Truninger,K., Kock,J., Wirth,H.P., Muellhaupt,B., Arnold,C., von Weizsacker,F., Seifert,B., Ammann,R.W. and Blum,H.E.
    Trypsinogen gene mutations in patients with chronic or recurrent acute pancreatitis
    Pancreas22, 18-23. PubMed  Europe PubMed DOI
    69. 2000
  69. Chen,J.M. and Ferec,C.
    Genes, cloned cDNAs, and proteins of human trypsinogens and pancreatitis-associated cationic trypsinogen mutations
    Pancreas21, 57-62. PubMed  Europe PubMed DOI
  70. Chen,J.M. and Ferec,C.
    Molecular basis of hereditary pancreatitis
    Eur J Hum Genet8, 473-479. PubMed  Europe PubMed DOI
  71. Halangk,W., Lerch,M.M., Brandt-Nedelev,B., Roth,W., Ruthenbuerger,M., Reinheckel,T., Domschke,W., Lippert,H., Peters,C. and Deussing,J.
    Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis
    J Clin Invest106, 773-781. PubMed  Europe PubMed DOI  K
  72. O'Reilly,D.A. and Kingsnorth,A.N.
    Hereditary pancreatitis and mutations of the cationic trypsinogen gene
    Br J Surg87, 708-717. PubMed  Europe PubMed DOI
  73. [YEAR:19-11-2000]Sahin-Toth,M. and Toth,M.
    Gain-of-function mutations associated with hereditary pancreatitis enhance autoactivation of human cationic trypsinogen
    Biochem Biophys Res Commun278, 286-289. PubMed  Europe PubMed DOI
  74. [YEAR:28-7-2000]Sahin-Toth,M.
    Human cationic trypsinogen. Role of Asn-21 in zymogen activation and implications in hereditary pancreatitis
    J Biol Chem275, 22750-22755. PubMed  Europe PubMed DOI
    75. 1999
  75. Chen,J.M., Mercier,B. and Ferec,C.
    Strong evidence that the N21I substitution in the cationic trypsinogen gene causes disease in hereditary pancreatitis
    Gut45, 916-916. PubMed  Europe PubMed
  76. [YEAR:3-7-1999]Creighton,J., Lyall,R., Wilson,D.I., Curtis,A. and Charnley,R.
    Mutations of the cationic trypsinogen gene in patients with chronic pancreatitis
    Lancet354, 42-43. PubMed  Europe PubMed DOI
  77. Miyata,S., Koshikawa,N., Higashi,S., Miyagi,Y., Nagashima,Y., Yanoma,S., Kato,Y., Yasumitsu,H. and Miyazaki,K.
    Expression of trypsin in human cancer cell lines and cancer tissues and its tight binding to soluble form of Alzheimer amyloid precursor protein in culture
    J Biochem125, 1067-1076. PubMed  Europe PubMed
  78. Nishimori,I., Kamakura,M., Fujikawa-Adachi,K., Morita,M., Onishi,S., Yokoyama,K., Makino,I., Ishida,H., Yamamoto,M., Watanabe,S. and Ogawa,M.
    Mutations in exons 2 and 3 of the cationic trypsinogen gene in Japanese families with hereditary pancreatitis
    Gut44, 259-263. PubMed  Europe PubMed  K
  79. [YEAR:22-10-1999]Sahin-Toth,M., Graf,L. and Toth,M.
    Trypsinogen stabilization by mutation Arg117 - >His: a unifying pathomechanism for hereditary pancreatitis?
    Biochem Biophys Res Commun264, 505-508. PubMed  Europe PubMed DOI
  80. [YEAR:15-10-1999]Sahin-Toth,M.
    Hereditary pancreatitis-associated mutation Asn(21) - > Ile stabilizes rat trypsinogen in vitro
    J Biol Chem274, 29699-29704. PubMed  Europe PubMed DOI
  81. Witt,H., Luck,W. and Becker,M.
    A signal peptide cleavage site mutation in the cationic trypsinogen gene is strongly associated with chronic pancreatitis
    Gastroenterology117, 7-10. PubMed  Europe PubMed DOI  M
    82. 1998
  82. Koshikawa,N., Hasegawa,S., Nagashima,Y., Mitsuhashi,K., Tsubota,Y., Miyata,S., Miyagi,Y., Yasumitsu,H. and Miyazaki,K.
    Expression of trypsin by epithelial cells of various tissues, leukocytes, and neurons in human and mouse
    Am J Pathol153, 937-944. PubMed  Europe PubMed DOI
    83. 1997
  83. Gorry,M.C., Gabbaizedeh,D., Furey,W., Gates,L.K., Jr., Preston,R.A., Aston,C.E., Zhang,Y., Ulrich,C., Ehrlich,G.D. and Whitcomb,D.C.
    Mutations in the cationic trypsinogen gene are associated with recurrent acute and chronic pancreatitis
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