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Literature for peptidase S01.127: cationic trypsin (Homo sapiens-type)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, K Knockout, P Specificity, E Expression, V Review, M Mutation, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. [YEAR:27-3-2025]Whitcomb,D.C.<br>PRSS1-Related Hereditary Pancreatitis<br> (27-3-2025) PubMed  Europe PubMed
    2. 2023
  2. Masson,E., Zou,W.B., Pu,N., Rebours,V., Genin,E., Wu,H., Lin,J.H., Wang,Y.C., Abrantes,A., Aguilera Munoz,L., Albouys,J., Alric,L., Amiot,X., Archambeaud,I., Audiau,S., Bastide,L., Baudon,J., Bellaiche,G., Bellon,S., Bertrand,V., Bideau,K., Billiemaz,K., Billioud,C., Bonnefoy,S., Borderon,C., Bournet,B., Breton,E., Brugel,M., Buscail,L., Cadiot,G., Camus,M., Causse,X., Chamouard,P., Chaput,U., Cholet,F., Ciocan,D.M., Clavel,C., Coffin,B., Coimet-Berger,L., Creveaux,I., Culetto,A., Daboussi,O., Mestier,L., Degand,T., D'engremont,C., Denis,B., Dermine,S., Desgrippes,R., D'Aubigny,A.D., Enaud,R., Fabre,A., Gargot,D., Gelsi,E., Gentilcore,E., Gincul,R., Ginglinger-Favre,E., Giovannini,M., Gomercic,C., Gondran,H., Grainville,T., Grandval,P., Grasset,D., Grimaldi,S., Grimbert,S., Hagege,H., Heissat,S., Hentic,O., Herber-Mayne,A., Hervouet,M., Hoibian,S., Jacques,J., Jais,B., Kaassis,M., Koch,S., Lacaze,E., Lacroute,J., Lamireau,T., Laurent,L., Guillou,X.L., Rhun,M.L., Leblanc,S., Levy,P., Lievre,A., Lorenzo,D., Maire,F., Marcel,K., Matias,C., Mauillon,J., Morgant,S., Moussata,D., Muller,N., Nambot,S., Napoleon,B., Olivier,A., Pagenault,M., Pelletier,A.L., Pennec,O., Pinard,F., Pioche,M., Prost,B., Queneherve,L., Rebours,V., Reboux,N., Rekik,S., Riachi,G., Rohmer,B., Roquelaure,B., Hezode,I.R., Rostain,F., Saurin,J.C., Servais,L., Stan-Iuga,R., Subtil,C., Texier,C., Thomassin,L., Tougeron,D., Tsakiris,L., Valats,J.C., Vuitton,L., Wallenhorst,T., Wangerme,M., Zanaldi,H. and Zerbib,F.<br>Classification of PRSS1 variants responsible for chronic pancreatitis: An expert perspective from the Franco-Chinese GREPAN study group<br>Pancreatology (2023) 23, 491-506. PubMed  Europe PubMed DOI
    3. 2022
  3. Girodon,E., Rebours,V., Chen,J.M., Pagin,A., Levy,P., Ferec,C. and Bienvenu,T.<br>Clinical interpretation of PRSS1 gene variants in patients with pancreatitis<br>Clin Res Hepatol Gastroenterol (2022) 46, 101531-101531. PubMed  Europe PubMed DOI  V
  4. Thiel,F., Reiser,M. and Weiss,F.U.<br>A rare PRSS1 p.S127C mutation is associated with chronic pancreatitis and causes misfolding-induced ER-stress<br>Pancreatology (2022) 22, 1112-1119. PubMed  Europe PubMed DOI
    5. 2021
  5. Akhmedov,V.A. and Gaus,O.V.<br>[Inflammatory diseases of the pancreas: what new do we know about the mechanisms of their development in the 21st century?]<br>Ter Arkh (2021) 93, 66-70. PubMed  Europe PubMed DOI
    6. 2020
  6. Dong,Z.M., Cheng,L., Zhang,P. and Zhao,G.C.<br>Label-free analytical performances of a peptide-based QCM biosensor for trypsin<br>Analyst (2020) 145, 3329-3338. PubMed  Europe PubMed DOI  A
  7. Gui,F., Zhang,Y., Wan,J., Zhan,X., Yao,Y., Li,Y., Haddock,A.N., Shi,J., Guo,J., Chen,J., Zhu,X., Edenfield,B.H., Zhuang,L., Hu,C., Wang,Y., Mukhopadhyay,D., Radisky,E.S., Zhang,L., Lugea,A., Pandol,S.J., Bi,Y. and Ji,B.<br>Trypsin activity governs increased susceptibility to pancreatitis in mice expressing human PRSS1R122H<br>J Clin Invest (2020) 130, 189-202. PubMed  Europe PubMed DOI
  8. Jancso,Z. and Sahin-Toth,M.<br>Mutation that promotes activation of trypsinogen increases severity of secretagogue-induced pancreatitis in mice<br>Gastroenterology (2020) 158, 1083-1094. PubMed  Europe PubMed DOI
  9. Klaassen,K., Stankovic,B., Zukic,B., Kotur,N., Gasic,V., Pavlovic,S. and Stojiljkovic,M.<br>Functional prediction and comparative population analysis of variants in genes for proteases and innate immunity related to SARS-CoV-2 infection<br>Infect Genet Evol (2020) 84, 104498-104498. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Li,G., Wei,H., Bi,J., Ding,X., Li,L., Xu,S., Yang,G. and Ren,W.<br>Insights into dietary switch in cetaceans: evidence from molecular evolution of proteinases and lipases<br>J Mol Evol (2020) PubMed  Europe PubMed DOI
  11. Li,X., Peng,Y., Liu,H., Xu,Y., Wang,X., Zhang,C. and Ma,X.<br>Comparative studies on the interaction of nine flavonoids with trypsin<br>Spectrochim Acta A Mol Biomol Spectrosc (2020) 238, 118440-118440. PubMed  Europe PubMed DOI  I
  12. Malthouse,J.P.G.<br>Kinetic studies of the effect of pH on the trypsin-catalyzed hydrolysis of N-alpha-benzyloxycarbonyl-l-lysine-p-nitroanilide: mechanism of trypsin catalysis<br>ACS Omega (2020) 5, 4915-4923. PubMed  Europe PubMed DOI  PMC  EPMC
  13. Mosztbacher,D., Demcsak,A. and Sahin-Toth,M.<br>Measuring digestive protease activation in the mouse pancreas<br>Pancreatology (2020) 20, 288-292. PubMed  Europe PubMed DOI  A
  14. Ni Chonchubhair,H.M., Duggan,S.N., Egan,S.M., Kenyon,M., O'Toole,D., McManus,R. and Conlon,K.C.<br>A high prevalence of genetic polymorphisms in idiopathic and alcohol-associated chronic pancreatitis patients in Ireland<br>HPB (Oxford) (2020) PubMed  Europe PubMed DOI
    15. 2019
  15. Demcsak,A., Geisz,A. and Sahin-Toth,M.<br>Engineering mouse cationic trypsinogen for rapid and selective activation by cathepsin B<br>Sci Rep (2019) 9, 9188-9188. PubMed  Europe PubMed DOI  PMC  EPMC
  16. Jancso,Z., Oracz,G., Kujko,A.A., Kolodziejczyk,E., Radisky,E.S., Rygiel,A.M. and Sahin-Toth,M.<br>Novel pathogenic PRSS1 variant p.Glu190Lys in a case of chronic pancreatitis<br>Front Genet (2019) 10, 46-46. PubMed  Europe PubMed DOI  PMC  EPMC  M
  17. Malicki,S., Ksiazek,M., Majewski,P., Pecak,A., Mydel,P., Grudnik,P. and Dubin,G.<br>Development of a novel, high-affinity ssDNA trypsin inhibitor<br>J Enzyme Inhib Med Chem (2019) 34, 638-643. PubMed  Europe PubMed DOI  I
  18. Zhou,Z., Liu,W., Wang,Y., Ding,F., Liu,X., Zhao,Q., Zou,P., Wang,X. and Rao,H.<br>A fluorometric and colorimetric method for determination of trypsin by exploiting the gold nanocluster-induced aggregation of hemoglobin-coated gold nanoparticles<br>Mikrochim Acta (2019) 186, 272-272. PubMed  Europe PubMed DOI  A
    19. 2018
  19. Schilling,O., Biniossek,M.L., Mayer,B., Elsasser,B., Brandstetter,H., Goettig,P., Stenman,U.H. and Koistinen,H.<br>Specificity profiling of human trypsin-isoenzymes<br>Biol Chem (2018) 399, 997-1007. PubMed  Europe PubMed DOI  P
  20. Sendler,M., Weiss,F.U., Golchert,J., Homuth,G., van den Brandt,C., Mahajan,U.M., Partecke,L.I., Doring,P., Gukovsky,I., Gukovskaya,A.S., Wagh,P.R., Lerch,M.M. and Mayerle,J.<br>Cathepsin B-mediated activation of trypsinogen in endocytosing macrophages increases severity of pancreatitis in mice<br>Gastroenterology (2018) 154, 704-718. PubMed  Europe PubMed DOI
    21. 2017
  21. Masuda,Y., Yamaotsu,N. and Hirono,S.<br>Gibbs free energy of hydrolytic water molecule in acyl-enzyme intermediates of a serine protease: a potential application for computer-aided discovery of mechanism-based reversible covalent inhibitors<br>Chem Pharm Bull (Tokyo) (2017) 65, 889-892. PubMed  Europe PubMed DOI
    22. 2016
  22. Brandl,T., Simic,O., Skaanderup,P.R., Namoto,K., Berst,F., Ehrhardt,C., Schiering,N., Mueller,I. and Woelcke,J.<br>Trypsin inhibitors for the treatment of pancreatitis<br>Bioorg Med Chem Lett (2016) 26, 4340-4344. PubMed  Europe PubMed DOI  I
  23. Kayode,O., Wang,R., Pendlebury,D.F., Cohen,I., Henin,R.D., Hockla,A., Soares,A.S., Papo,N., Caulfield,T.R. and Radisky,E.S.<br>An acrobatic substrate metamorphosis reveals a requirement for substrate conformational dynamics in trypsin proteolysis<br>J Biol Chem (2016) 291, 26304-26319. PubMed  Europe PubMed DOI  PMC  EPMC  S
  24. Yi,Q., Dong,F., Lin,L., Liu,Q., Chen,S., Gao,F. and He,Q.<br>PRSS1 mutations and the proteinase/antiproteinase imbalance in the pathogenesis of pancreatic cancer<br>Tumour Biol (2016) 37, 5805-5810. PubMed  Europe PubMed DOI  M
  25. Zhuo,C.X., Wang,L.H., Feng,J.J. and Zhang,Y.D.<br>Label-free fluorescent detection of trypsin activity based on DNA-stabilized silver nanocluster-peptide conjugates<br>Sensors (Basel) (2016) 16 PubMed  Europe PubMed DOI  A
    26. 2015
  26. Alloy,A.P., Kayode,O., Wang,R., Hockla,A., Soares,A.S. and Radisky,E.S.<br>Mesotrypsin has evolved four unique residues to cleave trypsin inhibitors as substrates<br>J Biol Chem (2015) 290, 21523-21535. PubMed  Europe PubMed DOI
    27. 2014
  27. Chang,M.C., Jan,I.S., Liang,P.C., Jeng,Y.M., Yang,C.Y., Tien,Y.W., Wong,J.M. and Chang,Y.T.<br>Human cationic trypsinogen but not serine peptidase inhibitor, Kazal type 1 variants increase the risk of type 1 autoimmune pancreatitis<br>J Gastroenterol Hepatol (2014) 29, 2038-2042. PubMed  Europe PubMed DOI  M
  28. Chen,Q., Xue,H., Chen,M., Gao,F., Xu,J., Liu,Q., Yang,X., Zheng,L. and Chen,H.<br>High serum trypsin levels and the -409 T/T genotype of PRSS1 gene are susceptible to neonatal sepsis<br>Inflammation (2014) 37, 1751-1756. PubMed  Europe PubMed DOI  M
  29. Haerteis,S., Krappitz,A., Krappitz,M., Murphy,J.E., Bertog,M., Krueger,B., Nacken,R., Chung,H., Hollenberg,M.D., Knecht,W., Bunnett,N.W. and Korbmacher,C.<br>Proteolytic activation of the human epithelial sodium channel by trypsin IV and trypsin I involves distinct cleavage sites<br>J Biol Chem (2014) 289, 19067-19078. PubMed  Europe PubMed DOI  P
  30. Hegyi,E., Cierna,I., Vavrova,L., Ilencikova,D., Konecny,M. and Kovacs,L.<br>Chronic pancreatitis associated with the p.G208A variant of PRSS1 gene in a European patient<br>JOP (2014) 15, 49-52. PubMed  Europe PubMed  M
  31. Masamune,A.<br>Genetics of pancreatitis: the 2014 update<br>Tohoku J Exp Med (2014) 232, 69-77. PubMed  Europe PubMed DOI  M
  32. Nemeth,B.C. and Sahin-Toth,M.<br>Human cationic trypsinogen (PRSS1) variants and chronic pancreatitis<br>Am J Physiol Gastrointest Liver Physiol (2014) 306, G466-G473. PubMed  Europe PubMed DOI  M
  33. Ravi Kanth,V. and Nageshwar Reddy,D.<br>Genetics of acute and chronic pancreatitis: an update<br>World J Gastrointest Pathophysiol (2014) 5, 427-437. PubMed  Europe PubMed DOI  PMC  EPMC  M
  34. Szabo,A., Radisky,E.S. and Sahin-Toth,M.<br>Zymogen activation confers thermodynamic stability on a key peptide bond and protects human cationic trypsin from degradation<br>J Biol Chem (2014) 289, 4753-4761. PubMed  Europe PubMed DOI
  35. Szabo,A., Salameh,M.A., Ludwig,M., Radisky,E.S. and Sahin-Toth,M.<br>Tyrosine sulfation of human trypsin steers S2' subsite selectivity towards basic amino acids<br>PLoS ONE (2014) 9, e102063-e102063. PubMed  Europe PubMed DOI  P
    36. 2013
  36. Gao,F., Li,Y.M., Hong,G.L., Xu,Z.F., Liu,Q.C., He,Q.L., Lin,L.Q. and Weng,S.H.<br>PRSS1_p.Leu81Met mutation results in autoimmune pancreatitis<br>World J Gastroenterol (2013) 19, 3332-3338. PubMed  Europe PubMed DOI  PMC  EPMC  M
  37. Geisz,A., Hegyi,P. and Sahin-Toth,M.<br>Robust autoactivation, chymotrypsin C independence and diminished secretion define a subset of hereditary pancreatitis-associated cationic trypsinogen mutants<br>FEBS J (2013) 280, 2888-2899. PubMed  Europe PubMed DOI  M
  38. Miao,P., Liu,T., Li,X., Ning,L., Yin,J. and Han,K.<br>Highly sensitive, label-free colorimetric assay of trypsin using silver nanoparticles<br>Biosens Bioelectron (2013) 49, 20-24. PubMed  Europe PubMed DOI  A
    39. 2012
  39. Chen,J.M., Radisky,E.S. and Ferec,C.<br>Human trypsins<br>[ISSN:978-0-12-407742-3] (2012) 3, 2600-2609. DOI
  40. Chen,J.M. and Ferec,C.<br>Cationic trypsin (human)<br>[ISSN:978-0-12-407742-3] (2012) 3, 2609-2614. DOI
  41. Karstad,R., Isaksen,G., Wynendaele,E., Guttormsen,Y., De Spiegeleer,B., Brandsdal,B.O., Svendsen,J.S. and Svenson,J.<br>Targeting the S1 and S3 subsite of trypsin with unnatural cationic amino acids generates antimicrobial peptides with potential for oral administration<br>J Med Chem (2012) 55, 6294-6305. PubMed  Europe PubMed DOI  I
  42. Orlichenko,L., Stolz,D.B., Noel,P., Behari,J., Liu,S. and Singh,V.P.<br>ADP-ribosylation factor 1 protein regulates trypsinogen activation via organellar trafficking of procathepsin B protein and autophagic maturation in acute pancreatitis<br>J Biol Chem (2012) 287, 24284-24293. PubMed  Europe PubMed DOI
  43. Petronella,N. and Drouin,G.<br>Strong purifying selection against gene conversions in the trypsin genes of primates<br>Hum Genet (2012) 131, 1739-1749. PubMed  Europe PubMed DOI
  44. Szabo,A. and Sahin-Toth,M.<br>Increased activation of hereditary pancreatitis-associated human cationic trypsinogen mutants in presence of chymotrypsin C<br>J Biol Chem (2012) 287, 20701-20710. PubMed  Europe PubMed DOI  M
  45. Szabo,A. and Sahin-Toth,M.<br>Determinants of chymotrypsin C cleavage specificity in the calcium-binding loop of human cationic trypsinogen<br>FEBS J (2012) 279, 4283-4292. PubMed  Europe PubMed DOI
    46. 2008
  46. Felderbauer,P., Schnekenburger,J., Lebert,R., Bulut,K., Parry,M., Meister,T., Schick,V., Schmitz,F., Domschke,W. and Schmidt,W.E.<br>A novel A121T mutation in human cationic trypsinogen associated with hereditary pancreatitis: functional data indicating a loss-of-function mutation influencing the R122 trypsin cleavage site<br>J Med Genet (2008) 45, 507-512. PubMed  Europe PubMed DOI  M
  47. Liu,Q.C., Gao,F., Cheng,Z.J. and Ou,Q.S.<br>Multisite mutations of the PRSS1 gene in a Chinese patient with chronic pancreatitis<br>Hepatobiliary Pancreat Dis Int (2008) 7, 331-332. PubMed  Europe PubMed  M
  48. Teich,N. and Mossner,J.<br>Hereditary chronic pancreatitis<br>Best Pract Res Clin Gastroenterol (2008) 22, 115-130. PubMed  Europe PubMed DOI  V
    49. 2007
  49. Lee,T.Y., Oh,H.C., Kim,M.H., Kwon,S., Lee,S.S., Seo,D.W. and Lee,S.K.<br>[Three cases of hereditary pancreatitis in two households in the same family associated with R122H mutation in cationic trypsinogen gene]<br>Korean J Gastroenterol (2007) 49, 395-399. PubMed  Europe PubMed  M
  50. Liu,Q.C., Cheng,Z.J., Yang,Y. and Ou,Q.S.<br>[A novel mutation of PRSS1 gene in a Chinese hereditary pancreatitis family]<br>Yi Chuan (2007) 29, 1067-1070. PubMed  Europe PubMed  M
  51. Tzetis,M., Kaliakatsos,M., Fotoulaki,M., Papatheodorou,A., Doudounakis,S., Tsezou,A., Makrythanasis,P., Kanavakis,E. and Nousia-Arvanitakis,S.<br>Contribution of the CFTR gene, the pancreatic secretory trypsin inhibitor gene (SPINK1) and the cationic trypsinogen gene (PRSS1) to the etiology of recurrent pancreatitis<br>Clin Genet (2007) 71, 451-457. PubMed  Europe PubMed DOI  M
    52. 2006
  52. Kiraly,O., Guan,L., Szepessy,E., Toth,M., Kukor,Z. and Sahin-Toth,M.<br>Expression of human cationic trypsinogen with an authentic N terminus using intein-mediated splicing in aminopeptidase P deficient Escherichia coli<br>Protein Expr Purif (2006) 48, 104-111. PubMed  Europe PubMed DOI  PMC  EPMC  E
    53. 2005
  53. [YEAR:21-3-2005]Pho-Iam,T., Thongnoppakhun,W., Yenchitsomanus,P.T. and Limwongse,C.<br>A Thai family with hereditary pancreatitis and increased cancer risk due to a mutation in PRSS1 gene<br>World J Gastroenterol (21-3-2005) 11, 1634-1638. PubMed  Europe PubMed  M
  54. Teich,N., Nemoda,Z., Kohler,H., Heinritz,W., Mossner,J., Keim,V. and Sahin-Toth,M.<br>Gene conversion between functional trypsinogen genes PRSS1 and PRSS2 associated with chronic pancreatitis in a six-year-old girl<br>Hum Mutat (2005) 25, 343-347. PubMed  Europe PubMed DOI  PMC  EPMC  M
    55. 2004
  55. Chandak,G.R., Idris,M.M., Reddy,D.N., Mani,K.R., Bhaskar,S., Rao,G.V. and Singh,L.<br>Absence of PRSS1 mutations and association of SPINK1 trypsin inhibitor mutations in hereditary and non-hereditary chronic pancreatitis<br>Gut (2004) 53, 723-728. PubMed  Europe PubMed DOI  PMC  EPMC
  56. Chen,J.M. and Ferec,C.<br>Human trypsins<br>[ISSN:0-12-079610-4] (2004) 2, 1489-1493.  V
  57. [YEAR:8-4-2004]Hohenblum,H., Vorauer-Uhl,K., Katinger,H. and Mattanovich,D.<br>Bacterial expression and refolding of human trypsinogen<br>J Biotechnol (8-4-2004) 109, 3-11. PubMed  Europe PubMed DOI
  58. Teich,N., Le Marechal,C., Kukor,Z., Caca,K., Witzigmann,H., Chen,J.M., Toth,M., Mossner,J., Keim,V., Ferec,C. and Sahin-Toth,M.<br>Interaction between trypsinogen isoforms in genetically determined pancreatitis: mutation E79K in cationic trypsin (PRSS1) causes increased transactivation of anionic trypsinogen (PRSS2)<br>Hum Mutat (2004) 23, 22-31. PubMed  Europe PubMed DOI
    59. 2002
  59. [YEAR:22-2-2002]Kukor,Z., Toth,M., Pal,G. and Sahin-Toth,M.<br>Human cationic trypsinogen. Arg(117) is the reactive site of an inhibitory surface loop that controls spontaneous zymogen activation<br>J Biol Chem (22-2-2002) 277, 6111-6117. PubMed  Europe PubMed DOI
  60. Pfutzer,R., Myers,E., Applebaum-Shapiro,S., Finch,R., Ellis,I., Neoptolemos,J., Kant,J.A. and Whitcomb,D.C.<br>Novel cationic trypsinogen (PRSS1) N29T and R122C mutations cause autosomal dominant hereditary pancreatitis<br>Gut (2002) 50, 271-272. PubMed  Europe PubMed DOI  PMC  EPMC
  61. [YEAR:15-2-2002]Simon,P., Weiss,F.U., Sahin-Toth,M., Parry,M., Nayler,O., Lenfers,B., Schnekenburger,J., Mayerle,J., Domschke,W. and Lerch,M.M.<br>Hereditary pancreatitis caused by a novel PRSS1 mutation (Arg-122 - > Cys) that alters autoactivation and autodegradation of cationic trypsinogen<br>J Biol Chem (15-2-2002) 277, 5404-5410. PubMed  Europe PubMed DOI  M
  62. Teich,N., Bauer,N., Mossner,J. and Keim,V.<br>Mutational screening of patients with nonalcoholic chronic pancreatitis: Identification of further trypsinogen variants<br>Am J Gastroenterol (2002) 97, 341-346. PubMed  Europe PubMed DOI
    63. 2001
  63. Chen,J.M., Montier,T. and Ferec,C.<br>Molecular pathology and evolutionary and physiological implications of pancreatitis-associated cationic trypsinogen mutations<br>Hum Genet (2001) 109, 245-252. PubMed  Europe PubMed DOI  M
  64. Crawford,S.E., Mukherjee,S.K., Estes,M.K., Lawton,J.A., Shaw,A.L., Ramig,R.F. and Prasad,B.V.V.<br>Trypsin cleavage stabilizes the rotavirus VP4 spike<br>J Virol (2001) 75, 6052-6061. PubMed  Europe PubMed DOI  PMC  EPMC
  65. [YEAR:1-12-2001]Keim,V., Bauer,N., Teich,N., Simon,P., Lerch,M.M. and Mossner,J.<br>Clinical characterization of patients with hereditary pancreatitis and mutations in the cationic trypsinogen gene<br>Am J Med (1-12-2001) 111, 622-626. PubMed  Europe PubMed DOI
  66. [YEAR:6-7-2001]Szilagyi,L., Kenesi,E., Katona,G., Kaslik,G., Juhasz,G. and Graf,L.<br>Comparative in vitro studies on native and recombinant human cationic trypsins. Cathepsin B is a possible pathological activator of trypsinogen in pancreatitis<br>J Biol Chem (6-7-2001) 276, 24574-24580. PubMed  Europe PubMed DOI
  67. Tautermann,G., Ruebsamen,H., Beck,M., Dertinger,S., Drexel,H. and Lohse,P.<br>R116C mutation of cationic trypsinogen in a Turkish family with recurrent pancreatitis illustrates genetic microheterogeneity of hereditary pancreatitis<br>Digestion (2001) 64, 226-232. PubMed  Europe PubMed DOI
  68. Truninger,K., Kock,J., Wirth,H.P., Muellhaupt,B., Arnold,C., von Weizsacker,F., Seifert,B., Ammann,R.W. and Blum,H.E.<br>Trypsinogen gene mutations in patients with chronic or recurrent acute pancreatitis<br>Pancreas (2001) 22, 18-23. PubMed  Europe PubMed DOI
    69. 2000
  69. Chen,J.M. and Ferec,C.<br>Molecular basis of hereditary pancreatitis<br>Eur J Hum Genet (2000) 8, 473-479. PubMed  Europe PubMed DOI
  70. Chen,J.M. and Ferec,C.<br>Genes, cloned cDNAs, and proteins of human trypsinogens and pancreatitis-associated cationic trypsinogen mutations<br>Pancreas (2000) 21, 57-62. PubMed  Europe PubMed DOI
  71. Halangk,W., Lerch,M.M., Brandt-Nedelev,B., Roth,W., Ruthenbuerger,M., Reinheckel,T., Domschke,W., Lippert,H., Peters,C. and Deussing,J.<br>Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis<br>J Clin Invest (2000) 106, 773-781. PubMed  Europe PubMed DOI  PMC  EPMC  K
  72. O'Reilly,D.A. and Kingsnorth,A.N.<br>Hereditary pancreatitis and mutations of the cationic trypsinogen gene<br>Br J Surg (2000) 87, 708-717. PubMed  Europe PubMed DOI
  73. [YEAR:28-7-2000]Sahin-Toth,M.<br>Human cationic trypsinogen. Role of Asn-21 in zymogen activation and implications in hereditary pancreatitis<br>J Biol Chem (28-7-2000) 275, 22750-22755. PubMed  Europe PubMed DOI
  74. [YEAR:19-11-2000]Sahin-Toth,M. and Toth,M.<br>Gain-of-function mutations associated with hereditary pancreatitis enhance autoactivation of human cationic trypsinogen<br>Biochem Biophys Res Commun (19-11-2000) 278, 286-289. PubMed  Europe PubMed DOI
    75. 1999
  75. Chen,J.M., Mercier,B. and Ferec,C.<br>Strong evidence that the N21I substitution in the cationic trypsinogen gene causes disease in hereditary pancreatitis<br>Gut (1999) 45, 916-916. PubMed  Europe PubMed  PMC  EPMC
  76. [YEAR:3-7-1999]Creighton,J., Lyall,R., Wilson,D.I., Curtis,A. and Charnley,R.<br>Mutations of the cationic trypsinogen gene in patients with chronic pancreatitis<br>Lancet (3-7-1999) 354, 42-43. PubMed  Europe PubMed DOI
  77. Miyata,S., Koshikawa,N., Higashi,S., Miyagi,Y., Nagashima,Y., Yanoma,S., Kato,Y., Yasumitsu,H. and Miyazaki,K.<br>Expression of trypsin in human cancer cell lines and cancer tissues and its tight binding to soluble form of Alzheimer amyloid precursor protein in culture<br>J Biochem (1999) 125, 1067-1076. PubMed  Europe PubMed
  78. Nishimori,I., Kamakura,M., Fujikawa-Adachi,K., Morita,M., Onishi,S., Yokoyama,K., Makino,I., Ishida,H., Yamamoto,M., Watanabe,S. and Ogawa,M.<br>Mutations in exons 2 and 3 of the cationic trypsinogen gene in Japanese families with hereditary pancreatitis<br>Gut (1999) 44, 259-263. PubMed  Europe PubMed  PMC  EPMC  K
  79. [YEAR:15-10-1999]Sahin-Toth,M.<br>Hereditary pancreatitis-associated mutation Asn(21) - > Ile stabilizes rat trypsinogen in vitro<br>J Biol Chem (15-10-1999) 274, 29699-29704. PubMed  Europe PubMed DOI
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