$VAR1 = undef;

Summary for peptidase M24.009: aminopeptidase P1

Names
MEROPS Name	aminopeptidase P1
Other names	aminopeptidase P (eukaryote soluble type), XPNPEP1 g.p. (Homo sapiens), XPNPEPL g.p. (Homo sapiens), Xaa-Pro aminopeptidase 1 (Solanum lycopersicum), Xaa-Pro aminopeptidase 2 (Solanum lycopersicum), app1 g.p. (Solanum lycopersicum), app2 g.p. (Solanum lycopersicum)

Domain architecture

MEROPS Classification
Classification	Clan MG >> Subclan (none) >> Family M24 >> Subfamily B >> M24.009
Holotype	aminopeptidase P1 (Homo sapiens), Uniprot accession Q9NQW7 (peptidase unit: 317-574), MERNUM MER0004321
History	Identifier created: MEROPS 3.4 (5 November 1999)

Activity
Catalytic type	Metallo
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (3 cleavages)
Activity status	human: active (Cottrell et al., 2000) mouse: active (Czirjak et al. (1999))
Other databases	TREEFAM	http://www.treefam.org/family/TF314183
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/ryP/-/pgk/- (based on 18 cleavages)

Specificity matrix

Amino acid	P1	P1'	P2'	P3'	P4'
Gly	2	0	0	3	2
Pro	0	18	3	4	1
Ala	1	0	1	0	0
Val	0	0	1	0	0
Leu	0	0	1	0	0
Ile	0	0	0	0	0
Met	0	0	0	0	0
Phe	2	0	3	0	2
Tyr	5	0	0	0	0
Trp	0	0	0	0	0
Ser	0	0	1	0	0
Thr	0	0	0	0	0
Cys	0	0	0	0	0
Asn	0	0	0	0	0
Gln	0	0	0	0	0
Asp	0	0	0	0	0
Glu	0	0	0	0	0
Lys	1	0	1	1	0
Arg	6	0	1	0	0
His	1	0	0	0	0