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Literature for peptidase M24.009: aminopeptidase P1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, M Mutation, P Specificity, K Knockout, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2022
  1. Bae,Y.S., Yoon,S.H., Kim,Y.S., Oh,S.P., Song,W.S., Cha,J.H. and Kim,M.H.
    Suppression of exaggerated NMDAR activity by memantine treatment ameliorates neurological and behavioral deficits in aminopeptidase P1-deficient mice
    Exp Mol Med (2022) 54, 1109-1124. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Silva,N., Castellano-Pozo,M., Matsuzaki,K., Barroso,C., Roman-Trufero,M., Craig,H., Brooks,D.R., Isaac,R.E., Boulton,S.J. and Martinez-Perez,E.
    Proline-specific aminopeptidase P prevents replication-associated genome instability
    PLoS Genet (2022) 18, e1010025-e1010025. PubMed  Europe PubMed DOI  PMC  EPMC
  3. Zeng,J., Zhang,R., Ning Ma,K., Han,L.L., Yan,S.W., Liu,R.D., Zhang,X., Wang,Z.Q. and Cui,J.
    Characterization of a novel aminopeptidase P from Trichinella spiralis and its participation in the intrusion of intestinal epithelial cells
    Exp Parasitol (2022) 242, 108376-108376. PubMed  Europe PubMed DOI
    4. 2021
  4. Yoon,S.H., Bae,Y.S., Oh,S.P., Song,W.S., Chang,H. and Kim,M.H.
    Altered hippocampal gene expression, glial cell population, and neuronal excitability in aminopeptidase P1 deficiency
    Sci Rep (2021) 11, 932-932. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Zeng,J., Zhang,X.Z., Zhang,R., Yan,S.W., Song,Y.Y., Long,S.R., Dan Liu,R., Wang,Z.Q. and Cui,J.
    Vaccination of mice with recombinant novel aminopeptidase P and cathepsin X alone or in combination induces protective immunity against Trichinella spiralis infection
    Acta Trop (2021) 224, 106125-106125. PubMed  Europe PubMed DOI
    6. 2020
  6. Dunaevsky,Y.E., Tereshchenkova,V.F., Oppert,B., Belozersky,M.A., Filippova,I.Y. and Elpidina,E.N.
    Human proline specific peptidases: a comprehensive analysis
    Biochim Biophys Acta Gen Subj (2020) 1864, 129636-129636. PubMed  Europe PubMed DOI  V
    7. 2018
  7. Bae,Y.S., Yoon,S.H., Han,J.Y., Woo,J., Cho,Y.S., Kwon,S.K., Bae,Y.C., Kim,D., Kim,E. and Kim,M.H.
    Deficiency of aminopeptidase P1 causes behavioral hyperactivity, cognitive deficits, and hippocampal neurodegeneration
    Genes Brain Behav (2018) 17, 126-138. PubMed  Europe PubMed DOI  M
  8. Chang,H.C., Kung,C.C., Chang,T.T., Jao,S.C., Hsu,Y.T. and Li,W.S.
    Investigation of the proton relay system operative in human cystosolic aminopeptidase P
    PLoS ONE (2018) 13, e0190816-e0190816. PubMed  Europe PubMed DOI  PMC  EPMC
    9. 2017
  9. Drendel,V., Heckelmann,B., Chen,C.Y., Weisser,J., Espadas,G., Schell,C., Sabido,E., Werner,M., Jilg,C.A. and Schilling,O.
    Proteome profiling of clear cell renal cell carcinoma in von Hippel-Lindau patients highlights upregulation of Xaa-Pro aminopeptidase-1, an anti-proliferative and anti-migratory exoprotease
    Oncotarget (2017) 8, 100066-100078. PubMed  Europe PubMed DOI  PMC  EPMC
    10. 2015
  10. Hye Khan,M.A., Sharma,A., Rarick,K.R., Roman,R.J., Harder,D.R. and Imig,J.D.
    Elevated aminopeptidase P attenuates cerebral arterial responses to bradykinin in fawn-hooded hypertensive rats
    PLoS ONE (2015) 10, e0145335-e0145335. PubMed  Europe PubMed DOI  I
    11. 2012
  11. Cottrell,G.S. and Turner,A.J.
    Aminopeptidase P1
    [ISSN:978-0-12-407743-0] (2012) 3, 1525-1528. DOI
  12. Wu,S., Liu,S., Sim,S. and Pedersen,L.G.
    Weakly antiferromagentic coupling via superexchange interaction between Mn(II)-Mn(II) atoms: a QM/MM study of the active site of human cytosolic X-propyl aminopeptidase P
    J Phys Chem Lett (2012) 3, 2293-2297. PubMed  Europe PubMed DOI  PMC  EPMC
  13. Yoon,S.H., Bae,Y.S., Mun,M.S., Park,K.Y., Ye,S.K., Kim,E. and Kim,M.H.
    Developmental retardation, microcephaly, and peptiduria in mice without aminopeptidase P1
    Biochem Biophys Res Commun (2012) 429, 204-209. PubMed  Europe PubMed DOI  K
    14. 2011
  14. Kaewkiattiyot,S., Honsawek,S., Vejchapipat,P., Chongsrisawat,V. and Poovorawan,Y.
    Association of X-prolyl aminopeptidase 1 rs17095355 polymorphism with biliary atresia in Thai children
    Hepatol Res (2011) 41, 1249-1252. PubMed  Europe PubMed DOI  M
    15. 2009
  15. Abid,K., Rochat,B., Lassahn,P.G., Stocklin,R., Michalet,S., Brakch,N., Aubert,J.F., Vatansever,B., Tella,P., De Meester,I. and Grouzmann,E.
    Kinetic study of neuropeptide Y (NPY) proteolysis in blood and identification of NPY3-35: a new peptide generated by plasma kallikrein
    J Biol Chem (2009) 284, 24715-24724. PubMed  Europe PubMed DOI  PMC  EPMC  P
    16. 2008
  16. Hsu,Y.T., Su,C.Y., Du,H.C., Jao,S.C. and Li,W.S.
    Evaluation of organophosphorus chemicals-degrading enzymes: a comparison of Escherichia coli and human cytosolic aminopeptidase P
    Chem Biodivers (2008) 5, 1401-1411. PubMed  Europe PubMed DOI
  17. Li,X., Lou,Z., Li,X., Zhou,W., Ma,M., Cao,Y., Geng,Y., Bartlam,M., Zhang,X.C. and Rao,Z.
    Structure of human cytosolic X-prolyl aminopeptidase: a double Mn(II)-dependent dimeric enzyme with a novel three-domain subunit
    J Biol Chem (2008) 283, 22858-22866. PubMed  Europe PubMed DOI  S
    18. 2005
  18. [YEAR:15-3-2005]Ersahin,C., Szpaderska,A.M., Orawski,A.T. and Simmons,W.H.
    Aminopeptidase P isozyme expression in human tissues and peripheral blood mononuclear cell fractions
    Arch Biochem Biophys (15-3-2005) 435, 303-310. PubMed  Europe PubMed DOI
    19. 2004
  19. Turner,A.J. and Cottrell,G.S.
    Aminopeptidase P1
    [ISSN:0-12-079610-4] (2004) 2, 931-933.  V
    20. 2002
  20. [YEAR:15-6-2002]Adam,A., Cugno,M., Molinaro,G., Perez,M., Lepage,Y. and Agostoni,A.
    Aminopeptidase P in individuals with a history of angio-oedema on ACE inhibitors
    Lancet (15-6-2002) 359, 2088-2089. PubMed  Europe PubMed DOI
  21. Kulkarni,G.V. and Deobagkar,D.D.
    A cytosolic form of aminopeptidase P from Drosophila melanogaster: Molecular cloning and characterization
    J Biochem (2002) 131, 445-452. PubMed  Europe PubMed
    22. 2001
  22. [YEAR:24-8-2001]Hauser,F., Strassner,J. and Schaller,A.
    Cloning, expression, and characterization of tomato (Lycopersicon esculentum) aminopeptidase P
    J Biol Chem (24-8-2001) 276, 31732-31737. PubMed  Europe PubMed DOI
    23. 2000
  23. [YEAR:12-12-2000]Cottrell,G.S., Hooper,N.M. and Turner,A.J.
    Cloning, expression, and characterization of human cytosolic aminopeptidase P: a single manganese(II)-dependent enzyme
    Biochemistry (12-12-2000) 39, 15121-15128. PubMed  Europe PubMed DOI  E
  24. [YEAR:1-6-2000]Sprinkle,T.J., Caldwell,C. and Ryan,J.W.
    Cloning, chromosomal sublocalization of the human soluble aminopeptidase P gene (XPNPEP1) to 10q25.3 and conservation of the putative proton shuttle and metal ligand binding sites with XPNPEP2
    Arch Biochem Biophys (1-6-2000) 378, 51-56. PubMed  Europe PubMed DOI
    25. 1999
  25. [YEAR:19-3-1999]Czirjak,G., Burkhart,W.A., Moyer,M.B., Antal,J., Shears,S.B. and Enyedi,P.
    Cloning and functional expression of the cytoplasmic form of rat aminopeptidase P
    Biochim Biophys Acta (19-3-1999) 1444, 326-336. PubMed  Europe PubMed DOI
  26. Gilmartin,L. and O'Cuinn,G.
    Dipeptidyl aminopeptidase IV and aminopeptidase P, two proline specific enzymes from the cytoplasm of guinea-pig brain: their role in metabolism of peptides containing consecutive prolines
    Neurosci Res (1999) 34, 1-11. PubMed  Europe PubMed DOI
    27. 1997
  27. Vanhoof,G., Goossens,F., Juliano,M.A., Juliano,L., Hendriks,D., Schatteman,K., Lin,A.H. and Scharpe,S.
    Isolation and sequence analysis of a human cDNA clone (XPNPEPL) homologous to X-prolyl aminopeptidase (aminopeptidase P)
    Cytogenet Cell Genet (1997) 78, 275-280. PubMed  Europe PubMed
    28. 1992
  28. [YEAR:15-11-1992]Rusu,I. and Yaron,A.
    Aminopeptidase P from human leukocytes
    Eur J Biochem (15-11-1992) 210, 93-100. PubMed  Europe PubMed DOI
  29. Vanhoof,G., De Block,J., De Meester,I., Scharpe,S. and De Potter,W.P.
    Localization and characterization of aminopeptidase P in bovine adrenal medulla
    Neurochem Int (1992) 21, 203-208. PubMed  Europe PubMed DOI
    30. 1991
  30. Harbeck,H.T. and Mentlein,R.
    Aminopeptidase P from rat brain. Purification and action on bioactive peptides
    Eur J Biochem (1991) 198, 451-458. PubMed  Europe PubMed  P
    31. 1987
  31. [YEAR:1-5-1987]Holtzman,E.J., Pillay,G., Rosenthal,T. and Yaron,A.
    Aminopeptidase P activity in rat organs and human serum
    Anal Biochem (1-5-1987) 162, 476-484. PubMed  Europe PubMed

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