Literature for peptidase M24.009: aminopeptidase P1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, M Mutation, P Specificity, K Knockout, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2022

Bae,Y.S., Yoon,S.H., Kim,Y.S., Oh,S.P., Song,W.S., Cha,J.H. and Kim,M.H. Suppression of exaggerated NMDAR activity by memantine treatment ameliorates neurological and behavioral deficits in aminopeptidase P1-deficient mice Exp Mol Med (2022) 54, 1109-1124. PubMed Europe PubMed DOI PMC EPMC
Silva,N., Castellano-Pozo,M., Matsuzaki,K., Barroso,C., Roman-Trufero,M., Craig,H., Brooks,D.R., Isaac,R.E., Boulton,S.J. and Martinez-Perez,E. Proline-specific aminopeptidase P prevents replication-associated genome instability PLoS Genet (2022) 18, e1010025-e1010025. PubMed Europe PubMed DOI PMC EPMC
Zeng,J., Zhang,R., Ning Ma,K., Han,L.L., Yan,S.W., Liu,R.D., Zhang,X., Wang,Z.Q. and Cui,J. Characterization of a novel aminopeptidase P from Trichinella spiralis and its participation in the intrusion of intestinal epithelial cells Exp Parasitol (2022) 242, 108376-108376. PubMed Europe PubMed DOI

2021

Yoon,S.H., Bae,Y.S., Oh,S.P., Song,W.S., Chang,H. and Kim,M.H. Altered hippocampal gene expression, glial cell population, and neuronal excitability in aminopeptidase P1 deficiency Sci Rep (2021) 11, 932-932. PubMed Europe PubMed DOI PMC EPMC
Zeng,J., Zhang,X.Z., Zhang,R., Yan,S.W., Song,Y.Y., Long,S.R., Dan Liu,R., Wang,Z.Q. and Cui,J. Vaccination of mice with recombinant novel aminopeptidase P and cathepsin X alone or in combination induces protective immunity against Trichinella spiralis infection Acta Trop (2021) 224, 106125-106125. PubMed Europe PubMed DOI

2020

Dunaevsky,Y.E., Tereshchenkova,V.F., Oppert,B., Belozersky,M.A., Filippova,I.Y. and Elpidina,E.N. Human proline specific peptidases: a comprehensive analysis Biochim Biophys Acta Gen Subj (2020) 1864, 129636-129636. PubMed Europe PubMed DOI V

2018

Bae,Y.S., Yoon,S.H., Han,J.Y., Woo,J., Cho,Y.S., Kwon,S.K., Bae,Y.C., Kim,D., Kim,E. and Kim,M.H. Deficiency of aminopeptidase P1 causes behavioral hyperactivity, cognitive deficits, and hippocampal neurodegeneration Genes Brain Behav (2018) 17, 126-138. PubMed Europe PubMed DOI M
Chang,H.C., Kung,C.C., Chang,T.T., Jao,S.C., Hsu,Y.T. and Li,W.S. Investigation of the proton relay system operative in human cystosolic aminopeptidase P PLoS ONE (2018) 13, e0190816-e0190816. PubMed Europe PubMed DOI PMC EPMC

2017

Drendel,V., Heckelmann,B., Chen,C.Y., Weisser,J., Espadas,G., Schell,C., Sabido,E., Werner,M., Jilg,C.A. and Schilling,O. Proteome profiling of clear cell renal cell carcinoma in von Hippel-Lindau patients highlights upregulation of Xaa-Pro aminopeptidase-1, an anti-proliferative and anti-migratory exoprotease Oncotarget (2017) 8, 100066-100078. PubMed Europe PubMed DOI PMC EPMC

2015

Hye Khan,M.A., Sharma,A., Rarick,K.R., Roman,R.J., Harder,D.R. and Imig,J.D. Elevated aminopeptidase P attenuates cerebral arterial responses to bradykinin in fawn-hooded hypertensive rats PLoS ONE (2015) 10, e0145335-e0145335. PubMed Europe PubMed DOI I

2012

Cottrell,G.S. and Turner,A.J. Aminopeptidase P1 [ISSN:978-0-12-407743-0] (2012) 3, 1525-1528. DOI
Wu,S., Liu,S., Sim,S. and Pedersen,L.G. Weakly antiferromagentic coupling via superexchange interaction between Mn(II)-Mn(II) atoms: a QM/MM study of the active site of human cytosolic X-propyl aminopeptidase P J Phys Chem Lett (2012) 3, 2293-2297. PubMed Europe PubMed DOI PMC EPMC
Yoon,S.H., Bae,Y.S., Mun,M.S., Park,K.Y., Ye,S.K., Kim,E. and Kim,M.H. Developmental retardation, microcephaly, and peptiduria in mice without aminopeptidase P1 Biochem Biophys Res Commun (2012) 429, 204-209. PubMed Europe PubMed DOI K

2011

Kaewkiattiyot,S., Honsawek,S., Vejchapipat,P., Chongsrisawat,V. and Poovorawan,Y. Association of X-prolyl aminopeptidase 1 rs17095355 polymorphism with biliary atresia in Thai children Hepatol Res (2011) 41, 1249-1252. PubMed Europe PubMed DOI M

2009

Abid,K., Rochat,B., Lassahn,P.G., Stocklin,R., Michalet,S., Brakch,N., Aubert,J.F., Vatansever,B., Tella,P., De Meester,I. and Grouzmann,E. Kinetic study of neuropeptide Y (NPY) proteolysis in blood and identification of NPY3-35: a new peptide generated by plasma kallikrein J Biol Chem (2009) 284, 24715-24724. PubMed Europe PubMed DOI PMC EPMC P

2008

Hsu,Y.T., Su,C.Y., Du,H.C., Jao,S.C. and Li,W.S. Evaluation of organophosphorus chemicals-degrading enzymes: a comparison of Escherichia coli and human cytosolic aminopeptidase P Chem Biodivers (2008) 5, 1401-1411. PubMed Europe PubMed DOI
Li,X., Lou,Z., Li,X., Zhou,W., Ma,M., Cao,Y., Geng,Y., Bartlam,M., Zhang,X.C. and Rao,Z. Structure of human cytosolic X-prolyl aminopeptidase: a double Mn(II)-dependent dimeric enzyme with a novel three-domain subunit J Biol Chem (2008) 283, 22858-22866. PubMed Europe PubMed DOI S

2005

[YEAR:15-3-2005]Ersahin,C., Szpaderska,A.M., Orawski,A.T. and Simmons,W.H. Aminopeptidase P isozyme expression in human tissues and peripheral blood mononuclear cell fractions Arch Biochem Biophys (15-3-2005) 435, 303-310. PubMed Europe PubMed DOI

2004

Turner,A.J. and Cottrell,G.S. Aminopeptidase P1 [ISSN:0-12-079610-4] (2004) 2, 931-933. V

2002

[YEAR:15-6-2002]Adam,A., Cugno,M., Molinaro,G., Perez,M., Lepage,Y. and Agostoni,A. Aminopeptidase P in individuals with a history of angio-oedema on ACE inhibitors Lancet (15-6-2002) 359, 2088-2089. PubMed Europe PubMed DOI
Kulkarni,G.V. and Deobagkar,D.D. A cytosolic form of aminopeptidase P from Drosophila melanogaster: Molecular cloning and characterization J Biochem (2002) 131, 445-452. PubMed Europe PubMed

2001

[YEAR:24-8-2001]Hauser,F., Strassner,J. and Schaller,A. Cloning, expression, and characterization of tomato (Lycopersicon esculentum) aminopeptidase P J Biol Chem (24-8-2001) 276, 31732-31737. PubMed Europe PubMed DOI

2000

[YEAR:12-12-2000]Cottrell,G.S., Hooper,N.M. and Turner,A.J. Cloning, expression, and characterization of human cytosolic aminopeptidase P: a single manganese(II)-dependent enzyme Biochemistry (12-12-2000) 39, 15121-15128. PubMed Europe PubMed DOI E
[YEAR:1-6-2000]Sprinkle,T.J., Caldwell,C. and Ryan,J.W. Cloning, chromosomal sublocalization of the human soluble aminopeptidase P gene (XPNPEP1) to 10q25.3 and conservation of the putative proton shuttle and metal ligand binding sites with XPNPEP2 Arch Biochem Biophys (1-6-2000) 378, 51-56. PubMed Europe PubMed DOI

1999

[YEAR:19-3-1999]Czirjak,G., Burkhart,W.A., Moyer,M.B., Antal,J., Shears,S.B. and Enyedi,P. Cloning and functional expression of the cytoplasmic form of rat aminopeptidase P Biochim Biophys Acta (19-3-1999) 1444, 326-336. PubMed Europe PubMed DOI
Gilmartin,L. and O'Cuinn,G. Dipeptidyl aminopeptidase IV and aminopeptidase P, two proline specific enzymes from the cytoplasm of guinea-pig brain: their role in metabolism of peptides containing consecutive prolines Neurosci Res (1999) 34, 1-11. PubMed Europe PubMed DOI

1997

Vanhoof,G., Goossens,F., Juliano,M.A., Juliano,L., Hendriks,D., Schatteman,K., Lin,A.H. and Scharpe,S. Isolation and sequence analysis of a human cDNA clone (XPNPEPL) homologous to X-prolyl aminopeptidase (aminopeptidase P) Cytogenet Cell Genet (1997) 78, 275-280. PubMed Europe PubMed

1992

[YEAR:15-11-1992]Rusu,I. and Yaron,A. Aminopeptidase P from human leukocytes Eur J Biochem (15-11-1992) 210, 93-100. PubMed Europe PubMed DOI
Vanhoof,G., De Block,J., De Meester,I., Scharpe,S. and De Potter,W.P. Localization and characterization of aminopeptidase P in bovine adrenal medulla Neurochem Int (1992) 21, 203-208. PubMed Europe PubMed DOI

1991

Harbeck,H.T. and Mentlein,R. Aminopeptidase P from rat brain. Purification and action on bioactive peptides Eur J Biochem (1991) 198, 451-458. PubMed Europe PubMed P

1987

[YEAR:1-5-1987]Holtzman,E.J., Pillay,G., Rosenthal,T. and Yaron,A. Aminopeptidase P activity in rat organs and human serum Anal Biochem (1-5-1987) 162, 476-484. PubMed Europe PubMed